Miniscule differences between sex chromosomes in the giant genome of a salamander View Full Text


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Article Info

DATE

2018-12-14

AUTHORS

Melissa C. Keinath, Nataliya Timoshevskaya, Vladimir A. Timoshevskiy, S. Randal Voss, Jeramiah J. Smith

ABSTRACT

In the Mexican axolotl (Ambystoma mexicanum), sex is determined by a single Mendelian factor, yet its sex chromosomes do not exhibit morphological differentiation typical of many vertebrate taxa that possess a single sex-determining locus. As sex chromosomes are theorized to differentiate rapidly, species with undifferentiated sex chromosomes provide the opportunity to reconstruct early events in sex chromosome evolution. Whole genome sequencing of 48 salamanders, targeted chromosome sequencing and in situ hybridization were used to identify the homomorphic sex chromosome that carries an A. mexicanum sex-determining factor and sequences that are present only on the W chromosome. Altogether, these sequences cover ~300 kb of validated female-specific (W chromosome) sequence, representing ~1/100,000th of the 32 Gb genome. Notably, a recent duplication of ATRX, a gene associated with mammalian sex-determining pathways, is one of few functional (non-repetitive) genes identified among these W-specific sequences. This duplicated gene (ATRW) was used to develop highly predictive markers for diagnosing sex and represents a strong candidate for a recently-acquired sex determining locus (or sexually antagonistic gene) in A. mexicanum. More... »

PAGES

17882

References to SciGraph publications

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  • 2013-03-25. RNA sequencing reveals sexually dimorphic gene expression before gonadal differentiation in chicken and allows comprehensive annotation of the W-chromosome in GENOME BIOLOGY
  • 2017-01-31. Identification of Mutant Genes and Introgressed Tiger Salamander DNA in the Laboratory Axolotl, Ambystoma mexicanum in SCIENTIFIC REPORTS
  • 2018-01-24. The axolotl genome and the evolution of key tissue formation regulators in NATURE
  • 1982-03. Cytogenetics of diploid and triploid salamanders of the Ambystoma jeffersonianum complex in CHROMOSOMA
  • 2014-04-23. Origins and functional evolution of Y chromosomes across mammals in NATURE
  • 2009-03-04. Amphibian sex determination: segregation and linkage analysis using members of the tiger salamander species complex (Ambystoma mexicanum and A. t. tigrinum) in HEREDITY
  • 2012-12-27. SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler in GIGASCIENCE
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  • 2018-01-22. The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution in NATURE GENETICS
  • 2012-04-19. Exploiting sparseness in de novo genome assembly in BMC BIOINFORMATICS
  • 2009-03-04. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome in GENOME BIOLOGY
  • 2005-05-25. Steps in the evolution of heteromorphic sex chromosomes in HEREDITY
  • 2005-12-16. Sal-Site: Integrating new and existing ambystomatid salamander research and informational resources in BMC GENOMICS
  • 2015-11-10. Initial characterization of the large genome of the salamander Ambystoma mexicanum using shotgun and laser capture chromosome sequencing in SCIENTIFIC REPORTS
  • 2011-06-14. ATRX has a critical and conserved role in mammalian sexual differentiation in BMC DEVELOPMENTAL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-36209-2

    DOI

    http://dx.doi.org/10.1038/s41598-018-36209-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110510370

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30552368


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