Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Young-Je Kim, Mi Ji Choi, Dong-Ho Bak, Byung Chul Lee, Eun Jung Ko, Ga Ram Ahn, Seung Won Ahn, Moo Joong Kim, Jungtae Na, Beom Joon Kim

ABSTRACT

Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a complex, heterogeneous pathogenesis including skin barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) is essential for epithelial homeostasis and wound healing, the effect of EGF on AD remains to be explored. To develop a new therapy for AD, the anti-AD potential of EGF was investigated by inducing AD-like skin lesions in NC/Nga mice using 2,4-dinitrochlorobenzene (DNCB). EGF was administrated to NC/Nga mice to evaluate its therapeutic effect on DNCB-induced AD. EGF treatment improved dermatitis score, ear thickness, epidermal hyperplasia, serum total immunoglobulin E level, and transepidermal water loss in NC/Nga mice with DNCB-induced AD. In addition, levels of skin barrier-related proteins such as filaggrin, involucrin, loricrin, occludin, and zonula occludens-1 (ZO-1) were increased by EGF treatment. These beneficial effects of EGF on AD may be mediated by EGF regulation of Th1/Th2-mediated cytokines, mast cell hyperplasia, and protease activated receptor-2 (PAR-2) and thymic stromal lymphopoietin (TSLP), which are triggers of AD. Taken together, our findings suggest that EGF may potentially protect against AD lesional skin via regulation of skin barrier function and immune response. More... »

PAGES

11895

References to SciGraph publications

  • 2013-11. UVB Induces HIF-1α-Dependent TSLP Expression via the JNK and ERK Pathways in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2008-02. Comparison of Skin Hydration Evaluation Sites and Correlations among Skin Hydration, Transepidermal Water Loss, SCORAD Index, Nottingham Eczema Severity Score, and Quality of Life in Patients with Atopic Dermatitis in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • 2004-11. EGFR Enhances Early Healing After Cutaneous Incisional Wounding in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-12. Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic dermatitis via generation of CD4+CD25+Foxp3+ T cells in BMC IMMUNOLOGY
  • 2009-05. A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming in NATURE GENETICS
  • 2008-08. Proteolytically Active Allergens Cause Barrier Breakdown in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2002-07. Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP in NATURE IMMUNOLOGY
  • 2014-07. TNF-α and Th2 Cytokines Induce Atopic Dermatitis–Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-03. Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2013-02. Netherton syndrome: skin inflammation and allergy by loss of protease inhibition in CELL AND TISSUE RESEARCH
  • 2008-06. The Epidermal Growth Factor Receptor System in Skin Repair and Inflammation in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2003-09. Itch Associated with Skin Disease in AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-30404-x

    DOI

    http://dx.doi.org/10.1038/s41598-018-30404-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105993639

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30093649


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Young-Je", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea", 
                "Department of Medicine, Graduate School, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Choi", 
            "givenName": "Mi Ji", 
            "id": "sg:person.010347030462.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347030462.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea", 
                "Department of Medicine, Graduate School, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bak", 
            "givenName": "Dong-Ho", 
            "id": "sg:person.0621726435.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621726435.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea", 
                "Department of Medicine, Graduate School, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "Byung Chul", 
            "id": "sg:person.010365644370.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365644370.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Myongji Hospital", 
              "id": "https://www.grid.ac/institutes/grid.416355.0", 
              "name": [
                "Myongji Hospital, College of Medicine, Seonam University, 10475, Goyang, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ko", 
            "givenName": "Eun Jung", 
            "id": "sg:person.0663577444.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663577444.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahn", 
            "givenName": "Ga Ram", 
            "id": "sg:person.010723501261.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010723501261.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Oracle Dermatologic Clinic, 06103, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ahn", 
            "givenName": "Seung Won", 
            "id": "sg:person.012556165770.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012556165770.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fort Hays State University", 
              "id": "https://www.grid.ac/institutes/grid.256032.0", 
              "name": [
                "Fort Hays State University, 67601, Hays, Kansas, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Moo Joong", 
            "id": "sg:person.013353546370.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013353546370.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Na", 
            "givenName": "Jungtae", 
            "id": "sg:person.01070043766.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070043766.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chung-Ang University", 
              "id": "https://www.grid.ac/institutes/grid.254224.7", 
              "name": [
                "Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea", 
                "Department of Medicine, Graduate School, Chung-Ang University, 06973, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Beom Joon", 
            "id": "sg:person.0631021136.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631021136.96"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/jid.2008.168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001214044", 
              "https://doi.org/10.1038/jid.2008.168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2011.01.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001984532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20100249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002441891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20100249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002441891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003764615", 
              "https://doi.org/10.1038/ng.358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2172-13-44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003987775", 
              "https://doi.org/10.1186/1471-2172-13-44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20082242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005159130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2012.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006802090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2005.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007004568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2007.00519.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007007027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0002-9343(90)90490-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008491306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00128071-200809010-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010130377", 
              "https://doi.org/10.2165/00128071-200809010-00005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.jid.5701184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010914597", 
              "https://doi.org/10.1038/sj.jid.5701184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0104938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012931143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013495728", 
              "https://doi.org/10.1038/ni805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013495728", 
              "https://doi.org/10.1038/ni805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.p030338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014579289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0625.2010.01108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016482481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0625.2010.01108.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016482481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0404217101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016529471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2012.01.068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016646077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.0022-202x.2004.23478.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016792400", 
              "https://doi.org/10.1111/j.0022-202x.2004.23478.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00128071-200304090-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017007562", 
              "https://doi.org/10.2165/00128071-200304090-00004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00128071-200304090-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017007562", 
              "https://doi.org/10.2165/00128071-200304090-00004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2006.07191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017885082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2133.2006.07191.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017885082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4168/aair.2014.6.4.276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018043948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/exd.12293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018328214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-2999(03)01828-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018379029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-2999(03)01828-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018379029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1301062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018407957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2014.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018743145", 
              "https://doi.org/10.1038/jid.2014.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0952-7915(99)80010-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019460961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2010.02326.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020409164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2010.02326.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020409164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0091-6749(97)70128-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020777362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2011.01027.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021464207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/all.12184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022495181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2012.09.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023032011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mjd.2001.109815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023397460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2013.203", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025629413", 
              "https://doi.org/10.1038/jid.2013.203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/mai.2000.104783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029281869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-481x.2009.00622.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030281861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(03)12570-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030657645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5625/lar.2010.26.1.95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031771943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1081-1206(10)62968-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034495533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jid.2008.280", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034709356", 
              "https://doi.org/10.1038/jid.2008.280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000235551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035432278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaci.2009.07.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039099121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaad.2006.09.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039342696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63654-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039405801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/003655200750056664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040152950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdermsci.2004.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043020652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20050959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043165122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20050959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043165122"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/gast.2001.25478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044284871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0900904", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044676760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.08.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045011777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-013-1558-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048331208", 
              "https://doi.org/10.1007/s00441-013-1558-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-013-1558-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048331208", 
              "https://doi.org/10.1007/s00441-013-1558-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajpath.2015.06.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050299576"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3346/jkms.2010.25.6.829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050981952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb4100014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052440564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb4100014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052440564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/msb4100014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052440564"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/000155500750042943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058254411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1358/dot.2002.38.1.677132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065063361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074720095", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.2003.83.3.835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075310758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077070363", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077070363", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078793874", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdermsci.2017.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099711754"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a complex, heterogeneous pathogenesis including skin barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) is essential for epithelial homeostasis and wound healing, the effect of EGF on AD remains to be explored. To develop a new therapy for AD, the anti-AD potential of EGF was investigated by inducing AD-like skin lesions in NC/Nga mice using 2,4-dinitrochlorobenzene (DNCB). EGF was administrated to NC/Nga mice to evaluate its therapeutic effect on DNCB-induced AD. EGF treatment improved dermatitis score, ear thickness, epidermal hyperplasia, serum total immunoglobulin E level, and transepidermal water loss in NC/Nga mice with DNCB-induced AD. In addition, levels of skin barrier-related proteins such as filaggrin, involucrin, loricrin, occludin, and zonula occludens-1 (ZO-1) were increased by EGF treatment. These beneficial effects of EGF on AD may be mediated by EGF regulation of Th1/Th2-mediated cytokines, mast cell hyperplasia, and protease activated receptor-2 (PAR-2) and thymic stromal lymphopoietin (TSLP), which are triggers of AD. Taken together, our findings suggest that EGF may potentially protect against AD lesional skin via regulation of skin barrier function and immune response.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-30404-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice", 
        "pagination": "11895", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "c1253f99fc6d0ca492d1de678965a896074c1a475e9f017ba7fe4c6ec76e9fef"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30093649"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-30404-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1105993639"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-30404-x", 
          "https://app.dimensions.ai/details/publication/pub.1105993639"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000571.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-30404-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30404-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30404-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30404-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30404-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    331 TRIPLES      21 PREDICATES      90 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-30404-x schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author Nb88205b2261e420fafca33dde7e359d2
    4 schema:citation sg:pub.10.1007/s00441-013-1558-1
    5 sg:pub.10.1038/jid.2008.168
    6 sg:pub.10.1038/jid.2008.280
    7 sg:pub.10.1038/jid.2013.203
    8 sg:pub.10.1038/jid.2014.83
    9 sg:pub.10.1038/ng.358
    10 sg:pub.10.1038/ni805
    11 sg:pub.10.1038/sj.jid.5701184
    12 sg:pub.10.1111/j.0022-202x.2004.23478.x
    13 sg:pub.10.1186/1471-2172-13-44
    14 sg:pub.10.2165/00128071-200304090-00004
    15 sg:pub.10.2165/00128071-200809010-00005
    16 https://app.dimensions.ai/details/publication/pub.1074720095
    17 https://app.dimensions.ai/details/publication/pub.1077070363
    18 https://app.dimensions.ai/details/publication/pub.1078793874
    19 https://doi.org/10.1016/0002-9343(90)90490-5
    20 https://doi.org/10.1016/j.ajpath.2011.01.053
    21 https://doi.org/10.1016/j.ajpath.2012.06.005
    22 https://doi.org/10.1016/j.ajpath.2015.06.021
    23 https://doi.org/10.1016/j.cell.2013.08.057
    24 https://doi.org/10.1016/j.immuni.2012.09.023
    25 https://doi.org/10.1016/j.jaad.2005.10.010
    26 https://doi.org/10.1016/j.jaad.2006.09.005
    27 https://doi.org/10.1016/j.jaci.2009.07.012
    28 https://doi.org/10.1016/j.jaci.2012.01.068
    29 https://doi.org/10.1016/j.jdermsci.2004.02.013
    30 https://doi.org/10.1016/j.jdermsci.2017.12.008
    31 https://doi.org/10.1016/s0002-9440(10)63654-1
    32 https://doi.org/10.1016/s0014-2999(03)01828-4
    33 https://doi.org/10.1016/s0091-6749(97)70128-3
    34 https://doi.org/10.1016/s0140-6736(03)12570-6
    35 https://doi.org/10.1016/s0952-7915(99)80010-7
    36 https://doi.org/10.1016/s1081-1206(10)62968-7
    37 https://doi.org/10.1038/msb4100014
    38 https://doi.org/10.1042/bj20050959
    39 https://doi.org/10.1042/bj20100249
    40 https://doi.org/10.1053/gast.2001.25478
    41 https://doi.org/10.1067/mai.2000.104783
    42 https://doi.org/10.1067/mjd.2001.109815
    43 https://doi.org/10.1073/pnas.0404217101
    44 https://doi.org/10.1080/000155500750042943
    45 https://doi.org/10.1080/003655200750056664
    46 https://doi.org/10.1084/jem.20082242
    47 https://doi.org/10.1111/all.12184
    48 https://doi.org/10.1111/exd.12293
    49 https://doi.org/10.1111/j.1365-2133.2006.07191.x
    50 https://doi.org/10.1111/j.1398-9995.2010.02326.x
    51 https://doi.org/10.1111/j.1600-0625.2010.01108.x
    52 https://doi.org/10.1111/j.1600-065x.2007.00519.x
    53 https://doi.org/10.1111/j.1600-065x.2011.01027.x
    54 https://doi.org/10.1111/j.1742-481x.2009.00622.x
    55 https://doi.org/10.1152/physrev.2003.83.3.835
    56 https://doi.org/10.1159/000235551
    57 https://doi.org/10.1194/jlr.p030338
    58 https://doi.org/10.1358/dot.2002.38.1.677132
    59 https://doi.org/10.1371/journal.pone.0104938
    60 https://doi.org/10.3346/jkms.2010.25.6.829
    61 https://doi.org/10.4049/jimmunol.0900904
    62 https://doi.org/10.4049/jimmunol.1301062
    63 https://doi.org/10.4168/aair.2014.6.4.276
    64 https://doi.org/10.5625/lar.2010.26.1.95
    65 schema:datePublished 2018-12
    66 schema:datePublishedReg 2018-12-01
    67 schema:description Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a complex, heterogeneous pathogenesis including skin barrier dysfunction, immunology, and pruritus. Although epidermal growth factor (EGF) is essential for epithelial homeostasis and wound healing, the effect of EGF on AD remains to be explored. To develop a new therapy for AD, the anti-AD potential of EGF was investigated by inducing AD-like skin lesions in NC/Nga mice using 2,4-dinitrochlorobenzene (DNCB). EGF was administrated to NC/Nga mice to evaluate its therapeutic effect on DNCB-induced AD. EGF treatment improved dermatitis score, ear thickness, epidermal hyperplasia, serum total immunoglobulin E level, and transepidermal water loss in NC/Nga mice with DNCB-induced AD. In addition, levels of skin barrier-related proteins such as filaggrin, involucrin, loricrin, occludin, and zonula occludens-1 (ZO-1) were increased by EGF treatment. These beneficial effects of EGF on AD may be mediated by EGF regulation of Th1/Th2-mediated cytokines, mast cell hyperplasia, and protease activated receptor-2 (PAR-2) and thymic stromal lymphopoietin (TSLP), which are triggers of AD. Taken together, our findings suggest that EGF may potentially protect against AD lesional skin via regulation of skin barrier function and immune response.
    68 schema:genre research_article
    69 schema:inLanguage en
    70 schema:isAccessibleForFree true
    71 schema:isPartOf N8ee35cc418e144adb88000fe818042b2
    72 Na8e9b50b2db54c948389095587a7c485
    73 sg:journal.1045337
    74 schema:name Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice
    75 schema:pagination 11895
    76 schema:productId N08aeaee708e44edba2cff4d8eef8b2f7
    77 N1ade1141e0e04246b0237b6e7dac6203
    78 N56fee6a606ce46bc9b92faf0ccc7d5c5
    79 Nb185be27c653474f88ed63fb6bff995b
    80 Nd1e0717d7a9c4c4dbfad529ef7f1063c
    81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105993639
    82 https://doi.org/10.1038/s41598-018-30404-x
    83 schema:sdDatePublished 2019-04-10T17:40
    84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    85 schema:sdPublisher Nf9086ec3ba8442e388669b98e0996f1d
    86 schema:url https://www.nature.com/articles/s41598-018-30404-x
    87 sgo:license sg:explorer/license/
    88 sgo:sdDataset articles
    89 rdf:type schema:ScholarlyArticle
    90 N01ea935966e84eeaaf6f8f3341f545b6 rdf:first sg:person.010347030462.15
    91 rdf:rest Nd5574d161eee4b30b8fc85f09681eeea
    92 N03ae29b80204401a9bff3d3240aa77bd rdf:first sg:person.0663577444.30
    93 rdf:rest N23a3fadb0e2847ef9085d9ef234fa972
    94 N08aeaee708e44edba2cff4d8eef8b2f7 schema:name doi
    95 schema:value 10.1038/s41598-018-30404-x
    96 rdf:type schema:PropertyValue
    97 N0efdfa7c092a4d2aba39baec3b3b6d53 rdf:first sg:person.013353546370.05
    98 rdf:rest N52df6c020ee14237aa89afb90f041fed
    99 N1ade1141e0e04246b0237b6e7dac6203 schema:name nlm_unique_id
    100 schema:value 101563288
    101 rdf:type schema:PropertyValue
    102 N23a3fadb0e2847ef9085d9ef234fa972 rdf:first sg:person.010723501261.77
    103 rdf:rest N9a366fa7788c439e8d41e56f11c94077
    104 N4548695fb08548dbb1a544c33979e1fb schema:name Oracle Dermatologic Clinic, 06103, Seoul, Korea
    105 rdf:type schema:Organization
    106 N52df6c020ee14237aa89afb90f041fed rdf:first sg:person.01070043766.46
    107 rdf:rest Nd0352e3dc06a4e8eab2d424d771bae28
    108 N56fee6a606ce46bc9b92faf0ccc7d5c5 schema:name readcube_id
    109 schema:value c1253f99fc6d0ca492d1de678965a896074c1a475e9f017ba7fe4c6ec76e9fef
    110 rdf:type schema:PropertyValue
    111 N7b3c8fb436604139b26ccbde6f1a805f rdf:first sg:person.010365644370.22
    112 rdf:rest N03ae29b80204401a9bff3d3240aa77bd
    113 N8ee35cc418e144adb88000fe818042b2 schema:issueNumber 1
    114 rdf:type schema:PublicationIssue
    115 N96d9dc9064824928a21ef5dea04c4557 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    116 schema:familyName Kim
    117 schema:givenName Young-Je
    118 rdf:type schema:Person
    119 N9a366fa7788c439e8d41e56f11c94077 rdf:first sg:person.012556165770.60
    120 rdf:rest N0efdfa7c092a4d2aba39baec3b3b6d53
    121 Na8e9b50b2db54c948389095587a7c485 schema:volumeNumber 8
    122 rdf:type schema:PublicationVolume
    123 Nb185be27c653474f88ed63fb6bff995b schema:name dimensions_id
    124 schema:value pub.1105993639
    125 rdf:type schema:PropertyValue
    126 Nb88205b2261e420fafca33dde7e359d2 rdf:first N96d9dc9064824928a21ef5dea04c4557
    127 rdf:rest N01ea935966e84eeaaf6f8f3341f545b6
    128 Nd0352e3dc06a4e8eab2d424d771bae28 rdf:first sg:person.0631021136.96
    129 rdf:rest rdf:nil
    130 Nd1e0717d7a9c4c4dbfad529ef7f1063c schema:name pubmed_id
    131 schema:value 30093649
    132 rdf:type schema:PropertyValue
    133 Nd5574d161eee4b30b8fc85f09681eeea rdf:first sg:person.0621726435.37
    134 rdf:rest N7b3c8fb436604139b26ccbde6f1a805f
    135 Nf9086ec3ba8442e388669b98e0996f1d schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    138 schema:name Medical and Health Sciences
    139 rdf:type schema:DefinedTerm
    140 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    141 schema:name Clinical Sciences
    142 rdf:type schema:DefinedTerm
    143 sg:journal.1045337 schema:issn 2045-2322
    144 schema:name Scientific Reports
    145 rdf:type schema:Periodical
    146 sg:person.010347030462.15 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    147 schema:familyName Choi
    148 schema:givenName Mi Ji
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347030462.15
    150 rdf:type schema:Person
    151 sg:person.010365644370.22 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    152 schema:familyName Lee
    153 schema:givenName Byung Chul
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010365644370.22
    155 rdf:type schema:Person
    156 sg:person.01070043766.46 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    157 schema:familyName Na
    158 schema:givenName Jungtae
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070043766.46
    160 rdf:type schema:Person
    161 sg:person.010723501261.77 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    162 schema:familyName Ahn
    163 schema:givenName Ga Ram
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010723501261.77
    165 rdf:type schema:Person
    166 sg:person.012556165770.60 schema:affiliation N4548695fb08548dbb1a544c33979e1fb
    167 schema:familyName Ahn
    168 schema:givenName Seung Won
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012556165770.60
    170 rdf:type schema:Person
    171 sg:person.013353546370.05 schema:affiliation https://www.grid.ac/institutes/grid.256032.0
    172 schema:familyName Kim
    173 schema:givenName Moo Joong
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013353546370.05
    175 rdf:type schema:Person
    176 sg:person.0621726435.37 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    177 schema:familyName Bak
    178 schema:givenName Dong-Ho
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621726435.37
    180 rdf:type schema:Person
    181 sg:person.0631021136.96 schema:affiliation https://www.grid.ac/institutes/grid.254224.7
    182 schema:familyName Kim
    183 schema:givenName Beom Joon
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631021136.96
    185 rdf:type schema:Person
    186 sg:person.0663577444.30 schema:affiliation https://www.grid.ac/institutes/grid.416355.0
    187 schema:familyName Ko
    188 schema:givenName Eun Jung
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663577444.30
    190 rdf:type schema:Person
    191 sg:pub.10.1007/s00441-013-1558-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048331208
    192 https://doi.org/10.1007/s00441-013-1558-1
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/jid.2008.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001214044
    195 https://doi.org/10.1038/jid.2008.168
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/jid.2008.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034709356
    198 https://doi.org/10.1038/jid.2008.280
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/jid.2013.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025629413
    201 https://doi.org/10.1038/jid.2013.203
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/jid.2014.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018743145
    204 https://doi.org/10.1038/jid.2014.83
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ng.358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003764615
    207 https://doi.org/10.1038/ng.358
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ni805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013495728
    210 https://doi.org/10.1038/ni805
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/sj.jid.5701184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010914597
    213 https://doi.org/10.1038/sj.jid.5701184
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1111/j.0022-202x.2004.23478.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016792400
    216 https://doi.org/10.1111/j.0022-202x.2004.23478.x
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1186/1471-2172-13-44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003987775
    219 https://doi.org/10.1186/1471-2172-13-44
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.2165/00128071-200304090-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017007562
    222 https://doi.org/10.2165/00128071-200304090-00004
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.2165/00128071-200809010-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010130377
    225 https://doi.org/10.2165/00128071-200809010-00005
    226 rdf:type schema:CreativeWork
    227 https://app.dimensions.ai/details/publication/pub.1074720095 schema:CreativeWork
    228 https://app.dimensions.ai/details/publication/pub.1077070363 schema:CreativeWork
    229 https://app.dimensions.ai/details/publication/pub.1078793874 schema:CreativeWork
    230 https://doi.org/10.1016/0002-9343(90)90490-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008491306
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/j.ajpath.2011.01.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001984532
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/j.ajpath.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006802090
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/j.ajpath.2015.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050299576
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.cell.2013.08.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045011777
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.immuni.2012.09.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023032011
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.jaad.2005.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007004568
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.jaad.2006.09.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039342696
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.jaci.2009.07.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039099121
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.jaci.2012.01.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016646077
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.jdermsci.2004.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043020652
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.jdermsci.2017.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099711754
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/s0002-9440(10)63654-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039405801
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1016/s0014-2999(03)01828-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018379029
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1016/s0091-6749(97)70128-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020777362
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1016/s0140-6736(03)12570-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030657645
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1016/s0952-7915(99)80010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019460961
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1016/s1081-1206(10)62968-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034495533
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1038/msb4100014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052440564
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1042/bj20050959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043165122
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1042/bj20100249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002441891
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1053/gast.2001.25478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044284871
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1067/mai.2000.104783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029281869
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1067/mjd.2001.109815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023397460
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1073/pnas.0404217101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016529471
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1080/000155500750042943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058254411
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1080/003655200750056664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040152950
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1084/jem.20082242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005159130
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1111/all.12184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022495181
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1111/exd.12293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018328214
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1111/j.1365-2133.2006.07191.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017885082
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1111/j.1398-9995.2010.02326.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020409164
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1111/j.1600-0625.2010.01108.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016482481
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1111/j.1600-065x.2007.00519.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007007027
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1111/j.1600-065x.2011.01027.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021464207
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1111/j.1742-481x.2009.00622.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030281861
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1152/physrev.2003.83.3.835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075310758
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1159/000235551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035432278
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1194/jlr.p030338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014579289
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1358/dot.2002.38.1.677132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065063361
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1371/journal.pone.0104938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012931143
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.3346/jkms.2010.25.6.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050981952
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.4049/jimmunol.0900904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044676760
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.4049/jimmunol.1301062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018407957
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.4168/aair.2014.6.4.276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018043948
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.5625/lar.2010.26.1.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031771943
    321 rdf:type schema:CreativeWork
    322 https://www.grid.ac/institutes/grid.254224.7 schema:alternateName Chung-Ang University
    323 schema:name Department of Dermatology, College of Medicine, Chung-Ang University, 06973, Seoul, Korea
    324 Department of Medicine, Graduate School, Chung-Ang University, 06973, Seoul, Korea
    325 rdf:type schema:Organization
    326 https://www.grid.ac/institutes/grid.256032.0 schema:alternateName Fort Hays State University
    327 schema:name Fort Hays State University, 67601, Hays, Kansas, USA
    328 rdf:type schema:Organization
    329 https://www.grid.ac/institutes/grid.416355.0 schema:alternateName Myongji Hospital
    330 schema:name Myongji Hospital, College of Medicine, Seonam University, 10475, Goyang, Korea
    331 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...