Behaviors of Glioblastoma Cells in in Vitro Microenvironments View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Wenwen Diao, Xuezhi Tong, Cheng Yang, Fengrong Zhang, Chun Bao, Hao Chen, Liyu Liu, Ming Li, Fangfu Ye, Qihui Fan, Jiangfei Wang, Zhong-Can Ou-Yang

ABSTRACT

Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, migration, and invasion, some of which were rarely observed before. Furthermore, how the cells invaded into the surrounding ECM and the corresponding specific invasion patterns were observed in details, implying that the four types of cells have different features during their development in cancer. This complex in vitro model, if applied to patient derived cells, possesses the potential of becoming a clinically relevant predictive model. More... »

PAGES

85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7

DOI

http://dx.doi.org/10.1038/s41598-018-36347-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111273917

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30643153


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7'


 

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297 Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, 325001, Wenzhou, China
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.410726.6 schema:alternateName University of Chinese Academy of Sciences
300 schema:name Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, 55 East Zhongguancun Road, 100190, Beijing, China
301 School of Physical Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, 100049, Beijing, China
302 rdf:type schema:Organization
303 https://www.grid.ac/institutes/grid.458438.6 schema:alternateName Institute of Physics
304 schema:name Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China
305 School of Physical Sciences, University of Chinese Academy of Sciences, No. 19A Yuquan Road, 100049, Beijing, China
306 rdf:type schema:Organization
 




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