Ontology type: schema:ScholarlyArticle Open Access: True
2018-07-12
AUTHORSNobuhiro Terao, Hideki Koizumi, Kentaro Kojima, Tetsuya Yamagishi, Yuji Yamamoto, Kengo Yoshii, Koji Kitazawa, Asako Hiraga, Munetoyo Toda, Shigeru Kinoshita, Chie Sotozono, Junji Hamuro
ABSTRACTThis study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p = 0.03) but was almost identical to that in the control group (p = 0.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r = 0.78, p < 0.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r = 0.68, p = 0.002) and IL-8 and MCP-1 (r = 0.68, p = 0.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p = 0.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD. More... »
PAGES10520
http://scigraph.springernature.com/pub.10.1038/s41598-018-28484-w
DOIhttp://dx.doi.org/10.1038/s41598-018-28484-w
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105391109
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30002400
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1113",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Ophthalmology and Optometry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Angiogenesis Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aqueous Humor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Choroidal Neovascularization",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inflammation Mediators",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intravitreal Injections",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Macular Degeneration",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Placenta Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prospective Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Vascular Endothelial Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombinant Fusion Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vascular Endothelial Growth Factor A",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Terao",
"givenName": "Nobuhiro",
"id": "sg:person.011172270207.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172270207.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, University of the Ryukyus, Okinawa, Japan",
"id": "http://www.grid.ac/institutes/grid.267625.2",
"name": [
"Department of Ophthalmology, University of the Ryukyus, Okinawa, Japan"
],
"type": "Organization"
},
"familyName": "Koizumi",
"givenName": "Hideki",
"id": "sg:person.0774335446.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774335446.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kojima",
"givenName": "Kentaro",
"id": "sg:person.01170452201.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170452201.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yamagishi",
"givenName": "Tetsuya",
"id": "sg:person.01231327314.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231327314.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Yuji",
"id": "sg:person.013661171714.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013661171714.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Mathematics and Statistics in Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yoshii",
"givenName": "Kengo",
"id": "sg:person.0704057742.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704057742.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kitazawa",
"givenName": "Koji",
"id": "sg:person.01036575112.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036575112.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Hiraga",
"givenName": "Asako",
"id": "sg:person.010620324205.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010620324205.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Toda",
"givenName": "Munetoyo",
"id": "sg:person.0632253513.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632253513.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Kinoshita",
"givenName": "Shigeru",
"id": "sg:person.01016754101.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016754101.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Sotozono",
"givenName": "Chie",
"id": "sg:person.0624777723.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624777723.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Hamuro",
"givenName": "Junji",
"id": "sg:person.01236565401.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236565401.72"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/srep16204",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024172246",
"https://doi.org/10.1038/srep16204"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.eye.6702498",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041327045",
"https://doi.org/10.1038/sj.eye.6702498"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep45081",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084132929",
"https://doi.org/10.1038/srep45081"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1103-1350",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041679425",
"https://doi.org/10.1038/nm1103-1350"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nri3459",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041736997",
"https://doi.org/10.1038/nri3459"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-07-12",
"datePublishedReg": "2018-07-12",
"description": "This study investigated the pathophysiological features of pachychoroid neovasculopathy (PNV) and neovascular age-related macular degeneration (nAMD) by analysing and comparing cytokine profiles in aqueous humour (AH) collected from 18 PNV, 18 nAMD and 11 control patients. Responses to intravitreal injection of aflibercept were also analysed in the PNV and nAMD groups. In the PNV group, vascular endothelial growth factor (VEGF)-A was significantly lower than in the nAMD group (p\u2009=\u20090.03) but was almost identical to that in the control group (p\u2009=\u20090.86). The nAMD group showed positive correlations between interleukin (IL)-6 and IL-8 (r\u2009=\u20090.78, p\u2009<\u20090.001), IL-6 and monocyte chemoattractant protein (MCP)-1 (r\u2009=\u20090.68, p\u2009=\u20090.002) and IL-8 and MCP-1 (r\u2009=\u20090.68, p\u2009=\u20090.002). In the nAMD group, eyes with dry maculae one month after the first aflibercept injection showed significantly lower VEGF-A and placental growth factor (PlGF) at baseline than those with wet maculae (p\u2009=\u20090.02 for both). However, there was no significant difference between dry and wet maculae in the PNV group. The results suggest that angiogenic factors and proinflammatory cytokines may play the distinct roles in the pathogenesis of PNV and nAMD.",
"genre": "article",
"id": "sg:pub.10.1038/s41598-018-28484-w",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"keywords": [
"neovascular age-related macular degeneration",
"nAMD group",
"pachychoroid neovasculopathy",
"cytokine profile",
"IL-8",
"PNV group",
"macular degeneration",
"aqueous humor",
"aqueous humor cytokine profiles",
"age-related macular degeneration",
"growth factor",
"injections of aflibercept",
"first aflibercept injection",
"placental growth factor",
"monocyte chemoattractant protein",
"vascular endothelial growth factor",
"endothelial growth factor",
"aflibercept injections",
"Neovascular Age",
"control patients",
"pathophysiological features",
"proinflammatory cytokines",
"IL-6",
"MCP-1",
"chemoattractant protein",
"low VEGF",
"control group",
"angiogenic factors",
"one month",
"significant differences",
"patients",
"macula",
"degeneration",
"positive correlation",
"injection",
"group",
"distinct roles",
"aflibercept",
"interleukin",
"cytokines",
"pathogenesis",
"factors",
"baseline",
"months",
"VEGF",
"age",
"eyes",
"profile",
"response",
"differences",
"protein",
"study",
"humor",
"role",
"correlation",
"features",
"results"
],
"name": "Distinct Aqueous Humour Cytokine Profiles of Patients with Pachychoroid Neovasculopathy and Neovascular Age-related Macular Degeneration",
"pagination": "10520",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105391109"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-018-28484-w"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30002400"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-018-28484-w",
"https://app.dimensions.ai/details/publication/pub.1105391109"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:06",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_782.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/s41598-018-28484-w"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28484-w'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28484-w'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28484-w'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-28484-w'
This table displays all metadata directly associated to this object as RDF triples.
289 TRIPLES
21 PREDICATES
104 URIs
91 LITERALS
24 BLANK NODES