A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

D. Bosc, L. Vezenkov, S. Bortnik, J. An, J. Xu, C. Choutka, A. M. Hannigan, S. Kovacic, S. Loo, P. G. K. Clark, G. Chen, R. N. Guay-Ross, K. Yang, W. H. Dragowska, F. Zhang, N. E. Go, A. Leung, N. S. Honson, T. A. Pfeifer, M. Gleave, M. Bally, S. J. Jones, S. M. Gorski, R. N. Young

ABSTRACT

The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions and potential therapeutic applications, we employed a chemical biology approach to identify ATG4B inhibitors. Here, we describe the discovery of 4-28, a styrylquinoline identified by a combined computational modeling, in silico screening, high content cell-based screening and biochemical assay approach. A structure-activity relationship study led to the development of a more stable and potent compound LV-320. We demonstrated that LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts. More... »

PAGES

11653

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-29900-x

DOI

http://dx.doi.org/10.1038/s41598-018-29900-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105917951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30076329


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada", 
            "Inserm, Institut Pasteur de Lille, U1177 Drugs & Molecules for Living Systems, Universit\u00e9 de Lille, F-59000, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bosc", 
        "givenName": "D.", 
        "id": "sg:person.01037117624.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037117624.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Biomol\u00e9cules Max Mousseron", 
          "id": "https://www.grid.ac/institutes/grid.462008.8", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada", 
            "Institut des Biomol\u00e9cules Max Mousseron (IBMM), UMR 5247 CNRS, Universit\u00e9 de Montpellier, ENSCM, Facult\u00e9 de Pharmacie, 15 avenue Charles Flahault, 34093, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vezenkov", 
        "givenName": "L.", 
        "id": "sg:person.01006776363.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006776363.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bortnik", 
        "givenName": "S.", 
        "id": "sg:person.01366737154.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366737154.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "An", 
        "givenName": "J.", 
        "id": "sg:person.01107054306.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107054306.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "J.", 
        "id": "sg:person.01163675466.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163675466.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choutka", 
        "givenName": "C.", 
        "id": "sg:person.01004470156.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004470156.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hannigan", 
        "givenName": "A. M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kovacic", 
        "givenName": "S.", 
        "id": "sg:person.01336107740.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336107740.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Loo", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clark", 
        "givenName": "P. G. K.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "G.", 
        "id": "sg:person.01222171136.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222171136.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guay-Ross", 
        "givenName": "R. N.", 
        "id": "sg:person.012700150122.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012700150122.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "K.", 
        "id": "sg:person.01114370334.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114370334.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Experimental Therapeutics, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dragowska", 
        "givenName": "W. H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, V6H 3Z6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "F.", 
        "id": "sg:person.0661700365.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661700365.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Go", 
        "givenName": "N. E.", 
        "id": "sg:person.01121663044.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121663044.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leung", 
        "givenName": "A.", 
        "id": "sg:person.01354414632.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354414632.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Drug Research and Development", 
          "id": "https://www.grid.ac/institutes/grid.440037.4", 
          "name": [
            "Centre for Drug Research and Development, 2405 Wesbrook Mall \u2013 4th Floor, V6T 1Z3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honson", 
        "givenName": "N. S.", 
        "id": "sg:person.01057132103.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057132103.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre for Drug Research and Development", 
          "id": "https://www.grid.ac/institutes/grid.440037.4", 
          "name": [
            "Centre for Drug Research and Development, 2405 Wesbrook Mall \u2013 4th Floor, V6T 1Z3, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfeifer", 
        "givenName": "T. A.", 
        "id": "sg:person.01212257761.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212257761.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, V6H 3Z6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gleave", 
        "givenName": "M.", 
        "id": "sg:person.01147006714.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147006714.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Experimental Therapeutics, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bally", 
        "givenName": "M.", 
        "id": "sg:person.0603542512.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603542512.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "S. J.", 
        "id": "sg:person.011076371162.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada", 
            "Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada", 
            "Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gorski", 
        "givenName": "S. M.", 
        "id": "sg:person.01170733304.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170733304.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Simon Fraser University", 
          "id": "https://www.grid.ac/institutes/grid.61971.38", 
          "name": [
            "Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Young", 
        "givenName": "R. N.", 
        "id": "sg:person.01357046162.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357046162.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/onc.2015.99", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000775044", 
          "https://doi.org/10.1038/onc.2015.99"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057110392996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000864704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057110392996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000864704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tet.2014.10.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001076691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0734-189x(85)90016-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002019535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810375810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003106200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810375810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003106200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2013-07-516807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005310421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2015.04.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006804220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1118193109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007968658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.32229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009094867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci73937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009836979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y89-004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011120621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.540150503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012967303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.19652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013219126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5mb00466g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014995332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m401461200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017190708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb3053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018419527", 
          "https://doi.org/10.1038/ncb3053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020454207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020454207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0134(1997)1+<215::aid-prot29>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021292465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2009.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021429763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.046250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022252125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0018143908030065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022516372", 
          "https://doi.org/10.1134/s0018143908030065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425255.1.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026291348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/17425255.1.1.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026291348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/513481a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026294014", 
          "https://doi.org/10.1038/513481a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208247200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028813351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208247200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028813351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.11408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028941654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-03-0312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030048509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/17.9.1989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032695846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1205406", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033005246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2013.161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034112529", 
          "https://doi.org/10.1038/cr.2013.161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034818944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci42601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034818944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036040104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejps.2005.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037765966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2005.11.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037976789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038097885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.199059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038718356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0907344106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040716011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.8.2.18373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041321479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m509158200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041505754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13277-015-4587-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041779951", 
          "https://doi.org/10.1007/s13277-015-4587-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201607039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045227391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd3802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045716500", 
          "https://doi.org/10.1038/nrd3802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046035901", 
          "https://doi.org/10.1038/nchembio.1867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m400159-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046707383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e03-09-0704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047037381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.24797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047507607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2015.05.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049011241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2013.10.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051941271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0074222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053181693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acsmedchemlett.6b00208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055136703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm501586m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055954979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2015.1033601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058406528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2015.1034409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058406535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2015.1078962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058406593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/adt.2013.561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059222669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057116639202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063973717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1087057116639202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063973717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/2212697x02666150331202809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069245152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.20828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072289550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.29556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.4451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072290231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/auto.8.2.18554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072291148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2017.1287651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083870074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2017.06.119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086084433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21769/bioprotoc.2571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092019939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2017.11.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099645809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15548627.2018.1437341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101125565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2018.03.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101331457"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions and potential therapeutic applications, we employed a chemical biology approach to identify ATG4B inhibitors. Here, we describe the discovery of 4-28, a styrylquinoline identified by a combined computational modeling, in silico screening, high content cell-based screening and biochemical assay approach. A structure-activity relationship study led to the development of a more stable and potent compound LV-320. We demonstrated that LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-29900-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B", 
    "pagination": "11653", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ba4e58175222a79ff3893c248eed239a312a4966373ecad683d578b20dc53aca"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30076329"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-29900-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105917951"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-29900-x", 
      "https://app.dimensions.ai/details/publication/pub.1105917951"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000571.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-29900-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29900-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29900-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29900-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29900-x'


 

This table displays all metadata directly associated to this object as RDF triples.

451 TRIPLES      21 PREDICATES      95 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-29900-x schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N4a351b6f037541c899cf1b8594ea93a9
4 schema:citation sg:pub.10.1007/s13277-015-4587-4
5 sg:pub.10.1038/513481a
6 sg:pub.10.1038/cr.2013.161
7 sg:pub.10.1038/ncb3053
8 sg:pub.10.1038/nchembio.1867
9 sg:pub.10.1038/nrd3802
10 sg:pub.10.1038/onc.2015.99
11 sg:pub.10.1134/s0018143908030065
12 https://doi.org/10.1002/(sici)1097-0134(1997)1+<215::aid-prot29>3.0.co;2-q
13 https://doi.org/10.1002/jcc.540150503
14 https://doi.org/10.1016/0734-189x(85)90016-7
15 https://doi.org/10.1016/j.abb.2018.03.001
16 https://doi.org/10.1016/j.bbrc.2013.10.117
17 https://doi.org/10.1016/j.bcp.2017.06.119
18 https://doi.org/10.1016/j.bmc.2015.04.064
19 https://doi.org/10.1016/j.ccell.2017.11.005
20 https://doi.org/10.1016/j.ejps.2005.12.007
21 https://doi.org/10.1016/j.jmb.2005.11.018
22 https://doi.org/10.1016/j.molcel.2015.05.031
23 https://doi.org/10.1016/j.tet.2014.10.057
24 https://doi.org/10.1021/acsmedchemlett.6b00208
25 https://doi.org/10.1021/jm501586m
26 https://doi.org/10.1038/emboj.2009.80
27 https://doi.org/10.1038/sj.emboj.7601623
28 https://doi.org/10.1039/c5mb00466g
29 https://doi.org/10.1056/nejmra1205406
30 https://doi.org/10.1073/pnas.0907344106
31 https://doi.org/10.1073/pnas.1118193109
32 https://doi.org/10.1074/jbc.m110.199059
33 https://doi.org/10.1074/jbc.m208247200
34 https://doi.org/10.1074/jbc.m401461200
35 https://doi.org/10.1074/jbc.m509158200
36 https://doi.org/10.1074/mcp.m400159-mcp200
37 https://doi.org/10.1080/15548627.2015.1033601
38 https://doi.org/10.1080/15548627.2015.1034409
39 https://doi.org/10.1080/15548627.2015.1078962
40 https://doi.org/10.1080/15548627.2017.1287651
41 https://doi.org/10.1080/15548627.2018.1437341
42 https://doi.org/10.1083/jcb.201607039
43 https://doi.org/10.1089/adt.2013.561
44 https://doi.org/10.1091/mbc.e03-09-0704
45 https://doi.org/10.1091/mbc.e08-03-0312
46 https://doi.org/10.1093/carcin/17.9.1989
47 https://doi.org/10.1139/y89-004
48 https://doi.org/10.1172/jci42601
49 https://doi.org/10.1172/jci43238
50 https://doi.org/10.1172/jci73937
51 https://doi.org/10.1177/0300985810375810
52 https://doi.org/10.1177/1087057110392996
53 https://doi.org/10.1177/1087057116639202
54 https://doi.org/10.1182/blood-2013-07-516807
55 https://doi.org/10.1242/jcs.01131
56 https://doi.org/10.1242/jcs.046250
57 https://doi.org/10.1371/journal.pone.0074222
58 https://doi.org/10.1517/17425255.1.1.91
59 https://doi.org/10.18632/oncotarget.11408
60 https://doi.org/10.2174/2212697x02666150331202809
61 https://doi.org/10.21769/bioprotoc.2571
62 https://doi.org/10.4161/auto.19652
63 https://doi.org/10.4161/auto.20828
64 https://doi.org/10.4161/auto.24797
65 https://doi.org/10.4161/auto.29556
66 https://doi.org/10.4161/auto.32229
67 https://doi.org/10.4161/auto.4451
68 https://doi.org/10.4161/auto.8.2.18373
69 https://doi.org/10.4161/auto.8.2.18554
70 schema:datePublished 2018-12
71 schema:datePublishedReg 2018-12-01
72 schema:description The cysteine protease ATG4B is a key component of the autophagy machinery, acting to proteolytically prime and recycle its substrate MAP1LC3B. The roles of ATG4B in cancer and other diseases appear to be context dependent but are still not well understood. To help further explore ATG4B functions and potential therapeutic applications, we employed a chemical biology approach to identify ATG4B inhibitors. Here, we describe the discovery of 4-28, a styrylquinoline identified by a combined computational modeling, in silico screening, high content cell-based screening and biochemical assay approach. A structure-activity relationship study led to the development of a more stable and potent compound LV-320. We demonstrated that LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N1587944de4364027aaeedebf8e72e386
77 Nc3ed1ec77fbb448eac91fd5c7dd2af12
78 sg:journal.1045337
79 schema:name A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B
80 schema:pagination 11653
81 schema:productId N25c72db7858b43e5896ad9891d1bfc89
82 N28540587c258405e8ea3601016148005
83 Nbb6ea46b98994698883d3930003a8f44
84 Nd4e23dab5f4b4f799f64e73bfdbd2833
85 Ndf73063a198e4ff286716bad95aa4624
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105917951
87 https://doi.org/10.1038/s41598-018-29900-x
88 schema:sdDatePublished 2019-04-10T20:55
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N15f9bdacc1414ed9a9866555687adee9
91 schema:url https://www.nature.com/articles/s41598-018-29900-x
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0974f997263940cca820dcde6f2988fa rdf:first sg:person.01107054306.11
96 rdf:rest Nefc980f172bd4f919bfbd22ec72d002d
97 N1587944de4364027aaeedebf8e72e386 schema:issueNumber 1
98 rdf:type schema:PublicationIssue
99 N15f9bdacc1414ed9a9866555687adee9 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N1821a9e10ab041d382429c02dabee5b0 rdf:first sg:person.01354414632.07
102 rdf:rest N8fe3412e257f418ea11764e8170957f7
103 N25c72db7858b43e5896ad9891d1bfc89 schema:name doi
104 schema:value 10.1038/s41598-018-29900-x
105 rdf:type schema:PropertyValue
106 N28540587c258405e8ea3601016148005 schema:name readcube_id
107 schema:value ba4e58175222a79ff3893c248eed239a312a4966373ecad683d578b20dc53aca
108 rdf:type schema:PropertyValue
109 N288333d77aa543c79cd81848736bcb93 rdf:first sg:person.011076371162.80
110 rdf:rest Ndb61e3973b2e40eeab447a86fb916f43
111 N35ce38bb7aee4212b65df043422fdec6 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
112 schema:familyName Hannigan
113 schema:givenName A. M.
114 rdf:type schema:Person
115 N3b271fd8d6014cdca4adab661ed02274 rdf:first N49797f1cbbef459b93b264f93648231e
116 rdf:rest Needd940871454dcf877c2c700b589e1f
117 N3d476e9dfe534c9ca237d0b20f4b2be4 rdf:first Ncd52122500be47829644d9cba872768a
118 rdf:rest N67aca8c68cff4c82b69a1ac3487f26bb
119 N455370bca56e45ecaf7091f9d5538644 rdf:first sg:person.01357046162.51
120 rdf:rest rdf:nil
121 N48a84a6d76eb41a1a742a9d315a0f9f4 rdf:first sg:person.01147006714.34
122 rdf:rest N815b4927513341b89a2a7bcc9995bac7
123 N49797f1cbbef459b93b264f93648231e schema:affiliation https://www.grid.ac/institutes/grid.61971.38
124 schema:familyName Clark
125 schema:givenName P. G. K.
126 rdf:type schema:Person
127 N4a351b6f037541c899cf1b8594ea93a9 rdf:first sg:person.01037117624.05
128 rdf:rest N7397f292ae814909a87f2fcd1878506c
129 N4beb03d36bbf431186353ce416906789 rdf:first sg:person.01121663044.52
130 rdf:rest N1821a9e10ab041d382429c02dabee5b0
131 N51f1abe3b19b440b81e0878b97f32e6f rdf:first sg:person.01004470156.88
132 rdf:rest Nd031be99f07442de80b2030c0b30ec89
133 N67aca8c68cff4c82b69a1ac3487f26bb rdf:first sg:person.0661700365.23
134 rdf:rest N4beb03d36bbf431186353ce416906789
135 N6a963c160294409eae0129eff2061ff6 rdf:first sg:person.01212257761.29
136 rdf:rest N48a84a6d76eb41a1a742a9d315a0f9f4
137 N7397f292ae814909a87f2fcd1878506c rdf:first sg:person.01006776363.42
138 rdf:rest N7af344629ff14b61a5b90e987581060a
139 N74201521272e41389df3af78e40b0e95 rdf:first sg:person.01114370334.52
140 rdf:rest N3d476e9dfe534c9ca237d0b20f4b2be4
141 N7af344629ff14b61a5b90e987581060a rdf:first sg:person.01366737154.27
142 rdf:rest N0974f997263940cca820dcde6f2988fa
143 N815b4927513341b89a2a7bcc9995bac7 rdf:first sg:person.0603542512.56
144 rdf:rest N288333d77aa543c79cd81848736bcb93
145 N89b95f05f9974ec3a9b54683256b4028 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
146 schema:familyName Loo
147 schema:givenName S.
148 rdf:type schema:Person
149 N8fe3412e257f418ea11764e8170957f7 rdf:first sg:person.01057132103.74
150 rdf:rest N6a963c160294409eae0129eff2061ff6
151 N984facf245e5475596169e2937007d5c rdf:first sg:person.012700150122.80
152 rdf:rest N74201521272e41389df3af78e40b0e95
153 Nbb6ea46b98994698883d3930003a8f44 schema:name pubmed_id
154 schema:value 30076329
155 rdf:type schema:PropertyValue
156 Nc3ed1ec77fbb448eac91fd5c7dd2af12 schema:volumeNumber 8
157 rdf:type schema:PublicationVolume
158 Ncd52122500be47829644d9cba872768a schema:affiliation https://www.grid.ac/institutes/grid.248762.d
159 schema:familyName Dragowska
160 schema:givenName W. H.
161 rdf:type schema:Person
162 Nd031be99f07442de80b2030c0b30ec89 rdf:first N35ce38bb7aee4212b65df043422fdec6
163 rdf:rest Nfb0826a9430949b5a70ad7be15282e4e
164 Nd4e23dab5f4b4f799f64e73bfdbd2833 schema:name nlm_unique_id
165 schema:value 101563288
166 rdf:type schema:PropertyValue
167 Ndb61e3973b2e40eeab447a86fb916f43 rdf:first sg:person.01170733304.61
168 rdf:rest N455370bca56e45ecaf7091f9d5538644
169 Ndf73063a198e4ff286716bad95aa4624 schema:name dimensions_id
170 schema:value pub.1105917951
171 rdf:type schema:PropertyValue
172 Needd940871454dcf877c2c700b589e1f rdf:first sg:person.01222171136.34
173 rdf:rest N984facf245e5475596169e2937007d5c
174 Nefc980f172bd4f919bfbd22ec72d002d rdf:first sg:person.01163675466.40
175 rdf:rest N51f1abe3b19b440b81e0878b97f32e6f
176 Nf1c0a6bef310480a81c4cf8451d9ac58 rdf:first N89b95f05f9974ec3a9b54683256b4028
177 rdf:rest N3b271fd8d6014cdca4adab661ed02274
178 Nfb0826a9430949b5a70ad7be15282e4e rdf:first sg:person.01336107740.74
179 rdf:rest Nf1c0a6bef310480a81c4cf8451d9ac58
180 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
181 schema:name Biological Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
184 schema:name Biochemistry and Cell Biology
185 rdf:type schema:DefinedTerm
186 sg:journal.1045337 schema:issn 2045-2322
187 schema:name Scientific Reports
188 rdf:type schema:Periodical
189 sg:person.01004470156.88 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
190 schema:familyName Choutka
191 schema:givenName C.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004470156.88
193 rdf:type schema:Person
194 sg:person.01006776363.42 schema:affiliation https://www.grid.ac/institutes/grid.462008.8
195 schema:familyName Vezenkov
196 schema:givenName L.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006776363.42
198 rdf:type schema:Person
199 sg:person.01037117624.05 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
200 schema:familyName Bosc
201 schema:givenName D.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037117624.05
203 rdf:type schema:Person
204 sg:person.01057132103.74 schema:affiliation https://www.grid.ac/institutes/grid.440037.4
205 schema:familyName Honson
206 schema:givenName N. S.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057132103.74
208 rdf:type schema:Person
209 sg:person.01107054306.11 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
210 schema:familyName An
211 schema:givenName J.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107054306.11
213 rdf:type schema:Person
214 sg:person.011076371162.80 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
215 schema:familyName Jones
216 schema:givenName S. J.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80
218 rdf:type schema:Person
219 sg:person.01114370334.52 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
220 schema:familyName Yang
221 schema:givenName K.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114370334.52
223 rdf:type schema:Person
224 sg:person.01121663044.52 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
225 schema:familyName Go
226 schema:givenName N. E.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121663044.52
228 rdf:type schema:Person
229 sg:person.01147006714.34 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
230 schema:familyName Gleave
231 schema:givenName M.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147006714.34
233 rdf:type schema:Person
234 sg:person.01163675466.40 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
235 schema:familyName Xu
236 schema:givenName J.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163675466.40
238 rdf:type schema:Person
239 sg:person.01170733304.61 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
240 schema:familyName Gorski
241 schema:givenName S. M.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170733304.61
243 rdf:type schema:Person
244 sg:person.01212257761.29 schema:affiliation https://www.grid.ac/institutes/grid.440037.4
245 schema:familyName Pfeifer
246 schema:givenName T. A.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212257761.29
248 rdf:type schema:Person
249 sg:person.01222171136.34 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
250 schema:familyName Chen
251 schema:givenName G.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222171136.34
253 rdf:type schema:Person
254 sg:person.012700150122.80 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
255 schema:familyName Guay-Ross
256 schema:givenName R. N.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012700150122.80
258 rdf:type schema:Person
259 sg:person.01336107740.74 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
260 schema:familyName Kovacic
261 schema:givenName S.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336107740.74
263 rdf:type schema:Person
264 sg:person.01354414632.07 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
265 schema:familyName Leung
266 schema:givenName A.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354414632.07
268 rdf:type schema:Person
269 sg:person.01357046162.51 schema:affiliation https://www.grid.ac/institutes/grid.61971.38
270 schema:familyName Young
271 schema:givenName R. N.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357046162.51
273 rdf:type schema:Person
274 sg:person.01366737154.27 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
275 schema:familyName Bortnik
276 schema:givenName S.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366737154.27
278 rdf:type schema:Person
279 sg:person.0603542512.56 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
280 schema:familyName Bally
281 schema:givenName M.
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603542512.56
283 rdf:type schema:Person
284 sg:person.0661700365.23 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
285 schema:familyName Zhang
286 schema:givenName F.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661700365.23
288 rdf:type schema:Person
289 sg:pub.10.1007/s13277-015-4587-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041779951
290 https://doi.org/10.1007/s13277-015-4587-4
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/513481a schema:sameAs https://app.dimensions.ai/details/publication/pub.1026294014
293 https://doi.org/10.1038/513481a
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/cr.2013.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034112529
296 https://doi.org/10.1038/cr.2013.161
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/ncb3053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018419527
299 https://doi.org/10.1038/ncb3053
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nchembio.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046035901
302 https://doi.org/10.1038/nchembio.1867
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nrd3802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045716500
305 https://doi.org/10.1038/nrd3802
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/onc.2015.99 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000775044
308 https://doi.org/10.1038/onc.2015.99
309 rdf:type schema:CreativeWork
310 sg:pub.10.1134/s0018143908030065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022516372
311 https://doi.org/10.1134/s0018143908030065
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/(sici)1097-0134(1997)1+<215::aid-prot29>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1021292465
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1002/jcc.540150503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012967303
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/0734-189x(85)90016-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002019535
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.abb.2018.03.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101331457
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.bbrc.2013.10.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051941271
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.bcp.2017.06.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086084433
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.bmc.2015.04.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006804220
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.ccell.2017.11.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099645809
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.ejps.2005.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037765966
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.jmb.2005.11.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037976789
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.molcel.2015.05.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049011241
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.tet.2014.10.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001076691
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1021/acsmedchemlett.6b00208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055136703
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1021/jm501586m schema:sameAs https://app.dimensions.ai/details/publication/pub.1055954979
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1038/emboj.2009.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021429763
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1038/sj.emboj.7601623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036040104
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1039/c5mb00466g schema:sameAs https://app.dimensions.ai/details/publication/pub.1014995332
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1056/nejmra1205406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033005246
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1073/pnas.0907344106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040716011
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1073/pnas.1118193109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007968658
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1074/jbc.m110.199059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038718356
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1074/jbc.m208247200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028813351
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1074/jbc.m401461200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017190708
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1074/jbc.m509158200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041505754
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1074/mcp.m400159-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046707383
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1080/15548627.2015.1033601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058406528
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1080/15548627.2015.1034409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058406535
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1080/15548627.2015.1078962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058406593
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1080/15548627.2017.1287651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083870074
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1080/15548627.2018.1437341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101125565
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1083/jcb.201607039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045227391
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1089/adt.2013.561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059222669
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1091/mbc.e03-09-0704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047037381
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1091/mbc.e08-03-0312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030048509
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/carcin/17.9.1989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032695846
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1139/y89-004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011120621
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1172/jci42601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034818944
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1172/jci43238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020454207
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1172/jci73937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009836979
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1177/0300985810375810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003106200
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1177/1087057110392996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000864704
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1177/1087057116639202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063973717
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1182/blood-2013-07-516807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005310421
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1242/jcs.01131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038097885
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1242/jcs.046250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022252125
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1371/journal.pone.0074222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053181693
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1517/17425255.1.1.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026291348
406 rdf:type schema:CreativeWork
407 https://doi.org/10.18632/oncotarget.11408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028941654
408 rdf:type schema:CreativeWork
409 https://doi.org/10.2174/2212697x02666150331202809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069245152
410 rdf:type schema:CreativeWork
411 https://doi.org/10.21769/bioprotoc.2571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092019939
412 rdf:type schema:CreativeWork
413 https://doi.org/10.4161/auto.19652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013219126
414 rdf:type schema:CreativeWork
415 https://doi.org/10.4161/auto.20828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289550
416 rdf:type schema:CreativeWork
417 https://doi.org/10.4161/auto.24797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047507607
418 rdf:type schema:CreativeWork
419 https://doi.org/10.4161/auto.29556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290077
420 rdf:type schema:CreativeWork
421 https://doi.org/10.4161/auto.32229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009094867
422 rdf:type schema:CreativeWork
423 https://doi.org/10.4161/auto.4451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290231
424 rdf:type schema:CreativeWork
425 https://doi.org/10.4161/auto.8.2.18373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041321479
426 rdf:type schema:CreativeWork
427 https://doi.org/10.4161/auto.8.2.18554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072291148
428 rdf:type schema:CreativeWork
429 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
430 schema:name Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada
431 Department of Urologic Sciences and Vancouver Prostate Centre, University of British Columbia, V6H 3Z6, Vancouver, BC, Canada
432 Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada
433 rdf:type schema:Organization
434 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
435 schema:name Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada
436 Experimental Therapeutics, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada
437 rdf:type schema:Organization
438 https://www.grid.ac/institutes/grid.440037.4 schema:alternateName Centre for Drug Research and Development
439 schema:name Centre for Drug Research and Development, 2405 Wesbrook Mall – 4th Floor, V6T 1Z3, Vancouver, BC, Canada
440 rdf:type schema:Organization
441 https://www.grid.ac/institutes/grid.462008.8 schema:alternateName Institut des Biomolécules Max Mousseron
442 schema:name Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada
443 Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS, Université de Montpellier, ENSCM, Faculté de Pharmacie, 15 avenue Charles Flahault, 34093, Montpellier, France
444 rdf:type schema:Organization
445 https://www.grid.ac/institutes/grid.61971.38 schema:alternateName Simon Fraser University
446 schema:name Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, V5Z 4E6, Vancouver, BC, Canada
447 Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada
448 Department of Molecular Biology and Biochemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada
449 Inserm, Institut Pasteur de Lille, U1177 Drugs & Molecules for Living Systems, Université de Lille, F-59000, Lille, France
450 Interdisciplinary Oncology Program, University of British Columbia, Vancouver, Canada
451 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...