Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSJessie Adams, Melissa Feuerborn, Joshua A. Molina, Alexa R. Wilden, Babita Adhikari, Theodore Budden, Stella Y. Lee
ABSTRACTNeuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative lysosomal storage disorders. CLN5 deficiency causes a subtype of NCL, referred to as CLN5 disease. CLN5 is a soluble lysosomal protein with an unclear function in the cell. Increased levels of the autophagy marker protein LC3-II have been reported in several subtypes of NCLs. In this report, we examine whether autophagy is altered in CLN5 disease. We found that the basal level of LC3-II was elevated in both CLN5 disease patient fibroblasts and CLN5-deficient HeLa cells. Further analysis using tandem fluorescent mRFP-GFP-LC3 showed the autophagy flux was increased. We found the alpha-synuclein (α-syn) gene SNCA was highly up-regulated in CLN5 disease patient fibroblasts. The aggregated form of α-syn is well known for its role in the pathogenicity of Parkinson's disease. Higher α-syn protein levels confirmed the SNCA up-regulation in both patient cells and CLN5 knockdown HeLa cells. Furthermore, α-syn was localized to the vicinity of lysosomes in CLN5 deficient cells, indicating it may have a lysosome-related function. Intriguingly, knocking down SNCA reversed lysosomal perinuclear clustering caused by CLN5 deficiency. These results suggest α-syn may affect lysosomal clustering in non-neuronal cells, similar to its role in presynaptic vesicles in neurons. More... »
PAGES151
http://scigraph.springernature.com/pub.10.1038/s41598-018-36379-z
DOIhttp://dx.doi.org/10.1038/s41598-018-36379-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111375519
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30655561
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of South Florida",
"id": "https://www.grid.ac/institutes/grid.170693.a",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA",
"Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 33602, Tampa, FL, USA"
],
"type": "Organization"
},
"familyName": "Adams",
"givenName": "Jessie",
"id": "sg:person.01175333445.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175333445.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Kansas",
"id": "https://www.grid.ac/institutes/grid.266515.3",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA",
"University of Kansas School of Medicine, 66160, Kansas City, KS, USA"
],
"type": "Organization"
},
"familyName": "Feuerborn",
"givenName": "Melissa",
"id": "sg:person.010640630546.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010640630546.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kansas State University",
"id": "https://www.grid.ac/institutes/grid.36567.31",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA"
],
"type": "Organization"
},
"familyName": "Molina",
"givenName": "Joshua A.",
"id": "sg:person.010043250146.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010043250146.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kansas State University",
"id": "https://www.grid.ac/institutes/grid.36567.31",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA"
],
"type": "Organization"
},
"familyName": "Wilden",
"givenName": "Alexa R.",
"id": "sg:person.016546321346.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016546321346.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kansas State University",
"id": "https://www.grid.ac/institutes/grid.36567.31",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA"
],
"type": "Organization"
},
"familyName": "Adhikari",
"givenName": "Babita",
"id": "sg:person.016312356103.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016312356103.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Kansas Medical Center",
"id": "https://www.grid.ac/institutes/grid.412016.0",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA",
"Department of Orthopedic Surgery, University of Kansas Medical Center, 66160, Kansas City, KS, USA"
],
"type": "Organization"
},
"familyName": "Budden",
"givenName": "Theodore",
"id": "sg:person.01165127571.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165127571.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kansas State University",
"id": "https://www.grid.ac/institutes/grid.36567.31",
"name": [
"Division of Biology, Kansas State University, 66506, Manhattan, KS, USA"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Stella Y.",
"id": "sg:person.01233242771.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233242771.82"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1074/jbc.m300227200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000332011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajhg.2011.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001055600"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m208194200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001641761"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0035493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002386351"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajhg.2014.10.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002693673"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddt057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003635894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajhg.2011.06.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006220593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1750-3639.2000.tb00255.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006254443"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m801992200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006846701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(93)80908-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007519583"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e09-09-0801",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008457297"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.06726-11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008599778"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbadis.2006.06.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008781236"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.4787-13.2014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009554920"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.6194-10.2011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009926654"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/jmn:22:3:199",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010639236",
"https://doi.org/10.1385/jmn:22:3:199"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.5575-11.2012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011431693"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.5575-11.2012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011431693"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.201011118",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013113147"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ncb3324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013915833",
"https://doi.org/10.1038/ncb3324"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bpj.2010.07.056",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014897289"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ajmg.1320420428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014930303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ajmg.1320420428",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014930303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2004.11.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015586351"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10059-000-0065-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016050333",
"https://doi.org/10.1007/s10059-000-0065-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnen/59.7.592",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016223561"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005564509027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016576150",
"https://doi.org/10.1023/a:1005564509027"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1994.2816",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016864383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.00592",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017234519"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e02-01-0031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018594598"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2011.06.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023783863"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gene.2014.02.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024167338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.107.5.1643",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024952877"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1129462",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025044407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0074299",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026024090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.3821-06.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026309516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddm289",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028388472"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m602180200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028854132"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddh312",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028995454"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/42166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029460877",
"https://doi.org/10.1038/42166"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/42166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029460877",
"https://doi.org/10.1038/42166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuroscience.2011.08.030",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030718575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0896-6273(95)90302-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032314170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.2575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032787407",
"https://doi.org/10.1038/nn.2575"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.2575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032787407",
"https://doi.org/10.1038/nn.2575"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2009.12.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032907012"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2007.04.108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033813216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/dmm.010140",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033939844"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1195227",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034877229"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m110.213538",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035661814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.nbd.2007.06.012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036837275"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.nbd.2017.01.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037092009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1010554107",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042076070"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-011-0913-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043492028",
"https://doi.org/10.1007/s00018-011-0913-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/brb3.401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044892602"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2004.10.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045932078"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.201003122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046751612"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.0987-13.2013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047562485"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.yexcr.2015.08.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048725365"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2012.11.033",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049441028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ymgme.2011.06.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050676216"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0076-6879(08)04021-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050898975"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m112.418871",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051732717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9440(10)61253-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051824597"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15548627.2015.1100356",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058406632"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddv615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059645784"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e31825f0547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e31825f0547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e31825f0547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0b013e31825f0547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064357037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/auto.27344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072289933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/auto.4451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072290231"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4161/auto.4600",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072290239"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cels.2017.01.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074217155"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.08-08-02804.1988",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079730265"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1994.tb06381.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082668465"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-01716-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085321928",
"https://doi.org/10.1038/s41598-017-01716-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cellsig.2017.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092597279"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative lysosomal storage disorders. CLN5 deficiency causes a subtype of NCL, referred to as CLN5 disease. CLN5 is a soluble lysosomal protein with an unclear function in the cell. Increased levels of the autophagy marker protein LC3-II have been reported in several subtypes of NCLs. In this report, we examine whether autophagy is altered in CLN5 disease. We found that the basal level of LC3-II was elevated in both CLN5 disease patient fibroblasts and CLN5-deficient HeLa cells. Further analysis using tandem fluorescent mRFP-GFP-LC3 showed the autophagy flux was increased. We found the alpha-synuclein (\u03b1-syn) gene SNCA was highly up-regulated in CLN5 disease patient fibroblasts. The aggregated form of \u03b1-syn is well known for its role in the pathogenicity of Parkinson's disease. Higher \u03b1-syn protein levels confirmed the SNCA up-regulation in both patient cells and CLN5 knockdown HeLa cells. Furthermore, \u03b1-syn was localized to the vicinity of lysosomes in CLN5 deficient cells, indicating it may have a lysosome-related function. Intriguingly, knocking down SNCA reversed lysosomal perinuclear clustering caused by CLN5 deficiency. These results suggest \u03b1-syn may affect lysosomal clustering in non-neuronal cells, similar to its role in presynaptic vesicles in neurons.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-018-36379-z",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2437874",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Autophagy\u2013lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease",
"pagination": "151",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"8b5d2e1cd3c2bfaa48e949912cc2af4320e5bd96d3219e44c782c30659bc7d0d"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30655561"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-018-36379-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111375519"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-018-36379-z",
"https://app.dimensions.ai/details/publication/pub.1111375519"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T08:43",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000322_0000000322/records_65008_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-018-36379-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36379-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36379-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36379-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36379-z'
This table displays all metadata directly associated to this object as RDF triples.
345 TRIPLES
21 PREDICATES
100 URIs
21 LITERALS
9 BLANK NODES