Effect of therapy on Quantiferon-Plus response in patients with active and latent tuberculosis infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Elisa Petruccioli, Teresa Chiacchio, Valentina Vanini, Gilda Cuzzi, Luigi Ruffo Codecasa, Maurizio Ferrarese, Vincenzo Schininà, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti

ABSTRACT

Lack of biomarkers for treatment monitoring is listed among the main requirements for next generation assays, as identified globally among tuberculosis (TB) researchers. In this study, we evaluated in a low TB endemic country such as Italy, the effect of preventive therapy on the results obtained in the QuantiFERON TB Plus (QFT-Plus), in a cohort of subjects with latent TB infection (LTBI) and active TB. We found that TB therapy significantly decreased IFN-γ values and number of responders to TB1- and TB2- peptides stimulation in both LTBI and active TB patients. Stratifying LTBI subjects according to the type of preventive TB therapy used, we found that INH treatment but not INH and RIF significantly decreased IFN-γ production. Stratifying the active TB patients according the microbiological status, we found that TB therapy significantly decreased IFN-γ response to antigen present in QFT-Plus test in patients with clinical diagnosis compared to those with a microbiological diagnosis. In conclusions, we demonstrated that TB therapy decreases IFN-γ level in response to antigen present in QFT-Plus test in LTBI and active TB patients. Future studies are needed to better characterize Mtb-specifc response as a potential marker for monitoring TB therapy and preventive treatment effects. More... »

PAGES

15626

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-33825-w

DOI

http://dx.doi.org/10.1038/s41598-018-33825-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107689563

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30353115


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petruccioli", 
        "givenName": "Elisa", 
        "id": "sg:person.01316222666.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316222666.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiacchio", 
        "givenName": "Teresa", 
        "id": "sg:person.01250107466.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250107466.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vanini", 
        "givenName": "Valentina", 
        "id": "sg:person.0650313551.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650313551.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cuzzi", 
        "givenName": "Gilda", 
        "id": "sg:person.0604346205.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604346205.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Niguarda Ca' Granda", 
          "id": "https://www.grid.ac/institutes/grid.416200.1", 
          "name": [
            "Regional TB Reference Centre, Istituto Villa Marelli, Ospedale Niguarda, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Codecasa", 
        "givenName": "Luigi Ruffo", 
        "id": "sg:person.01353206452.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353206452.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Niguarda Ca' Granda", 
          "id": "https://www.grid.ac/institutes/grid.416200.1", 
          "name": [
            "Regional TB Reference Centre, Istituto Villa Marelli, Ospedale Niguarda, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrarese", 
        "givenName": "Maurizio", 
        "id": "sg:person.01136266127.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136266127.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Clinical Department National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schinin\u00e0", 
        "givenName": "Vincenzo", 
        "id": "sg:person.01260364730.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260364730.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Clinical Department National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palmieri", 
        "givenName": "Fabrizio", 
        "id": "sg:person.0655031534.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655031534.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ippolito", 
        "givenName": "Giuseppe", 
        "id": "sg:person.0710457221.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710457221.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani", 
          "id": "https://www.grid.ac/institutes/grid.419423.9", 
          "name": [
            "Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goletti", 
        "givenName": "Delia", 
        "id": "sg:person.01200446072.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200446072.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.4081/idr.2016.6568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001183725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciu795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005103859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/jiu821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006491241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.02033-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008896092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.02033-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008896092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.02033-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008896092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/589471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012175672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.diagmicrobio.2016.06.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019143909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2016.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021797973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2013.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021896499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01012-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023521447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01012-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023521447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01012-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023521447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200306-837oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024153366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201203-0430oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027426983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5588/ijtld.16.0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027584486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201107-1355oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027624133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00214014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036681216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00214014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036681216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00214014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036681216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0094949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039228578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.201243262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039240940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2014.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041064148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01179-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043420403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01179-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043420403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01179-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043420403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1101122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045956991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00510-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047198239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00510-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047198239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00510-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047198239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01245-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01245-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01245-2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050983905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077828069", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078179913", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.02498-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084222000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01976-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084249655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01976-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084249655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.01976-2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084249655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tube.2017.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086329656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.201704-0817oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090885387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0183846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091325245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jiac.2017.09.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092271637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tube.2017.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093057560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/resp.13272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101104270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1701737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101564675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1701737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101564675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1701737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101564675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1701737", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101564675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00153-2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101702153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00153-2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101702153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00153-2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101702153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/13993003.00153-2018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101702153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0193589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103158935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imlet.2018.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103185105"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Lack of biomarkers for treatment monitoring is listed among the main requirements for next generation assays, as identified globally among tuberculosis (TB) researchers. In this study, we evaluated in a low TB endemic country such as Italy, the effect of preventive therapy on the results obtained in the QuantiFERON TB Plus (QFT-Plus), in a cohort of subjects with latent TB infection (LTBI) and active TB. We found that TB therapy significantly decreased IFN-\u03b3 values and number of responders to TB1- and TB2- peptides stimulation in both LTBI and active TB patients. Stratifying LTBI subjects according to the type of preventive TB therapy used, we found that INH treatment but not INH and RIF significantly decreased IFN-\u03b3 production. Stratifying the active TB patients according the microbiological status, we found that TB therapy significantly decreased IFN-\u03b3 response to antigen present in QFT-Plus test in patients with clinical diagnosis compared to those with a microbiological diagnosis. In conclusions, we demonstrated that TB therapy decreases IFN-\u03b3 level in response to antigen present in QFT-Plus test in LTBI and active TB patients. Future studies are needed to better characterize Mtb-specifc response as a potential marker for monitoring TB therapy and preventive treatment effects.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-33825-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5476030", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3939966", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Effect of therapy on Quantiferon-Plus response in patients with active and latent tuberculosis infection", 
    "pagination": "15626", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03e2a164b53605e65c1e699c76da7430029f3fc9dc65cb1e0f040eb5798147fb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30353115"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-33825-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1107689563"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-33825-w", 
      "https://app.dimensions.ai/details/publication/pub.1107689563"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-33825-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-33825-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-33825-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-33825-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-33825-w'


 

This table displays all metadata directly associated to this object as RDF triples.

243 TRIPLES      21 PREDICATES      64 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-33825-w schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N5eb8abb5f3ca47c8869b6347e8a95a9b
4 schema:citation https://app.dimensions.ai/details/publication/pub.1077828069
5 https://app.dimensions.ai/details/publication/pub.1078179913
6 https://doi.org/10.1002/eji.201243262
7 https://doi.org/10.1016/j.diagmicrobio.2016.06.007
8 https://doi.org/10.1016/j.imlet.2018.04.001
9 https://doi.org/10.1016/j.jiac.2017.09.012
10 https://doi.org/10.1016/j.jinf.2013.02.004
11 https://doi.org/10.1016/j.jinf.2014.06.009
12 https://doi.org/10.1016/j.jinf.2016.09.008
13 https://doi.org/10.1016/j.tube.2017.06.002
14 https://doi.org/10.1016/j.tube.2017.11.014
15 https://doi.org/10.1093/cid/ciu795
16 https://doi.org/10.1093/infdis/jiu821
17 https://doi.org/10.1111/resp.13272
18 https://doi.org/10.1128/jcm.02498-16
19 https://doi.org/10.1155/2015/589471
20 https://doi.org/10.1164/rccm.200306-837oc
21 https://doi.org/10.1164/rccm.201107-1355oc
22 https://doi.org/10.1164/rccm.201203-0430oc
23 https://doi.org/10.1164/rccm.201704-0817oc
24 https://doi.org/10.1183/09031936.00214014
25 https://doi.org/10.1183/13993003.00153-2018
26 https://doi.org/10.1183/13993003.00510-2016
27 https://doi.org/10.1183/13993003.01012-2016
28 https://doi.org/10.1183/13993003.01179-2015
29 https://doi.org/10.1183/13993003.01245-2015
30 https://doi.org/10.1183/13993003.01976-2016
31 https://doi.org/10.1183/13993003.02033-2015
32 https://doi.org/10.1371/journal.pone.0094949
33 https://doi.org/10.1371/journal.pone.0183846
34 https://doi.org/10.1371/journal.pone.0193589
35 https://doi.org/10.4049/jimmunol.1101122
36 https://doi.org/10.4049/jimmunol.1701737
37 https://doi.org/10.4081/idr.2016.6568
38 https://doi.org/10.5588/ijtld.16.0342
39 schema:datePublished 2018-12
40 schema:datePublishedReg 2018-12-01
41 schema:description Lack of biomarkers for treatment monitoring is listed among the main requirements for next generation assays, as identified globally among tuberculosis (TB) researchers. In this study, we evaluated in a low TB endemic country such as Italy, the effect of preventive therapy on the results obtained in the QuantiFERON TB Plus (QFT-Plus), in a cohort of subjects with latent TB infection (LTBI) and active TB. We found that TB therapy significantly decreased IFN-γ values and number of responders to TB1- and TB2- peptides stimulation in both LTBI and active TB patients. Stratifying LTBI subjects according to the type of preventive TB therapy used, we found that INH treatment but not INH and RIF significantly decreased IFN-γ production. Stratifying the active TB patients according the microbiological status, we found that TB therapy significantly decreased IFN-γ response to antigen present in QFT-Plus test in patients with clinical diagnosis compared to those with a microbiological diagnosis. In conclusions, we demonstrated that TB therapy decreases IFN-γ level in response to antigen present in QFT-Plus test in LTBI and active TB patients. Future studies are needed to better characterize Mtb-specifc response as a potential marker for monitoring TB therapy and preventive treatment effects.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree true
45 schema:isPartOf N212b09f493ea44c18898055cdebfd0f3
46 Nd9dd5802ba2148708473f2c4a3d011c0
47 sg:journal.1045337
48 schema:name Effect of therapy on Quantiferon-Plus response in patients with active and latent tuberculosis infection
49 schema:pagination 15626
50 schema:productId N12a8ea4008db4c748c333541b984a249
51 N52cd5678e8fc4702a7c4f9a963e3a0b2
52 Na14cfcbb98994999a3918144d989bd50
53 Nd76e19d71f2242ad8d50018d5ef07521
54 Ndc5ea261c6494af9864062b9d279c5ae
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107689563
56 https://doi.org/10.1038/s41598-018-33825-w
57 schema:sdDatePublished 2019-04-10T21:48
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher Nd7354455cdb045e3bcb480fcd42678e1
60 schema:url https://www.nature.com/articles/s41598-018-33825-w
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N0ab7a28c43734d128c4b08fcba36f168 rdf:first sg:person.0604346205.97
65 rdf:rest N75e295d9c6424b06b44d4fe8a1842692
66 N12a8ea4008db4c748c333541b984a249 schema:name pubmed_id
67 schema:value 30353115
68 rdf:type schema:PropertyValue
69 N205ae1ea1b704fadb3848e382ffe3111 rdf:first sg:person.0710457221.03
70 rdf:rest Nce7b172313834b6cacb888a50f6a4a1e
71 N20d6b43e6e424ffeaab86079f602228c rdf:first sg:person.0655031534.49
72 rdf:rest N205ae1ea1b704fadb3848e382ffe3111
73 N212b09f493ea44c18898055cdebfd0f3 schema:issueNumber 1
74 rdf:type schema:PublicationIssue
75 N3a345644b60a4d3786ce90a34e7def3d rdf:first sg:person.01260364730.58
76 rdf:rest N20d6b43e6e424ffeaab86079f602228c
77 N4ecddcbe34f24d2d9b52c13cdd233fd4 rdf:first sg:person.0650313551.19
78 rdf:rest N0ab7a28c43734d128c4b08fcba36f168
79 N52cd5678e8fc4702a7c4f9a963e3a0b2 schema:name dimensions_id
80 schema:value pub.1107689563
81 rdf:type schema:PropertyValue
82 N5eb8abb5f3ca47c8869b6347e8a95a9b rdf:first sg:person.01316222666.31
83 rdf:rest Nc39eed2c81a84b40b20c19e66d22fad0
84 N75e295d9c6424b06b44d4fe8a1842692 rdf:first sg:person.01353206452.52
85 rdf:rest N8965221295154e34b7c3602d0b4a63f8
86 N8965221295154e34b7c3602d0b4a63f8 rdf:first sg:person.01136266127.09
87 rdf:rest N3a345644b60a4d3786ce90a34e7def3d
88 Na14cfcbb98994999a3918144d989bd50 schema:name readcube_id
89 schema:value 03e2a164b53605e65c1e699c76da7430029f3fc9dc65cb1e0f040eb5798147fb
90 rdf:type schema:PropertyValue
91 Nc39eed2c81a84b40b20c19e66d22fad0 rdf:first sg:person.01250107466.00
92 rdf:rest N4ecddcbe34f24d2d9b52c13cdd233fd4
93 Nce7b172313834b6cacb888a50f6a4a1e rdf:first sg:person.01200446072.99
94 rdf:rest rdf:nil
95 Nd7354455cdb045e3bcb480fcd42678e1 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 Nd76e19d71f2242ad8d50018d5ef07521 schema:name nlm_unique_id
98 schema:value 101563288
99 rdf:type schema:PropertyValue
100 Nd9dd5802ba2148708473f2c4a3d011c0 schema:volumeNumber 8
101 rdf:type schema:PublicationVolume
102 Ndc5ea261c6494af9864062b9d279c5ae schema:name doi
103 schema:value 10.1038/s41598-018-33825-w
104 rdf:type schema:PropertyValue
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
109 schema:name Clinical Sciences
110 rdf:type schema:DefinedTerm
111 sg:grant.3939966 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-33825-w
112 rdf:type schema:MonetaryGrant
113 sg:grant.5476030 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-33825-w
114 rdf:type schema:MonetaryGrant
115 sg:journal.1045337 schema:issn 2045-2322
116 schema:name Scientific Reports
117 rdf:type schema:Periodical
118 sg:person.01136266127.09 schema:affiliation https://www.grid.ac/institutes/grid.416200.1
119 schema:familyName Ferrarese
120 schema:givenName Maurizio
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136266127.09
122 rdf:type schema:Person
123 sg:person.01200446072.99 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
124 schema:familyName Goletti
125 schema:givenName Delia
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200446072.99
127 rdf:type schema:Person
128 sg:person.01250107466.00 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
129 schema:familyName Chiacchio
130 schema:givenName Teresa
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250107466.00
132 rdf:type schema:Person
133 sg:person.01260364730.58 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
134 schema:familyName Schininà
135 schema:givenName Vincenzo
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260364730.58
137 rdf:type schema:Person
138 sg:person.01316222666.31 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
139 schema:familyName Petruccioli
140 schema:givenName Elisa
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316222666.31
142 rdf:type schema:Person
143 sg:person.01353206452.52 schema:affiliation https://www.grid.ac/institutes/grid.416200.1
144 schema:familyName Codecasa
145 schema:givenName Luigi Ruffo
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353206452.52
147 rdf:type schema:Person
148 sg:person.0604346205.97 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
149 schema:familyName Cuzzi
150 schema:givenName Gilda
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604346205.97
152 rdf:type schema:Person
153 sg:person.0650313551.19 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
154 schema:familyName Vanini
155 schema:givenName Valentina
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650313551.19
157 rdf:type schema:Person
158 sg:person.0655031534.49 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
159 schema:familyName Palmieri
160 schema:givenName Fabrizio
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655031534.49
162 rdf:type schema:Person
163 sg:person.0710457221.03 schema:affiliation https://www.grid.ac/institutes/grid.419423.9
164 schema:familyName Ippolito
165 schema:givenName Giuseppe
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710457221.03
167 rdf:type schema:Person
168 https://app.dimensions.ai/details/publication/pub.1077828069 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1078179913 schema:CreativeWork
170 https://doi.org/10.1002/eji.201243262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039240940
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.diagmicrobio.2016.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019143909
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.imlet.2018.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103185105
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.jiac.2017.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092271637
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.jinf.2013.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021896499
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.jinf.2014.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041064148
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.jinf.2016.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021797973
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.tube.2017.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086329656
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.tube.2017.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093057560
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1093/cid/ciu795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005103859
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/infdis/jiu821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006491241
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1111/resp.13272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101104270
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1128/jcm.02498-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084222000
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1155/2015/589471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012175672
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1164/rccm.200306-837oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1024153366
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1164/rccm.201107-1355oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1027624133
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1164/rccm.201203-0430oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1027426983
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1164/rccm.201704-0817oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1090885387
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1183/09031936.00214014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036681216
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1183/13993003.00153-2018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101702153
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1183/13993003.00510-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047198239
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1183/13993003.01012-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023521447
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1183/13993003.01179-2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043420403
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1183/13993003.01245-2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050983905
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1183/13993003.01976-2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084249655
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1183/13993003.02033-2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008896092
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1371/journal.pone.0094949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039228578
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1371/journal.pone.0183846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091325245
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1371/journal.pone.0193589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103158935
227 rdf:type schema:CreativeWork
228 https://doi.org/10.4049/jimmunol.1101122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045956991
229 rdf:type schema:CreativeWork
230 https://doi.org/10.4049/jimmunol.1701737 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101564675
231 rdf:type schema:CreativeWork
232 https://doi.org/10.4081/idr.2016.6568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001183725
233 rdf:type schema:CreativeWork
234 https://doi.org/10.5588/ijtld.16.0342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027584486
235 rdf:type schema:CreativeWork
236 https://www.grid.ac/institutes/grid.416200.1 schema:alternateName Ospedale Niguarda Ca' Granda
237 schema:name Regional TB Reference Centre, Istituto Villa Marelli, Ospedale Niguarda, Milano, Italy
238 rdf:type schema:Organization
239 https://www.grid.ac/institutes/grid.419423.9 schema:alternateName Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
240 schema:name Clinical Department National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
241 Scientific Direction, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy
242 Translational Research Unit National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, Rome, Italy
243 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...