Correlation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Claudia Kesch, Jan-Philipp Radtke, Axel Wintsche, Manuel Wiesenfarth, Mariska Luttje, Claudia Gasch, Svenja Dieffenbacher, Carine Pecqueux, Dogu Teber, Gencay Hatiboglu, Joanne Nyarangi-Dix, Tobias Simpfendörfer, Gita Schönberg, Antonia Dimitrakopoulou-Strauss, Martin Freitag, Anette Duensing, Carsten Grüllich, Dirk Jäger, Michael Götz, Niels Grabe, Michal-Ruth Schweiger, Sascha Pahernik, Sven Perner, Esther Herpel, Wilfried Roth, Kathrin Wieczorek, Klaus Maier-Hein, Jürgen Debus, Uwe Haberkorn, Frederik Giesel, Jörg Galle, Boris Hadaschik, Heinz-Peter Schlemmer, Markus Hohenfellner, David Bonekamp, Holger Sültmann, Stefan Duensing

ABSTRACT

Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether and to what extent lesions detected by these imaging techniques correlate with genomic features of PCa. The aim of this study was therefore to define a genomic index lesion based on chromosomal copy number alterations (CNAs) as marker for tumor aggressiveness in prostate biopsies in direct correlation to multiparametric (mp) MRI and 68Ga-PSMA-PET/CT imaging features. CNA profiles of 46 biopsies from five consecutive patients with clinically high-risk PCa were obtained from radiologically suspicious and unsuspicious areas. All patients underwent mpMRI, MRI/TRUS-fusion biopsy, 68Ga-PSMA-PET/CT and a radical prostatectomy. CNAs were directly correlated to imaging features and radiogenomic analyses were performed. Highly significant CNAs (≥10 Mbp) were found in 22 of 46 biopsies. Chromosome 8p, 13q and 5q losses were the most common findings. There was an strong correspondence between the radiologic and the genomic index lesions. The radiogenomic analyses suggest the feasibility of developing radiologic signatures that can distinguish between genomically more or less aggressive lesions. In conclusion, imaging features of mpMRI and 68Ga-PSMA-PET/CT can guide to the genomically most aggressive lesion of a PCa. Radiogenomics may help to better differentiate between indolent and aggressive PCa in the future. More... »

PAGES

16708

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-35058-3

DOI

http://dx.doi.org/10.1038/s41598-018-35058-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1108060357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30420756


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447 https://www.grid.ac/institutes/grid.7692.a schema:alternateName University Medical Center Utrecht
448 schema:name Imaging Division, University Medical Center Utrecht, Heidelberglaan 100, 3584, CX Utrecht, The Netherlands
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450 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
451 schema:name Hamamatsu Tissue Imaging and Analysis Center (TIGA), BIOQUANT, University of Heidelberg, Im Neuenheimer Feld 267, D-69120, Heidelberg, Germany
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453 https://www.grid.ac/institutes/grid.9647.c schema:alternateName Leipzig University
454 schema:name Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany
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