Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tadashi Inuzuka, Yoshihide Ueda, Soichi Arasawa, Haruhiko Takeda, Tomonori Matsumoto, Yukio Osaki, Shinji Uemoto, Hiroshi Seno, Hiroyuki Marusawa

ABSTRACT

HBV reactivation could be induced under immunosuppressive conditions in patients with resolved infection. This study aimed to clarify the viral factors associated with the pathogenesis of HBV reactivation in association with the immunosuppressive status. Whole HBV genome sequences were determined from the sera of 24 patients with HBV reactivation, including 8 cases under strong immunosuppression mediated by hematopoietic stem cell transplantation (HSCT) and 16 cases without HSCT. Ultra-deep sequencing revealed that the prevalence of genotype B and the ratio of non-synonymous to synonymous evolutionary changes in the surface (S) gene were significantly higher in non-HSCT cases than in patients with HSCT. Those non-synonymous variants included immune escape (6/16 cases) and MHC class II-restricted T-cell epitope variants (6/16 cases). Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region. In conclusion, virologic features of reactivated HBV clones differed depending on the intensity of the immunosuppressive condition. HBV reactivation triggered by immunosuppressive conditions, especially those without HSCT, was characterized by the expansion of variants associated with immune escape, MHC class II-restricted T-cell epitope alterations, and/or impaired virion secretion. More... »

PAGES

18070

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-36093-w

DOI

http://dx.doi.org/10.1038/s41598-018-36093-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110837785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30584239


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Japan Society for the Promotion of Science", 
          "id": "https://www.grid.ac/institutes/grid.54432.34", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "Research Center for Hepatitis and Immunology National Center for Global Health and Medicine, Chiba, Japan", 
            "Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inuzuka", 
        "givenName": "Tadashi", 
        "id": "sg:person.01064237155.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064237155.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Yoshihide", 
        "id": "sg:person.01124604543.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124604543.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arasawa", 
        "givenName": "Soichi", 
        "id": "sg:person.01223204452.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223204452.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Society for the Promotion of Science", 
          "id": "https://www.grid.ac/institutes/grid.54432.34", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeda", 
        "givenName": "Haruhiko", 
        "id": "sg:person.01106635674.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106635674.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Society for the Promotion of Science", 
          "id": "https://www.grid.ac/institutes/grid.54432.34", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Tomonori", 
        "id": "sg:person.0710264117.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710264117.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka Red Cross Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417000.2", 
          "name": [
            "Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Osaki", 
        "givenName": "Yukio", 
        "id": "sg:person.01371557334.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557334.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uemoto", 
        "givenName": "Shinji", 
        "id": "sg:person.01110137562.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110137562.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kyoto University", 
          "id": "https://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seno", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01077750644.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077750644.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka Red Cross Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417000.2", 
          "name": [
            "Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan", 
            "Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marusawa", 
        "givenName": "Hiroyuki", 
        "id": "sg:person.07716522037.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07716522037.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.04.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001942505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1703614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003569798", 
          "https://doi.org/10.1038/sj.bmt.1703614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.7.3262-3270.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003631300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.29022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005007826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510270138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005458362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2002.30903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006282733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.20610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007030657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.27604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009388670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00819-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014322705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbmt.2007.05.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017842158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2016.09.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019732231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022769827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200101043440120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022791059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2012.04.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023432450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01123-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025149986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.04.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027753144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028830986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/civ344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030245981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.00121-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031964934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00905-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032319901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02701-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033604835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2003.50484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036850624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510310232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039428181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2015.06.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039462453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2001.27221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039463531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.3.1059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053368334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/protein/3.5.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059980516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.79.21.13483-13496.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062713277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.29082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074233628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083851566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-00694-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084130805", 
          "https://doi.org/10.1038/s41598-017-00694-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2018.02.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101551831"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "HBV reactivation could be induced under immunosuppressive conditions in patients with resolved infection. This study aimed to clarify the viral factors associated with the pathogenesis of HBV reactivation in association with the immunosuppressive status. Whole HBV genome sequences were determined from the sera of 24 patients with HBV reactivation, including 8 cases under strong immunosuppression mediated by hematopoietic stem cell transplantation (HSCT) and 16 cases without HSCT. Ultra-deep sequencing revealed that the prevalence of genotype B and the ratio of non-synonymous to synonymous evolutionary changes in the surface (S) gene were significantly higher in non-HSCT cases than in patients with HSCT. Those non-synonymous variants included immune escape (6/16 cases) and MHC class II-restricted T-cell epitope variants (6/16 cases). Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region. In conclusion, virologic features of reactivated HBV clones differed depending on the intensity of the immunosuppressive condition. HBV reactivation triggered by immunosuppressive conditions, especially those without HSCT, was characterized by the expansion of variants associated with immune escape, MHC class II-restricted T-cell epitope alterations, and/or impaired virion secretion.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-36093-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6822122", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5580930", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection", 
    "pagination": "18070", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9c2f73f0d064f880f309196ca53bdd572ee8f05a66ec182fd564236dae6abbc9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30584239"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-36093-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1110837785"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-36093-w", 
      "https://app.dimensions.ai/details/publication/pub.1110837785"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000309_0000000309/records_106274_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-36093-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36093-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36093-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36093-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-36093-w'


 

This table displays all metadata directly associated to this object as RDF triples.

236 TRIPLES      21 PREDICATES      61 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-36093-w schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nb047fbab83dc4d36a7431bbd22fdfe45
4 schema:citation sg:pub.10.1038/s41598-017-00694-8
5 sg:pub.10.1038/sj.bmt.1703614
6 https://doi.org/10.1002/hep.21345
7 https://doi.org/10.1002/hep.27604
8 https://doi.org/10.1002/hep.29022
9 https://doi.org/10.1002/hep.29082
10 https://doi.org/10.1002/hep.510270138
11 https://doi.org/10.1002/hep.510310232
12 https://doi.org/10.1002/jmv.20610
13 https://doi.org/10.1016/j.bbmt.2007.05.009
14 https://doi.org/10.1016/j.jcv.2012.04.027
15 https://doi.org/10.1016/j.jhep.2014.04.033
16 https://doi.org/10.1016/j.jhep.2014.04.041
17 https://doi.org/10.1016/j.jhep.2016.09.005
18 https://doi.org/10.1016/j.jhep.2018.02.033
19 https://doi.org/10.1016/j.virol.2015.06.017
20 https://doi.org/10.1053/j.gastro.2017.02.009
21 https://doi.org/10.1053/jhep.2001.27221
22 https://doi.org/10.1053/jhep.2002.30903
23 https://doi.org/10.1053/jhep.2003.50484
24 https://doi.org/10.1056/nejm200101043440120
25 https://doi.org/10.1073/pnas.88.3.1059
26 https://doi.org/10.1093/cid/civ344
27 https://doi.org/10.1093/nar/gkl315
28 https://doi.org/10.1093/protein/3.5.433
29 https://doi.org/10.1128/jcm.00121-06
30 https://doi.org/10.1128/jvi.00819-11
31 https://doi.org/10.1128/jvi.00905-09
32 https://doi.org/10.1128/jvi.01123-15
33 https://doi.org/10.1128/jvi.02701-12
34 https://doi.org/10.1128/jvi.78.7.3262-3270.2004
35 https://doi.org/10.1128/jvi.79.21.13483-13496.2005
36 schema:datePublished 2018-12
37 schema:datePublishedReg 2018-12-01
38 schema:description HBV reactivation could be induced under immunosuppressive conditions in patients with resolved infection. This study aimed to clarify the viral factors associated with the pathogenesis of HBV reactivation in association with the immunosuppressive status. Whole HBV genome sequences were determined from the sera of 24 patients with HBV reactivation, including 8 cases under strong immunosuppression mediated by hematopoietic stem cell transplantation (HSCT) and 16 cases without HSCT. Ultra-deep sequencing revealed that the prevalence of genotype B and the ratio of non-synonymous to synonymous evolutionary changes in the surface (S) gene were significantly higher in non-HSCT cases than in patients with HSCT. Those non-synonymous variants included immune escape (6/16 cases) and MHC class II-restricted T-cell epitope variants (6/16 cases). Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region. In conclusion, virologic features of reactivated HBV clones differed depending on the intensity of the immunosuppressive condition. HBV reactivation triggered by immunosuppressive conditions, especially those without HSCT, was characterized by the expansion of variants associated with immune escape, MHC class II-restricted T-cell epitope alterations, and/or impaired virion secretion.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N21db5c723ac34ce9bb25fc75d190dcba
43 N5851bc322ad5423ba5c4fd6e990c2257
44 sg:journal.1045337
45 schema:name Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection
46 schema:pagination 18070
47 schema:productId N1afbd457da924536b6ee8de7d0ea6bb5
48 N2d90d0659e7f474b8623bda3381dbf0c
49 N57c141e9d52f43de9942899370d4dc50
50 Ne30e9de70bf74ae39d59c641642b79f5
51 Neb84507eca8344b3ae541920c3b84497
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110837785
53 https://doi.org/10.1038/s41598-018-36093-w
54 schema:sdDatePublished 2019-04-11T08:31
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Ndee763a313664d65b0257e190309924b
57 schema:url https://www.nature.com/articles/s41598-018-36093-w
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N1afbd457da924536b6ee8de7d0ea6bb5 schema:name nlm_unique_id
62 schema:value 101563288
63 rdf:type schema:PropertyValue
64 N21db5c723ac34ce9bb25fc75d190dcba schema:issueNumber 1
65 rdf:type schema:PublicationIssue
66 N2d90d0659e7f474b8623bda3381dbf0c schema:name dimensions_id
67 schema:value pub.1110837785
68 rdf:type schema:PropertyValue
69 N57c141e9d52f43de9942899370d4dc50 schema:name doi
70 schema:value 10.1038/s41598-018-36093-w
71 rdf:type schema:PropertyValue
72 N5851bc322ad5423ba5c4fd6e990c2257 schema:volumeNumber 8
73 rdf:type schema:PublicationVolume
74 N834ed5ae6e4e4d8d849925af918366e0 rdf:first sg:person.0710264117.40
75 rdf:rest Nf6469b50b9dd42d68b2f69b779670024
76 N8a316804e1d54fa683167a40ce1a481e rdf:first sg:person.01077750644.53
77 rdf:rest Na2d3a311a2264d6ca18ae19f9d5a6943
78 Na2d3a311a2264d6ca18ae19f9d5a6943 rdf:first sg:person.07716522037.60
79 rdf:rest rdf:nil
80 Nabbb090fdd884874bcdd0808d9f3ee7f rdf:first sg:person.01110137562.01
81 rdf:rest N8a316804e1d54fa683167a40ce1a481e
82 Nacfb176664ef44a08c4ad8fccda1d937 rdf:first sg:person.01124604543.21
83 rdf:rest Necf98eff796b4700a7b4665b33e2136f
84 Nb047fbab83dc4d36a7431bbd22fdfe45 rdf:first sg:person.01064237155.06
85 rdf:rest Nacfb176664ef44a08c4ad8fccda1d937
86 Ndee763a313664d65b0257e190309924b schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 Ne17b092ec0d54c9ba0ebc1a82a21cd64 rdf:first sg:person.01106635674.05
89 rdf:rest N834ed5ae6e4e4d8d849925af918366e0
90 Ne30e9de70bf74ae39d59c641642b79f5 schema:name readcube_id
91 schema:value 9c2f73f0d064f880f309196ca53bdd572ee8f05a66ec182fd564236dae6abbc9
92 rdf:type schema:PropertyValue
93 Neb84507eca8344b3ae541920c3b84497 schema:name pubmed_id
94 schema:value 30584239
95 rdf:type schema:PropertyValue
96 Necf98eff796b4700a7b4665b33e2136f rdf:first sg:person.01223204452.03
97 rdf:rest Ne17b092ec0d54c9ba0ebc1a82a21cd64
98 Nf6469b50b9dd42d68b2f69b779670024 rdf:first sg:person.01371557334.04
99 rdf:rest Nabbb090fdd884874bcdd0808d9f3ee7f
100 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
101 schema:name Medical and Health Sciences
102 rdf:type schema:DefinedTerm
103 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
104 schema:name Immunology
105 rdf:type schema:DefinedTerm
106 sg:grant.5580930 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36093-w
107 rdf:type schema:MonetaryGrant
108 sg:grant.6822122 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-36093-w
109 rdf:type schema:MonetaryGrant
110 sg:journal.1045337 schema:issn 2045-2322
111 schema:name Scientific Reports
112 rdf:type schema:Periodical
113 sg:person.01064237155.06 schema:affiliation https://www.grid.ac/institutes/grid.54432.34
114 schema:familyName Inuzuka
115 schema:givenName Tadashi
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064237155.06
117 rdf:type schema:Person
118 sg:person.01077750644.53 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
119 schema:familyName Seno
120 schema:givenName Hiroshi
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077750644.53
122 rdf:type schema:Person
123 sg:person.01106635674.05 schema:affiliation https://www.grid.ac/institutes/grid.54432.34
124 schema:familyName Takeda
125 schema:givenName Haruhiko
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106635674.05
127 rdf:type schema:Person
128 sg:person.01110137562.01 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
129 schema:familyName Uemoto
130 schema:givenName Shinji
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110137562.01
132 rdf:type schema:Person
133 sg:person.01124604543.21 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
134 schema:familyName Ueda
135 schema:givenName Yoshihide
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124604543.21
137 rdf:type schema:Person
138 sg:person.01223204452.03 schema:affiliation https://www.grid.ac/institutes/grid.258799.8
139 schema:familyName Arasawa
140 schema:givenName Soichi
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223204452.03
142 rdf:type schema:Person
143 sg:person.01371557334.04 schema:affiliation https://www.grid.ac/institutes/grid.417000.2
144 schema:familyName Osaki
145 schema:givenName Yukio
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371557334.04
147 rdf:type schema:Person
148 sg:person.0710264117.40 schema:affiliation https://www.grid.ac/institutes/grid.54432.34
149 schema:familyName Matsumoto
150 schema:givenName Tomonori
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710264117.40
152 rdf:type schema:Person
153 sg:person.07716522037.60 schema:affiliation https://www.grid.ac/institutes/grid.417000.2
154 schema:familyName Marusawa
155 schema:givenName Hiroyuki
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07716522037.60
157 rdf:type schema:Person
158 sg:pub.10.1038/s41598-017-00694-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084130805
159 https://doi.org/10.1038/s41598-017-00694-8
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/sj.bmt.1703614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003569798
162 https://doi.org/10.1038/sj.bmt.1703614
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1002/hep.21345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028830986
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1002/hep.27604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009388670
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/hep.29022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005007826
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/hep.29082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074233628
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/hep.510270138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458362
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1002/hep.510310232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428181
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1002/jmv.20610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007030657
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.bbmt.2007.05.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017842158
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.jcv.2012.04.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023432450
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.jhep.2014.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027753144
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.jhep.2014.04.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001942505
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jhep.2016.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019732231
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jhep.2018.02.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101551831
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.virol.2015.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039462453
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1053/j.gastro.2017.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083851566
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1053/jhep.2001.27221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039463531
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1053/jhep.2002.30903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006282733
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1053/jhep.2003.50484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036850624
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1056/nejm200101043440120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022791059
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1073/pnas.88.3.1059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053368334
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/cid/civ344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030245981
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1093/nar/gkl315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022769827
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/protein/3.5.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059980516
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1128/jcm.00121-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031964934
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1128/jvi.00819-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014322705
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1128/jvi.00905-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032319901
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1128/jvi.01123-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025149986
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1128/jvi.02701-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033604835
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1128/jvi.78.7.3262-3270.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003631300
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1128/jvi.79.21.13483-13496.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062713277
223 rdf:type schema:CreativeWork
224 https://www.grid.ac/institutes/grid.258799.8 schema:alternateName Kyoto University
225 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
226 Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.417000.2 schema:alternateName Osaka Red Cross Hospital
229 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
230 Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan
231 rdf:type schema:Organization
232 https://www.grid.ac/institutes/grid.54432.34 schema:alternateName Japan Society for the Promotion of Science
233 schema:name Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
234 Research Center for Hepatitis and Immunology National Center for Global Health and Medicine, Chiba, Japan
235 Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan
236 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...