Predictability and persistence of prebiotic dietary supplementation in a healthy human cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Thomas Gurry, , Sean M. Gibbons, Le Thanh Tu Nguyen, Sean M. Kearney, Ashwin Ananthakrishnan, Xiaofang Jiang, Claire Duvallet, Zain Kassam, Eric J. Alm

ABSTRACT

Dietary interventions to manipulate the human gut microbiome for improved health have received increasing attention. However, their design has been limited by a lack of understanding of the quantitative impact of diet on a host's microbiota. We present a highly controlled diet perturbation experiment in a healthy, human cohort in which individual micronutrients are spiked in against a standardized background. We identify strong and predictable responses of specific microbes across participants consuming prebiotic spike-ins, at the level of both strains and functional genes, suggesting fine-scale resource partitioning in the human gut. No predictable responses to non-prebiotic micronutrients were found. Surprisingly, we did not observe decreases in day-to-day variability of the microbiota compared to a complex, varying diet, and instead found evidence of diet-induced stress and an associated loss of biodiversity. Our data offer insights into the effect of a low complexity diet on the gut microbiome, and suggest that effective personalized dietary interventions will rely on functional, strain-level characterization of a patient's microbiota. More... »

PAGES

12699

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-30783-1

    DOI

    http://dx.doi.org/10.1038/s41598-018-30783-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106199559

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30139999


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