Mendelian randomization provides support for obesity as a risk factor for meningioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hannah Takahashi, Alex J. Cornish, Amit Sud, Philip J. Law, Linden Disney-Hogg, Lisa Calvocoressi, Lingeng Lu, Helen M. Hansen, Ivan Smirnov, Kyle M. Walsh, Johannes Schramm, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Joellen M. Schildkraut, Matthias Simon, Melissa Bondy, Margaret Wrensch, Joseph L. Wiemels, Elizabeth B. Claus, Clare Turnbull, Richard S. Houlston

ABSTRACT

Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic variants associated with obesity-related traits to assess the relationship with meningioma risk using Mendelian randomization (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. We considered 11 obesity-related traits, identified genetic instruments for these factors, and assessed their association with meningioma risk using data from a genome-wide association study comprising 1,606 meningioma patients and 9,823 controls. To evaluate the causal relationship between the obesity-related traits and meningioma risk, we consider the estimated odds ratio (OR) of meningioma for each genetic instrument. We identified positive associations between body mass index (odds ratio [ORSD] = 1.27, 95% confidence interval [CI] = 1.03-1.56, P = 0.028) and body fat percentage (ORSD = 1.28, 95% CI = 1.01-1.63, P = 0.042) with meningioma risk, albeit non-significant after correction for multiple testing. Associations for basal metabolic rate, diastolic blood pressure, fasting glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, total cholesterol, triglycerides and waist circumference with risk of meningioma were non-significant. Our analysis provides additional support for obesity being associated with an increased risk of meningioma. More... »

PAGES

309

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36186-6

DOI

http://dx.doi.org/10.1038/s41598-018-36186-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111605978

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30670737


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