Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSCarlijn R. Hooijmans, Martin Hlavica, Florian A. F. Schuler, Nicolas Good, Andrin Good, Lisa Baumgartner, Gianluca Galeno, Marc P. Schneider, Tarzis Jung, Rob de Vries, Benjamin V. Ineichen
ABSTRACTAn unmet but urgent medical need is the development of myelin repair promoting therapies for Multiple Sclerosis (MS). Many such therapies have been pre-clinically tested using different models of toxic demyelination such as cuprizone, ethidium bromide, or lysolecithin and some of the therapies already entered clinical trials. However, keeping track on all these possible new therapies and their efficacy has become difficult with the increasing number of studies. In this study, we aimed at summarizing the current evidence on such therapies through a systematic review and at providing an estimate of the effects of tested interventions by a meta-analysis. We show that 88 different therapies have been pre-clinically tested for remyelination. 25 of them (28%) entered clinical trials. Our meta-analysis also identifies 16 promising therapies which did not enter a clinical trial for MS so far, among them Pigment epithelium-derived factor, Plateled derived growth factor, and Tocopherol derivate TFA-12.We also show that failure in bench to bedside translation from certain therapies may in part be attributable to poor study quality. By addressing these problems, clinical translation might be smoother and possibly animal numbers could be reduced. More... »
PAGES822
http://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4
DOIhttp://dx.doi.org/10.1038/s41598-018-35734-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111747640
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30696832
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE), Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Hooijmans",
"givenName": "Carlijn R.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Hlavica",
"givenName": "Martin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Swiss Federal Institute of Technology in Zurich",
"id": "https://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland",
"Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"
],
"type": "Organization"
},
"familyName": "Schuler",
"givenName": "Florian A. F.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Good",
"givenName": "Nicolas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Good",
"givenName": "Andrin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Baumgartner",
"givenName": "Lisa",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Galeno",
"givenName": "Gianluca",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Schneider",
"givenName": "Marc P.",
"type": "Person"
},
{
"affiliation": {
"name": [
"Waidspital Zurich, Department of Radiology, Tiechestrasse 99, 8037, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Jung",
"givenName": "Tarzis",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE), Department of Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "de Vries",
"givenName": "Rob",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zurich",
"id": "https://www.grid.ac/institutes/grid.7400.3",
"name": [
"Brain Research Institute, University of Zurich and Department of Health Sciences and Technology, 8057 Zurich, ETH Zurich, Switzerland",
"Waidspital Zurich, Department of Radiology, Tiechestrasse 99, 8037, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Ineichen",
"givenName": "Benjamin V.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.nbd.2014.08.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000836954"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neulet.2016.12.057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003519292"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-016-1631-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004296822",
"https://doi.org/10.1007/s00401-016-1631-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-016-1631-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004296822",
"https://doi.org/10.1007/s00401-016-1631-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-444-52001-2.00008-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005351527"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(11)70144-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010583559"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1352458510379612",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011223530"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1352458510379612",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011223530"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1352458510379612",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011223530"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jnr.20763",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011553846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jnr.20763",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011553846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2005.09.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012474806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuron.2005.09.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012474806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1000412",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013958828"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.phrs.2014.03.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017813827"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-009-0591-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018098897",
"https://doi.org/10.1007/s00401-009-0591-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-009-0591-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018098897",
"https://doi.org/10.1007/s00401-009-0591-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00401-009-0591-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018098897",
"https://doi.org/10.1007/s00401-009-0591-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1590/s0004-282x2011000300021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018386804"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1025747832215",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019112021",
"https://doi.org/10.1023/a:1025747832215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(13)62242-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019906430"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/nan.12373",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020623694"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021323608",
"https://doi.org/10.1038/nm1279"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021323608",
"https://doi.org/10.1038/nm1279"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021323608",
"https://doi.org/10.1038/nm1279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.20769",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022230915"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1606468",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024224305"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01102943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025537245",
"https://doi.org/10.1007/bf01102943"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01102943",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025537245",
"https://doi.org/10.1007/bf01102943"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nn.2172",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025905692",
"https://doi.org/10.1038/nn.2172"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1472-6882-12-209",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026849083",
"https://doi.org/10.1186/1472-6882-12-209"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn3475",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027727146",
"https://doi.org/10.1038/nrn3475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000254462.75851.22",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028796649"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000254462.75851.22",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028796649"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.20441",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029733444"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/brain/121.12.2221",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029775345"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/brain/awf031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031219742"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2353/ajpath.2009.080947",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031320687"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12031-013-0026-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032489054",
"https://doi.org/10.1007/s12031-013-0026-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2008.101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034348098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2008.101",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034348098"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.immunol.23.021704.115707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035328244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.22547",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036989657"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2990.1979.tb00613.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038047210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1002333",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040242792"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1098-1136(19990201)25:3<216::aid-glia2>3.0.co;2-l",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040316472"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/j.pain.0000000000000296",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040811273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/j.pain.0000000000000296",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040811273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.410270603",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041059093"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-540-73677-6_8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041270072",
"https://doi.org/10.1007/978-3-540-73677-6_8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-540-73677-6_8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041270072",
"https://doi.org/10.1007/978-3-540-73677-6_8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/brain/awl075",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041929577"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041938674",
"https://doi.org/10.1038/nature09614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09614",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041938674",
"https://doi.org/10.1038/nature09614"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2288-14-43",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042142092",
"https://doi.org/10.1186/1471-2288-14-43"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pathophys.2010.04.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043584849"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jnr.10338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043894683"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pds.3692",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045673682"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pneurobio.2012.11.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046729623"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/sim.1186",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047418980"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/stem.480",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047703361"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2990.1997.tb01185.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047718346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mcn.2003.10.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048944200"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(99)04149-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049432046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa010994",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053291936"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s40263-017-0407-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053988991",
"https://doi.org/10.1007/s40263-017-0407-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s40263-017-0407-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053988991",
"https://doi.org/10.1007/s40263-017-0407-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.20-17-06404.2000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074691705"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075317573",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079665066",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080286257",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080841823",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(17)30113-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085909341"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.24260",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091501163"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn.2017.136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092710806",
"https://doi.org/10.1038/nrn.2017.136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bcp.2017.12.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099675558"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0187271",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100338194"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "An unmet but urgent medical need is the development of myelin repair promoting therapies for Multiple Sclerosis (MS). Many such therapies have been pre-clinically tested using different models of toxic demyelination such as cuprizone, ethidium bromide, or lysolecithin and some of the therapies already entered clinical trials. However, keeping track on all these possible new therapies and their efficacy has become difficult with the increasing number of studies. In this study, we aimed at summarizing the current evidence on such therapies through a systematic review and at providing an estimate of the effects of tested interventions by a meta-analysis. We show that 88 different therapies have been pre-clinically tested for remyelination. 25 of them (28%) entered clinical trials. Our meta-analysis also identifies 16 promising therapies which did not enter a clinical trial for MS so far, among them Pigment epithelium-derived factor, Plateled derived growth factor, and Tocopherol derivate TFA-12.We also show that failure in bench to bedside translation from certain therapies may in part be attributable to poor study quality. By addressing these problems, clinical translation might be smoother and possibly animal numbers could be reduced.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-018-35734-4",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis",
"pagination": "822",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"58d7f945f432d706395234dc9c49307b5cab593888fbbad77d226d89f07e575c"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30696832"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-018-35734-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111747640"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-018-35734-4",
"https://app.dimensions.ai/details/publication/pub.1111747640"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T08:59",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68477_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-018-35734-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4'
This table displays all metadata directly associated to this object as RDF triples.
330 TRIPLES
21 PREDICATES
90 URIs
21 LITERALS
9 BLANK NODES