Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-07-23

AUTHORS

Beatriz González, Ferran Fece de la Cruz, Johanna Kristina Samuelsson, Andreu Alibés, Sergio Alonso

ABSTRACT

VWA2 encodes AMACO, a secreted protein up-regulated in most colorectal carcinomas (CRC), constituting a promising biomarker. The mechanism responsible for its aberrant up-regulation has not been previously described. In this work, we analyzed VWA2 DNA methylation in over 400 primary CRCs. No epigenetic alterations were found in its promoter-associated CpG island. However, the region located downstream of the transcriptional start site was hypomethylated in most CRCs. ChIP-Seq revealed increased levels of the active mark H3K4me3 and reduction of the repressive mark H3K27me3. In contrast, several CRC cell lines exhibited hypermethylation of VWA2. 5-AZA-2-deoxycitidine treatment led to transcriptional activation of VWA2, supporting a functional link between DNA methylation and transcription. VWA2 expression in primary CRCs correlated with that of Myc and Myc-target genes. Transcriptional up-regulation of VWA2 is extremely frequent (78%) and strong (average fold change >15) in CRC, but not in other types of cancer. VWA2 undergoes hypomethylation in the majority of CRCs. This alteration could partly underlie the previously reported over-expression of AMACO. Co-expression profiling suggests that VWA2 might be a constituent of a larger oncogenic transcriptional program regulated by c-Myc. Up-regulation of VWA2 is virtually exclusive of CRC, reinforcing its potential as a specific biomarker. More... »

PAGES

11097

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-29378-7

DOI

http://dx.doi.org/10.1038/s41598-018-29378-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105646404

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30038405


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Azacitidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Methylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epigenesis, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Code", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Introns", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-myc", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.429186.0", 
          "name": [
            "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez", 
        "givenName": "Beatriz", 
        "id": "sg:person.01007631605.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007631605.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain", 
            "Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fece de la Cruz", 
        "givenName": "Ferran", 
        "id": "sg:person.0672673661.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672673661.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Active Motif, Inc, 92008, Carlsbad, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.421926.a", 
          "name": [
            "Active Motif, Inc, 92008, Carlsbad, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samuelsson", 
        "givenName": "Johanna Kristina", 
        "id": "sg:person.01363674331.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363674331.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.429186.0", 
          "name": [
            "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alib\u00e9s", 
        "givenName": "Andreu", 
        "id": "sg:person.01044406021.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044406021.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.429186.0", 
          "name": [
            "Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Sergio", 
        "id": "sg:person.01240515061.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240515061.54"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2105-12-323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021902674", 
          "https://doi.org/10.1186/1471-2105-12-323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050075164", 
          "https://doi.org/10.1038/nmeth.3252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032369744", 
          "https://doi.org/10.1038/ng.298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619765", 
          "https://doi.org/10.1038/nature11252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052944075", 
          "https://doi.org/10.1038/nmeth.3115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029065430", 
          "https://doi.org/10.1038/nature11247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2009.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043574219", 
          "https://doi.org/10.1038/nprot.2009.97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1385/1-59259-182-5:071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052070938", 
          "https://doi.org/10.1385/1-59259-182-5:071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-11-587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025448148", 
          "https://doi.org/10.1186/1471-2105-11-587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0576-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038464714", 
          "https://doi.org/10.1186/s13059-014-0576-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015800755", 
          "https://doi.org/10.1038/sj.onc.1208134"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-07-23", 
    "datePublishedReg": "2018-07-23", 
    "description": "VWA2 encodes AMACO, a secreted protein up-regulated in most colorectal carcinomas (CRC), constituting a promising biomarker. The mechanism responsible for its aberrant up-regulation has not been previously described. In this work, we analyzed VWA2 DNA methylation in over 400 primary CRCs. No epigenetic alterations were found in its promoter-associated CpG island. However, the region located downstream of the transcriptional start site was hypomethylated in most CRCs. ChIP-Seq revealed increased levels of the active mark H3K4me3 and reduction of the repressive mark H3K27me3. In contrast, several CRC cell lines exhibited hypermethylation of VWA2. 5-AZA-2-deoxycitidine treatment led to transcriptional activation of VWA2, supporting a functional link between DNA methylation and transcription. VWA2 expression in primary CRCs correlated with that of Myc and Myc-target genes. Transcriptional up-regulation of VWA2 is extremely frequent (78%) and strong (average fold change >15) in CRC, but not in other types of cancer. VWA2 undergoes hypomethylation in the majority of CRCs. This alteration could partly underlie the previously reported over-expression of AMACO. Co-expression profiling suggests that VWA2 might be a constituent of a larger oncogenic transcriptional program regulated by c-Myc. Up-regulation of VWA2 is virtually exclusive of CRC, reinforcing its potential as a specific biomarker.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-29378-7", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8098312", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "DNA methylation", 
      "promoter-associated CpG islands", 
      "active mark H3K4me3", 
      "repressive mark H3K27me3", 
      "oncogenic transcriptional program", 
      "MYC target genes", 
      "transcriptional start site", 
      "co-expression profiling", 
      "most colorectal carcinomas", 
      "ChIP-seq", 
      "transcriptional programs", 
      "transcriptional activation", 
      "CpG islands", 
      "start site", 
      "transcriptional dysregulation", 
      "epigenetic alterations", 
      "majority of CRC", 
      "oncogenic program", 
      "functional link", 
      "CRC cell lines", 
      "c-Myc", 
      "AMACO", 
      "cell lines", 
      "types of cancer", 
      "methylation", 
      "MYC", 
      "expression", 
      "H3K4me3", 
      "H3K27me3", 
      "transcription", 
      "genes", 
      "hypomethylation", 
      "hypermethylation", 
      "protein", 
      "profiling", 
      "alterations", 
      "specific biomarkers", 
      "dysregulation", 
      "promising biomarker", 
      "activation", 
      "islands", 
      "colorectal carcinoma", 
      "biomarkers", 
      "cancer", 
      "sites", 
      "mechanism", 
      "lines", 
      "primary colorectal carcinoma", 
      "region", 
      "colorectal cancer", 
      "contrast", 
      "levels", 
      "constituents", 
      "potential", 
      "link", 
      "majority", 
      "types", 
      "program", 
      "reduction", 
      "carcinoma", 
      "treatment", 
      "work"
    ], 
    "name": "Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer", 
    "pagination": "11097", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105646404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-29378-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30038405"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-29378-7", 
      "https://app.dimensions.ai/details/publication/pub.1105646404"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_776.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-29378-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29378-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29378-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29378-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-29378-7'


 

This table displays all metadata directly associated to this object as RDF triples.

304 TRIPLES      22 PREDICATES      124 URIs      103 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-29378-7 schema:about N081337d8df044020a4d3990e82b31b52
2 N0ef8dbc87ff54594a0efb0fe3e564706
3 N0f4a99ad0c5141fea8bad7cb46100f86
4 N145b8b72cc3048c2b630bdefd7d765d7
5 N2095c709737f41d6b8ef333f44000480
6 N2553fbc2e79a4fff85277d0dc815f52e
7 N289dee2d85054f58b6150f570fabd833
8 N29410db1892d4a21b0b4cf6711d74a56
9 N705445468926436699d0b96fd58e65bb
10 N96d1b41e1459497ebfa3d72ae42bec23
11 N98bc259c1f0a4c6b92923083c051813a
12 N9958004e38694b0b8a2d3593c23301b5
13 Na5a4c7be82cf43e689f97bc161532a4b
14 Nc0befb58db3443f78fde726c9bd76314
15 Nc19674f8d8614662bbc1387af0d65e98
16 Nc2a48ce043ad476e972fb8a45e28fc4d
17 Nd09f51baa505465dad85b2798a2ef576
18 Nd252f42b504c4391bdafc6e0d6d5cbd6
19 Ne9e853e1225949238caa324cc4095dd4
20 Neaa2297b575f40cbadeea3a9a8a33fec
21 Ned468d036562423496a42c6d3bdd3c12
22 Nf60083c359464d53a7e3074531cb47e9
23 Nfba2ef03d5a043109b5f0330a38b6865
24 anzsrc-for:06
25 anzsrc-for:0604
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author Nabd4468137bd4422b95418459f644dde
29 schema:citation sg:pub.10.1038/nature11247
30 sg:pub.10.1038/nature11252
31 sg:pub.10.1038/ng.298
32 sg:pub.10.1038/nmeth.3115
33 sg:pub.10.1038/nmeth.3252
34 sg:pub.10.1038/nprot.2009.97
35 sg:pub.10.1038/sj.onc.1208134
36 sg:pub.10.1186/1471-2105-11-587
37 sg:pub.10.1186/1471-2105-12-323
38 sg:pub.10.1186/s13059-014-0576-y
39 sg:pub.10.1385/1-59259-182-5:071
40 schema:datePublished 2018-07-23
41 schema:datePublishedReg 2018-07-23
42 schema:description VWA2 encodes AMACO, a secreted protein up-regulated in most colorectal carcinomas (CRC), constituting a promising biomarker. The mechanism responsible for its aberrant up-regulation has not been previously described. In this work, we analyzed VWA2 DNA methylation in over 400 primary CRCs. No epigenetic alterations were found in its promoter-associated CpG island. However, the region located downstream of the transcriptional start site was hypomethylated in most CRCs. ChIP-Seq revealed increased levels of the active mark H3K4me3 and reduction of the repressive mark H3K27me3. In contrast, several CRC cell lines exhibited hypermethylation of VWA2. 5-AZA-2-deoxycitidine treatment led to transcriptional activation of VWA2, supporting a functional link between DNA methylation and transcription. VWA2 expression in primary CRCs correlated with that of Myc and Myc-target genes. Transcriptional up-regulation of VWA2 is extremely frequent (78%) and strong (average fold change >15) in CRC, but not in other types of cancer. VWA2 undergoes hypomethylation in the majority of CRCs. This alteration could partly underlie the previously reported over-expression of AMACO. Co-expression profiling suggests that VWA2 might be a constituent of a larger oncogenic transcriptional program regulated by c-Myc. Up-regulation of VWA2 is virtually exclusive of CRC, reinforcing its potential as a specific biomarker.
43 schema:genre article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N589b1df81b004b658f6213ec7383bf33
47 N8453ef94aede4b50a3347f9c44ea5741
48 sg:journal.1045337
49 schema:keywords AMACO
50 CRC cell lines
51 ChIP-seq
52 CpG islands
53 DNA methylation
54 H3K27me3
55 H3K4me3
56 MYC
57 MYC target genes
58 activation
59 active mark H3K4me3
60 alterations
61 biomarkers
62 c-Myc
63 cancer
64 carcinoma
65 cell lines
66 co-expression profiling
67 colorectal cancer
68 colorectal carcinoma
69 constituents
70 contrast
71 dysregulation
72 epigenetic alterations
73 expression
74 functional link
75 genes
76 hypermethylation
77 hypomethylation
78 islands
79 levels
80 lines
81 link
82 majority
83 majority of CRC
84 mechanism
85 methylation
86 most colorectal carcinomas
87 oncogenic program
88 oncogenic transcriptional program
89 potential
90 primary colorectal carcinoma
91 profiling
92 program
93 promising biomarker
94 promoter-associated CpG islands
95 protein
96 reduction
97 region
98 repressive mark H3K27me3
99 sites
100 specific biomarkers
101 start site
102 transcription
103 transcriptional activation
104 transcriptional dysregulation
105 transcriptional programs
106 transcriptional start site
107 treatment
108 types
109 types of cancer
110 work
111 schema:name Epigenetic and transcriptional dysregulation of VWA2 associated with a MYC-driven oncogenic program in colorectal cancer
112 schema:pagination 11097
113 schema:productId N20210b1fce344daf863cd246c8b674db
114 N297ef63d2f3f4dabad0a5dded3eaad7c
115 N3bea454d96b04572abc1f1a305eaaca0
116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105646404
117 https://doi.org/10.1038/s41598-018-29378-7
118 schema:sdDatePublished 2022-05-20T07:34
119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
120 schema:sdPublisher Nf9269dab7aff4313b6d2d2e54fac0bc6
121 schema:url https://doi.org/10.1038/s41598-018-29378-7
122 sgo:license sg:explorer/license/
123 sgo:sdDataset articles
124 rdf:type schema:ScholarlyArticle
125 N081337d8df044020a4d3990e82b31b52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Azacitidine
127 rdf:type schema:DefinedTerm
128 N0ef8dbc87ff54594a0efb0fe3e564706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Proto-Oncogene Proteins c-myc
130 rdf:type schema:DefinedTerm
131 N0f4a99ad0c5141fea8bad7cb46100f86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Colorectal Neoplasms
133 rdf:type schema:DefinedTerm
134 N145b8b72cc3048c2b630bdefd7d765d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Transcription, Genetic
136 rdf:type schema:DefinedTerm
137 N1cf5011caff84f3da91f2429d9e0509d rdf:first sg:person.01240515061.54
138 rdf:rest rdf:nil
139 N20210b1fce344daf863cd246c8b674db schema:name dimensions_id
140 schema:value pub.1105646404
141 rdf:type schema:PropertyValue
142 N2095c709737f41d6b8ef333f44000480 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Calcium-Binding Proteins
144 rdf:type schema:DefinedTerm
145 N2553fbc2e79a4fff85277d0dc815f52e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Genetic Loci
147 rdf:type schema:DefinedTerm
148 N289dee2d85054f58b6150f570fabd833 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Biomarkers, Tumor
150 rdf:type schema:DefinedTerm
151 N29410db1892d4a21b0b4cf6711d74a56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cell Line, Tumor
153 rdf:type schema:DefinedTerm
154 N297ef63d2f3f4dabad0a5dded3eaad7c schema:name doi
155 schema:value 10.1038/s41598-018-29378-7
156 rdf:type schema:PropertyValue
157 N3bea454d96b04572abc1f1a305eaaca0 schema:name pubmed_id
158 schema:value 30038405
159 rdf:type schema:PropertyValue
160 N501c5471e1254a3696ef0f3df99b5fca rdf:first sg:person.01363674331.14
161 rdf:rest N8aaa686f8cb6436689afa12df041af44
162 N589b1df81b004b658f6213ec7383bf33 schema:issueNumber 1
163 rdf:type schema:PublicationIssue
164 N705445468926436699d0b96fd58e65bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Wnt Proteins
166 rdf:type schema:DefinedTerm
167 N8453ef94aede4b50a3347f9c44ea5741 schema:volumeNumber 8
168 rdf:type schema:PublicationVolume
169 N8aaa686f8cb6436689afa12df041af44 rdf:first sg:person.01044406021.06
170 rdf:rest N1cf5011caff84f3da91f2429d9e0509d
171 N93235694ef8e4348bb50f7cc9574920e rdf:first sg:person.0672673661.18
172 rdf:rest N501c5471e1254a3696ef0f3df99b5fca
173 N96d1b41e1459497ebfa3d72ae42bec23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Up-Regulation
175 rdf:type schema:DefinedTerm
176 N98bc259c1f0a4c6b92923083c051813a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name DNA Methylation
178 rdf:type schema:DefinedTerm
179 N9958004e38694b0b8a2d3593c23301b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Gene Expression Regulation, Neoplastic
181 rdf:type schema:DefinedTerm
182 Na5a4c7be82cf43e689f97bc161532a4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name RNA, Messenger
184 rdf:type schema:DefinedTerm
185 Nabd4468137bd4422b95418459f644dde rdf:first sg:person.01007631605.68
186 rdf:rest N93235694ef8e4348bb50f7cc9574920e
187 Nc0befb58db3443f78fde726c9bd76314 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Introns
189 rdf:type schema:DefinedTerm
190 Nc19674f8d8614662bbc1387af0d65e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Promoter Regions, Genetic
192 rdf:type schema:DefinedTerm
193 Nc2a48ce043ad476e972fb8a45e28fc4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Female
195 rdf:type schema:DefinedTerm
196 Nd09f51baa505465dad85b2798a2ef576 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Epigenesis, Genetic
198 rdf:type schema:DefinedTerm
199 Nd252f42b504c4391bdafc6e0d6d5cbd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Carcinogenesis
201 rdf:type schema:DefinedTerm
202 Ne9e853e1225949238caa324cc4095dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Histone Code
204 rdf:type schema:DefinedTerm
205 Neaa2297b575f40cbadeea3a9a8a33fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Male
207 rdf:type schema:DefinedTerm
208 Ned468d036562423496a42c6d3bdd3c12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Aged
210 rdf:type schema:DefinedTerm
211 Nf60083c359464d53a7e3074531cb47e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Humans
213 rdf:type schema:DefinedTerm
214 Nf9269dab7aff4313b6d2d2e54fac0bc6 schema:name Springer Nature - SN SciGraph project
215 rdf:type schema:Organization
216 Nfba2ef03d5a043109b5f0330a38b6865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Middle Aged
218 rdf:type schema:DefinedTerm
219 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
220 schema:name Biological Sciences
221 rdf:type schema:DefinedTerm
222 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
223 schema:name Genetics
224 rdf:type schema:DefinedTerm
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
229 schema:name Oncology and Carcinogenesis
230 rdf:type schema:DefinedTerm
231 sg:grant.8098312 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-29378-7
232 rdf:type schema:MonetaryGrant
233 sg:journal.1045337 schema:issn 2045-2322
234 schema:name Scientific Reports
235 schema:publisher Springer Nature
236 rdf:type schema:Periodical
237 sg:person.01007631605.68 schema:affiliation grid-institutes:grid.429186.0
238 schema:familyName González
239 schema:givenName Beatriz
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007631605.68
241 rdf:type schema:Person
242 sg:person.01044406021.06 schema:affiliation grid-institutes:grid.429186.0
243 schema:familyName Alibés
244 schema:givenName Andreu
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044406021.06
246 rdf:type schema:Person
247 sg:person.01240515061.54 schema:affiliation grid-institutes:grid.429186.0
248 schema:familyName Alonso
249 schema:givenName Sergio
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240515061.54
251 rdf:type schema:Person
252 sg:person.01363674331.14 schema:affiliation grid-institutes:grid.421926.a
253 schema:familyName Samuelsson
254 schema:givenName Johanna Kristina
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363674331.14
256 rdf:type schema:Person
257 sg:person.0672673661.18 schema:affiliation grid-institutes:grid.32224.35
258 schema:familyName Fece de la Cruz
259 schema:givenName Ferran
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672673661.18
261 rdf:type schema:Person
262 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
263 https://doi.org/10.1038/nature11247
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
266 https://doi.org/10.1038/nature11252
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/ng.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032369744
269 https://doi.org/10.1038/ng.298
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/nmeth.3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052944075
272 https://doi.org/10.1038/nmeth.3115
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/nmeth.3252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050075164
275 https://doi.org/10.1038/nmeth.3252
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/nprot.2009.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043574219
278 https://doi.org/10.1038/nprot.2009.97
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/sj.onc.1208134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015800755
281 https://doi.org/10.1038/sj.onc.1208134
282 rdf:type schema:CreativeWork
283 sg:pub.10.1186/1471-2105-11-587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025448148
284 https://doi.org/10.1186/1471-2105-11-587
285 rdf:type schema:CreativeWork
286 sg:pub.10.1186/1471-2105-12-323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021902674
287 https://doi.org/10.1186/1471-2105-12-323
288 rdf:type schema:CreativeWork
289 sg:pub.10.1186/s13059-014-0576-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038464714
290 https://doi.org/10.1186/s13059-014-0576-y
291 rdf:type schema:CreativeWork
292 sg:pub.10.1385/1-59259-182-5:071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052070938
293 https://doi.org/10.1385/1-59259-182-5:071
294 rdf:type schema:CreativeWork
295 grid-institutes:grid.32224.35 schema:alternateName Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA
296 schema:name Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA, USA
297 Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain
298 rdf:type schema:Organization
299 grid-institutes:grid.421926.a schema:alternateName Active Motif, Inc, 92008, Carlsbad, CA, USA
300 schema:name Active Motif, Inc, 92008, Carlsbad, CA, USA
301 rdf:type schema:Organization
302 grid-institutes:grid.429186.0 schema:alternateName Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain
303 schema:name Program of Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute, (IGTP-PMPPC), Campus Can Ruti, 08916 Badalona, Barcelona, Spain
304 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...