Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Young Bin Joo, Jiwoo Lim, Betty P. Tsao, Swapan K. Nath, Kwangwoo Kim, Sang-Cheol Bae

ABSTRACT

Impact of genetic variants on the age of systemic lupus erythematosus (SLE) onset was not fully understood. We investigated a cumulative effect of SLE-risk variants on the age of SLE onset and scanned genome-wide SNPs to search for new risk loci of childhood-onset SLE (cSLE). We analyzed 781 Korean single-center SLE subjects who previously genotyped by both Immunochip and genome-wide SNP arrays. Individual genetic risk scores (GRS) from well-validated SLE susceptibility loci were calculated and tested for their association with cSLE (<16 years at onset). Single-variant association tests were performed using a multivariable logistic regression adjusting for population stratification. GRS from SLE susceptibility loci was significantly higher in cSLE than aSLE (p = 1.23 × 10-3). Two SNPs, rs7460469 in XKR6 (p = 1.26 × 10-8, OR = 5.58) and rs7300146 in GLT1D1 p = 1.49 × 10-8, OR = 2.85), showed the most significant associations with cSLE. The model consisting of GRS of SLE and two newly identified loci showed an area under curve (AUC) of 0.71 in a receiver operating characteristics (ROC) curve for prediction of cSLE. In conclusion, cSLE is associated with a high cumulative SLE-risk effect and two novel SNPs rs7460469 and rs7300146, providing the first predictive model for cSLE in Koreans. More... »

PAGES

9962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-28128-z

DOI

http://dx.doi.org/10.1038/s41598-018-28128-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105156460

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29967481


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