Porcine Alveolar Macrophage-like cells are pro-inflammatory Pulmonary Intravascular Macrophages that produce large titers of Porcine Reproductive and Respiratory Syndrome Virus View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Elise Bordet, Pauline Maisonnasse, Patricia Renson, Edwige Bouguyon, Elisa Crisci, Mathieu Tiret, Delphyne Descamps, Cindy Bernelin-Cottet, Céline Urien, François Lefèvre, Luc Jouneau, Olivier Bourry, Jean-Jacques Leplat, Isabelle Schwartz-Cornil, Nicolas Bertho

ABSTRACT

Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed that AM-like cells are macrophages phagocytosing blood-borne particles, in agreement with a pulmonary intravascular macrophages (PIM) identity. PIM have been described microscopically long time ago in species from the Laurasiatheria superorder such as bovine, swine, cats or cetaceans. We observed that PIM were more inflammatory than AM upon infection with the porcine reproductive and respiratory syndrome virus (PRRSV), a major swine pathogen. Moreover, whereas PRRSV was thought to mainly target AM, we observed that PIM were a major producer of virus. The PIM infection was more correlated with viremia in vivo than AM infection. Finally like AM, PIM-expressed genes were characteristic of an embryonic monocyte-derived macrophage population, whose turnover is independent of bone marrow-derived hematopoietic precursors. This last observation raised the interesting possibility that AM and PIM originate from the same lung precursor. More... »

PAGES

10172

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-28234-y

DOI

http://dx.doi.org/10.1038/s41598-018-28234-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105236527

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29977043


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