Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice View Full Text


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Article Info

DATE

2018-10-23

AUTHORS

Zi-Lun Lai, Ching-Hung Tseng, Hsiu J. Ho, Cynthia K. Y. Cheung, Jian-Yong Lin, Yi-Ju Chen, Fu-Chou Cheng, Yao-Chun Hsu, Jaw-Town Lin, Emad M. El-Omar, Chun-Ying Wu

ABSTRACT

Diet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity. More... »

PAGES

15625

References to SciGraph publications

  • 2013-10-12. HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota in MICROBIOME
  • 2011-11-07. A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein in LABORATORY INVESTIGATION
  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2012-09-12. Functional interactions between the gut microbiota and host metabolism in NATURE
  • 2014-09-17. Artificial sweeteners induce glucose intolerance by altering the gut microbiota in NATURE
  • 2013-08-18. UPARSE: highly accurate OTU sequences from microbial amplicon reads in NATURE METHODS
  • 2015-09-23. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats in SCIENTIFIC REPORTS
  • 2015-06-23. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota in NATURE COMMUNICATIONS
  • 2014-10-03. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2010-01-17. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity in NATURE MEDICINE
  • 2013-07-04. Stochastic changes over time and not founder effects drive cage effects in microbial community assembly in a mouse model in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2013-11-13. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells in NATURE
  • 2012-12-13. An opportunistic pathogen isolated from the gut of an obese human causes obesity in germfree mice in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2012-09-12. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour in NATURE REVIEWS NEUROSCIENCE
  • 2010-08-04. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects in LIPIDS IN HEALTH AND DISEASE
  • 2002-10. Emerging roles of PPARS in inflammation and immunity in NATURE REVIEWS IMMUNOLOGY
  • 2011-03. Complete genome sequence of Odoribacter splanchnicus type strain (1651/6T) in ENVIRONMENTAL MICROBIOME
  • 2014-12-09. Antibiotics in early life and obesity in NATURE REVIEWS ENDOCRINOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-33893-y

    DOI

    http://dx.doi.org/10.1038/s41598-018-33893-y

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30353027


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