Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Carlijn R. Hooijmans, Martin Hlavica, Florian A. F. Schuler, Nicolas Good, Andrin Good, Lisa Baumgartner, Gianluca Galeno, Marc P. Schneider, Tarzis Jung, Rob de Vries, Benjamin V. Ineichen

ABSTRACT

An unmet but urgent medical need is the development of myelin repair promoting therapies for Multiple Sclerosis (MS). Many such therapies have been pre-clinically tested using different models of toxic demyelination such as cuprizone, ethidium bromide, or lysolecithin and some of the therapies already entered clinical trials. However, keeping track on all these possible new therapies and their efficacy has become difficult with the increasing number of studies. In this study, we aimed at summarizing the current evidence on such therapies through a systematic review and at providing an estimate of the effects of tested interventions by a meta-analysis. We show that 88 different therapies have been pre-clinically tested for remyelination. 25 of them (28%) entered clinical trials. Our meta-analysis also identifies 16 promising therapies which did not enter a clinical trial for MS so far, among them Pigment epithelium-derived factor, Plateled derived growth factor, and Tocopherol derivate TFA-12.We also show that failure in bench to bedside translation from certain therapies may in part be attributable to poor study quality. By addressing these problems, clinical translation might be smoother and possibly animal numbers could be reduced. More... »

PAGES

822

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-35734-4

DOI

http://dx.doi.org/10.1038/s41598-018-35734-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111747640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30696832


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