An interspecies barrier to tetraploid complementation and chimera formation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tomoyuki Yamaguchi, Hideyuki Sato, Toshihiro Kobayashi, Megumi Kato-itoh, Teppei Goto, Hiromasa Hara, Naoaki Mizuno, Ayaka Yanagida, Ayumi Umino, Sanae Hamanaka, Fabian Suchy, Hideki Masaki, Yasunori Ota, Masumi Hirabayashi, Hiromitsu Nakauchi

ABSTRACT

To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high donor chimerism was associated with anomalies or embryonic death. Organ to organ variation in donor chimerism was greater in interspecies chimeras than in intraspecies chimeras, suggesting species-specific affinity differences among interacting molecules necessary for organogenesis. In interspecies tetraploid complementation, embryo development was near normal until the stage of placental formation, after which no embryos survived. More... »

PAGES

15289

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-33690-7

DOI

http://dx.doi.org/10.1038/s41598-018-33690-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107542137

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30327488


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29 schema:description To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high donor chimerism was associated with anomalies or embryonic death. Organ to organ variation in donor chimerism was greater in interspecies chimeras than in intraspecies chimeras, suggesting species-specific affinity differences among interacting molecules necessary for organogenesis. In interspecies tetraploid complementation, embryo development was near normal until the stage of placental formation, after which no embryos survived.
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