Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-08-10

AUTHORS

Daniele Roberto Giacobbe, Alessandra di Masi, Loris Leboffe, Valerio Del Bono, Marianna Rossi, Dario Cappiello, Erika Coppo, Anna Marchese, Annarita Casulli, Alessio Signori, Andrea Novelli, Katja Perrone, Luigi Principe, Alessandra Bandera, Luca Enrico Vender, Andrea Misin, Pierpaolo Occhilupo, Marcello Melone, Paolo Ascenzi, Andrea Gori, Roberto Luzzati, Claudio Viscoli, Stefano Di Bella

ABSTRACT

This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin. Among the 170 patients included in the study, 71 (42%), 35 (21%), and 11 (6%) developed KDIGO stage 1 (K1-AKI), KDIGO stage 2 (K2-AKI), and KDIGO stage 3 (K3-AKI), respectively. In multivariable analyses, serum albumin <2.5 g/dL was independently associated with K1-AKI (subdistribution hazard ratio [sHR] 1.85, 95% confidence interval [CI] 1.17-2.93, p = 0.009) and K2-AKI (sHR 2.37, 95% CI 1.15-4.87, p = 0.019). Bioinformatic and biochemical analyses provided additional information nurturing the discussion on how hypoalbuminemia favors development of AKI during colistin therapy. In conclusion, severe hypoalbuminemia independently predicted AKI during colistin therapy in a large cohort of patients with BSI due to colistin-susceptible Gram-negative bacteria. Further study is needed to clarify the underlying causal pathways. More... »

PAGES

11968

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-30361-5

DOI

http://dx.doi.org/10.1038/s41598-018-30361-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106026202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30097635


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acute Kidney Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Bacterial Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colistin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoalbuminemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Conformation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Serum Albumin, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Structure-Activity Relationship", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giacobbe", 
        "givenName": "Daniele Roberto", 
        "id": "sg:person.01170447017.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170447017.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8509.4", 
          "name": [
            "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "di Masi", 
        "givenName": "Alessandra", 
        "id": "sg:person.0750336642.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750336642.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8509.4", 
          "name": [
            "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leboffe", 
        "givenName": "Loris", 
        "id": "sg:person.0630074525.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630074525.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy", 
          "id": "http://www.grid.ac/institutes/grid.413179.9", 
          "name": [
            "Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Bono", 
        "givenName": "Valerio", 
        "id": "sg:person.0763033015.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763033015.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rossi", 
        "givenName": "Marianna", 
        "id": "sg:person.0765212354.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765212354.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cappiello", 
        "givenName": "Dario", 
        "id": "sg:person.010566660630.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010566660630.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coppo", 
        "givenName": "Erika", 
        "id": "sg:person.01224745065.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224745065.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marchese", 
        "givenName": "Anna", 
        "id": "sg:person.0623706124.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623706124.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casulli", 
        "givenName": "Annarita", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Health Science (DISSAL), University of Genoa, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Department of Health Science (DISSAL), University of Genoa, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Signori", 
        "givenName": "Alessio", 
        "id": "sg:person.0650532461.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650532461.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8404.8", 
          "name": [
            "Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Novelli", 
        "givenName": "Andrea", 
        "id": "sg:person.0664473660.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664473660.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perrone", 
        "givenName": "Katja", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy", 
          "id": "http://www.grid.ac/institutes/grid.413175.5", 
          "name": [
            "Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Principe", 
        "givenName": "Luigi", 
        "id": "sg:person.0705414555.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705414555.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bandera", 
        "givenName": "Alessandra", 
        "id": "sg:person.01304527667.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304527667.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415025.7", 
          "name": [
            "Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vender", 
        "givenName": "Luca Enrico", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy", 
          "id": "http://www.grid.ac/institutes/grid.460062.6", 
          "name": [
            "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Misin", 
        "givenName": "Andrea", 
        "id": "sg:person.013247721567.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013247721567.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maria Cecilia Hospital \u2013 GVM Care & Research, Cotignola, Italy", 
          "id": "http://www.grid.ac/institutes/grid.417010.3", 
          "name": [
            "Maria Cecilia Hospital \u2013 GVM Care & Research, Cotignola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Occhilupo", 
        "givenName": "Pierpaolo", 
        "id": "sg:person.011651431437.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651431437.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Citt\u00e0 di Lecce Hospital \u2013 GVM Care and Research, Lecce, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melone", 
        "givenName": "Marcello", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.8509.4", 
          "name": [
            "Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ascenzi", 
        "givenName": "Paolo", 
        "id": "sg:person.0717574161.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717574161.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Milan and Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy", 
          "id": "http://www.grid.ac/institutes/grid.414818.0", 
          "name": [
            "University of Milan and Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gori", 
        "givenName": "Andrea", 
        "id": "sg:person.01170301267.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170301267.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy", 
          "id": "http://www.grid.ac/institutes/grid.460062.6", 
          "name": [
            "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luzzati", 
        "givenName": "Roberto", 
        "id": "sg:person.0740455776.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740455776.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy", 
          "id": "http://www.grid.ac/institutes/grid.5606.5", 
          "name": [
            "Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l\u2019Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viscoli", 
        "givenName": "Claudio", 
        "id": "sg:person.01241060757.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241060757.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy", 
          "id": "http://www.grid.ac/institutes/grid.460062.6", 
          "name": [
            "Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Bella", 
        "givenName": "Stefano", 
        "id": "sg:person.01156176207.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156176207.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc11454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016103624", 
          "https://doi.org/10.1186/cc11454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1928-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051936667", 
          "https://doi.org/10.1007/s00134-010-1928-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10822-016-0006-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027921139", 
          "https://doi.org/10.1007/s10822-016-0006-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s15010-017-1010-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084037664", 
          "https://doi.org/10.1007/s15010-017-1010-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-13-380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048745746", 
          "https://doi.org/10.1186/1471-2334-13-380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12941-015-0062-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017110947", 
          "https://doi.org/10.1186/s12941-015-0062-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-08-10", 
    "datePublishedReg": "2018-08-10", 
    "description": "This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin. Among the 170 patients included in the study, 71 (42%), 35 (21%), and 11 (6%) developed KDIGO stage 1 (K1-AKI), KDIGO stage 2 (K2-AKI), and KDIGO stage 3 (K3-AKI), respectively. In multivariable analyses, serum albumin <2.5\u2009g/dL was independently associated with K1-AKI (subdistribution hazard ratio [sHR] 1.85, 95% confidence interval [CI] 1.17-2.93, p\u2009=\u20090.009) and K2-AKI (sHR 2.37, 95% CI 1.15-4.87, p\u2009=\u20090.019). Bioinformatic and biochemical analyses provided additional information nurturing the discussion on how hypoalbuminemia favors development of AKI during colistin therapy. In conclusion, severe hypoalbuminemia independently predicted AKI during colistin therapy in a large cohort of patients with BSI due to colistin-susceptible Gram-negative bacteria. Further study is needed to clarify the underlying causal pathways.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-30361-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "acute kidney injury", 
      "colistin therapy", 
      "bloodstream infections", 
      "kidney injury", 
      "predictors of AKI", 
      "development of AKI", 
      "Global Outcomes criteria", 
      "KDIGO stage 1", 
      "KDIGO stage 2", 
      "KDIGO stage 3", 
      "serum albumin level", 
      "cohort of patients", 
      "retrospective clinical study", 
      "albumin levels", 
      "severe hypoalbuminemia", 
      "multivariable analysis", 
      "colistin treatment", 
      "kidney disease", 
      "clinical studies", 
      "large cohort", 
      "outcome criteria", 
      "hypoalbuminemia", 
      "therapy", 
      "patients", 
      "Gram-negative bacteria", 
      "serum albumin", 
      "stage 3", 
      "Further studies", 
      "stage 1", 
      "causal pathways", 
      "injury", 
      "cohort", 
      "stage 2", 
      "predictors", 
      "human serum albumin", 
      "biochemical analysis", 
      "possible interactions", 
      "albumin", 
      "colistin", 
      "study", 
      "infection", 
      "dl", 
      "disease", 
      "additional information", 
      "treatment", 
      "conclusion", 
      "pathway", 
      "bacteria", 
      "levels", 
      "criteria", 
      "role", 
      "biochemical characterization", 
      "analysis", 
      "development", 
      "part", 
      "information", 
      "interaction", 
      "discussion", 
      "characterization", 
      "colistin-susceptible Gram-negative bacteria", 
      "multicentre retrospective clinical study", 
      "K1-AKI", 
      "K2-AKI"
    ], 
    "name": "Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment", 
    "pagination": "11968", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106026202"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-30361-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30097635"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-30361-5", 
      "https://app.dimensions.ai/details/publication/pub.1106026202"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_759.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-30361-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30361-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30361-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30361-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-30361-5'


 

This table displays all metadata directly associated to this object as RDF triples.

393 TRIPLES      22 PREDICATES      111 URIs      97 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-30361-5 schema:about N25be5254c00844528bd11c285fe4f0d4
2 N41a6d165fa0a4c0a901f1e66c29950f5
3 N577c1cfdd44041ef8bc16f1857f46b35
4 N62b69deabe54443482fda01d0c3cfd3d
5 N64da6d6cffa2425189040c76f21635cd
6 N795119945c6d46cba79bac73654ff0f5
7 N8e9989f8af9d4bf7aaf308aa78b8cf53
8 Na142d1e86f004e75bbb86ce0220180da
9 Na635e9ca51184684b87d67e14db0e040
10 Nb120785bff2942bda71c8b7a42459305
11 Nbc019788a99641f49e01545bca2fb630
12 Ncdabdc2ea23d4b4bafffe2d045f5bffb
13 Nd27b8a197710415a8e3d17612e20b15d
14 Nda8929c8ecad4039b14db6d9f44f21b0
15 Ne4399b2456a24ed4a7f3f2a68b9a2252
16 Nf3afd66aaa8e4706bffe25f700a01320
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author N7b8acebcf4774cd5a7761ac53f20b2ba
20 schema:citation sg:pub.10.1007/s00134-010-1928-z
21 sg:pub.10.1007/s10822-016-0006-1
22 sg:pub.10.1007/s15010-017-1010-7
23 sg:pub.10.1186/1471-2334-13-380
24 sg:pub.10.1186/cc11454
25 sg:pub.10.1186/s12941-015-0062-8
26 schema:datePublished 2018-08-10
27 schema:datePublishedReg 2018-08-10
28 schema:description This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin. Among the 170 patients included in the study, 71 (42%), 35 (21%), and 11 (6%) developed KDIGO stage 1 (K1-AKI), KDIGO stage 2 (K2-AKI), and KDIGO stage 3 (K3-AKI), respectively. In multivariable analyses, serum albumin <2.5 g/dL was independently associated with K1-AKI (subdistribution hazard ratio [sHR] 1.85, 95% confidence interval [CI] 1.17-2.93, p = 0.009) and K2-AKI (sHR 2.37, 95% CI 1.15-4.87, p = 0.019). Bioinformatic and biochemical analyses provided additional information nurturing the discussion on how hypoalbuminemia favors development of AKI during colistin therapy. In conclusion, severe hypoalbuminemia independently predicted AKI during colistin therapy in a large cohort of patients with BSI due to colistin-susceptible Gram-negative bacteria. Further study is needed to clarify the underlying causal pathways.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N70f4059ee6674f94b0e0e8bf775d0e57
33 Nb974451c7b5845f68fca2a726d0b7e50
34 sg:journal.1045337
35 schema:keywords Further studies
36 Global Outcomes criteria
37 Gram-negative bacteria
38 K1-AKI
39 K2-AKI
40 KDIGO stage 1
41 KDIGO stage 2
42 KDIGO stage 3
43 acute kidney injury
44 additional information
45 albumin
46 albumin levels
47 analysis
48 bacteria
49 biochemical analysis
50 biochemical characterization
51 bloodstream infections
52 causal pathways
53 characterization
54 clinical studies
55 cohort
56 cohort of patients
57 colistin
58 colistin therapy
59 colistin treatment
60 colistin-susceptible Gram-negative bacteria
61 conclusion
62 criteria
63 development
64 development of AKI
65 discussion
66 disease
67 dl
68 human serum albumin
69 hypoalbuminemia
70 infection
71 information
72 injury
73 interaction
74 kidney disease
75 kidney injury
76 large cohort
77 levels
78 multicentre retrospective clinical study
79 multivariable analysis
80 outcome criteria
81 part
82 pathway
83 patients
84 possible interactions
85 predictors
86 predictors of AKI
87 retrospective clinical study
88 role
89 serum albumin
90 serum albumin level
91 severe hypoalbuminemia
92 stage 1
93 stage 2
94 stage 3
95 study
96 therapy
97 treatment
98 schema:name Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment
99 schema:pagination 11968
100 schema:productId Nc5ef9096b39f4bbc9d10c3884233042a
101 Ne4f54aa701994bfb9a6152bf93b6f3a3
102 Nf6ef71611bab42a0aa76549d4d06187d
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106026202
104 https://doi.org/10.1038/s41598-018-30361-5
105 schema:sdDatePublished 2021-12-01T19:41
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N48cf431d320e4e8382acc51f367337b3
108 schema:url https://doi.org/10.1038/s41598-018-30361-5
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0915cf45f24b4a188d110804906515f6 rdf:first Nff85141217dc481c95e7ff1503f1bcde
113 rdf:rest N5979e2be43a841ccb4b1d18918ca6755
114 N25be5254c00844528bd11c285fe4f0d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Female
116 rdf:type schema:DefinedTerm
117 N29c3a342d87841ffb0832de371a46753 rdf:first sg:person.011651431437.34
118 rdf:rest N738a12d8fa114a90805efc201d7b07fd
119 N2e1e01c106664a519d75e3a3192adbcb rdf:first sg:person.01170301267.82
120 rdf:rest N5d7fc35ce53a466993a006280e30e29b
121 N2e6bbc96e6b64ea3bcf2fcb59b33ff29 rdf:first N947f98c3f3f94bffbf9ee7060a5af5fd
122 rdf:rest N5870a3f8b70f48c490fa81654df1999b
123 N39a9b8c25adc4323af74e7473744fc81 rdf:first sg:person.0717574161.37
124 rdf:rest N2e1e01c106664a519d75e3a3192adbcb
125 N3e2d7e31c3d44b81a52e548401f7cc54 rdf:first sg:person.0763033015.43
126 rdf:rest N6d6248af3156443085287a5e1b419afb
127 N41a6d165fa0a4c0a901f1e66c29950f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Incidence
129 rdf:type schema:DefinedTerm
130 N48cf431d320e4e8382acc51f367337b3 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N52ec88ad4cbf4bb58342628355d3498f schema:affiliation grid-institutes:None
133 schema:familyName Melone
134 schema:givenName Marcello
135 rdf:type schema:Person
136 N577c1cfdd44041ef8bc16f1857f46b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Hypoalbuminemia
138 rdf:type schema:DefinedTerm
139 N5870a3f8b70f48c490fa81654df1999b rdf:first sg:person.0705414555.25
140 rdf:rest Nf69402caec894d45971712330d9125b6
141 N5979e2be43a841ccb4b1d18918ca6755 rdf:first sg:person.013247721567.19
142 rdf:rest N29c3a342d87841ffb0832de371a46753
143 N5d7fc35ce53a466993a006280e30e29b rdf:first sg:person.0740455776.60
144 rdf:rest Nf5829979d5d34b61acdc67be0b116b05
145 N62b69deabe54443482fda01d0c3cfd3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 N64da6d6cffa2425189040c76f21635cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Models, Molecular
150 rdf:type schema:DefinedTerm
151 N6d6248af3156443085287a5e1b419afb rdf:first sg:person.0765212354.51
152 rdf:rest Ncde4a071aa9341688318033592c9c27a
153 N70f4059ee6674f94b0e0e8bf775d0e57 schema:volumeNumber 8
154 rdf:type schema:PublicationVolume
155 N738a12d8fa114a90805efc201d7b07fd rdf:first N52ec88ad4cbf4bb58342628355d3498f
156 rdf:rest N39a9b8c25adc4323af74e7473744fc81
157 N795119945c6d46cba79bac73654ff0f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Structure-Activity Relationship
159 rdf:type schema:DefinedTerm
160 N7b8acebcf4774cd5a7761ac53f20b2ba rdf:first sg:person.01170447017.52
161 rdf:rest Ncf3c7025e9574b63b8b332e661da1cec
162 N8948c837cd2f4c6a84b8366d6c1406ff rdf:first sg:person.0630074525.94
163 rdf:rest N3e2d7e31c3d44b81a52e548401f7cc54
164 N8e9989f8af9d4bf7aaf308aa78b8cf53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Acute Kidney Injury
166 rdf:type schema:DefinedTerm
167 N947f98c3f3f94bffbf9ee7060a5af5fd schema:affiliation grid-institutes:None
168 schema:familyName Perrone
169 schema:givenName Katja
170 rdf:type schema:Person
171 N972f6d4bb9ea44b09116bc2c4f173983 rdf:first sg:person.01156176207.36
172 rdf:rest rdf:nil
173 Na142d1e86f004e75bbb86ce0220180da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Molecular Conformation
175 rdf:type schema:DefinedTerm
176 Na635e9ca51184684b87d67e14db0e040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Anti-Bacterial Agents
178 rdf:type schema:DefinedTerm
179 Na88e230e09d846d4b95dedebc816ca43 rdf:first sg:person.01224745065.85
180 rdf:rest Nbae341e80025437a963dcfd41df9a424
181 Nb120785bff2942bda71c8b7a42459305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Retrospective Studies
183 rdf:type schema:DefinedTerm
184 Nb974451c7b5845f68fca2a726d0b7e50 schema:issueNumber 1
185 rdf:type schema:PublicationIssue
186 Nbae341e80025437a963dcfd41df9a424 rdf:first sg:person.0623706124.44
187 rdf:rest Ne3b40baddb18454794dd20c6d21e1b83
188 Nbc019788a99641f49e01545bca2fb630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Colistin
190 rdf:type schema:DefinedTerm
191 Nbe63180695764d51b644c1427de3a304 rdf:first sg:person.0664473660.88
192 rdf:rest N2e6bbc96e6b64ea3bcf2fcb59b33ff29
193 Nbf20923276b94c4f9d5b238bf03f9f03 schema:affiliation grid-institutes:grid.5606.5
194 schema:familyName Casulli
195 schema:givenName Annarita
196 rdf:type schema:Person
197 Nc5ef9096b39f4bbc9d10c3884233042a schema:name pubmed_id
198 schema:value 30097635
199 rdf:type schema:PropertyValue
200 Ncdabdc2ea23d4b4bafffe2d045f5bffb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Sepsis
202 rdf:type schema:DefinedTerm
203 Ncde4a071aa9341688318033592c9c27a rdf:first sg:person.010566660630.05
204 rdf:rest Na88e230e09d846d4b95dedebc816ca43
205 Ncf3c7025e9574b63b8b332e661da1cec rdf:first sg:person.0750336642.80
206 rdf:rest N8948c837cd2f4c6a84b8366d6c1406ff
207 Nd1c3a46ad98b42e9b4ab0b8ebdef1c4e rdf:first sg:person.0650532461.50
208 rdf:rest Nbe63180695764d51b644c1427de3a304
209 Nd27b8a197710415a8e3d17612e20b15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Severity of Illness Index
211 rdf:type schema:DefinedTerm
212 Nda8929c8ecad4039b14db6d9f44f21b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name Male
214 rdf:type schema:DefinedTerm
215 Ne3b40baddb18454794dd20c6d21e1b83 rdf:first Nbf20923276b94c4f9d5b238bf03f9f03
216 rdf:rest Nd1c3a46ad98b42e9b4ab0b8ebdef1c4e
217 Ne4399b2456a24ed4a7f3f2a68b9a2252 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Computational Biology
219 rdf:type schema:DefinedTerm
220 Ne4f54aa701994bfb9a6152bf93b6f3a3 schema:name dimensions_id
221 schema:value pub.1106026202
222 rdf:type schema:PropertyValue
223 Nf3afd66aaa8e4706bffe25f700a01320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
224 schema:name Serum Albumin, Human
225 rdf:type schema:DefinedTerm
226 Nf5829979d5d34b61acdc67be0b116b05 rdf:first sg:person.01241060757.05
227 rdf:rest N972f6d4bb9ea44b09116bc2c4f173983
228 Nf69402caec894d45971712330d9125b6 rdf:first sg:person.01304527667.81
229 rdf:rest N0915cf45f24b4a188d110804906515f6
230 Nf6ef71611bab42a0aa76549d4d06187d schema:name doi
231 schema:value 10.1038/s41598-018-30361-5
232 rdf:type schema:PropertyValue
233 Nff85141217dc481c95e7ff1503f1bcde schema:affiliation grid-institutes:grid.415025.7
234 schema:familyName Vender
235 schema:givenName Luca Enrico
236 rdf:type schema:Person
237 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
238 schema:name Medical and Health Sciences
239 rdf:type schema:DefinedTerm
240 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
241 schema:name Clinical Sciences
242 rdf:type schema:DefinedTerm
243 sg:journal.1045337 schema:issn 2045-2322
244 schema:name Scientific Reports
245 schema:publisher Springer Nature
246 rdf:type schema:Periodical
247 sg:person.010566660630.05 schema:affiliation grid-institutes:None
248 schema:familyName Cappiello
249 schema:givenName Dario
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010566660630.05
251 rdf:type schema:Person
252 sg:person.01156176207.36 schema:affiliation grid-institutes:grid.460062.6
253 schema:familyName Di Bella
254 schema:givenName Stefano
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156176207.36
256 rdf:type schema:Person
257 sg:person.011651431437.34 schema:affiliation grid-institutes:grid.417010.3
258 schema:familyName Occhilupo
259 schema:givenName Pierpaolo
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651431437.34
261 rdf:type schema:Person
262 sg:person.01170301267.82 schema:affiliation grid-institutes:grid.414818.0
263 schema:familyName Gori
264 schema:givenName Andrea
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170301267.82
266 rdf:type schema:Person
267 sg:person.01170447017.52 schema:affiliation grid-institutes:grid.5606.5
268 schema:familyName Giacobbe
269 schema:givenName Daniele Roberto
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170447017.52
271 rdf:type schema:Person
272 sg:person.01224745065.85 schema:affiliation grid-institutes:grid.5606.5
273 schema:familyName Coppo
274 schema:givenName Erika
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224745065.85
276 rdf:type schema:Person
277 sg:person.01241060757.05 schema:affiliation grid-institutes:grid.5606.5
278 schema:familyName Viscoli
279 schema:givenName Claudio
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241060757.05
281 rdf:type schema:Person
282 sg:person.01304527667.81 schema:affiliation grid-institutes:grid.415025.7
283 schema:familyName Bandera
284 schema:givenName Alessandra
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304527667.81
286 rdf:type schema:Person
287 sg:person.013247721567.19 schema:affiliation grid-institutes:grid.460062.6
288 schema:familyName Misin
289 schema:givenName Andrea
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013247721567.19
291 rdf:type schema:Person
292 sg:person.0623706124.44 schema:affiliation grid-institutes:grid.5606.5
293 schema:familyName Marchese
294 schema:givenName Anna
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623706124.44
296 rdf:type schema:Person
297 sg:person.0630074525.94 schema:affiliation grid-institutes:grid.8509.4
298 schema:familyName Leboffe
299 schema:givenName Loris
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630074525.94
301 rdf:type schema:Person
302 sg:person.0650532461.50 schema:affiliation grid-institutes:grid.5606.5
303 schema:familyName Signori
304 schema:givenName Alessio
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650532461.50
306 rdf:type schema:Person
307 sg:person.0664473660.88 schema:affiliation grid-institutes:grid.8404.8
308 schema:familyName Novelli
309 schema:givenName Andrea
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664473660.88
311 rdf:type schema:Person
312 sg:person.0705414555.25 schema:affiliation grid-institutes:grid.413175.5
313 schema:familyName Principe
314 schema:givenName Luigi
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705414555.25
316 rdf:type schema:Person
317 sg:person.0717574161.37 schema:affiliation grid-institutes:grid.8509.4
318 schema:familyName Ascenzi
319 schema:givenName Paolo
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717574161.37
321 rdf:type schema:Person
322 sg:person.0740455776.60 schema:affiliation grid-institutes:grid.460062.6
323 schema:familyName Luzzati
324 schema:givenName Roberto
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740455776.60
326 rdf:type schema:Person
327 sg:person.0750336642.80 schema:affiliation grid-institutes:grid.8509.4
328 schema:familyName di Masi
329 schema:givenName Alessandra
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750336642.80
331 rdf:type schema:Person
332 sg:person.0763033015.43 schema:affiliation grid-institutes:grid.413179.9
333 schema:familyName Del Bono
334 schema:givenName Valerio
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763033015.43
336 rdf:type schema:Person
337 sg:person.0765212354.51 schema:affiliation grid-institutes:grid.415025.7
338 schema:familyName Rossi
339 schema:givenName Marianna
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765212354.51
341 rdf:type schema:Person
342 sg:pub.10.1007/s00134-010-1928-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1051936667
343 https://doi.org/10.1007/s00134-010-1928-z
344 rdf:type schema:CreativeWork
345 sg:pub.10.1007/s10822-016-0006-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027921139
346 https://doi.org/10.1007/s10822-016-0006-1
347 rdf:type schema:CreativeWork
348 sg:pub.10.1007/s15010-017-1010-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084037664
349 https://doi.org/10.1007/s15010-017-1010-7
350 rdf:type schema:CreativeWork
351 sg:pub.10.1186/1471-2334-13-380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048745746
352 https://doi.org/10.1186/1471-2334-13-380
353 rdf:type schema:CreativeWork
354 sg:pub.10.1186/cc11454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016103624
355 https://doi.org/10.1186/cc11454
356 rdf:type schema:CreativeWork
357 sg:pub.10.1186/s12941-015-0062-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017110947
358 https://doi.org/10.1186/s12941-015-0062-8
359 rdf:type schema:CreativeWork
360 grid-institutes:None schema:alternateName Città di Lecce Hospital – GVM Care and Research, Lecce, Italy
361 schema:name Città di Lecce Hospital – GVM Care and Research, Lecce, Italy
362 rdf:type schema:Organization
363 grid-institutes:grid.413175.5 schema:alternateName Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy
364 schema:name Clinical Microbiology and Virology Unit, A. Manzoni Hospital, Lecco, Italy
365 rdf:type schema:Organization
366 grid-institutes:grid.413179.9 schema:alternateName Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy
367 schema:name Infectious Diseases Unit, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy
368 rdf:type schema:Organization
369 grid-institutes:grid.414818.0 schema:alternateName University of Milan and Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
370 schema:name University of Milan and Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
371 rdf:type schema:Organization
372 grid-institutes:grid.415025.7 schema:alternateName Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy
373 schema:name Clinic of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy
374 rdf:type schema:Organization
375 grid-institutes:grid.417010.3 schema:alternateName Maria Cecilia Hospital – GVM Care & Research, Cotignola, Italy
376 schema:name Maria Cecilia Hospital – GVM Care & Research, Cotignola, Italy
377 rdf:type schema:Organization
378 grid-institutes:grid.460062.6 schema:alternateName Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
379 schema:name Infectious Diseases Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy
380 rdf:type schema:Organization
381 grid-institutes:grid.5606.5 schema:alternateName Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
382 Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l’Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
383 Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l’Oncologia, Genoa, Italy
384 schema:name Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
385 Infectious Diseases Unit, Ospedale Policlinico San Martino - IRCCS per l’Oncologia and Department of Health Science (DISSAL), University of Genoa, Genoa, Italy
386 Microbiology Unit, University of Genoa (DISC) and Ospedale Policlinico San Martino - IRCCS per l’Oncologia, Genoa, Italy
387 rdf:type schema:Organization
388 grid-institutes:grid.8404.8 schema:alternateName Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy
389 schema:name Department of Health Sciences, Clinical Pharmacology and Oncology Section, University of Florence, Florence, Italy
390 rdf:type schema:Organization
391 grid-institutes:grid.8509.4 schema:alternateName Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy
392 schema:name Department of Sciences, Section Biomedical Sciences and Technology, Roma Tre University, Rome, Italy
393 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...