Soy-Induced Fecal Metabolome Changes in Ovariectomized and Intact Female Rats: Relationship with Cardiometabolic Health View Full Text


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Article Info

DATE

2018-11-15

AUTHORS

Victoria J. Vieira-Potter, Tzu-Wen L. Cross, Kelly S. Swanson, Saurav J. Sarma, Zhentian Lei, Lloyd W. Sumner, Cheryl S. Rosenfeld

ABSTRACT

Phytoestrogens are plant-derived compounds found in a variety of foods, most notably, soy. These compounds have been shown to improve immuno-metabolic health, yet mechanisms remain uncertain. We demonstrated previously that dietary phytoestrogen-rich soy (SOY) rescued metabolic dysfunction/inflammation following ovariectomy (OVX) in female rats; we also noted remarkable shifts in gut microbiota in SOY vs control diet-fed rats. Importantly, specific bacteria that significantly increased in those fed the SOY correlated positively with several favorable host metabolic parameters. One mechanism by which gut microbes might lead to such host effects is through production of bacterial metabolites. To test this possibility, we utilized non-targeted gas chromatography-mass spectrometry (GCMS) to assess the fecal metabolome in those previously studied animals. Partial least square discriminant analysis (PLSDA) revealed clear separation of fecal metabolomes based on diet and ovarian state. In particular, SOY-fed animals had greater fecal concentrations of the beneficial bacterial metabolite, S-equol, which was positively associated with several of the bacteria upregulated in the SOY group. S-equol was inversely correlated with important indicators of metabolic dysfunction and inflammation, suggesting that this metabolite might be a key mediator between SOY and gut microbiome-positive host health outcomes. More... »

PAGES

16896

References to SciGraph publications

  • 2016-10-18. Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial in EUROPEAN JOURNAL OF NUTRITION
  • 2013-04-09. Daidzein, R-(+)equol and S-(−)equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2 in EUROPEAN JOURNAL OF NUTRITION
  • 2012-02-12. MET-IDEA version 2.06; improved efficiency and additional functions for mass spectrometry-based metabolomics data processing in METABOLOMICS
  • 2008-09-27. Bioconversion of soy isoflavones daidzin and daidzein by Bifidobacterium strains in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2014-02-26. Obesity prevalence in relation to gut microbial environments capable of producing equol or O-desmethylangolensin from the isoflavone daidzein in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2017-04-17. Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones in BMC MICROBIOLOGY
  • 2017-11-22. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites in NATURE
  • 2017-08-23. Soy Improves Cardiometabolic Health and Cecal Microbiota in Female Low-Fit Rats in SCIENTIFIC REPORTS
  • 2011-03-16. Neuromodulation by soy diets or equol: Anti-depressive & anti-obesity-like influences, age- & hormone-dependent effects in BMC NEUROSCIENCE
  • 2006-11-16. Production of phytoestrogen S-equol from daidzein in mixed culture of two anaerobic bacteria in ARCHIVES OF MICROBIOLOGY
  • 2000-11. Stimulatory effect of genistein and daidzein on protein synthesis in osteoblastic MC3T3-E1 cells: Activation of aminoacyl-tRNA synthetase in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/s41598-018-35171-3

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    http://dx.doi.org/10.1038/s41598-018-35171-3

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30442926


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