Down-regulation of vascular GLP-1 receptor expression in human subjects with obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tomohiko Kimura, Atsushi Obata, Masashi Shimoda, Ikki Shimizu, Gabriela da Silva Xavier, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Tomoatsu Mune, Saeko Moriuchi, Arudo Hiraoka, Kentaro Tamura, Genta Chikazawa, Atsuhisa Ishida, Hidenori Yoshitaka, Guy A. Rutter, Kohei Kaku, Hideaki Kaneto

ABSTRACT

It has been thought that incretin signaling prevents arteriosclerosis, and very recently anti-arteriosclerotic effects through GLP-1 receptor were finally demonstrated in clinical human study. The purpose of this study was to investigate how vascular GLP-1 receptor expression is influenced in human subjects. First, we evaluated GLP-1 receptor expression in human arteries in immunostaining. Next, we separated the artery into the intima and media, and evaluated gene expression levels of various factors. We divided the subjects into obesity and non-obesity group and compared their expression levels between them. Finally, we evaluated which factors determine vascular GLP-1 receptor expression. GLP-1 receptor expression in intima and media was lower in obesity group compared to non-obesity group which was correlated with the alteration of TCF7L2 expression. Multiple regression analyses showed that BMI was an independent determining factor for GLP-1 receptor expression in the intima and media. Furthermore, using small interfering RNA method and TCF7L2-EGFP adenovirus, we showed that TCF7L2 was involved in GLP-1 receptor expression in human vascular cells. Taken together, vascular GLP-1 receptor and TCF7L2 expression was significantly down-regulated in human subjects with obesity. In addition, it is likely that TCF7L2 functions as a modulator of vascular GLP-1 receptor expression. More... »

PAGES

10644

References to SciGraph publications

  • 2013-09. Incretin hormones and the satiation signal in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-12. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus in NATURE REVIEWS ENDOCRINOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-28849-1

    DOI

    http://dx.doi.org/10.1038/s41598-018-28849-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105500915

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30006590


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28849-1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28849-1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28849-1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28849-1'


     

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