Microwave treatment of the cornea leads to localised disruption of the extracellular matrix View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09-13

AUTHORS

Siân R. Morgan, Osamu Hieda, Yoshinori Nakai, Craig Boote, Sally Hayes, Shigeru Kinoshita, Keith M. Meek, Andrew J. Quantock

ABSTRACT

Microwave keratoplasty is a thermo-refractive surgical procedure that can correct myopia (short-sightedness) and pathologic corneal steepening by using microwave energy to cause localised shrinkage around an annulus of the cornea leading to its flattening and vision correction. The effects on the corneal extracellular matrix, however, have not yet been evaluated, thus the current study to assess post-procedure ultrastructural changes in an in-vivo rabbit model. To achieve this a series of small-angle x-ray scattering (SAXS) experiments were carried out across whole transects of treated and untreated rabbit corneas at 0.25 mm intervals, which indicated no significant change in collagen intra-fibrillar parameters (i.e. collagen fibril diameter or axial D-period), whereas inter-fibrillar measures (i.e. fibril spacing and the degree of spatial order) were markedly altered in microwave-treated regions of the cornea. These structural matrix alterations in microwave-treated corneas have predicted implications for corneal biomechanical strength and tissue transparency, and, we contend, potentially render microwave-treated corneas resistant to surgical stabilization using corneal cross-linking procedures currently employed to combat refractive error caused by corneal steepening. More... »

PAGES

13742

References to SciGraph publications

  • 2002-05. Roles of lumican and keratocan on corneal transparency in GLYCOCONJUGATE JOURNAL
  • 2009-12-27. Structural and biochemical aspects of keratan sulphate in the cornea in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1964-12. Shrinkage Temperature of Eye Collagen in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-32110-0

    DOI

    http://dx.doi.org/10.1038/s41598-018-32110-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106859034

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30213993


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