Identification of 55,000 Replicated DNA Methylation QTL View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Allan F. McRae, Riccardo E. Marioni, Sonia Shah, Jian Yang, Joseph E. Powell, Sarah E. Harris, Jude Gibson, Anjali K. Henders, Lisa Bowdler, Jodie N. Painter, Lee Murphy, Nicholas G. Martin, John M. Starr, Naomi R. Wray, Ian J. Deary, Peter M. Visscher, Grant W. Montgomery

ABSTRACT

DNA methylation plays an important role in the regulation of transcription. Genetic control of DNA methylation is a potential candidate for explaining the many identified SNP associations with disease that are not found in coding regions. We replicated 52,916 cis and 2,025 trans DNA methylation quantitative trait loci (mQTL) using methylation from whole blood measured on Illumina HumanMethylation450 arrays in the Brisbane Systems Genetics Study (n = 614 from 177 families) and the Lothian Birth Cohorts of 1921 and 1936 (combined n = 1366). The trans mQTL SNPs were found to be over-represented in 1 Mbp subtelomeric regions, and on chromosomes 16 and 19. There was a significant increase in trans mQTL DNA methylation sites in upstream and 5' UTR regions. The genetic heritability of a number of complex traits and diseases was partitioned into components due to mQTL and the remainder of the genome. Significant enrichment was observed for height (p = 2.1 × 10-10), ulcerative colitis (p = 2 × 10-5), Crohn's disease (p = 6 × 10-8) and coronary artery disease (p = 5.5 × 10-6) when compared to a random sample of SNPs with matched minor allele frequency, although this enrichment is explained by the genomic location of the mQTL SNPs. More... »

PAGES

17605

References to SciGraph publications

  • 2012-08. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing in NATURE GENETICS
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2011-06. Genome partitioning of genetic variation for complex traits using common SNPs in NATURE GENETICS
  • 2007-12. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond in BMC GERIATRICS
  • 2015-03. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2014-12. Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type in BMC GENOMICS
  • 2015-02. Genetic studies of body mass index yield new insights for obesity biology in NATURE
  • 2014-07. Biological insights from 108 schizophrenia-associated genetic loci in NATURE
  • 2012-02. A linear complexity phasing method for thousands of genomes in NATURE METHODS
  • 2015-10. Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index in NATURE GENETICS
  • 2014-02. The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts in GENOME BIOLOGY
  • 2002-01. Merlin—rapid analysis of dense genetic maps using sparse gene flow trees in NATURE GENETICS
  • 2012-02. Population-specificity of human DNA methylation in GENOME BIOLOGY
  • 2009-02. DNA methylation profiles in monozygotic and dizygotic twins in NATURE GENETICS
  • 2012-12. Bayesian refinement of association signals for 14 loci in 3 common diseases in NATURE GENETICS
  • 2014-11. Defining the role of common variation in the genomic and biological architecture of adult human height in NATURE GENETICS
  • 2012-01. Dissecting the regulatory architecture of gene expression QTLs in GENOME BIOLOGY
  • 2016-12. Systematic identification of genetic influences on methylation across the human life course in GENOME BIOLOGY
  • 2011-03-06. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease in NATURE GENETICS
  • 2012-09. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes in NATURE GENETICS
  • 2014-02. Genetics of rheumatoid arthritis contributes to biology and drug discovery in NATURE
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2013-12. Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array in EPIGENETICS & CHROMATIN
  • 2011-01. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines in GENOME BIOLOGY
  • 2015-12. Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci in NATURE COMMUNICATIONS
  • 2013-03. DNA methylation dynamics in health and disease in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2014-05. Contribution of genetic variation to transgenerational inheritance of DNA methylation in GENOME BIOLOGY
  • 2012-11. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2010-10. Epigenetic modifications and human disease in NATURE BIOTECHNOLOGY
  • 2016-01. Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci in NATURE NEUROSCIENCE
  • 2015-11. Partitioning heritability by functional annotation using genome-wide association summary statistics in NATURE GENETICS
  • 2012-12. Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects in BMC GENOMICS
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    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-35871-w

    DOI

    http://dx.doi.org/10.1038/s41598-018-35871-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110288661

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30514905


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    433 schema:name Alzheimer Scotland Dementia Research Centre, University of Edinburgh, EH8 9JZ, Edinburgh, UK
    434 Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK
    435 Department of Psychology, University of Edinburgh, EH8 9JZ, Edinburgh, UK
    436 Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU, Edinburgh, UK
    437 Queensland Brain Institute, The University of Queensland, 4072, Brisbane, QLD, Australia
    438 The Institute for Molecular Bioscience, The University of Queensland, 4072, Brisbane, QLD, Australia
    439 rdf:type schema:Organization
     




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