Behaviors of Glioblastoma Cells in in Vitro Microenvironments View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-14

AUTHORS

Wenwen Diao, Xuezhi Tong, Cheng Yang, Fengrong Zhang, Chun Bao, Hao Chen, Liyu Liu, Ming Li, Fangfu Ye, Qihui Fan, Jiangfei Wang, Zhong-Can Ou-Yang

ABSTRACT

Glioblastoma (GBM) is the most malignant and highly aggressive brain tumor. In this study, four types of typical GBM cell lines (LN229, SNB19, U87, U251) were cultured in a microfabricated 3-D model to study their in vitro behaviors. The 3-D in vitro model provides hollow micro-chamber arrays containing a natural collagen interface and thus allows the GBM cells to grow in the 3-D chambers. The GBM cells in this model showed specific properties on the aspects of cell morphology, proliferation, migration, and invasion, some of which were rarely observed before. Furthermore, how the cells invaded into the surrounding ECM and the corresponding specific invasion patterns were observed in details, implying that the four types of cells have different features during their development in cancer. This complex in vitro model, if applied to patient derived cells, possesses the potential of becoming a clinically relevant predictive model. More... »

PAGES

85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36347-7

DOI

http://dx.doi.org/10.1038/s41598-018-36347-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111273917

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30643153


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