Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

James F. Hainfeld, Sharif M. Ridwan, Yaroslav Stanishevskiy, Nathaniel R. Smilowitz, James Davis, Henry M. Smilowitz

ABSTRACT

Standard clinical X-ray contrast agents are small iodine-containing molecules that are rapidly cleared by the kidneys and provide robust imaging for only a few seconds, thereby limiting more extensive vascular and tissue biodistribution imaging as well as optimal tumor uptake. They are also not generally useful for preclinical microCT imaging where longer scan times are required for high resolution image acquisition. We here describe a new iodine nanoparticle contrast agent that has a unique combination of properties: 20 nm hydrodynamic diameter, covalent PEG coating, 40 hour blood half-life, 50% liver clearance after six months, accumulation in tumors, and well-tolerated to at least 4 g iodine/kg body weight after intravenous administration in mice. These characteristics are unique among the other iodine nanoparticles that have been previously reported and provide extended-time high contrast vascular imaging and tumor loading. As such, it is useful for preclinical MicroCT animal studies. Potential human applications might include X-ray radiation dose enhancement for cancer therapy and vascular imaging for life-threatening situations where high levels of contrast are needed for extended periods of time. More... »

PAGES

13803

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-31940-2

DOI

http://dx.doi.org/10.1038/s41598-018-31940-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106921282

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30218059


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