Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yi Yang, Woo Kyun Bae, Ji-Yoon Lee, Yong Jae Choi, Kyung Hwa Lee, Myong-Suk Park, Young Hyun Yu, So-Yeon Park, Rui Zhou, İsa Taş, Chathurika Gamage, Man-Jeong Paik, Jae Hyuk Lee, Ik Joo Chung, Kyung Keun Kim, Jae-Seoun Hur, Sang Kyum Kim, Hyung-Ho Ha, Hangun Kim

ABSTRACT

Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model. KU treatment downregulated the epithelial-mesenchymal markers Twist, Snail, and Slug and the metastasis-related genes CAPN1, CDC42, CFL1, IGF1, WASF1, and WASL in cells and tumor tissues. The present results suggest the potential application of the water-soluble form of UA, KU, in anticancer therapy. More... »

PAGES

16234

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-34709-9

DOI

http://dx.doi.org/10.1038/s41598-018-34709-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107913033

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30390003


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