Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yasunari Kanda

ABSTRACT

Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50 nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the first step in neurogenesis. We further assessed the effect of TBT on neural differentiation and found that it reduced the expression of several neural differentiation marker genes, which were also downregulated by Mfn1 knockdown in iPSCs. Taken together, these results indicate that TBT induces developmental neurotoxicity via Mfn1-mediated mitochondrial dysfunction in iPSCs. More... »

PAGES

12155

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-30615-2

DOI

http://dx.doi.org/10.1038/s41598-018-30615-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106070397

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30108368


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.410797.c", 
          "name": [
            "Division of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan", 
            "Pharmacological Evaluation Institute of Japan (PEIJ), Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Shigeru", 
        "id": "sg:person.0750723306.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750723306.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.410797.c", 
          "name": [
            "Division of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kubo", 
        "givenName": "Yusuke", 
        "id": "sg:person.013370163633.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013370163633.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.410797.c", 
          "name": [
            "Division of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamazaki", 
        "givenName": "Daiju", 
        "id": "sg:person.01105062621.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105062621.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sekino", 
        "givenName": "Yuko", 
        "id": "sg:person.01127753246.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127753246.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Graduate Center, CUNY", 
          "id": "https://www.grid.ac/institutes/grid.253482.a", 
          "name": [
            "Department of Psychology, Queens College and The Graduate Center, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomura", 
        "givenName": "Yoko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Toyohashi University of Technology", 
          "id": "https://www.grid.ac/institutes/grid.412804.b", 
          "name": [
            "Department of Environmental and Life Sciences, Toyohashi University of Technology, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Sachiko", 
        "id": "sg:person.015660314374.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015660314374.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.410797.c", 
          "name": [
            "Division of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanda", 
        "givenName": "Yasunari", 
        "id": "sg:person.01133265106.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133265106.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1091/mbc.12.8.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000684296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2016.01.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002260952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002744128", 
          "https://doi.org/10.1038/nbt1374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cdd.2015.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003665649", 
          "https://doi.org/10.1038/cdd.2015.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3mt20268b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004347996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.15.5409-5420.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005376532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mod.2007.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006194263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2012.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006947705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0018535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006957473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.5669-08.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007370652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099793", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008110847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0925-4773(01)00451-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008859857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.13-230037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009020377"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200211046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009325952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep05952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009569882", 
          "https://doi.org/10.1038/srep05952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.01657", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011265112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012348184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2011.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013569351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015000233", 
          "https://doi.org/10.1038/ncb1161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015000233", 
          "https://doi.org/10.1038/ncb1161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0407043101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016931281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/taap.2000.9033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021459742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms140816732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022184604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tiv.2016.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022483839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.2352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024051956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.2352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024051956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1241359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024274950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/enrs.1999.3968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027545350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms5806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027818267", 
          "https://doi.org/10.1038/ncomms5806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-012-1122-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028333375", 
          "https://doi.org/10.1007/s00424-012-1122-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00424-012-1122-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028333375", 
          "https://doi.org/10.1007/s00424-012-1122-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.05.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028733856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036082106", 
          "https://doi.org/10.1038/nbt.1529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.41.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038931635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1219855", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040863295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2015.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041392647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-4274(91)90032-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041997555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-4274(91)90032-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041997555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2012.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042269897", 
          "https://doi.org/10.1038/nprot.2012.150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0892-0362(91)90033-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042935168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0892-0362(91)90033-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042935168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2012.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043421085", 
          "https://doi.org/10.1038/nprot.2012.116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1209979109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046664981"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2014.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049826587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052781219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddu506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052812755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5mt00033e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053075810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es049593u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055497663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/es049593u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055497663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2009-0261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x627507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071353203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/096368911x627507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071353203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep40925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074198445", 
          "https://doi.org/10.1038/srep40925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074796119", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079720399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2131/jts.42.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084385687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/antiox7010015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100509244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2018.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101148538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2018.1481238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104597049"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50\u2009nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the first step in neurogenesis. We further assessed the effect of TBT on neural differentiation and found that it reduced the expression of several neural differentiation marker genes, which were also downregulated by Mfn1 knockdown in iPSCs. Taken together, these results indicate that TBT induces developmental neurotoxicity via Mfn1-mediated mitochondrial dysfunction in iPSCs.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-30615-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6140817", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6150693", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells", 
    "pagination": "12155", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "943385911e9913eb3546627b6b9c8b5018e12f39f651ba92fb1b7f898410aafd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30108368"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-30615-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106070397"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-30615-2", 
      "https://app.dimensions.ai/details/publication/pub.1106070397"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000571.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-30615-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30615-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30615-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30615-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30615-2'


 

This table displays all metadata directly associated to this object as RDF triples.

287 TRIPLES      21 PREDICATES      81 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-30615-2 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nf6fb5b5d3110464395a6b09d5a43a07c
4 schema:citation sg:pub.10.1007/s00424-012-1122-y
5 sg:pub.10.1038/cdd.2015.43
6 sg:pub.10.1038/nbt.1529
7 sg:pub.10.1038/nbt1374
8 sg:pub.10.1038/ncb1161
9 sg:pub.10.1038/ncomms5806
10 sg:pub.10.1038/nprot.2012.116
11 sg:pub.10.1038/nprot.2012.150
12 sg:pub.10.1038/srep05952
13 sg:pub.10.1038/srep40925
14 https://app.dimensions.ai/details/publication/pub.1074796119
15 https://app.dimensions.ai/details/publication/pub.1079720399
16 https://doi.org/10.1002/stem.2352
17 https://doi.org/10.1006/enrs.1999.3968
18 https://doi.org/10.1006/taap.2000.9033
19 https://doi.org/10.1016/0378-4274(91)90032-2
20 https://doi.org/10.1016/0892-0362(91)90033-s
21 https://doi.org/10.1016/j.bbamcr.2012.06.025
22 https://doi.org/10.1016/j.bbrc.2016.01.182
23 https://doi.org/10.1016/j.celrep.2014.11.032
24 https://doi.org/10.1016/j.jsbmb.2015.10.010
25 https://doi.org/10.1016/j.mod.2007.07.005
26 https://doi.org/10.1016/j.neuron.2013.05.029
27 https://doi.org/10.1016/j.stem.2009.06.008
28 https://doi.org/10.1016/j.taap.2018.02.008
29 https://doi.org/10.1016/j.tiv.2016.04.013
30 https://doi.org/10.1016/j.tox.2011.06.001
31 https://doi.org/10.1016/s0925-4773(01)00451-8
32 https://doi.org/10.1021/es049593u
33 https://doi.org/10.1038/emboj.2011.407
34 https://doi.org/10.1039/c3mt20268b
35 https://doi.org/10.1039/c5mt00033e
36 https://doi.org/10.1073/pnas.0407043101
37 https://doi.org/10.1073/pnas.1209979109
38 https://doi.org/10.1080/17435390.2018.1481238
39 https://doi.org/10.1083/jcb.200211046
40 https://doi.org/10.1091/mbc.12.8.2245
41 https://doi.org/10.1093/hmg/ddu506
42 https://doi.org/10.1096/fj.13-230037
43 https://doi.org/10.1126/science.1099793
44 https://doi.org/10.1126/science.1219855
45 https://doi.org/10.1126/science.1241359
46 https://doi.org/10.1128/mcb.23.15.5409-5420.2003
47 https://doi.org/10.1210/me.2009-0261
48 https://doi.org/10.1242/dev.01657
49 https://doi.org/10.1371/journal.pone.0018535
50 https://doi.org/10.1523/jneurosci.5669-08.2009
51 https://doi.org/10.2131/jts.41.207
52 https://doi.org/10.2131/jts.42.193
53 https://doi.org/10.3390/antiox7010015
54 https://doi.org/10.3390/ijms140816732
55 https://doi.org/10.3727/096368911x627507
56 schema:datePublished 2018-12
57 schema:datePublishedReg 2018-12-01
58 schema:description Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50 nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the first step in neurogenesis. We further assessed the effect of TBT on neural differentiation and found that it reduced the expression of several neural differentiation marker genes, which were also downregulated by Mfn1 knockdown in iPSCs. Taken together, these results indicate that TBT induces developmental neurotoxicity via Mfn1-mediated mitochondrial dysfunction in iPSCs.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf Na6340dfdc1b24d3b9294f857af35fc12
63 Nf7916513414c41d496ea6210cc1a5793
64 sg:journal.1045337
65 schema:name Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells
66 schema:pagination 12155
67 schema:productId N3a6514a4fb26400d8e682d257bf0548b
68 N4e805eac42c34147ad6b5f346494c518
69 Nbb491e9624e84d64b114e4d17299fd3a
70 Nca9c03bae2db47f698128cec71fe1dc7
71 Nedbd8996cbb84e809d1edddbe88f44e3
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106070397
73 https://doi.org/10.1038/s41598-018-30615-2
74 schema:sdDatePublished 2019-04-11T02:24
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N61663a618bad4de48071fef11c67db3e
77 schema:url https://www.nature.com/articles/s41598-018-30615-2
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N3a6514a4fb26400d8e682d257bf0548b schema:name doi
82 schema:value 10.1038/s41598-018-30615-2
83 rdf:type schema:PropertyValue
84 N3ee560ad5e9d42c9ae62099e4c68a597 rdf:first sg:person.01105062621.11
85 rdf:rest Ncc3b71fed1e04301ac19c7f6201eea7c
86 N4e805eac42c34147ad6b5f346494c518 schema:name pubmed_id
87 schema:value 30108368
88 rdf:type schema:PropertyValue
89 N61663a618bad4de48071fef11c67db3e schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 Na2559b30c1404e099f090a094c6ffd92 rdf:first sg:person.015660314374.10
92 rdf:rest Ncbf5520b8798471f8f4d0afa7ad89db9
93 Na5298aeed6664556a21e9c5bfcaf4f8b rdf:first Ndfa759fa7836441394b1a689e46b02a8
94 rdf:rest Na2559b30c1404e099f090a094c6ffd92
95 Na6340dfdc1b24d3b9294f857af35fc12 schema:volumeNumber 8
96 rdf:type schema:PublicationVolume
97 Naa2c1abf2a8b45bea75002c837ad5107 rdf:first sg:person.013370163633.28
98 rdf:rest N3ee560ad5e9d42c9ae62099e4c68a597
99 Nbb491e9624e84d64b114e4d17299fd3a schema:name dimensions_id
100 schema:value pub.1106070397
101 rdf:type schema:PropertyValue
102 Nca9c03bae2db47f698128cec71fe1dc7 schema:name readcube_id
103 schema:value 943385911e9913eb3546627b6b9c8b5018e12f39f651ba92fb1b7f898410aafd
104 rdf:type schema:PropertyValue
105 Ncbf5520b8798471f8f4d0afa7ad89db9 rdf:first sg:person.01133265106.29
106 rdf:rest rdf:nil
107 Ncc3b71fed1e04301ac19c7f6201eea7c rdf:first sg:person.01127753246.01
108 rdf:rest Na5298aeed6664556a21e9c5bfcaf4f8b
109 Ndfa759fa7836441394b1a689e46b02a8 schema:affiliation https://www.grid.ac/institutes/grid.253482.a
110 schema:familyName Nomura
111 schema:givenName Yoko
112 rdf:type schema:Person
113 Nedbd8996cbb84e809d1edddbe88f44e3 schema:name nlm_unique_id
114 schema:value 101563288
115 rdf:type schema:PropertyValue
116 Nf6fb5b5d3110464395a6b09d5a43a07c rdf:first sg:person.0750723306.29
117 rdf:rest Naa2c1abf2a8b45bea75002c837ad5107
118 Nf7916513414c41d496ea6210cc1a5793 schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biological Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
124 schema:name Genetics
125 rdf:type schema:DefinedTerm
126 sg:grant.6140817 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-30615-2
127 rdf:type schema:MonetaryGrant
128 sg:grant.6150693 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-30615-2
129 rdf:type schema:MonetaryGrant
130 sg:journal.1045337 schema:issn 2045-2322
131 schema:name Scientific Reports
132 rdf:type schema:Periodical
133 sg:person.01105062621.11 schema:affiliation https://www.grid.ac/institutes/grid.410797.c
134 schema:familyName Yamazaki
135 schema:givenName Daiju
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105062621.11
137 rdf:type schema:Person
138 sg:person.01127753246.01 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
139 schema:familyName Sekino
140 schema:givenName Yuko
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127753246.01
142 rdf:type schema:Person
143 sg:person.01133265106.29 schema:affiliation https://www.grid.ac/institutes/grid.410797.c
144 schema:familyName Kanda
145 schema:givenName Yasunari
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133265106.29
147 rdf:type schema:Person
148 sg:person.013370163633.28 schema:affiliation https://www.grid.ac/institutes/grid.410797.c
149 schema:familyName Kubo
150 schema:givenName Yusuke
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013370163633.28
152 rdf:type schema:Person
153 sg:person.015660314374.10 schema:affiliation https://www.grid.ac/institutes/grid.412804.b
154 schema:familyName Yoshida
155 schema:givenName Sachiko
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015660314374.10
157 rdf:type schema:Person
158 sg:person.0750723306.29 schema:affiliation https://www.grid.ac/institutes/grid.410797.c
159 schema:familyName Yamada
160 schema:givenName Shigeru
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750723306.29
162 rdf:type schema:Person
163 sg:pub.10.1007/s00424-012-1122-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028333375
164 https://doi.org/10.1007/s00424-012-1122-y
165 rdf:type schema:CreativeWork
166 sg:pub.10.1038/cdd.2015.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003665649
167 https://doi.org/10.1038/cdd.2015.43
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nbt.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036082106
170 https://doi.org/10.1038/nbt.1529
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nbt1374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002744128
173 https://doi.org/10.1038/nbt1374
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/ncb1161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015000233
176 https://doi.org/10.1038/ncb1161
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/ncomms5806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027818267
179 https://doi.org/10.1038/ncomms5806
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nprot.2012.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043421085
182 https://doi.org/10.1038/nprot.2012.116
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nprot.2012.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042269897
185 https://doi.org/10.1038/nprot.2012.150
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/srep05952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009569882
188 https://doi.org/10.1038/srep05952
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/srep40925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074198445
191 https://doi.org/10.1038/srep40925
192 rdf:type schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1074796119 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1079720399 schema:CreativeWork
195 https://doi.org/10.1002/stem.2352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024051956
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1006/enrs.1999.3968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027545350
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1006/taap.2000.9033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021459742
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/0378-4274(91)90032-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041997555
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0892-0362(91)90033-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1042935168
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.bbamcr.2012.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006947705
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.bbrc.2016.01.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002260952
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.celrep.2014.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049826587
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.jsbmb.2015.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041392647
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.mod.2007.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006194263
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.neuron.2013.05.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028733856
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.stem.2009.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052781219
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.taap.2018.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101148538
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.tiv.2016.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022483839
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.tox.2011.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013569351
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0925-4773(01)00451-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008859857
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1021/es049593u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055497663
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1038/emboj.2011.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012348184
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1039/c3mt20268b schema:sameAs https://app.dimensions.ai/details/publication/pub.1004347996
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1039/c5mt00033e schema:sameAs https://app.dimensions.ai/details/publication/pub.1053075810
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.0407043101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016931281
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.1209979109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046664981
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1080/17435390.2018.1481238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104597049
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1083/jcb.200211046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009325952
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1091/mbc.12.8.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000684296
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1093/hmg/ddu506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052812755
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1096/fj.13-230037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009020377
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1126/science.1099793 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008110847
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1126/science.1219855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040863295
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.1241359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024274950
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1128/mcb.23.15.5409-5420.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005376532
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1210/me.2009-0261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328378
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1242/dev.01657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011265112
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1371/journal.pone.0018535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006957473
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1523/jneurosci.5669-08.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007370652
264 rdf:type schema:CreativeWork
265 https://doi.org/10.2131/jts.41.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038931635
266 rdf:type schema:CreativeWork
267 https://doi.org/10.2131/jts.42.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084385687
268 rdf:type schema:CreativeWork
269 https://doi.org/10.3390/antiox7010015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100509244
270 rdf:type schema:CreativeWork
271 https://doi.org/10.3390/ijms140816732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022184604
272 rdf:type schema:CreativeWork
273 https://doi.org/10.3727/096368911x627507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071353203
274 rdf:type schema:CreativeWork
275 https://www.grid.ac/institutes/grid.253482.a schema:alternateName The Graduate Center, CUNY
276 schema:name Department of Psychology, Queens College and The Graduate Center, New York, USA
277 rdf:type schema:Organization
278 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
279 schema:name Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.410797.c schema:alternateName National Institute of Health Sciences
282 schema:name Division of Pharmacology, National Institute of Health Sciences, Kanagawa, Japan
283 Pharmacological Evaluation Institute of Japan (PEIJ), Kanagawa, Japan
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.412804.b schema:alternateName Toyohashi University of Technology
286 schema:name Department of Environmental and Life Sciences, Toyohashi University of Technology, Toyohashi, Japan
287 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...