COMP-Angiopoietin-1 accelerates muscle regeneration through N-cadherin activation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-17

AUTHORS

Seock-Won Youn, Hyun-Chae Lee, Sae-Won Lee, Jaewon Lee, Hyunduk Jang, Eun Ju Lee, Hyo-Soo Kim

ABSTRACT

Angiopoietin-1 modulates vascular stability via Tie2 on endothelial cells. In our previous study, we also showed it acts as an inhibitor of cardiomyocyte death. However, it remains poorly understood how Ang1 regulates myogenesis during muscle regeneration. Here we found that COMP-Ang1 (cAng1) enhances muscle regeneration through N-cadherin activation. Muscle fiber regeneration after limb muscle damage by ischemic injury was enhanced with cAng1 treatment. Mechanistically cAng1 directly bound to N-cadherin on the myoblast surface in a Ca2+ dependent manner. The interaction enhanced N-cadherin activation via N-cadherin/p120-catenin complex formation, which in turn activated p38MAPK (but not AKT or ERK) and myogenin expression (but not myoD) as well as increasing myogenin+ cells in/ex vivo. After transplantation of GFP-expressing myoblasts (GFP-MB), we showed an increased generation of GFP+ myotubes with adenovirus cAng1 (Adv-cAng1) injection. Adv-cAng1, however, could not stimulate myotube formation in N-cadherin-depleted GFP-MB. Taken together, this study uncovers the mechanism of how cAng1 promotes myoblast differentiation and muscle regeneration through the N-cadherin/p120-catenin/p38MAPK/myogenin axis. More... »

PAGES

12323

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-30513-7

DOI

http://dx.doi.org/10.1038/s41598-018-30513-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106133542

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30120297


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