Associations between Antibiotics for Non-tuberculous Mycobacterial Infection and Incident Sjögren’s Syndrome: A Nationwide, Population-based Case-control Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Wen-Cheng Chao, Ching-Heng Lin, Yi-Ming Chen, Chiann-Yi Hsu, Jun-Peng Chen, Hsin-Hua Chen

ABSTRACT

This study aimed to address the association between the usage of antibiotics to treat nontuberculous mycobacteria (NTM) infection and the risk of Sjögren's syndrome (SS). We identified 5,553 patients with newly diagnosed SS between 2002 and 2013 using Taiwan's National Health Insurance Research Database and compared them with 83,295 non-SS controls matched (1:15) for age, sex, and the year of their first SS diagnosis. An increased risk of SS was found in patients receiving new macrolides (adjusted odds ratios (aOR) 1.95, 95% confidence intervals (CI) 1.80-2.11), fluoroquinolones (aOR 1.52, 95% CI 1.41-1.64), and tetracyclines (aOR 1.69, 95% CI 1.59-1.79) compared with non-SS controls after adjusting for the Charlson comorbidity index, bronchiectasis and Helicobacter pylori infection. Notably, the association was consistent among each antibiotic in these three groups of antibiotics. In contrast to these three groups of antibiotics, the use of amikacin tended to have a negative association with incident SS (aOR 0.68, 95% CI 0.53-0.87). In conclusion, new macrolides, fluoroquinolones and tetracyclines were associated with a higher incidence of SS. These findings indicate the need for vigilance of SS in prescribing these antibiotics and warrant further mechanistic studies. More... »

PAGES

16007

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-34495-4

DOI

http://dx.doi.org/10.1038/s41598-018-34495-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107829232

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30375488


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Changhua University of Education", 
          "id": "https://www.grid.ac/institutes/grid.412038.c", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Business Administration, National Changhua University of Education, Changhua, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chao", 
        "givenName": "Wen-Cheng", 
        "id": "sg:person.0650611653.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650611653.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Taipei University of Nursing and Health Science", 
          "id": "https://www.grid.ac/institutes/grid.412146.4", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Department of Healthcare Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Ching-Heng", 
        "id": "sg:person.01216002731.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002731.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Yang Ming University", 
          "id": "https://www.grid.ac/institutes/grid.260770.4", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan", 
            "Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "School of Medicine, National Yang-Ming University, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yi-Ming", 
        "id": "sg:person.015037671374.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015037671374.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taichung Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410764.0", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Chiann-Yi", 
        "id": "sg:person.01242775042.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242775042.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Taichung Veterans General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410764.0", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jun-Peng", 
        "id": "sg:person.014041214635.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014041214635.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tunghai University", 
          "id": "https://www.grid.ac/institutes/grid.265231.1", 
          "name": [
            "Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan", 
            "Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan", 
            "School of Medicine, National Yang-Ming University, Taipei, Taiwan", 
            "School of Medicine, Chung-Shan Medical University, Taichung, Taiwan", 
            "Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan", 
            "Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hsin-Hua", 
        "id": "sg:person.01244154362.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244154362.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1601-0825.2011.01796.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000356735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2009.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000961557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccm.2010.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005029286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5114/aoms.2014.44857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005045077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08820130903062194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006973095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.329.7456.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009651897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semarthrit.2007.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012779432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1377/hlthaff.22.3.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014036853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.berh.2008.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200604-571st", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017257548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1422.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019128658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0895-4356(92)90133-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021035388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200629020-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021511165", 
          "https://doi.org/10.2165/00002018-200629020-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002018-200629020-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021511165", 
          "https://doi.org/10.2165/00002018-200629020-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00130832-200308000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023115479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14740338.2015.995089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024347958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2008.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026662546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1c525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029703100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1c525", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029703100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036384047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036384047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/472978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038286728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diagmicrobio.2004.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038628933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.61.6.554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039471766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2133.2000.03357.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039683801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.autrev.2012.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043331496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.159.5.493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044484297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2014.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045735814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hel.12165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051099661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3283542d0b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052856309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/bor.0b013e3283542d0b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052856309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2013-002857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053359464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/515104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058789494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/32.2.215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059734011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkv227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059735952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7024.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062774535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7024.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062774535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v20.i3.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071371179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-140-10-200405180-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073706989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-140-10-200405180-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073706997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074481306", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hel.12380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084212946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0176549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085376474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrrheum.2017.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085581465", 
          "https://doi.org/10.1038/nrrheum.2017.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijantimicag.2017.01.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085861837"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "This study aimed to address the association between the usage of antibiotics to treat nontuberculous mycobacteria (NTM) infection and the risk of Sj\u00f6gren's syndrome (SS). We identified 5,553 patients with newly diagnosed SS between 2002 and 2013 using Taiwan's National Health Insurance Research Database and compared them with 83,295 non-SS controls matched (1:15) for age, sex, and the year of their first SS diagnosis. An increased risk of SS was found in patients receiving new macrolides (adjusted odds ratios (aOR) 1.95, 95% confidence intervals (CI) 1.80-2.11), fluoroquinolones (aOR 1.52, 95% CI 1.41-1.64), and tetracyclines (aOR 1.69, 95% CI 1.59-1.79) compared with non-SS controls after adjusting for the Charlson comorbidity index, bronchiectasis and Helicobacter pylori infection. Notably, the association was consistent among each antibiotic in these three groups of antibiotics. In contrast to these three groups of antibiotics, the use of amikacin tended to have a negative association with incident SS (aOR 0.68, 95% CI 0.53-0.87). In conclusion, new macrolides, fluoroquinolones and tetracyclines were associated with a higher incidence of SS. These findings indicate the need for vigilance of SS in prescribing these antibiotics and warrant further mechanistic studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-34495-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Associations between Antibiotics for Non-tuberculous Mycobacterial Infection and Incident Sj\u00f6gren\u2019s Syndrome: A Nationwide, Population-based Case-control Study", 
    "pagination": "16007", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c0bdb7c6c970a4b38df4fe61b0a2803aa7b6411911a44f1e461e0b33990edb40"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30375488"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-34495-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107829232"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-34495-4", 
      "https://app.dimensions.ai/details/publication/pub.1107829232"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000575.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-34495-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-34495-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-34495-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-34495-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-34495-4'


 

This table displays all metadata directly associated to this object as RDF triples.

248 TRIPLES      21 PREDICATES      69 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-34495-4 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N3cb5d073acc8451d86dc9330fcd36d96
4 schema:citation sg:pub.10.1038/nrrheum.2017.86
5 sg:pub.10.2165/00002018-200629020-00006
6 https://app.dimensions.ai/details/publication/pub.1074481306
7 https://doi.org/10.1001/archinte.159.5.493
8 https://doi.org/10.1016/0895-4356(92)90133-8
9 https://doi.org/10.1016/j.autrev.2012.12.005
10 https://doi.org/10.1016/j.berh.2008.09.007
11 https://doi.org/10.1016/j.ccm.2010.05.007
12 https://doi.org/10.1016/j.diagmicrobio.2004.09.004
13 https://doi.org/10.1016/j.ijantimicag.2017.01.042
14 https://doi.org/10.1016/j.jaut.2009.11.012
15 https://doi.org/10.1016/j.jaut.2014.01.005
16 https://doi.org/10.1016/j.jpeds.2008.03.013
17 https://doi.org/10.1016/j.semarthrit.2007.10.001
18 https://doi.org/10.1046/j.1365-2133.2000.03357.x
19 https://doi.org/10.1080/08820130903062194
20 https://doi.org/10.1086/515104
21 https://doi.org/10.1093/jac/32.2.215
22 https://doi.org/10.1093/jac/dkv227
23 https://doi.org/10.1097/00130832-200308000-00003
24 https://doi.org/10.1097/bor.0b013e3283542d0b
25 https://doi.org/10.1111/hel.12165
26 https://doi.org/10.1111/hel.12380
27 https://doi.org/10.1111/j.1601-0825.2011.01796.x
28 https://doi.org/10.1136/ard.61.6.554
29 https://doi.org/10.1136/bmj.312.7024.138
30 https://doi.org/10.1136/bmj.329.7456.15
31 https://doi.org/10.1136/bmjopen-2013-002857
32 https://doi.org/10.1155/2014/472978
33 https://doi.org/10.1164/rccm.200604-571st
34 https://doi.org/10.1196/annals.1422.019
35 https://doi.org/10.1345/aph.1a350
36 https://doi.org/10.1345/aph.1c525
37 https://doi.org/10.1371/journal.pone.0176549
38 https://doi.org/10.1377/hlthaff.22.3.61
39 https://doi.org/10.1517/14740338.2015.995089
40 https://doi.org/10.3748/wjg.v20.i3.613
41 https://doi.org/10.5114/aoms.2014.44857
42 https://doi.org/10.7326/0003-4819-140-10-200405180-00009
43 https://doi.org/10.7326/0003-4819-140-10-200405180-00017
44 schema:datePublished 2018-12
45 schema:datePublishedReg 2018-12-01
46 schema:description This study aimed to address the association between the usage of antibiotics to treat nontuberculous mycobacteria (NTM) infection and the risk of Sjögren's syndrome (SS). We identified 5,553 patients with newly diagnosed SS between 2002 and 2013 using Taiwan's National Health Insurance Research Database and compared them with 83,295 non-SS controls matched (1:15) for age, sex, and the year of their first SS diagnosis. An increased risk of SS was found in patients receiving new macrolides (adjusted odds ratios (aOR) 1.95, 95% confidence intervals (CI) 1.80-2.11), fluoroquinolones (aOR 1.52, 95% CI 1.41-1.64), and tetracyclines (aOR 1.69, 95% CI 1.59-1.79) compared with non-SS controls after adjusting for the Charlson comorbidity index, bronchiectasis and Helicobacter pylori infection. Notably, the association was consistent among each antibiotic in these three groups of antibiotics. In contrast to these three groups of antibiotics, the use of amikacin tended to have a negative association with incident SS (aOR 0.68, 95% CI 0.53-0.87). In conclusion, new macrolides, fluoroquinolones and tetracyclines were associated with a higher incidence of SS. These findings indicate the need for vigilance of SS in prescribing these antibiotics and warrant further mechanistic studies.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N258f3c2e7104440fadca6333830ef31a
51 Ncca91c99db0c4413866ddda8eeae2497
52 sg:journal.1045337
53 schema:name Associations between Antibiotics for Non-tuberculous Mycobacterial Infection and Incident Sjögren’s Syndrome: A Nationwide, Population-based Case-control Study
54 schema:pagination 16007
55 schema:productId N6000d4fa082c46c2be45fa0128bd0f78
56 N770cf1045b2c454e844c063d731a8b81
57 Nb5af1e703a234cfabfadccea48abf3a4
58 Nd9be16b6dd1944eea073617d27dbbf1a
59 Ne40692ad1c5a4a13a1f35fa773c4e053
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107829232
61 https://doi.org/10.1038/s41598-018-34495-4
62 schema:sdDatePublished 2019-04-10T20:07
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N1982499d5145409dbd89b6be22d1067f
65 schema:url https://www.nature.com/articles/s41598-018-34495-4
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N1982499d5145409dbd89b6be22d1067f schema:name Springer Nature - SN SciGraph project
70 rdf:type schema:Organization
71 N258f3c2e7104440fadca6333830ef31a schema:issueNumber 1
72 rdf:type schema:PublicationIssue
73 N3cb5d073acc8451d86dc9330fcd36d96 rdf:first sg:person.0650611653.42
74 rdf:rest N8844e530a0e2402eb875bd24ad3b5157
75 N4baa92ecacd54f2ab6c1033c7ae9abb4 rdf:first sg:person.01242775042.99
76 rdf:rest N681d14f1b5f541f6b530092b7b0b5558
77 N6000d4fa082c46c2be45fa0128bd0f78 schema:name nlm_unique_id
78 schema:value 101563288
79 rdf:type schema:PropertyValue
80 N681d14f1b5f541f6b530092b7b0b5558 rdf:first sg:person.014041214635.89
81 rdf:rest N9540c847b5564fd399c5a6f0957eaea9
82 N770cf1045b2c454e844c063d731a8b81 schema:name pubmed_id
83 schema:value 30375488
84 rdf:type schema:PropertyValue
85 N8844e530a0e2402eb875bd24ad3b5157 rdf:first sg:person.01216002731.11
86 rdf:rest Nfe79a3a3b2284379b01b6358ec7f8bb5
87 N9540c847b5564fd399c5a6f0957eaea9 rdf:first sg:person.01244154362.23
88 rdf:rest rdf:nil
89 Nb5af1e703a234cfabfadccea48abf3a4 schema:name readcube_id
90 schema:value c0bdb7c6c970a4b38df4fe61b0a2803aa7b6411911a44f1e461e0b33990edb40
91 rdf:type schema:PropertyValue
92 Ncca91c99db0c4413866ddda8eeae2497 schema:volumeNumber 8
93 rdf:type schema:PublicationVolume
94 Nd9be16b6dd1944eea073617d27dbbf1a schema:name doi
95 schema:value 10.1038/s41598-018-34495-4
96 rdf:type schema:PropertyValue
97 Ne40692ad1c5a4a13a1f35fa773c4e053 schema:name dimensions_id
98 schema:value pub.1107829232
99 rdf:type schema:PropertyValue
100 Nfe79a3a3b2284379b01b6358ec7f8bb5 rdf:first sg:person.015037671374.14
101 rdf:rest N4baa92ecacd54f2ab6c1033c7ae9abb4
102 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
103 schema:name Medical and Health Sciences
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
106 schema:name Clinical Sciences
107 rdf:type schema:DefinedTerm
108 sg:journal.1045337 schema:issn 2045-2322
109 schema:name Scientific Reports
110 rdf:type schema:Periodical
111 sg:person.01216002731.11 schema:affiliation https://www.grid.ac/institutes/grid.412146.4
112 schema:familyName Lin
113 schema:givenName Ching-Heng
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216002731.11
115 rdf:type schema:Person
116 sg:person.01242775042.99 schema:affiliation https://www.grid.ac/institutes/grid.410764.0
117 schema:familyName Hsu
118 schema:givenName Chiann-Yi
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242775042.99
120 rdf:type schema:Person
121 sg:person.01244154362.23 schema:affiliation https://www.grid.ac/institutes/grid.265231.1
122 schema:familyName Chen
123 schema:givenName Hsin-Hua
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244154362.23
125 rdf:type schema:Person
126 sg:person.014041214635.89 schema:affiliation https://www.grid.ac/institutes/grid.410764.0
127 schema:familyName Chen
128 schema:givenName Jun-Peng
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014041214635.89
130 rdf:type schema:Person
131 sg:person.015037671374.14 schema:affiliation https://www.grid.ac/institutes/grid.260770.4
132 schema:familyName Chen
133 schema:givenName Yi-Ming
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015037671374.14
135 rdf:type schema:Person
136 sg:person.0650611653.42 schema:affiliation https://www.grid.ac/institutes/grid.412038.c
137 schema:familyName Chao
138 schema:givenName Wen-Cheng
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650611653.42
140 rdf:type schema:Person
141 sg:pub.10.1038/nrrheum.2017.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085581465
142 https://doi.org/10.1038/nrrheum.2017.86
143 rdf:type schema:CreativeWork
144 sg:pub.10.2165/00002018-200629020-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021511165
145 https://doi.org/10.2165/00002018-200629020-00006
146 rdf:type schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1074481306 schema:CreativeWork
148 https://doi.org/10.1001/archinte.159.5.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044484297
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/0895-4356(92)90133-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021035388
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.autrev.2012.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043331496
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.berh.2008.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014184442
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.ccm.2010.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005029286
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.diagmicrobio.2004.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038628933
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.ijantimicag.2017.01.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085861837
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.jaut.2009.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000961557
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.jaut.2014.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045735814
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.jpeds.2008.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026662546
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.semarthrit.2007.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012779432
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1046/j.1365-2133.2000.03357.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039683801
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1080/08820130903062194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006973095
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1086/515104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058789494
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1093/jac/32.2.215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059734011
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1093/jac/dkv227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059735952
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1097/00130832-200308000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023115479
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1097/bor.0b013e3283542d0b schema:sameAs https://app.dimensions.ai/details/publication/pub.1052856309
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1111/hel.12165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051099661
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1111/hel.12380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084212946
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1111/j.1601-0825.2011.01796.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000356735
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1136/ard.61.6.554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039471766
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1136/bmj.312.7024.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062774535
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1136/bmj.329.7456.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009651897
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1136/bmjopen-2013-002857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053359464
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1155/2014/472978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038286728
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1164/rccm.200604-571st schema:sameAs https://app.dimensions.ai/details/publication/pub.1017257548
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1196/annals.1422.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019128658
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1345/aph.1a350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036384047
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1345/aph.1c525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029703100
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1371/journal.pone.0176549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085376474
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1377/hlthaff.22.3.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014036853
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1517/14740338.2015.995089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024347958
213 rdf:type schema:CreativeWork
214 https://doi.org/10.3748/wjg.v20.i3.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371179
215 rdf:type schema:CreativeWork
216 https://doi.org/10.5114/aoms.2014.44857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005045077
217 rdf:type schema:CreativeWork
218 https://doi.org/10.7326/0003-4819-140-10-200405180-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073706989
219 rdf:type schema:CreativeWork
220 https://doi.org/10.7326/0003-4819-140-10-200405180-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073706997
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.260770.4 schema:alternateName National Yang Ming University
223 schema:name Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
224 Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
225 Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan
226 School of Medicine, National Yang-Ming University, Taipei, Taiwan
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.265231.1 schema:alternateName Tunghai University
229 schema:name Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, Taiwan
230 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
231 Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
232 Institute of Biomedical Science and Rong-Hsing Research Center for Translational Medicine, Chung-Hsing University, Taichung, Taiwan
233 Institute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan
234 School of Medicine, Chung-Shan Medical University, Taichung, Taiwan
235 School of Medicine, National Yang-Ming University, Taipei, Taiwan
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.410764.0 schema:alternateName Taichung Veterans General Hospital
238 schema:name Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
239 rdf:type schema:Organization
240 https://www.grid.ac/institutes/grid.412038.c schema:alternateName National Changhua University of Education
241 schema:name Department of Business Administration, National Changhua University of Education, Changhua, Taiwan
242 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
243 Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
244 rdf:type schema:Organization
245 https://www.grid.ac/institutes/grid.412146.4 schema:alternateName National Taipei University of Nursing and Health Science
246 schema:name Department of Healthcare Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan
247 Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
248 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...