A comprehensive analysis of the faecal microbiome and metabolome of Strongyloides stercoralis infected volunteers from a non-endemic area View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Timothy P. Jenkins, Fabio Formenti, Cecilia Castro, Chiara Piubelli, Francesca Perandin, Dora Buonfrate, Domenico Otranto, Julian L. Griffin, Lutz Krause, Zeno Bisoffi, Cinzia Cantacessi

ABSTRACT

Data from recent studies support the hypothesis that infections by human gastrointestinal (GI) helminths impact, directly and/or indirectly, on the composition of the host gut microbial flora. However, to the best of our knowledge, these studies have been conducted in helminth-endemic areas with multi-helminth infections and/or in volunteers with underlying gut disorders. Therefore, in this study, we explore the impact of natural mono-infections by the human parasite Strongyloides stercoralis on the faecal microbiota and metabolic profiles of a cohort of human volunteers from a non-endemic area of northern Italy (S+), pre- and post-anthelmintic treatment, and compare the findings with data obtained from a cohort of uninfected controls from the same geographical area (S-). Analyses of bacterial 16S rRNA high-throughput sequencing data revealed increased microbial alpha diversity and decreased beta diversity in the faecal microbial profiles of S+ subjects compared to S-. Furthermore, significant differences in the abundance of several bacterial taxa were observed between samples from S+ and S- subjects, and between S+ samples collected pre- and post-anthelmintic treatment. Faecal metabolite analysis detected marked increases in the abundance of selected amino acids in S+ subjects, and of short chain fatty acids in S- subjects. Overall, our work adds valuable knowledge to current understanding of parasite-microbiota associations and will assist future mechanistic studies aimed to unravel the causality of these relationships. More... »

PAGES

15651

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-33937-3

    DOI

    http://dx.doi.org/10.1038/s41598-018-33937-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1107689578

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30353019


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