Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tori A. Stromp, Tyler J. Spear, Rebecca M. Holtkamp, Kristin N. Andres, Joshua C. Kaine, Wissam H. Alghuraibawi, Steve W. Leung, Brandon K. Fornwalt, Moriel H. Vandsburger

ABSTRACT

Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, and probe correlations with widely used surrogate markers including cardiac structure and contractile function in patients with ESRD. In a sub-group of patients who returned for follow-up imaging after one year, we examine the correlation between changes in fibrosis and ventricular structure/function. Quantification of changes in MT revealed significantly greater fibrotic burden in patients with ESRD compared to a healthy age matched control cohort. Ventricular mechanics, including circumferential strain and diastolic strain rate were unchanged in patients with ESRD. No correlation was observed between fibrotic burden and concomitant measures of either circumferential or longitudinal strains or strain rates. However, among patients who returned for follow up examination a strong correlation existed between initial fibrotic burden and subsequent loss of contractile function. Gadolinium-free myocardial fibrosis imaging in patients with ESRD revealed a complex and longitudinal, not contemporary, association between fibrosis and ventricular contractile function. More... »

PAGES

16972

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-35394-4

DOI

http://dx.doi.org/10.1038/s41598-018-35394-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1109934428

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30451960


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Arkema (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419047.f", 
          "name": [
            "Department of Physiology, University of Kentucky, Lexington, KY, USA", 
            "Glaxo Smith Kline Research and Development, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stromp", 
        "givenName": "Tori A.", 
        "id": "sg:person.01172140765.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172140765.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spear", 
        "givenName": "Tyler J.", 
        "id": "sg:person.0710540740.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710540740.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holtkamp", 
        "givenName": "Rebecca M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "College of Medicine, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andres", 
        "givenName": "Kristin N.", 
        "id": "sg:person.01306367365.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306367365.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "College of Medicine, University of Kentucky, Lexington, KY, USA", 
            "Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaine", 
        "givenName": "Joshua C.", 
        "id": "sg:person.07543353555.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07543353555.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alghuraibawi", 
        "givenName": "Wissam H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kentucky", 
          "id": "https://www.grid.ac/institutes/grid.266539.d", 
          "name": [
            "Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leung", 
        "givenName": "Steve W.", 
        "id": "sg:person.01322251413.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322251413.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Imaging Science and Innovation, Geisinger, Danville, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fornwalt", 
        "givenName": "Brandon K.", 
        "id": "sg:person.01011604351.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011604351.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, Berkeley", 
          "id": "https://www.grid.ac/institutes/grid.47840.3f", 
          "name": [
            "Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandsburger", 
        "givenName": "Moriel H.", 
        "id": "sg:person.01166030757.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166030757.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.99.6.744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002968070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000349966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007196834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.03350509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007293441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.108.844506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008517286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1755.1999.00786.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011271480", 
          "https://doi.org/10.1046/j.1523-1755.1999.00786.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2015.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011881099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ki.5000249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013013643", 
          "https://doi.org/10.1038/sj.ki.5000249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ki.5000259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021845918", 
          "https://doi.org/10.1038/sj.ki.5000259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2013.10.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023312309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcmg.2008.03.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027928349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028142427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ehjci/jew005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028362136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjcard.2015.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029067515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000095029.57483.60", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032652740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-015-0194-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034330828", 
          "https://doi.org/10.1186/s12968-015-0194-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci46122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034665932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.04470709", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036322767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036767620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1523-1755.2005.00086.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037369801", 
          "https://doi.org/10.1111/j.1523-1755.2005.00086.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.kint.2016.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037491256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.kint.2016.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037491256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2013.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037712022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ehjci/jeu123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039461638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2004.12.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039862862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10641963.2015.1047943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046189111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10554-013-0337-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046424874", 
          "https://doi.org/10.1007/s10554-013-0337-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.00904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046638800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hypertensionaha.111.00904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046638800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050182213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1081/jcmr-120025230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058431707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/5.1.39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059932519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.02700316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069331155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2215/cjn.02700316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069331155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5414/cn108940", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072832291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-017-0334-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083644015", 
          "https://doi.org/10.1186/s12968-017-0334-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-017-0334-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083644015", 
          "https://doi.org/10.1186/s12968-017-0334-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-017-0337-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083783237", 
          "https://doi.org/10.1186/s12968-017-0337-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12968-017-0337-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083783237", 
          "https://doi.org/10.1186/s12968-017-0337-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2017.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085572442"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, and probe correlations with widely used surrogate markers including cardiac structure and contractile function in patients with ESRD. In a sub-group of patients who returned for follow-up imaging after one year, we examine the correlation between changes in fibrosis and ventricular structure/function. Quantification of changes in MT revealed significantly greater fibrotic burden in patients with ESRD compared to a healthy age matched control cohort. Ventricular mechanics, including circumferential strain and diastolic strain rate were unchanged in patients with ESRD. No correlation was observed between fibrotic burden and concomitant measures of either circumferential or longitudinal strains or strain rates. However, among patients who returned for follow up examination a strong correlation existed between initial fibrotic burden and subsequent loss of contractile function. Gadolinium-free myocardial fibrosis imaging in patients with ESRD revealed a complex and longitudinal, not contemporary, association between fibrosis and ventricular contractile function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-35394-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5503396", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705214", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4242330", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2686674", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline", 
    "pagination": "16972", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9a4decfec915ea5e9014e17817362433346b0593a03b635992ea34ae18cff611"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30451960"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-35394-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1109934428"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-35394-4", 
      "https://app.dimensions.ai/details/publication/pub.1109934428"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78970_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-35394-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35394-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35394-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35394-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-35394-4'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-35394-4 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N2393299b7a2d43c6b666706fa14bf8e1
4 schema:citation sg:pub.10.1007/s10554-013-0337-0
5 sg:pub.10.1038/sj.ki.5000249
6 sg:pub.10.1038/sj.ki.5000259
7 sg:pub.10.1046/j.1523-1755.1999.00786.x
8 sg:pub.10.1111/j.1523-1755.2005.00086.x
9 sg:pub.10.1186/s12968-015-0194-1
10 sg:pub.10.1186/s12968-017-0334-x
11 sg:pub.10.1186/s12968-017-0337-7
12 https://doi.org/10.1001/jama.2012.120
13 https://doi.org/10.1016/j.ahj.2017.05.008
14 https://doi.org/10.1016/j.amjcard.2015.02.015
15 https://doi.org/10.1016/j.jacc.2004.12.057
16 https://doi.org/10.1016/j.jacc.2013.10.084
17 https://doi.org/10.1016/j.jcmg.2008.03.011
18 https://doi.org/10.1016/j.kint.2016.06.014
19 https://doi.org/10.1053/j.ajkd.2013.11.010
20 https://doi.org/10.1053/j.ajkd.2015.12.014
21 https://doi.org/10.1081/jcmr-120025230
22 https://doi.org/10.1093/ehjci/jeu123
23 https://doi.org/10.1093/ehjci/jew005
24 https://doi.org/10.1093/eurheartj/ehr391
25 https://doi.org/10.1093/eurheartj/ehr481
26 https://doi.org/10.1093/ndt/5.1.39
27 https://doi.org/10.1159/000349966
28 https://doi.org/10.1161/01.cir.0000095029.57483.60
29 https://doi.org/10.1161/01.cir.99.6.744
30 https://doi.org/10.1161/circulationaha.108.844506
31 https://doi.org/10.1161/hypertensionaha.111.00904
32 https://doi.org/10.1172/jci46122
33 https://doi.org/10.2215/cjn.02700316
34 https://doi.org/10.2215/cjn.03350509
35 https://doi.org/10.2215/cjn.04470709
36 https://doi.org/10.3109/10641963.2015.1047943
37 https://doi.org/10.5414/cn108940
38 schema:datePublished 2018-12
39 schema:datePublishedReg 2018-12-01
40 schema:description Patients with end stage renal disease (ESRD) suffer high mortality from arrhythmias linked to fibrosis, but are contraindicated to late gadolinium enhancement magnetic resonance imaging (MRI). We present a quantitative method for gadolinium-free cardiac fibrosis imaging using magnetization transfer (MT) weighted MRI, and probe correlations with widely used surrogate markers including cardiac structure and contractile function in patients with ESRD. In a sub-group of patients who returned for follow-up imaging after one year, we examine the correlation between changes in fibrosis and ventricular structure/function. Quantification of changes in MT revealed significantly greater fibrotic burden in patients with ESRD compared to a healthy age matched control cohort. Ventricular mechanics, including circumferential strain and diastolic strain rate were unchanged in patients with ESRD. No correlation was observed between fibrotic burden and concomitant measures of either circumferential or longitudinal strains or strain rates. However, among patients who returned for follow up examination a strong correlation existed between initial fibrotic burden and subsequent loss of contractile function. Gadolinium-free myocardial fibrosis imaging in patients with ESRD revealed a complex and longitudinal, not contemporary, association between fibrosis and ventricular contractile function.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N301b39df897e4174aadc7fcaea0aee39
45 N6847c641820d45c6bbaae7b0a8b93468
46 sg:journal.1045337
47 schema:name Quantitative Gadolinium-Free Cardiac Fibrosis Imaging in End Stage Renal Disease Patients Reveals A Longitudinal Correlation with Structural and Functional Decline
48 schema:pagination 16972
49 schema:productId N1863c10758ff4869a0bb87d0a356f9b7
50 N7d5be348afa04eb1a0ab78e1cc286441
51 N8b859ad48e974314adc430242a372fca
52 N8cf4a19ffead4e2989cd530d9fd684d7
53 Nb433fc3842d7471e90f674b2ef76dfb0
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1109934428
55 https://doi.org/10.1038/s41598-018-35394-4
56 schema:sdDatePublished 2019-04-11T13:20
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher Nc0bbdc257ee442ea9c970cc21f9114b7
59 schema:url https://www.nature.com/articles/s41598-018-35394-4
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0e9d044aeaa648b782add19d0e16ee1a schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
64 schema:familyName Alghuraibawi
65 schema:givenName Wissam H.
66 rdf:type schema:Person
67 N1863c10758ff4869a0bb87d0a356f9b7 schema:name dimensions_id
68 schema:value pub.1109934428
69 rdf:type schema:PropertyValue
70 N2393299b7a2d43c6b666706fa14bf8e1 rdf:first sg:person.01172140765.71
71 rdf:rest Ne8ac185d81884e428f24486872757de2
72 N296c7f419b834e59aece89b013e80d3c schema:affiliation https://www.grid.ac/institutes/grid.266539.d
73 schema:familyName Holtkamp
74 schema:givenName Rebecca M.
75 rdf:type schema:Person
76 N301b39df897e4174aadc7fcaea0aee39 schema:issueNumber 1
77 rdf:type schema:PublicationIssue
78 N6847c641820d45c6bbaae7b0a8b93468 schema:volumeNumber 8
79 rdf:type schema:PublicationVolume
80 N747979086685426f9aeaeda26ddd1c70 rdf:first N296c7f419b834e59aece89b013e80d3c
81 rdf:rest Neea109982309443b9cb22a84b324705a
82 N7d5be348afa04eb1a0ab78e1cc286441 schema:name pubmed_id
83 schema:value 30451960
84 rdf:type schema:PropertyValue
85 N8b859ad48e974314adc430242a372fca schema:name readcube_id
86 schema:value 9a4decfec915ea5e9014e17817362433346b0593a03b635992ea34ae18cff611
87 rdf:type schema:PropertyValue
88 N8cf4a19ffead4e2989cd530d9fd684d7 schema:name nlm_unique_id
89 schema:value 101563288
90 rdf:type schema:PropertyValue
91 N9d19f82c4b1e4ff9b6a19d5fccb433ab rdf:first sg:person.07543353555.16
92 rdf:rest Ndd6ddeac9d084d2385bb2096e36b8b28
93 Na154a23b61ea4ef598b284de965651ab rdf:first sg:person.01166030757.16
94 rdf:rest rdf:nil
95 Nb433fc3842d7471e90f674b2ef76dfb0 schema:name doi
96 schema:value 10.1038/s41598-018-35394-4
97 rdf:type schema:PropertyValue
98 Nb4376b4ac74242a09f8b87f7eb676b65 schema:name Department of Imaging Science and Innovation, Geisinger, Danville, PA, USA
99 rdf:type schema:Organization
100 Nb98d1eeb80ac429bb49c47d93455f34b rdf:first sg:person.01322251413.94
101 rdf:rest Ncd70e60eb99b4ad886a363f31693453c
102 Nc0bbdc257ee442ea9c970cc21f9114b7 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 Ncd70e60eb99b4ad886a363f31693453c rdf:first sg:person.01011604351.47
105 rdf:rest Na154a23b61ea4ef598b284de965651ab
106 Ndd6ddeac9d084d2385bb2096e36b8b28 rdf:first N0e9d044aeaa648b782add19d0e16ee1a
107 rdf:rest Nb98d1eeb80ac429bb49c47d93455f34b
108 Ne8ac185d81884e428f24486872757de2 rdf:first sg:person.0710540740.90
109 rdf:rest N747979086685426f9aeaeda26ddd1c70
110 Neea109982309443b9cb22a84b324705a rdf:first sg:person.01306367365.06
111 rdf:rest N9d19f82c4b1e4ff9b6a19d5fccb433ab
112 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical and Health Sciences
114 rdf:type schema:DefinedTerm
115 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
116 schema:name Clinical Sciences
117 rdf:type schema:DefinedTerm
118 sg:grant.2686674 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-35394-4
119 rdf:type schema:MonetaryGrant
120 sg:grant.2705214 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-35394-4
121 rdf:type schema:MonetaryGrant
122 sg:grant.4242330 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-35394-4
123 rdf:type schema:MonetaryGrant
124 sg:grant.5503396 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-35394-4
125 rdf:type schema:MonetaryGrant
126 sg:journal.1045337 schema:issn 2045-2322
127 schema:name Scientific Reports
128 rdf:type schema:Periodical
129 sg:person.01011604351.47 schema:affiliation Nb4376b4ac74242a09f8b87f7eb676b65
130 schema:familyName Fornwalt
131 schema:givenName Brandon K.
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011604351.47
133 rdf:type schema:Person
134 sg:person.01166030757.16 schema:affiliation https://www.grid.ac/institutes/grid.47840.3f
135 schema:familyName Vandsburger
136 schema:givenName Moriel H.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166030757.16
138 rdf:type schema:Person
139 sg:person.01172140765.71 schema:affiliation https://www.grid.ac/institutes/grid.419047.f
140 schema:familyName Stromp
141 schema:givenName Tori A.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172140765.71
143 rdf:type schema:Person
144 sg:person.01306367365.06 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
145 schema:familyName Andres
146 schema:givenName Kristin N.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306367365.06
148 rdf:type schema:Person
149 sg:person.01322251413.94 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
150 schema:familyName Leung
151 schema:givenName Steve W.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322251413.94
153 rdf:type schema:Person
154 sg:person.0710540740.90 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
155 schema:familyName Spear
156 schema:givenName Tyler J.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710540740.90
158 rdf:type schema:Person
159 sg:person.07543353555.16 schema:affiliation https://www.grid.ac/institutes/grid.266539.d
160 schema:familyName Kaine
161 schema:givenName Joshua C.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07543353555.16
163 rdf:type schema:Person
164 sg:pub.10.1007/s10554-013-0337-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046424874
165 https://doi.org/10.1007/s10554-013-0337-0
166 rdf:type schema:CreativeWork
167 sg:pub.10.1038/sj.ki.5000249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013013643
168 https://doi.org/10.1038/sj.ki.5000249
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/sj.ki.5000259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021845918
171 https://doi.org/10.1038/sj.ki.5000259
172 rdf:type schema:CreativeWork
173 sg:pub.10.1046/j.1523-1755.1999.00786.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011271480
174 https://doi.org/10.1046/j.1523-1755.1999.00786.x
175 rdf:type schema:CreativeWork
176 sg:pub.10.1111/j.1523-1755.2005.00086.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037369801
177 https://doi.org/10.1111/j.1523-1755.2005.00086.x
178 rdf:type schema:CreativeWork
179 sg:pub.10.1186/s12968-015-0194-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034330828
180 https://doi.org/10.1186/s12968-015-0194-1
181 rdf:type schema:CreativeWork
182 sg:pub.10.1186/s12968-017-0334-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1083644015
183 https://doi.org/10.1186/s12968-017-0334-x
184 rdf:type schema:CreativeWork
185 sg:pub.10.1186/s12968-017-0337-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083783237
186 https://doi.org/10.1186/s12968-017-0337-7
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1001/jama.2012.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028142427
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.ahj.2017.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085572442
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.amjcard.2015.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029067515
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.jacc.2004.12.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039862862
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.jacc.2013.10.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023312309
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.jcmg.2008.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027928349
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.kint.2016.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037491256
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1053/j.ajkd.2013.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037712022
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1053/j.ajkd.2015.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011881099
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1081/jcmr-120025230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058431707
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/ehjci/jeu123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039461638
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/ehjci/jew005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028362136
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1093/eurheartj/ehr391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050182213
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1093/eurheartj/ehr481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036767620
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1093/ndt/5.1.39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059932519
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1159/000349966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007196834
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1161/01.cir.0000095029.57483.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032652740
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1161/01.cir.99.6.744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002968070
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1161/circulationaha.108.844506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008517286
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1161/hypertensionaha.111.00904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046638800
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1172/jci46122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034665932
229 rdf:type schema:CreativeWork
230 https://doi.org/10.2215/cjn.02700316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069331155
231 rdf:type schema:CreativeWork
232 https://doi.org/10.2215/cjn.03350509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007293441
233 rdf:type schema:CreativeWork
234 https://doi.org/10.2215/cjn.04470709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036322767
235 rdf:type schema:CreativeWork
236 https://doi.org/10.3109/10641963.2015.1047943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046189111
237 rdf:type schema:CreativeWork
238 https://doi.org/10.5414/cn108940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072832291
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.266539.d schema:alternateName University of Kentucky
241 schema:name College of Medicine, University of Kentucky, Lexington, KY, USA
242 Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA
243 Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.419047.f schema:alternateName Arkema (United States)
246 schema:name Department of Physiology, University of Kentucky, Lexington, KY, USA
247 Glaxo Smith Kline Research and Development, Philadelphia, PA, USA
248 rdf:type schema:Organization
249 https://www.grid.ac/institutes/grid.47840.3f schema:alternateName University of California, Berkeley
250 schema:name Department of Bioengineering, University of California Berkeley, Berkeley, CA, USA
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...