JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3-L1 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue, White", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diet, High-Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterocyclic Compounds, 4 or More Rings", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Obese", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sirtuin 1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Metabolism and Nutrition, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
            "Department of Metabolism and Nutrition, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nawaz", 
        "givenName": "Allah", 
        "id": "sg:person.0725155054.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725155054.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences, Barrett Hodgson University, Karachi, Pakistan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
            "Department of Biosciences, Barrett Hodgson University, Karachi, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mehmood", 
        "givenName": "Arshad", 
        "id": "sg:person.014434266734.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014434266734.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kanatani", 
        "givenName": "Yukiko", 
        "id": "sg:person.0701623651.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701623651.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kado", 
        "givenName": "Tomonobu", 
        "id": "sg:person.07553705317.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07553705317.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Igarashi", 
        "givenName": "Yoshiko", 
        "id": "sg:person.0657226337.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657226337.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takikawa", 
        "givenName": "Akiko", 
        "id": "sg:person.01327033420.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327033420.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "Department of Pathology, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Seiji", 
        "id": "sg:person.01205554101.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205554101.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okabe", 
        "givenName": "Keisuke", 
        "id": "sg:person.01262122516.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262122516.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Metabolism and Nutrition, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "Department of Metabolism and Nutrition, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakagawa", 
        "givenName": "Takashi", 
        "id": "sg:person.01067673130.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067673130.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yagi", 
        "givenName": "Kunimasa", 
        "id": "sg:person.015207640272.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015207640272.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujisaka", 
        "givenName": "Shiho", 
        "id": "sg:person.01071255514.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071255514.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267346.2", 
          "name": [
            "First Department of Internal Medicine, University of Toyama, 2630 Sugitani, 930-0194, Toyama-shi, Toyama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tobe", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.01100423277.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100423277.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00109-016-1402-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024058725", 
          "https://doi.org/10.1007/s00109-016-1402-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-017-2527-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084864689", 
          "https://doi.org/10.1007/s00018-017-2527-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep00070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051971895", 
          "https://doi.org/10.1038/srep00070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2015.110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003328639", 
          "https://doi.org/10.1038/nprot.2015.110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s13340-015-0213-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006207216", 
          "https://doi.org/10.1007/s13340-015-0213-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037496132", 
          "https://doi.org/10.1038/nature02583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00231-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091148236", 
          "https://doi.org/10.1038/s41467-017-00231-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35001622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019839382", 
          "https://doi.org/10.1038/35001622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022068765", 
          "https://doi.org/10.1038/nature06261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-013-2885-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049185943", 
          "https://doi.org/10.1007/s00125-013-2885-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014665053", 
          "https://doi.org/10.1038/nature05354"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07-27", 
    "datePublishedReg": "2018-07-27", 
    "description": "Sirt1 plays an important role in regulating glucose and lipid metabolism in obese animal models. Impaired adipose tissue angiogenesis in the obese state decreases adipogenesis and thereby contributes to glucose intolerance and lipid metabolism. However, the mechanism by which Sirt1 activation affects obesity-associated impairments in angiogenesis in the adipose tissue is not fully understood. Here, we show that SRT1720 treatment induces angiogenic genes in cultured 3T3-L1 preadipocytes and ex vivo preadipocytes. siRNA-mediated knockdown of Sirt1 in 3T3-L1 preadipocytes downregulated angiogenic genes in the preadipocytes. SRT1720 treatment upregulated metabolically favorable genes and reduced inflammatory gene expressions in the adipose tissue of diet-induced obese (DIO) mice. Collectively, these findings suggest a novel role of SRT1720-induced Sirt1 activation in the induction of angiogenic genes in preadipocytes, thereby reducing inflammation and fibrosis in white adipose tissue (WAT) and promoting insulin sensitivity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-29773-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7535335", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7545334", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7537034", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6152603", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6052145", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6834201", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "diet-induced obese mice", 
      "white adipose tissue", 
      "adipose tissue", 
      "SRT1720 treatment", 
      "obese mice", 
      "angiogenic genes", 
      "SIRT1 activation", 
      "lipid metabolism", 
      "obese animal models", 
      "obesity-associated impairment", 
      "inflammatory gene expression", 
      "knockdown of SIRT1", 
      "insulin resistance", 
      "obese state", 
      "insulin sensitivity", 
      "tissue angiogenesis", 
      "animal models", 
      "ex vivo", 
      "proangiogenic genes", 
      "preadipocytes", 
      "novel role", 
      "mice", 
      "SIRT1", 
      "tissue", 
      "angiogenesis", 
      "treatment", 
      "metabolism", 
      "activation", 
      "gene expression", 
      "inflammation", 
      "fibrosis", 
      "genes", 
      "intolerance", 
      "impairment", 
      "important role", 
      "adipogenesis", 
      "siRNA", 
      "vivo", 
      "knockdown", 
      "role", 
      "induction", 
      "glucose", 
      "expression", 
      "activator", 
      "findings", 
      "sensitivity", 
      "resistance", 
      "mechanism", 
      "model", 
      "state", 
      "favorable genes"
    ], 
    "name": "Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice", 
    "pagination": "11370", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105781429"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-29773-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30054532"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-29773-0", 
      "https://app.dimensions.ai/details/publication/pub.1105781429"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T10:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_781.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-29773-0"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

329 TRIPLES      22 PREDICATES      107 URIs      86 LITERALS      24 BLANK NODES