C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Kiat Hwa Chan, Wei Hao Lee, Ming Ni, Yihua Loo, Charlotte A. E. Hauser

ABSTRACT

Single molecular changes on a tripeptide can have dramatic effects on their self-assembly and hydrogelation. Herein, we explore C-terminal residue variation on two consistent ultrashort peptide backbones, i.e. acetylated-Leu-Ile-Val-Ala-Gly-Xaa and acetylated-Ile-Val-Xaa (Xaa = His, Arg, Asn). The objective of this study is to identify candidates that can form hydrogels for small-molecule drug (SMD) delivery. Haemolysis and cytotoxicity (with human adipose-derived mesenchymal stem cells) assays showed that the new soluble peptides (Xaa = His, Arg) are cytocompatible. Gelation studies showed that all but acetylated-Ile-Val-Arg could gel under physiological conditions. Longer peptidic backbones drive self-assembly more effectively as reflected in field emission scanning electron microscopy (FESEM) and circular dichroism spectroscopy studies. Rheological studies revealed that the resultant hydrogels have varying stiffness and yield stress, depending on the backbone and C-terminal residue. Visible spectroscopy-based elution studies with SMDs (naltrexone, methotrexate, doxorubicin) showed that besides the C-terminal residue, the shape of the SMD also determines the rate and extent of SMD elution. Based on the elution assays, infrared spectroscopy, and FESEM, we propose models for the peptide fibril-SMD interaction. Our findings highlight the importance of matching the molecular properties of the self-assembling peptide and SMD in order to achieve the desired SMD release profile. More... »

PAGES

17127

References to SciGraph publications

  • 2017-08. Sulfated glycopeptide nanostructures for multipotent protein activation in NATURE NANOTECHNOLOGY
  • 2002-07. Neurodegenerative disease: Amyloid pores from pathogenic mutations in NATURE
  • 2015-01. Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels in NATURE CHEMISTRY
  • 2007-10-31. Measurement of the red blood cell lysis by bacterial hemolysin in PROTOCOL EXCHANGE
  • 2011-02. Apolipoproteins and amyloid fibril formation in atherosclerosis in PROTEIN & CELL
  • 2010-03. Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils—current status in CHEMISTRY CENTRAL JOURNAL
  • 2015-09. Activity of Novel Synthetic Peptides against Candida albicans in SCIENTIFIC REPORTS
  • 2016-12. Designing hydrogels for controlled drug delivery in NATURE REVIEWS MATERIALS
  • 2013-12. The multiple roles of histidine in protein interactions in CHEMISTRY CENTRAL JOURNAL
  • 2003-10. Fabrication of novel biomaterials through molecular self-assembly in NATURE BIOTECHNOLOGY
  • 2011-08-02. Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering in PEPTIDE-BASED MATERIALS
  • 2017-12. Systematic Moiety Variations of Ultrashort Peptides Produce Profound Effects on Self-Assembly, Nanostructure Formation, Hydrogelation, and Phase Transition in SCIENTIFIC REPORTS
  • 1998-07. β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy in NATURE MEDICINE
  • 2011-07. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation in NATURE
  • 2018-02. Structure-based inhibitors of tau aggregation in NATURE CHEMISTRY
  • 2012-08. Room-temperature ferroelectricity in supramolecular networks of charge-transfer complexes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-35431-2

    DOI

    http://dx.doi.org/10.1038/s41598-018-35431-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109946089

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30459362


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Macromolecular and Materials Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Yale-NUS College", 
              "id": "https://www.grid.ac/institutes/grid.463064.3", 
              "name": [
                "Division of Science, Yale-NUS College, 16 College Avenue West, 138527, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Kiat Hwa", 
            "id": "sg:person.01362361265.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362361265.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Department of Chemistry, Krieger School of Arts & Sciences, 3400 North Charles Street, Johns Hopkins University, Baltimore, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Wei Hao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "School of Biological Sciences & Engineering, Yachay Tech University, Hacienda San Jos\u00e9 s/n, 100105, San Miguel de Urcuqu\u00ed, Ecuador"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ni", 
            "givenName": "Ming", 
            "id": "sg:person.0707432143.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707432143.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Bioengineering and Nanotechnology", 
              "id": "https://www.grid.ac/institutes/grid.418830.6", 
              "name": [
                "Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, 138669, Singapore, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loo", 
            "givenName": "Yihua", 
            "id": "sg:person.01030377744.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030377744.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "King Abdullah University of Science and Technology", 
              "id": "https://www.grid.ac/institutes/grid.45672.32", 
              "name": [
                "Laboratory for Nanomedicine, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Saudi Arabia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hauser", 
            "givenName": "Charlotte A. E.", 
            "id": "sg:person.011115364220.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011115364220.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1039/b605536m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001002222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2008.11.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001061933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3ra40598b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001553749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/masy.200551128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001608573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/masy.200551128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001608573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c1cs15180k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001651153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.1050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003058147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.272.19.12601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003216996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jchromb.2011.03.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003657911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0734-9750(02)00026-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004975025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0734-9750(02)00026-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004975025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006452361", 
              "https://doi.org/10.1038/nature11395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.12.6728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006965450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0000190", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007349362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.25.15458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007670583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.112193999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009366710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/128_2011_206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010236404", 
              "https://doi.org/10.1007/128_2011_206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/128_2011_206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010236404", 
              "https://doi.org/10.1007/128_2011_206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar3002969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011217393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418291a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011410794", 
              "https://doi.org/10.1038/418291a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/418291a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011410794", 
              "https://doi.org/10.1038/418291a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.072089599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011917181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.17.9459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012555403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1217742110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013449069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1014796108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013544439"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1003718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016060410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp8110474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016307744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp8110474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016307744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.360250307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016500038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2302/kjm.54.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016547538"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2042-7158.2012.01567.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016684884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b919449p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018297326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/b919449p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018297326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-2952(03)00468-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018564899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2006.06.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022870441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms160511766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022922578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.4550102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023663630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3sc51930a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023927114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/star.200300242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024372895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2007.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024520555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025200827", 
              "https://doi.org/10.1038/nbt874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025200827", 
              "https://doi.org/10.1038/nbt874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0407843102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026742377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265074.83288.09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026893896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265074.83288.09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026893896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.142309999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028430147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1367-5931(02)00391-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029597674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1367-5931(02)00391-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029597674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2008.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032037617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2009.09.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032390750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/natrevmats.2016.71", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033293457", 
              "https://doi.org/10.1038/natrevmats.2016.71"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cplu.201402120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033709689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2014.02.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034730323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcc.21212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035008356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jmb.2008.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035922901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/17425247.2012.642362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037913218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1445-2197.2009.04852.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038438266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1445-2197.2009.04852.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038438266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0798-822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038769601", 
              "https://doi.org/10.1038/nm0798-822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja904411z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039293339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja904411z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039293339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2014.04.102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039908186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1063187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040112811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c5cs00470e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040963286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.nanolett.5b02859", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041322156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13238-011-1013-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041730600", 
              "https://doi.org/10.1007/s13238-011-1013-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13238-011-1013-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041730600", 
              "https://doi.org/10.1007/s13238-011-1013-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12154-009-0027-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042648616", 
              "https://doi.org/10.1007/s12154-009-0027-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12154-009-0027-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042648616", 
              "https://doi.org/10.1007/s12154-009-0027-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0807506106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043555292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/chem.201602624", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046537554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046762856", 
              "https://doi.org/10.1038/nchem.2122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046762856", 
              "https://doi.org/10.1038/nchem.2122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja991755c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047741047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja991755c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047741047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c3nr06752a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048629003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep09657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049976206", 
              "https://doi.org/10.1038/srep09657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biomaterials.2010.08.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051795768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052435615", 
              "https://doi.org/10.1038/nature10154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-153x-7-44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052570661", 
              "https://doi.org/10.1186/1752-153x-7-44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.chemmater.6b01367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053746800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00465a022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055177312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm900544e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055224390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm900544e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055224390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja00265a036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055718737"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja028539f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055831759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja028539f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055831759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja7109822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055857531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja7109822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055857531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja9042142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055861645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja9042142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055861645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja905539h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055861996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja905539h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055861996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja908560n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055862755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ja908560n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055862755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056464397", 
              "https://doi.org/10.1038/nprot.2007.483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1088/0957-4484/27/40/402002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059117641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5246.163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062551966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.13172/2052-9643-1-1-787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065007823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ijn.s126154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083763204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.accounts.6b00553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083803885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jacs.7b00847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084126023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/acs.biochem.7b00035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084818693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2017.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086070663", 
              "https://doi.org/10.1038/nnano.2017.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nnano.2017.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086070663", 
              "https://doi.org/10.1038/nnano.2017.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41598-017-12694-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092092336", 
              "https://doi.org/10.1038/s41598-017-12694-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchem.2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092795271", 
              "https://doi.org/10.1038/nchem.2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c7cs00827a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101315983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c8cs00177d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103945558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/bem-2018-0003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104239460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/bem-2018-0003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104239460"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Single molecular changes on a tripeptide can have dramatic effects\u00a0on their self-assembly and hydrogelation. Herein, we explore C-terminal residue variation on two consistent ultrashort peptide backbones, i.e. acetylated-Leu-Ile-Val-Ala-Gly-Xaa and acetylated-Ile-Val-Xaa (Xaa\u2009=\u2009His, Arg, Asn). The objective of this study is to identify candidates that can form hydrogels for small-molecule drug (SMD) delivery. Haemolysis and cytotoxicity (with human adipose-derived mesenchymal stem cells) assays showed that the new soluble peptides (Xaa\u2009=\u2009His, Arg) are cytocompatible. Gelation studies showed that all but acetylated-Ile-Val-Arg could gel under physiological conditions. Longer peptidic backbones drive self-assembly more effectively as reflected in field emission scanning electron microscopy (FESEM) and circular dichroism spectroscopy studies. Rheological studies revealed that the resultant hydrogels have varying stiffness and yield stress, depending on the backbone and C-terminal residue. Visible spectroscopy-based elution studies with SMDs (naltrexone, methotrexate, doxorubicin) showed that besides the C-terminal residue, the shape of the SMD also determines the rate and extent of SMD elution. Based on the elution assays, infrared spectroscopy, and FESEM, we propose models for the peptide fibril-SMD interaction. Our findings highlight the importance of matching the molecular properties of the self-assembling peptide and SMD in order to achieve the desired SMD release profile.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-35431-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs", 
        "pagination": "17127", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5d63e72ec0d8721d2272466dfb90fc54ff186353b948b5b4e0ab9f81992a5720"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30459362"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-35431-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1109946089"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-35431-2", 
          "https://app.dimensions.ai/details/publication/pub.1109946089"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000278_0000000278/records_79653_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-35431-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35431-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35431-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35431-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35431-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    386 TRIPLES      21 PREDICATES      117 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-35431-2 schema:about anzsrc-for:03
    2 anzsrc-for:0303
    3 schema:author N50bca23e588245d9ac8f98e3270f4b54
    4 schema:citation sg:pub.10.1007/128_2011_206
    5 sg:pub.10.1007/s12154-009-0027-5
    6 sg:pub.10.1007/s13238-011-1013-6
    7 sg:pub.10.1038/418291a
    8 sg:pub.10.1038/natrevmats.2016.71
    9 sg:pub.10.1038/nature10154
    10 sg:pub.10.1038/nature11395
    11 sg:pub.10.1038/nbt874
    12 sg:pub.10.1038/nchem.2122
    13 sg:pub.10.1038/nchem.2889
    14 sg:pub.10.1038/nm0798-822
    15 sg:pub.10.1038/nnano.2017.109
    16 sg:pub.10.1038/nprot.2007.483
    17 sg:pub.10.1038/s41598-017-12694-9
    18 sg:pub.10.1038/srep09657
    19 sg:pub.10.1186/1752-153x-7-44
    20 https://doi.org/10.1002/bip.360250307
    21 https://doi.org/10.1002/chem.201602624
    22 https://doi.org/10.1002/cplu.201402120
    23 https://doi.org/10.1002/jcc.21212
    24 https://doi.org/10.1002/masy.200551128
    25 https://doi.org/10.1002/prot.1050
    26 https://doi.org/10.1002/star.200300242
    27 https://doi.org/10.1016/j.biomaterials.2008.11.019
    28 https://doi.org/10.1016/j.biomaterials.2010.08.047
    29 https://doi.org/10.1016/j.biomaterials.2014.02.047
    30 https://doi.org/10.1016/j.biomaterials.2014.04.102
    31 https://doi.org/10.1016/j.jaad.2007.01.007
    32 https://doi.org/10.1016/j.jchromb.2011.03.043
    33 https://doi.org/10.1016/j.jconrel.2006.06.031
    34 https://doi.org/10.1016/j.jmb.2008.11.006
    35 https://doi.org/10.1016/j.jmb.2009.09.056
    36 https://doi.org/10.1016/j.jsb.2008.02.002
    37 https://doi.org/10.1016/s0006-2952(03)00468-4
    38 https://doi.org/10.1016/s0734-9750(02)00026-5
    39 https://doi.org/10.1016/s1367-5931(02)00391-5
    40 https://doi.org/10.1021/acs.accounts.6b00553
    41 https://doi.org/10.1021/acs.biochem.7b00035
    42 https://doi.org/10.1021/acs.chemmater.6b01367
    43 https://doi.org/10.1021/acs.nanolett.5b02859
    44 https://doi.org/10.1021/ar3002969
    45 https://doi.org/10.1021/bi00465a022
    46 https://doi.org/10.1021/bm900544e
    47 https://doi.org/10.1021/ja00265a036
    48 https://doi.org/10.1021/ja028539f
    49 https://doi.org/10.1021/ja7109822
    50 https://doi.org/10.1021/ja9042142
    51 https://doi.org/10.1021/ja904411z
    52 https://doi.org/10.1021/ja905539h
    53 https://doi.org/10.1021/ja908560n
    54 https://doi.org/10.1021/ja991755c
    55 https://doi.org/10.1021/jacs.7b00847
    56 https://doi.org/10.1021/jp8110474
    57 https://doi.org/10.1039/b605536m
    58 https://doi.org/10.1039/b919449p
    59 https://doi.org/10.1039/c1cs15180k
    60 https://doi.org/10.1039/c3nr06752a
    61 https://doi.org/10.1039/c3ra40598b
    62 https://doi.org/10.1039/c3sc51930a
    63 https://doi.org/10.1039/c5cs00470e
    64 https://doi.org/10.1039/c7cs00827a
    65 https://doi.org/10.1039/c8cs00177d
    66 https://doi.org/10.1073/pnas.0407843102
    67 https://doi.org/10.1073/pnas.072089599
    68 https://doi.org/10.1073/pnas.0807506106
    69 https://doi.org/10.1073/pnas.1014796108
    70 https://doi.org/10.1073/pnas.112193999
    71 https://doi.org/10.1073/pnas.1217742110
    72 https://doi.org/10.1073/pnas.142309999
    73 https://doi.org/10.1073/pnas.96.17.9459
    74 https://doi.org/10.1073/pnas.97.12.6728
    75 https://doi.org/10.1074/jbc.272.19.12601
    76 https://doi.org/10.1074/jbc.273.25.15458
    77 https://doi.org/10.1088/0957-4484/27/40/402002
    78 https://doi.org/10.1110/ps.4550102
    79 https://doi.org/10.1111/j.1445-2197.2009.04852.x
    80 https://doi.org/10.1111/j.2042-7158.2012.01567.x
    81 https://doi.org/10.1126/science.1063187
    82 https://doi.org/10.1126/science.271.5246.163
    83 https://doi.org/10.1161/01.res.0000265074.83288.09
    84 https://doi.org/10.13172/2052-9643-1-1-787
    85 https://doi.org/10.1371/journal.pcbi.1003718
    86 https://doi.org/10.1371/journal.pone.0000190
    87 https://doi.org/10.1517/17425247.2012.642362
    88 https://doi.org/10.2147/ijn.s126154
    89 https://doi.org/10.2217/bem-2018-0003
    90 https://doi.org/10.2302/kjm.54.132
    91 https://doi.org/10.3390/ijms160511766
    92 schema:datePublished 2018-12
    93 schema:datePublishedReg 2018-12-01
    94 schema:description Single molecular changes on a tripeptide can have dramatic effects on their self-assembly and hydrogelation. Herein, we explore C-terminal residue variation on two consistent ultrashort peptide backbones, i.e. acetylated-Leu-Ile-Val-Ala-Gly-Xaa and acetylated-Ile-Val-Xaa (Xaa = His, Arg, Asn). The objective of this study is to identify candidates that can form hydrogels for small-molecule drug (SMD) delivery. Haemolysis and cytotoxicity (with human adipose-derived mesenchymal stem cells) assays showed that the new soluble peptides (Xaa = His, Arg) are cytocompatible. Gelation studies showed that all but acetylated-Ile-Val-Arg could gel under physiological conditions. Longer peptidic backbones drive self-assembly more effectively as reflected in field emission scanning electron microscopy (FESEM) and circular dichroism spectroscopy studies. Rheological studies revealed that the resultant hydrogels have varying stiffness and yield stress, depending on the backbone and C-terminal residue. Visible spectroscopy-based elution studies with SMDs (naltrexone, methotrexate, doxorubicin) showed that besides the C-terminal residue, the shape of the SMD also determines the rate and extent of SMD elution. Based on the elution assays, infrared spectroscopy, and FESEM, we propose models for the peptide fibril-SMD interaction. Our findings highlight the importance of matching the molecular properties of the self-assembling peptide and SMD in order to achieve the desired SMD release profile.
    95 schema:genre research_article
    96 schema:inLanguage en
    97 schema:isAccessibleForFree true
    98 schema:isPartOf N400aa3ac31094d5192a95b0c78abbd0c
    99 N8af2da80809944b9b9265bc12af20fed
    100 sg:journal.1045337
    101 schema:name C-Terminal Residue of Ultrashort Peptides Impacts on Molecular Self-Assembly, Hydrogelation, and Interaction with Small-Molecule Drugs
    102 schema:pagination 17127
    103 schema:productId N03a573b52e134fa9a1784bbb14ad2bdb
    104 N1562f2e0377e4fca8aca971d3bffae55
    105 N248e98de873a4da0ab1c0d73adbcad20
    106 Na06f23a623a149fb93056cb8d3ca2d95
    107 Nd38ab9451049400fb4b821fb125d5792
    108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109946089
    109 https://doi.org/10.1038/s41598-018-35431-2
    110 schema:sdDatePublished 2019-04-11T08:16
    111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    112 schema:sdPublisher N75993869017a4631b37796267af54f87
    113 schema:url https://www.nature.com/articles/s41598-018-35431-2
    114 sgo:license sg:explorer/license/
    115 sgo:sdDataset articles
    116 rdf:type schema:ScholarlyArticle
    117 N03a573b52e134fa9a1784bbb14ad2bdb schema:name pubmed_id
    118 schema:value 30459362
    119 rdf:type schema:PropertyValue
    120 N1562f2e0377e4fca8aca971d3bffae55 schema:name nlm_unique_id
    121 schema:value 101563288
    122 rdf:type schema:PropertyValue
    123 N1d7ae8793a764fa69a4cb9ae7041b090 rdf:first sg:person.011115364220.04
    124 rdf:rest rdf:nil
    125 N248e98de873a4da0ab1c0d73adbcad20 schema:name readcube_id
    126 schema:value 5d63e72ec0d8721d2272466dfb90fc54ff186353b948b5b4e0ab9f81992a5720
    127 rdf:type schema:PropertyValue
    128 N400aa3ac31094d5192a95b0c78abbd0c schema:volumeNumber 8
    129 rdf:type schema:PublicationVolume
    130 N50bca23e588245d9ac8f98e3270f4b54 rdf:first sg:person.01362361265.55
    131 rdf:rest Na274b463776541fe85c15829fa021339
    132 N73874ff8ab444ddc8aba3c2f34db7b40 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    133 schema:familyName Lee
    134 schema:givenName Wei Hao
    135 rdf:type schema:Person
    136 N75993869017a4631b37796267af54f87 schema:name Springer Nature - SN SciGraph project
    137 rdf:type schema:Organization
    138 N7bc76b46b18e45b1b6ebcded900795f3 rdf:first sg:person.01030377744.68
    139 rdf:rest N1d7ae8793a764fa69a4cb9ae7041b090
    140 N8af2da80809944b9b9265bc12af20fed schema:issueNumber 1
    141 rdf:type schema:PublicationIssue
    142 N9450e72ca81f490daacec3a3cc508461 rdf:first sg:person.0707432143.62
    143 rdf:rest N7bc76b46b18e45b1b6ebcded900795f3
    144 Na06f23a623a149fb93056cb8d3ca2d95 schema:name dimensions_id
    145 schema:value pub.1109946089
    146 rdf:type schema:PropertyValue
    147 Na274b463776541fe85c15829fa021339 rdf:first N73874ff8ab444ddc8aba3c2f34db7b40
    148 rdf:rest N9450e72ca81f490daacec3a3cc508461
    149 Nd38ab9451049400fb4b821fb125d5792 schema:name doi
    150 schema:value 10.1038/s41598-018-35431-2
    151 rdf:type schema:PropertyValue
    152 Ne284c7f3674841498ae03603b0f76b65 schema:name School of Biological Sciences & Engineering, Yachay Tech University, Hacienda San José s/n, 100105, San Miguel de Urcuquí, Ecuador
    153 rdf:type schema:Organization
    154 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Chemical Sciences
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Macromolecular and Materials Chemistry
    159 rdf:type schema:DefinedTerm
    160 sg:journal.1045337 schema:issn 2045-2322
    161 schema:name Scientific Reports
    162 rdf:type schema:Periodical
    163 sg:person.01030377744.68 schema:affiliation https://www.grid.ac/institutes/grid.418830.6
    164 schema:familyName Loo
    165 schema:givenName Yihua
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030377744.68
    167 rdf:type schema:Person
    168 sg:person.011115364220.04 schema:affiliation https://www.grid.ac/institutes/grid.45672.32
    169 schema:familyName Hauser
    170 schema:givenName Charlotte A. E.
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011115364220.04
    172 rdf:type schema:Person
    173 sg:person.01362361265.55 schema:affiliation https://www.grid.ac/institutes/grid.463064.3
    174 schema:familyName Chan
    175 schema:givenName Kiat Hwa
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362361265.55
    177 rdf:type schema:Person
    178 sg:person.0707432143.62 schema:affiliation Ne284c7f3674841498ae03603b0f76b65
    179 schema:familyName Ni
    180 schema:givenName Ming
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707432143.62
    182 rdf:type schema:Person
    183 sg:pub.10.1007/128_2011_206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010236404
    184 https://doi.org/10.1007/128_2011_206
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s12154-009-0027-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042648616
    187 https://doi.org/10.1007/s12154-009-0027-5
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s13238-011-1013-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041730600
    190 https://doi.org/10.1007/s13238-011-1013-6
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/418291a schema:sameAs https://app.dimensions.ai/details/publication/pub.1011410794
    193 https://doi.org/10.1038/418291a
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/natrevmats.2016.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033293457
    196 https://doi.org/10.1038/natrevmats.2016.71
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nature10154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052435615
    199 https://doi.org/10.1038/nature10154
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nature11395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006452361
    202 https://doi.org/10.1038/nature11395
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nbt874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025200827
    205 https://doi.org/10.1038/nbt874
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nchem.2122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046762856
    208 https://doi.org/10.1038/nchem.2122
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nchem.2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092795271
    211 https://doi.org/10.1038/nchem.2889
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nm0798-822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038769601
    214 https://doi.org/10.1038/nm0798-822
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nnano.2017.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086070663
    217 https://doi.org/10.1038/nnano.2017.109
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nprot.2007.483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056464397
    220 https://doi.org/10.1038/nprot.2007.483
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/s41598-017-12694-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092092336
    223 https://doi.org/10.1038/s41598-017-12694-9
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1038/srep09657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049976206
    226 https://doi.org/10.1038/srep09657
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1186/1752-153x-7-44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052570661
    229 https://doi.org/10.1186/1752-153x-7-44
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1002/bip.360250307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016500038
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/chem.201602624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046537554
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1002/cplu.201402120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033709689
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1002/jcc.21212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035008356
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1002/masy.200551128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001608573
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1002/prot.1050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003058147
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1002/star.200300242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024372895
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.biomaterials.2008.11.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001061933
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.biomaterials.2010.08.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051795768
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.biomaterials.2014.02.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034730323
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.biomaterials.2014.04.102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039908186
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/j.jaad.2007.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024520555
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.jchromb.2011.03.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003657911
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.jconrel.2006.06.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022870441
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.jmb.2008.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035922901
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.jmb.2009.09.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032390750
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.jsb.2008.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032037617
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/s0006-2952(03)00468-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018564899
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/s0734-9750(02)00026-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004975025
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/s1367-5931(02)00391-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029597674
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1021/acs.accounts.6b00553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083803885
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1021/acs.biochem.7b00035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084818693
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1021/acs.chemmater.6b01367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053746800
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1021/acs.nanolett.5b02859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041322156
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1021/ar3002969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011217393
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1021/bi00465a022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055177312
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1021/bm900544e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055224390
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1021/ja00265a036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055718737
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/ja028539f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055831759
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/ja7109822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055857531
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1021/ja9042142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055861645
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1021/ja904411z schema:sameAs https://app.dimensions.ai/details/publication/pub.1039293339
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1021/ja905539h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055861996
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1021/ja908560n schema:sameAs https://app.dimensions.ai/details/publication/pub.1055862755
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1021/ja991755c schema:sameAs https://app.dimensions.ai/details/publication/pub.1047741047
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1021/jacs.7b00847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084126023
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1021/jp8110474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016307744
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1039/b605536m schema:sameAs https://app.dimensions.ai/details/publication/pub.1001002222
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1039/b919449p schema:sameAs https://app.dimensions.ai/details/publication/pub.1018297326
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1039/c1cs15180k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001651153
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1039/c3nr06752a schema:sameAs https://app.dimensions.ai/details/publication/pub.1048629003
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1039/c3ra40598b schema:sameAs https://app.dimensions.ai/details/publication/pub.1001553749
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1039/c3sc51930a schema:sameAs https://app.dimensions.ai/details/publication/pub.1023927114
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1039/c5cs00470e schema:sameAs https://app.dimensions.ai/details/publication/pub.1040963286
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1039/c7cs00827a schema:sameAs https://app.dimensions.ai/details/publication/pub.1101315983
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1039/c8cs00177d schema:sameAs https://app.dimensions.ai/details/publication/pub.1103945558
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1073/pnas.0407843102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026742377
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1073/pnas.072089599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011917181
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1073/pnas.0807506106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043555292
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1073/pnas.1014796108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013544439
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1073/pnas.112193999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009366710
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1073/pnas.1217742110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013449069
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1073/pnas.142309999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028430147
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1073/pnas.96.17.9459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012555403
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.97.12.6728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006965450
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1074/jbc.272.19.12601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003216996
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1074/jbc.273.25.15458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007670583
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1088/0957-4484/27/40/402002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059117641
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1110/ps.4550102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023663630
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1111/j.1445-2197.2009.04852.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038438266
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1111/j.2042-7158.2012.01567.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016684884
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1126/science.1063187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040112811
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1126/science.271.5246.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551966
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1161/01.res.0000265074.83288.09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026893896
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.13172/2052-9643-1-1-787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065007823
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1371/journal.pcbi.1003718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016060410
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1371/journal.pone.0000190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007349362
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1517/17425247.2012.642362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037913218
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.2147/ijn.s126154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083763204
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.2217/bem-2018-0003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104239460
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.2302/kjm.54.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016547538
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.3390/ijms160511766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022922578
    374 rdf:type schema:CreativeWork
    375 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    376 schema:name Department of Chemistry, Krieger School of Arts & Sciences, 3400 North Charles Street, Johns Hopkins University, Baltimore, Maryland, USA
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.418830.6 schema:alternateName Institute of Bioengineering and Nanotechnology
    379 schema:name Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, 138669, Singapore, Singapore
    380 rdf:type schema:Organization
    381 https://www.grid.ac/institutes/grid.45672.32 schema:alternateName King Abdullah University of Science and Technology
    382 schema:name Laboratory for Nanomedicine, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Saudi Arabia
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.463064.3 schema:alternateName Yale-NUS College
    385 schema:name Division of Science, Yale-NUS College, 16 College Avenue West, 138527, Singapore, Singapore
    386 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...