Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

S. Marina Casalino-Matsuda, Naizhen Wang, Peder T. Ruhoff, Hiroaki Matsuda, Marie C. Nlend, Aisha Nair, Igal Szleifer, Greg J. Beitel, Jacob I. Sznajder, Peter H. S. Sporn

ABSTRACT

Hypercapnia, the elevation of CO2 in blood and tissues, commonly occurs in severe acute and chronic respiratory diseases, and is associated with increased risk of mortality. Recent studies have shown that hypercapnia adversely affects innate immunity, host defense, lung edema clearance and cell proliferation. Airway epithelial dysfunction is a feature of advanced lung disease, but the effect of hypercapnia on airway epithelium is unknown. Thus, in the current study we examined the effect of normoxic hypercapnia (20% CO2 for 24 h) vs normocapnia (5% CO2), on global gene expression in differentiated normal human airway epithelial cells. Gene expression was assessed on Affymetrix microarrays, and subjected to gene ontology analysis for biological process and cluster-network representation. We found that hypercapnia downregulated the expression of 183 genes and upregulated 126. Among these, major gene clusters linked to immune responses and nucleosome assembly were largely downregulated, while lipid metabolism genes were largely upregulated. The overwhelming majority of these genes were not previously known to be regulated by CO2. These changes in gene expression indicate the potential for hypercapnia to impact bronchial epithelial cell function in ways that may contribute to poor clinical outcomes in patients with severe acute or advanced chronic lung diseases. More... »

PAGES

13508

References to SciGraph publications

  • 2016-12. CXCL14 as an emerging immune and inflammatory modulator in JOURNAL OF INFLAMMATION
  • 2013-01. Histone chaperones in nucleosome assembly and human disease in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2010-04. Histone variants — ancient wrap artists of the epigenome in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-02. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome in INTENSIVE CARE MEDICINE
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 2015-12. Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis in CELL COMMUNICATION AND SIGNALING
  • 2006-12. Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit in BMC PULMONARY MEDICINE
  • 2014-12. Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases in NATURE COMMUNICATIONS
  • 2015-01. Respiratory epithelial cells orchestrate pulmonary innate immunity in NATURE IMMUNOLOGY
  • 2004-09. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • 2004-04. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance in NATURE IMMUNOLOGY
  • 2007-12. Epithelial expression of TLR4 is modulated in COPD and by steroids, salmeterol and cigarette smoke in RESPIRATORY RESEARCH
  • 2000-11. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus in NATURE IMMUNOLOGY
  • 2003-10. APACHE II Predicts long-term survival in COPD patients admitted to a general medical ward in JOURNAL OF GENERAL INTERNAL MEDICINE
  • 2015-03. Histone exchange, chromatin structure and the regulation of transcription in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-32008-x

    DOI

    http://dx.doi.org/10.1038/s41598-018-32008-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106681236

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30202079


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Casalino-Matsuda", 
            "givenName": "S. Marina", 
            "id": "sg:person.01070561503.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070561503.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Naizhen", 
            "id": "sg:person.015136247273.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015136247273.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Southern Denmark", 
              "id": "https://www.grid.ac/institutes/grid.10825.3e", 
              "name": [
                "Department of Technology and Innovation, University of Southern Denmark, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruhoff", 
            "givenName": "Peder T.", 
            "id": "sg:person.012127673165.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012127673165.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wilbur Wright College", 
              "id": "https://www.grid.ac/institutes/grid.443944.a", 
              "name": [
                "Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America", 
                "Department of Physical Sciences & Engineering, Wilbur Wright College, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuda", 
            "givenName": "Hiroaki", 
            "id": "sg:person.0615776360.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615776360.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Thermo Fisher Scientific (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418190.5", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America", 
                "Division of Protein and Cellular Analysis, Thermo Fisher Scientific, Rockford, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nlend", 
            "givenName": "Marie C.", 
            "id": "sg:person.01065105332.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065105332.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nair", 
            "givenName": "Aisha", 
            "id": "sg:person.01210443565.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210443565.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America", 
                "Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America", 
                "Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Szleifer", 
            "givenName": "Igal", 
            "id": "sg:person.0732122243.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732122243.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beitel", 
            "givenName": "Greg J.", 
            "id": "sg:person.01220641520.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220641520.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Northwestern University", 
              "id": "https://www.grid.ac/institutes/grid.16753.36", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sznajder", 
            "givenName": "Jacob I.", 
            "id": "sg:person.013761134037.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013761134037.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Jesse Brown VA Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.280892.9", 
              "name": [
                "Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America", 
                "Jesse Brown VA Medical Center, Chicago, Illinois, United States of America"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sporn", 
            "givenName": "Peter H. S.", 
            "id": "sg:person.01005546670.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005546670.40"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.jcv.2009.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000496291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1000701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000899376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.124.2.459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002469251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.124.2.459", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002469251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.04.00014304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002783277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/ajrcmb.14.1.8534481", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002967338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004991127", 
              "https://doi.org/10.1038/nrm3941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/15412555.2013.777400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005817098"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.122.6_suppl.314s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009005273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.122.6_suppl.314s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009005273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.82.3.310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010707517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0905925106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010738154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr1282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011364425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbalip.2009.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013385233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4021/jocmr612w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014321771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/intimm/dxh052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015502770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/ajrcmb.20.4.3442", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015654037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1500150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015659829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200410-1369oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015692518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/rcmb.2012-0487oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015933345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016098431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2443.2009.01361.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016742195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2443.2009.01361.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016742195"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.72.2.788-794.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017805427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018457673", 
              "https://doi.org/10.1186/gb-2004-5-10-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-136895", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018769680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0001238", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020004684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2466-6-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020253315", 
              "https://doi.org/10.1186/1471-2466-6-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1465-9921-8-84", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020496063", 
              "https://doi.org/10.1186/1465-9921-8-84"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drudis.2015.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020518266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.intimp.2015.04.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021457438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.79.19.12125-12131.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022993154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200607-1029oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023048388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023414120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023509855", 
              "https://doi.org/10.1038/nrm2861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023509855", 
              "https://doi.org/10.1038/nrm2861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s2213-2600(14)70153-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023518594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200939819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024411139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.200939819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024411139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ppul.20984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024639972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ppul.20984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024639972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026099411", 
              "https://doi.org/10.1038/ni1050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026099411", 
              "https://doi.org/10.1038/ni1050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027151439", 
              "https://doi.org/10.1038/ncomms4423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/meth.2001.1262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027621591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/meth.2001.1262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027621591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1513/pats.200605-126sf", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028475222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2011.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032963120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.2089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035817137", 
              "https://doi.org/10.1038/nmeth.2089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks865", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036199832"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.emboj.7600120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036301591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/rcmb.2011-0011rt", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037782107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2011.01033.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038224360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1046/j.1525-1497.2003.20615.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039438481", 
              "https://doi.org/10.1046/j.1525-1497.2003.20615.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.1973.03220340019004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039786839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/80833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040794429", 
              "https://doi.org/10.1038/80833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040803973", 
              "https://doi.org/10.1038/ni.3045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0800353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041633279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/japplphysiol.01031.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041973758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12950-015-0109-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042069486", 
              "https://doi.org/10.1186/s12950-015-0109-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.2461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042448082", 
              "https://doi.org/10.1038/nsmb.2461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(99)02388-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042552020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.169.6.3155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043365566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1501708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043396093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2016.07.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043660515"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000598", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043783906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gks1147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044402199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31817d1b59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045783785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e31817d1b59", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045783785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1165/rcmb.2005-0386oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048373592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjmed.2004.10.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050956530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m111.290056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052548203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12964-015-0115-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052557638", 
              "https://doi.org/10.1186/s12964-015-0115-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032713-120145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053315409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biochi.2008.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053687266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4611-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054039100", 
              "https://doi.org/10.1007/s00134-016-4611-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-016-4611-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054039100", 
              "https://doi.org/10.1007/s00134-016-4611-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.225.7.705", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054130026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci29723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/me.2014-1049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064329100"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/copd.2007.2.1.55", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069103165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajplung.2000.278.6.l1118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074647529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.2.810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074975202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.5.2356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075002205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078948383", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1402634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079085868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jir.2016.0076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083843897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2017.4451", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085460260"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Hypercapnia, the elevation of CO2 in blood and tissues, commonly occurs in severe acute and chronic respiratory diseases, and is associated with increased risk of mortality. Recent studies have shown that hypercapnia adversely affects innate immunity, host defense, lung edema clearance and cell proliferation. Airway epithelial dysfunction is a feature of advanced lung disease, but the effect of hypercapnia on airway epithelium is unknown. Thus, in the current study we examined the effect of normoxic hypercapnia (20% CO2 for 24\u2009h) vs normocapnia (5% CO2), on global gene expression in differentiated normal human airway epithelial cells. Gene expression was assessed on Affymetrix microarrays, and subjected to gene ontology analysis for biological process and cluster-network representation. We found that hypercapnia downregulated the expression of 183 genes and upregulated 126. Among these, major gene clusters linked to immune responses and nucleosome assembly were largely downregulated, while lipid metabolism genes were largely upregulated. The overwhelming majority of these genes were not previously known to be regulated by CO2. These changes in gene expression indicate the potential for hypercapnia to impact bronchial epithelial cell function in ways that may contribute to poor clinical outcomes in patients with severe acute or advanced chronic lung diseases.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-32008-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2543256", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.4103393", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6377707", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7027424", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2541136", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells", 
        "pagination": "13508", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e0f445b76143586f1d648ec8da045da037bcb29340c23f277abed69197422681"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30202079"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-32008-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1106681236"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-32008-x", 
          "https://app.dimensions.ai/details/publication/pub.1106681236"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:20", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78970_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-32008-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-32008-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-32008-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-32008-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-32008-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    408 TRIPLES      21 PREDICATES      107 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-32008-x schema:about anzsrc-for:11
    2 anzsrc-for:1102
    3 schema:author N65b7d761c93242ca9d23000479d1a02b
    4 schema:citation sg:pub.10.1007/s00134-016-4611-1
    5 sg:pub.10.1038/80833
    6 sg:pub.10.1038/ncomms4423
    7 sg:pub.10.1038/ni.3045
    8 sg:pub.10.1038/ni1050
    9 sg:pub.10.1038/nmeth.2089
    10 sg:pub.10.1038/nrm2861
    11 sg:pub.10.1038/nrm3941
    12 sg:pub.10.1038/nsmb.2461
    13 sg:pub.10.1046/j.1525-1497.2003.20615.x
    14 sg:pub.10.1186/1465-9921-8-84
    15 sg:pub.10.1186/1471-2466-6-27
    16 sg:pub.10.1186/gb-2004-5-10-r80
    17 sg:pub.10.1186/s12950-015-0109-9
    18 sg:pub.10.1186/s12964-015-0115-9
    19 https://app.dimensions.ai/details/publication/pub.1078948383
    20 https://doi.org/10.1001/jama.1973.03220340019004
    21 https://doi.org/10.1001/jama.2017.4451
    22 https://doi.org/10.1001/jama.225.7.705
    23 https://doi.org/10.1002/eji.200939819
    24 https://doi.org/10.1002/ppul.20984
    25 https://doi.org/10.1006/meth.2001.1262
    26 https://doi.org/10.1016/j.amjmed.2004.10.014
    27 https://doi.org/10.1016/j.bbalip.2009.01.007
    28 https://doi.org/10.1016/j.biochi.2008.07.003
    29 https://doi.org/10.1016/j.drudis.2015.11.001
    30 https://doi.org/10.1016/j.intimp.2015.04.031
    31 https://doi.org/10.1016/j.jcv.2009.07.010
    32 https://doi.org/10.1016/j.tim.2011.03.007
    33 https://doi.org/10.1016/j.virol.2016.07.030
    34 https://doi.org/10.1016/s0140-6736(99)02388-0
    35 https://doi.org/10.1016/s2213-2600(14)70153-5
    36 https://doi.org/10.1038/sj.emboj.7600120
    37 https://doi.org/10.1056/nejmra0800353
    38 https://doi.org/10.1073/pnas.0905925106
    39 https://doi.org/10.1074/jbc.m111.290056
    40 https://doi.org/10.1089/jir.2016.0076
    41 https://doi.org/10.1093/intimm/dxh052
    42 https://doi.org/10.1093/nar/gkr1282
    43 https://doi.org/10.1093/nar/gks1147
    44 https://doi.org/10.1093/nar/gks865
    45 https://doi.org/10.1093/nar/gkv007
    46 https://doi.org/10.1093/nar/gkw419
    47 https://doi.org/10.1096/fj.09-136895
    48 https://doi.org/10.1097/ccm.0b013e31817d1b59
    49 https://doi.org/10.1111/j.1365-2443.2009.01361.x
    50 https://doi.org/10.1111/j.1600-065x.2011.01033.x
    51 https://doi.org/10.1128/iai.72.2.788-794.2004
    52 https://doi.org/10.1128/jvi.79.19.12125-12131.2005
    53 https://doi.org/10.1146/annurev-immunol-032713-120145
    54 https://doi.org/10.1152/ajplung.2000.278.6.l1118
    55 https://doi.org/10.1152/japplphysiol.01031.2005
    56 https://doi.org/10.1164/rccm.200410-1369oc
    57 https://doi.org/10.1164/rccm.200607-1029oc
    58 https://doi.org/10.1165/ajrcmb.14.1.8534481
    59 https://doi.org/10.1165/ajrcmb.20.4.3442
    60 https://doi.org/10.1165/rcmb.2005-0386oc
    61 https://doi.org/10.1165/rcmb.2011-0011rt
    62 https://doi.org/10.1165/rcmb.2012-0487oc
    63 https://doi.org/10.1172/jci29723
    64 https://doi.org/10.1183/09031936.04.00014304
    65 https://doi.org/10.1210/me.2014-1049
    66 https://doi.org/10.1371/journal.pbio.1000598
    67 https://doi.org/10.1371/journal.pone.0001238
    68 https://doi.org/10.1378/chest.122.6_suppl.314s
    69 https://doi.org/10.1378/chest.124.2.459
    70 https://doi.org/10.1378/chest.82.3.310
    71 https://doi.org/10.1513/pats.200605-126sf
    72 https://doi.org/10.2147/copd.2007.2.1.55
    73 https://doi.org/10.3109/15412555.2013.777400
    74 https://doi.org/10.4021/jocmr612w
    75 https://doi.org/10.4049/jimmunol.1000701
    76 https://doi.org/10.4049/jimmunol.1402634
    77 https://doi.org/10.4049/jimmunol.1500150
    78 https://doi.org/10.4049/jimmunol.1501708
    79 https://doi.org/10.4049/jimmunol.168.2.810
    80 https://doi.org/10.4049/jimmunol.168.5.2356
    81 https://doi.org/10.4049/jimmunol.169.6.3155
    82 schema:datePublished 2018-12
    83 schema:datePublishedReg 2018-12-01
    84 schema:description Hypercapnia, the elevation of CO<sub>2</sub> in blood and tissues, commonly occurs in severe acute and chronic respiratory diseases, and is associated with increased risk of mortality. Recent studies have shown that hypercapnia adversely affects innate immunity, host defense, lung edema clearance and cell proliferation. Airway epithelial dysfunction is a feature of advanced lung disease, but the effect of hypercapnia on airway epithelium is unknown. Thus, in the current study we examined the effect of normoxic hypercapnia (20% CO<sub>2</sub> for 24 h) vs normocapnia (5% CO<sub>2</sub>), on global gene expression in differentiated normal human airway epithelial cells. Gene expression was assessed on Affymetrix microarrays, and subjected to gene ontology analysis for biological process and cluster-network representation. We found that hypercapnia downregulated the expression of 183 genes and upregulated 126. Among these, major gene clusters linked to immune responses and nucleosome assembly were largely downregulated, while lipid metabolism genes were largely upregulated. The overwhelming majority of these genes were not previously known to be regulated by CO<sub>2</sub>. These changes in gene expression indicate the potential for hypercapnia to impact bronchial epithelial cell function in ways that may contribute to poor clinical outcomes in patients with severe acute or advanced chronic lung diseases.
    85 schema:genre research_article
    86 schema:inLanguage en
    87 schema:isAccessibleForFree true
    88 schema:isPartOf N5d1102db39f540a5bb19ec38ff53923b
    89 N983c42af6a224bdf82c813959bdbd2eb
    90 sg:journal.1045337
    91 schema:name Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells
    92 schema:pagination 13508
    93 schema:productId N0825d7a9d9d04859babcae63b8c753d6
    94 N1df852881d2f4b52bf555b7c1a99faa1
    95 Nbd942356d63041bf9d3a9f1b649569e3
    96 Ne394fecfdf5e45e4b9146fcabb3f892c
    97 Nf42b641eb1ac41428ea6dc91b805328f
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106681236
    99 https://doi.org/10.1038/s41598-018-32008-x
    100 schema:sdDatePublished 2019-04-11T13:20
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N0408adb24e4e40e083f3fe325806763e
    103 schema:url https://www.nature.com/articles/s41598-018-32008-x
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N0408adb24e4e40e083f3fe325806763e schema:name Springer Nature - SN SciGraph project
    108 rdf:type schema:Organization
    109 N0825d7a9d9d04859babcae63b8c753d6 schema:name pubmed_id
    110 schema:value 30202079
    111 rdf:type schema:PropertyValue
    112 N1df852881d2f4b52bf555b7c1a99faa1 schema:name nlm_unique_id
    113 schema:value 101563288
    114 rdf:type schema:PropertyValue
    115 N302f818ddbe84009aab385cd10cb42c5 rdf:first sg:person.0732122243.82
    116 rdf:rest Nbeb218f98e2742cd8037f310b12276b3
    117 N486411ccdde64f97941f7786b5a90ec8 rdf:first sg:person.015136247273.26
    118 rdf:rest N83bf1f3d1dc54eb7b7caf4ce0b804cac
    119 N4f748576d1ec4da584824749ed38e22d rdf:first sg:person.01005546670.40
    120 rdf:rest rdf:nil
    121 N5d1102db39f540a5bb19ec38ff53923b schema:issueNumber 1
    122 rdf:type schema:PublicationIssue
    123 N65b7d761c93242ca9d23000479d1a02b rdf:first sg:person.01070561503.03
    124 rdf:rest N486411ccdde64f97941f7786b5a90ec8
    125 N6cc1935fe83c43589fabfffa4b183637 rdf:first sg:person.01065105332.78
    126 rdf:rest N92a54a8dd58543208e0bdb5b61066a77
    127 N736863a2042240d68b0c3d39cc534bab rdf:first sg:person.013761134037.57
    128 rdf:rest N4f748576d1ec4da584824749ed38e22d
    129 N83bf1f3d1dc54eb7b7caf4ce0b804cac rdf:first sg:person.012127673165.38
    130 rdf:rest Nbe86930732dd4459960f7f19136d8402
    131 N92a54a8dd58543208e0bdb5b61066a77 rdf:first sg:person.01210443565.42
    132 rdf:rest N302f818ddbe84009aab385cd10cb42c5
    133 N983c42af6a224bdf82c813959bdbd2eb schema:volumeNumber 8
    134 rdf:type schema:PublicationVolume
    135 Nbd942356d63041bf9d3a9f1b649569e3 schema:name doi
    136 schema:value 10.1038/s41598-018-32008-x
    137 rdf:type schema:PropertyValue
    138 Nbe86930732dd4459960f7f19136d8402 rdf:first sg:person.0615776360.49
    139 rdf:rest N6cc1935fe83c43589fabfffa4b183637
    140 Nbeb218f98e2742cd8037f310b12276b3 rdf:first sg:person.01220641520.92
    141 rdf:rest N736863a2042240d68b0c3d39cc534bab
    142 Ne394fecfdf5e45e4b9146fcabb3f892c schema:name readcube_id
    143 schema:value e0f445b76143586f1d648ec8da045da037bcb29340c23f277abed69197422681
    144 rdf:type schema:PropertyValue
    145 Nf42b641eb1ac41428ea6dc91b805328f schema:name dimensions_id
    146 schema:value pub.1106681236
    147 rdf:type schema:PropertyValue
    148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    149 schema:name Medical and Health Sciences
    150 rdf:type schema:DefinedTerm
    151 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    152 schema:name Cardiorespiratory Medicine and Haematology
    153 rdf:type schema:DefinedTerm
    154 sg:grant.2541136 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-32008-x
    155 rdf:type schema:MonetaryGrant
    156 sg:grant.2543256 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-32008-x
    157 rdf:type schema:MonetaryGrant
    158 sg:grant.4103393 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-32008-x
    159 rdf:type schema:MonetaryGrant
    160 sg:grant.6377707 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-32008-x
    161 rdf:type schema:MonetaryGrant
    162 sg:grant.7027424 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-32008-x
    163 rdf:type schema:MonetaryGrant
    164 sg:journal.1045337 schema:issn 2045-2322
    165 schema:name Scientific Reports
    166 rdf:type schema:Periodical
    167 sg:person.01005546670.40 schema:affiliation https://www.grid.ac/institutes/grid.280892.9
    168 schema:familyName Sporn
    169 schema:givenName Peter H. S.
    170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005546670.40
    171 rdf:type schema:Person
    172 sg:person.01065105332.78 schema:affiliation https://www.grid.ac/institutes/grid.418190.5
    173 schema:familyName Nlend
    174 schema:givenName Marie C.
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065105332.78
    176 rdf:type schema:Person
    177 sg:person.01070561503.03 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    178 schema:familyName Casalino-Matsuda
    179 schema:givenName S. Marina
    180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070561503.03
    181 rdf:type schema:Person
    182 sg:person.01210443565.42 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    183 schema:familyName Nair
    184 schema:givenName Aisha
    185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210443565.42
    186 rdf:type schema:Person
    187 sg:person.012127673165.38 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
    188 schema:familyName Ruhoff
    189 schema:givenName Peder T.
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012127673165.38
    191 rdf:type schema:Person
    192 sg:person.01220641520.92 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    193 schema:familyName Beitel
    194 schema:givenName Greg J.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220641520.92
    196 rdf:type schema:Person
    197 sg:person.013761134037.57 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    198 schema:familyName Sznajder
    199 schema:givenName Jacob I.
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013761134037.57
    201 rdf:type schema:Person
    202 sg:person.015136247273.26 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    203 schema:familyName Wang
    204 schema:givenName Naizhen
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015136247273.26
    206 rdf:type schema:Person
    207 sg:person.0615776360.49 schema:affiliation https://www.grid.ac/institutes/grid.443944.a
    208 schema:familyName Matsuda
    209 schema:givenName Hiroaki
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615776360.49
    211 rdf:type schema:Person
    212 sg:person.0732122243.82 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
    213 schema:familyName Szleifer
    214 schema:givenName Igal
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732122243.82
    216 rdf:type schema:Person
    217 sg:pub.10.1007/s00134-016-4611-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054039100
    218 https://doi.org/10.1007/s00134-016-4611-1
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/80833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040794429
    221 https://doi.org/10.1038/80833
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/ncomms4423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027151439
    224 https://doi.org/10.1038/ncomms4423
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/ni.3045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040803973
    227 https://doi.org/10.1038/ni.3045
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/ni1050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026099411
    230 https://doi.org/10.1038/ni1050
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/nmeth.2089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035817137
    233 https://doi.org/10.1038/nmeth.2089
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/nrm2861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023509855
    236 https://doi.org/10.1038/nrm2861
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/nrm3941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004991127
    239 https://doi.org/10.1038/nrm3941
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/nsmb.2461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042448082
    242 https://doi.org/10.1038/nsmb.2461
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1046/j.1525-1497.2003.20615.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039438481
    245 https://doi.org/10.1046/j.1525-1497.2003.20615.x
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1186/1465-9921-8-84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020496063
    248 https://doi.org/10.1186/1465-9921-8-84
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1186/1471-2466-6-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020253315
    251 https://doi.org/10.1186/1471-2466-6-27
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
    254 https://doi.org/10.1186/gb-2004-5-10-r80
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1186/s12950-015-0109-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069486
    257 https://doi.org/10.1186/s12950-015-0109-9
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/s12964-015-0115-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052557638
    260 https://doi.org/10.1186/s12964-015-0115-9
    261 rdf:type schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1078948383 schema:CreativeWork
    263 https://doi.org/10.1001/jama.1973.03220340019004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039786839
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1001/jama.2017.4451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085460260
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1001/jama.225.7.705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054130026
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/eji.200939819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024411139
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/ppul.20984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024639972
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.amjmed.2004.10.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050956530
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.bbalip.2009.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013385233
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.biochi.2008.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053687266
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.drudis.2015.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020518266
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.intimp.2015.04.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021457438
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.jcv.2009.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000496291
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.tim.2011.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032963120
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.virol.2016.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043660515
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/s0140-6736(99)02388-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042552020
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/s2213-2600(14)70153-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023518594
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1038/sj.emboj.7600120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036301591
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1056/nejmra0800353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041633279
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1073/pnas.0905925106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010738154
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1074/jbc.m111.290056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052548203
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1089/jir.2016.0076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083843897
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/intimm/dxh052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015502770
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/nar/gkr1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011364425
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/nar/gks1147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044402199
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1093/nar/gks865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199832
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/nar/gkv007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016098431
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/nar/gkw419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023414120
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1096/fj.09-136895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018769680
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1097/ccm.0b013e31817d1b59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045783785
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/j.1365-2443.2009.01361.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016742195
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1111/j.1600-065x.2011.01033.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038224360
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1128/iai.72.2.788-794.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017805427
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1128/jvi.79.19.12125-12131.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022993154
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1146/annurev-immunol-032713-120145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053315409
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1152/ajplung.2000.278.6.l1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074647529
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1152/japplphysiol.01031.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041973758
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1164/rccm.200410-1369oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1015692518
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1164/rccm.200607-1029oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1023048388
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1165/ajrcmb.14.1.8534481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002967338
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1165/ajrcmb.20.4.3442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015654037
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1165/rcmb.2005-0386oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1048373592
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1165/rcmb.2011-0011rt schema:sameAs https://app.dimensions.ai/details/publication/pub.1037782107
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1165/rcmb.2012-0487oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1015933345
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1172/jci29723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416930
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1183/09031936.04.00014304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002783277
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1210/me.2014-1049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064329100
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1371/journal.pbio.1000598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043783906
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1371/journal.pone.0001238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020004684
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1378/chest.122.6_suppl.314s schema:sameAs https://app.dimensions.ai/details/publication/pub.1009005273
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1378/chest.124.2.459 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002469251
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1378/chest.82.3.310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010707517
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1513/pats.200605-126sf schema:sameAs https://app.dimensions.ai/details/publication/pub.1028475222
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.2147/copd.2007.2.1.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069103165
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.3109/15412555.2013.777400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005817098
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.4021/jocmr612w schema:sameAs https://app.dimensions.ai/details/publication/pub.1014321771
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.4049/jimmunol.1000701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000899376
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.4049/jimmunol.1402634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079085868
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.4049/jimmunol.1500150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015659829
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.4049/jimmunol.1501708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043396093
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.4049/jimmunol.168.2.810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074975202
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.4049/jimmunol.168.5.2356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075002205
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.4049/jimmunol.169.6.3155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043365566
    386 rdf:type schema:CreativeWork
    387 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
    388 schema:name Department of Technology and Innovation, University of Southern Denmark, Odense, Denmark
    389 rdf:type schema:Organization
    390 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
    391 schema:name Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
    392 Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America
    393 Department of Chemistry, Northwestern University, Evanston, Illinois, United States of America
    394 Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    395 Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America
    396 rdf:type schema:Organization
    397 https://www.grid.ac/institutes/grid.280892.9 schema:alternateName Jesse Brown VA Medical Center
    398 schema:name Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    399 Jesse Brown VA Medical Center, Chicago, Illinois, United States of America
    400 rdf:type schema:Organization
    401 https://www.grid.ac/institutes/grid.418190.5 schema:alternateName Thermo Fisher Scientific (United States)
    402 schema:name Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    403 Division of Protein and Cellular Analysis, Thermo Fisher Scientific, Rockford, Illinois, United States of America
    404 rdf:type schema:Organization
    405 https://www.grid.ac/institutes/grid.443944.a schema:alternateName Wilbur Wright College
    406 schema:name Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America
    407 Department of Physical Sciences & Engineering, Wilbur Wright College, Chicago, Illinois, United States of America
    408 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...