Nutraceutical profile and evidence of alleviation of oxidative stress by Spirogyra porticalis (Muell.) Cleve inhabiting the high altitude Trans-Himalayan Region View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jatinder Kumar, Shahanshah Khan, S. K. Mandotra, Priyanka Dhar, Amol B. Tayade, Sheetal Verma, Kiran Toppo, Rajesh Arora, Dalip K. Upreti, Om P. Chaurasia

ABSTRACT

The high altitude trans-Himalayan region indeed is hostile domain for survival. Algae inhabiting this hostile terrain have evolutionarily developed mechanisms to produce unique adaptogenic molecules against climatic stressors. The present study has focused on the high altitude alga Spirogyra porticalis (Muell.) Cleve- a filamentous Charophyte, and reports the estimation of amino acids (AAs), fatty acids (FAs), vitamins and their efficacy against oxidative stress. Reverse phase-HPLC, GC-FID and rapid resolution-LC/tandem mass spectrometry were used for analysis of AAs, FAs and vitamins. Analysis of the alga revealed the presence of 19 AAs (239.51 ± 8.57 to 13102.40 ± 11.08 µg/g), dominated by alanine, proline and lysine. Enriched phenylalanine, cysteine-HCl and high lysine:arginine ratio could also have beneficial impact against hypoxia -induced cognitive impairment. A total of 9 FAs were detected (0.43 ± 0.00% to 34.76 ± 0.52%). Polyunsaturated and monounsaturated FAs were found to be dominant. The alga showed the presence of 8 vitamins within the range of 39.654 ± 3.198 to 5468.184 ± 106.859 µg/Kg, wherein Vitamin B5, B3 and B2 were dominant. 600 µg/ml of methanolic extract showed recovery of GSH and trolox equivalent antioxidants in rat blood/hemolysate, while 400 µg/ml of extract showed revival in superoxide dismutase (SOD) activity. The present study concludes that the alga S. porticalis has immense potential to counter oxidative stress as a nutraceutical supplement. More... »

PAGES

4091

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-35595-x

DOI

http://dx.doi.org/10.1038/s41598-018-35595-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112675343

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30858387


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275 https://www.grid.ac/institutes/grid.417642.2 schema:alternateName National Botanical Research Institute
276 schema:name National Botanical Research Institute, Rana Pratap Marg, 226 001, Lucknow, Uttar Pradesh, India
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278 https://www.grid.ac/institutes/grid.418939.e schema:alternateName Defence Institute of Physiology and Allied Sciences
279 schema:name Department of Phyto Analytical Chemistry and Toxicology; Nutrition, Biochemistry, Exercise Physiology and Yoga, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Delhi, India
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281 https://www.grid.ac/institutes/grid.440710.6 schema:alternateName Shri Mata Vaishno Devi University
282 schema:name Shri Mata Vaishno Devi University, 182 320, Katra, Jammu & Kashmir, India
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