Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Nguyen Tuan Hiep, Jaeyoung Kwon, Sungeun Hong, Nahyun Kim, Yuanqiang Guo, Bang Yeon Hwang, Woongchon Mar, Dongho Lee

ABSTRACT

Seven pairs of enantiomeric isoflavones (1a/1b-7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively. More... »

PAGES

1757

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36095-8

DOI

http://dx.doi.org/10.1038/s41598-018-36095-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112057958

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30741971


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Analytical Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Biosystems and Biotechnology, College of Life Science and Biotechnology, Korea University, 02841, Seoul, Republic of Korea", 
            "Department of Extraction Technology, Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hiep", 
        "givenName": "Nguyen Tuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Natural Constituents Research Center, Korea Institute of Science and Technology (KIST), 25451, Gangneung, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "Jaeyoung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Natural Products Research Institute, College of Pharmacy, Seoul National University, 151-742, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Sungeun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea Forest Service", 
          "id": "https://www.grid.ac/institutes/grid.418977.4", 
          "name": [
            "Forest Medicinal Resources Research Center, National Institute of Forest Science, 36040, Yeongju, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Nahyun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nankai University", 
          "id": "https://www.grid.ac/institutes/grid.216938.7", 
          "name": [
            "State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 300350, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Yuanqiang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chungbuk National University", 
          "id": "https://www.grid.ac/institutes/grid.254229.a", 
          "name": [
            "College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hwang", 
        "givenName": "Bang Yeon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Natural Products Research Institute, College of Pharmacy, Seoul National University, 151-742, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mar", 
        "givenName": "Woongchon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University", 
          "id": "https://www.grid.ac/institutes/grid.222754.4", 
          "name": [
            "Department of Biosystems and Biotechnology, College of Life Science and Biotechnology, Korea University, 02841, Seoul, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Dongho", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.neuron.2010.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004493689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.phytochem.2014.10.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005873762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbdv.200490164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006868281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tiv.2013.12.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007245414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2004.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008682897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2008.09.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015599635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2013.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016943611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2015.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026150260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2016.01.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026778692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.008276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029234966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2009.00387.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030570975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2009.00387.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030570975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-4949.2009.00387.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030570975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2014.03.067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033502934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1fo10025d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036530110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ptr.5754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036787088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.foodchem.2013.10.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037639707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10715769800300401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038473826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(02)01547-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039122783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2006.08.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041041195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.29.838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043797296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1248/bpb.29.838", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043797296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2008.04.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044833857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2005.08.099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051289542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12263-008-0091-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051986902", 
          "https://doi.org/10.1007/s12263-008-0091-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12263-008-0091-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051986902", 
          "https://doi.org/10.1007/s12263-008-0091-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c0fo00100g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053493871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.jnatprod.6b00204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055100960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00011a006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055698825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np500364x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056233646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-969453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057502220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-969660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057502427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ars.2010.3576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059231400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14737/journal.aavs/2014/2.8.438.446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067355499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/092986711795029735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069162034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3987/com-90-5416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071771037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078148193", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tet.2017.03.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084110574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jff.2017.12.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099923795"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Seven pairs of enantiomeric isoflavones (1a/1b-7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC50 values of 5.5\u2009\u00b5M, 4.0\u2009\u00b5M, and 10.0\u2009\u00b5M, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC50 values of 6.9\u2009\u00b5M, 4.5\u2009\u00b5M, and 9.5\u2009\u00b5M, respectively.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36095-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7502319", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7495856", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata", 
    "pagination": "1757", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5141f07b5dddf751b08d08e3ef654314e97455a72e6473c5444e6f099137230c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30741971"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36095-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112057958"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36095-8", 
      "https://app.dimensions.ai/details/publication/pub.1112057958"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47968_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36095-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36095-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36095-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36095-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36095-8'


 

This table displays all metadata directly associated to this object as RDF triples.

233 TRIPLES      21 PREDICATES      64 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36095-8 schema:about anzsrc-for:03
2 anzsrc-for:0301
3 schema:author Ne305ab9f51254783a54c20a3b96e24ae
4 schema:citation sg:pub.10.1007/s12263-008-0091-4
5 https://app.dimensions.ai/details/publication/pub.1078148193
6 https://doi.org/10.1002/cbdv.200490164
7 https://doi.org/10.1002/ptr.5754
8 https://doi.org/10.1016/j.bmc.2004.01.030
9 https://doi.org/10.1016/j.bmcl.2005.08.099
10 https://doi.org/10.1016/j.bmcl.2006.08.032
11 https://doi.org/10.1016/j.bmcl.2014.03.067
12 https://doi.org/10.1016/j.brainres.2013.07.004
13 https://doi.org/10.1016/j.foodchem.2013.10.095
14 https://doi.org/10.1016/j.ijpharm.2008.09.023
15 https://doi.org/10.1016/j.jff.2017.12.011
16 https://doi.org/10.1016/j.neuint.2015.08.002
17 https://doi.org/10.1016/j.neuint.2016.01.009
18 https://doi.org/10.1016/j.neulet.2008.04.058
19 https://doi.org/10.1016/j.neuron.2010.07.002
20 https://doi.org/10.1016/j.phytochem.2014.10.021
21 https://doi.org/10.1016/j.tet.2017.03.064
22 https://doi.org/10.1016/j.tiv.2013.12.002
23 https://doi.org/10.1016/s0024-3205(02)01547-3
24 https://doi.org/10.1021/acs.jnatprod.6b00204
25 https://doi.org/10.1021/ja00011a006
26 https://doi.org/10.1021/np500364x
27 https://doi.org/10.1039/c0fo00100g
28 https://doi.org/10.1039/c1fo10025d
29 https://doi.org/10.1055/s-2007-969453
30 https://doi.org/10.1055/s-2007-969660
31 https://doi.org/10.1080/10715769800300401
32 https://doi.org/10.1089/ars.2010.3576
33 https://doi.org/10.1111/j.1747-4949.2009.00387.x
34 https://doi.org/10.1242/dmm.008276
35 https://doi.org/10.1248/bpb.29.838
36 https://doi.org/10.14737/journal.aavs/2014/2.8.438.446
37 https://doi.org/10.2174/092986711795029735
38 https://doi.org/10.3987/com-90-5416
39 schema:datePublished 2019-12
40 schema:datePublishedReg 2019-12-01
41 schema:description Seven pairs of enantiomeric isoflavones (1a/1b-7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC<sub>50</sub> values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC<sub>50</sub> values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree true
45 schema:isPartOf N7e40b69f09114d8cbd0104e2f1640bdb
46 Ne4418c4928b44e4f81e55a9a71e6d03e
47 sg:journal.1045337
48 schema:name Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata
49 schema:pagination 1757
50 schema:productId N2d1e64e8f1f741fa9aeb310e28154f2f
51 N546a909a578648219aa3c1d564100673
52 N59adcb6b63154bcfa7aae3850a4ff482
53 Nc9468468a205443ba7a7d7e07a368e61
54 Nf862b37ff7744388bfd37ded39319d5f
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112057958
56 https://doi.org/10.1038/s41598-018-36095-8
57 schema:sdDatePublished 2019-04-11T09:10
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N97f20880092142caad2a626739a06548
60 schema:url https://www.nature.com/articles/s41598-018-36095-8
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N06fa25d8873f43dea8f02ffb6fef7ad8 rdf:first Ned311c86e20843a2b3beeaa77b3627f3
65 rdf:rest Na1c79b9159734a9e8ec37b8660868a97
66 N0d6c811fd47c4ba28938d1980a28001b rdf:first N69a8733900724b568fdc278f2b771b3f
67 rdf:rest N54ebdf7448834508afc27b3dd9131ec6
68 N0eeea8e3b5a7457fbccee1f94b572750 rdf:first N2d8a9871b7b34a678f0fd2a7801664db
69 rdf:rest N06fa25d8873f43dea8f02ffb6fef7ad8
70 N1d2d4c6cf1a448ca89c0c2f38da4f493 schema:affiliation https://www.grid.ac/institutes/grid.222754.4
71 schema:familyName Hiep
72 schema:givenName Nguyen Tuan
73 rdf:type schema:Person
74 N2d1e64e8f1f741fa9aeb310e28154f2f schema:name dimensions_id
75 schema:value pub.1112057958
76 rdf:type schema:PropertyValue
77 N2d8a9871b7b34a678f0fd2a7801664db schema:affiliation https://www.grid.ac/institutes/grid.216938.7
78 schema:familyName Guo
79 schema:givenName Yuanqiang
80 rdf:type schema:Person
81 N37c034ce09e248549277a71e9cdea514 schema:affiliation N5ad400713f1e45bfa5b399a57b8fc84f
82 schema:familyName Kwon
83 schema:givenName Jaeyoung
84 rdf:type schema:Person
85 N546a909a578648219aa3c1d564100673 schema:name pubmed_id
86 schema:value 30741971
87 rdf:type schema:PropertyValue
88 N54ebdf7448834508afc27b3dd9131ec6 rdf:first Nfee9979f33e945c8b0654e736e9b21b8
89 rdf:rest N0eeea8e3b5a7457fbccee1f94b572750
90 N59adcb6b63154bcfa7aae3850a4ff482 schema:name doi
91 schema:value 10.1038/s41598-018-36095-8
92 rdf:type schema:PropertyValue
93 N5ad400713f1e45bfa5b399a57b8fc84f schema:name Natural Constituents Research Center, Korea Institute of Science and Technology (KIST), 25451, Gangneung, Republic of Korea
94 rdf:type schema:Organization
95 N69a8733900724b568fdc278f2b771b3f schema:affiliation https://www.grid.ac/institutes/grid.31501.36
96 schema:familyName Hong
97 schema:givenName Sungeun
98 rdf:type schema:Person
99 N7e40b69f09114d8cbd0104e2f1640bdb schema:volumeNumber 9
100 rdf:type schema:PublicationVolume
101 N93e176ed81e64103b2fbf94f86c9c6b9 rdf:first Ne5529f77edc14c98879ead698e6853cb
102 rdf:rest rdf:nil
103 N97f20880092142caad2a626739a06548 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 Na1c79b9159734a9e8ec37b8660868a97 rdf:first Nd8c82b3bd0e0407fac8f405452a19826
106 rdf:rest N93e176ed81e64103b2fbf94f86c9c6b9
107 Nc9468468a205443ba7a7d7e07a368e61 schema:name nlm_unique_id
108 schema:value 101563288
109 rdf:type schema:PropertyValue
110 Nd5d0a9792955417e98e6d6324dd3477b rdf:first N37c034ce09e248549277a71e9cdea514
111 rdf:rest N0d6c811fd47c4ba28938d1980a28001b
112 Nd8c82b3bd0e0407fac8f405452a19826 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
113 schema:familyName Mar
114 schema:givenName Woongchon
115 rdf:type schema:Person
116 Ne305ab9f51254783a54c20a3b96e24ae rdf:first N1d2d4c6cf1a448ca89c0c2f38da4f493
117 rdf:rest Nd5d0a9792955417e98e6d6324dd3477b
118 Ne4418c4928b44e4f81e55a9a71e6d03e schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 Ne5529f77edc14c98879ead698e6853cb schema:affiliation https://www.grid.ac/institutes/grid.222754.4
121 schema:familyName Lee
122 schema:givenName Dongho
123 rdf:type schema:Person
124 Ned311c86e20843a2b3beeaa77b3627f3 schema:affiliation https://www.grid.ac/institutes/grid.254229.a
125 schema:familyName Hwang
126 schema:givenName Bang Yeon
127 rdf:type schema:Person
128 Nf862b37ff7744388bfd37ded39319d5f schema:name readcube_id
129 schema:value 5141f07b5dddf751b08d08e3ef654314e97455a72e6473c5444e6f099137230c
130 rdf:type schema:PropertyValue
131 Nfee9979f33e945c8b0654e736e9b21b8 schema:affiliation https://www.grid.ac/institutes/grid.418977.4
132 schema:familyName Kim
133 schema:givenName Nahyun
134 rdf:type schema:Person
135 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
136 schema:name Chemical Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
139 schema:name Analytical Chemistry
140 rdf:type schema:DefinedTerm
141 sg:grant.7495856 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36095-8
142 rdf:type schema:MonetaryGrant
143 sg:grant.7502319 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36095-8
144 rdf:type schema:MonetaryGrant
145 sg:journal.1045337 schema:issn 2045-2322
146 schema:name Scientific Reports
147 rdf:type schema:Periodical
148 sg:pub.10.1007/s12263-008-0091-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051986902
149 https://doi.org/10.1007/s12263-008-0091-4
150 rdf:type schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1078148193 schema:CreativeWork
152 https://doi.org/10.1002/cbdv.200490164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006868281
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1002/ptr.5754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036787088
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.bmc.2004.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008682897
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.bmcl.2005.08.099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051289542
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.bmcl.2006.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041041195
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.bmcl.2014.03.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033502934
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.brainres.2013.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016943611
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.foodchem.2013.10.095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037639707
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.ijpharm.2008.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015599635
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.jff.2017.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099923795
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.neuint.2015.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026150260
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.neuint.2016.01.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026778692
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.neulet.2008.04.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044833857
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.neuron.2010.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004493689
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.phytochem.2014.10.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005873762
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.tet.2017.03.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084110574
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.tiv.2013.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007245414
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/s0024-3205(02)01547-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039122783
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1021/acs.jnatprod.6b00204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055100960
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1021/ja00011a006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055698825
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1021/np500364x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056233646
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1039/c0fo00100g schema:sameAs https://app.dimensions.ai/details/publication/pub.1053493871
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1039/c1fo10025d schema:sameAs https://app.dimensions.ai/details/publication/pub.1036530110
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1055/s-2007-969453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057502220
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1055/s-2007-969660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057502427
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1080/10715769800300401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038473826
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1089/ars.2010.3576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059231400
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1747-4949.2009.00387.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030570975
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1242/dmm.008276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029234966
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1248/bpb.29.838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043797296
211 rdf:type schema:CreativeWork
212 https://doi.org/10.14737/journal.aavs/2014/2.8.438.446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067355499
213 rdf:type schema:CreativeWork
214 https://doi.org/10.2174/092986711795029735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162034
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3987/com-90-5416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071771037
217 rdf:type schema:CreativeWork
218 https://www.grid.ac/institutes/grid.216938.7 schema:alternateName Nankai University
219 schema:name State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, 300350, Tianjin, People’s Republic of China
220 rdf:type schema:Organization
221 https://www.grid.ac/institutes/grid.222754.4 schema:alternateName Korea University
222 schema:name Department of Biosystems and Biotechnology, College of Life Science and Biotechnology, Korea University, 02841, Seoul, Republic of Korea
223 Department of Extraction Technology, Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.254229.a schema:alternateName Chungbuk National University
226 schema:name College of Pharmacy, Chungbuk National University, 361-763, Cheongju, Republic of Korea
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
229 schema:name Natural Products Research Institute, College of Pharmacy, Seoul National University, 151-742, Seoul, Republic of Korea
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.418977.4 schema:alternateName Korea Forest Service
232 schema:name Forest Medicinal Resources Research Center, National Institute of Forest Science, 36040, Yeongju, Republic of Korea
233 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...