Imaging EGFR and HER3 through 89Zr-labeled MEHD7945A (Duligotuzumab) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Brooke N. McKnight, Akhila N. W. Kuda-Wedagedara, Kuntal K. Sevak, Dalya Abdel-Atti, Wendy N. Wiesend, Anson Ku, Dakshnamurthy Selvakumar, Sean D. Carlin, Jason S. Lewis, Nerissa T. Viola-Villegas

ABSTRACT

Tumor resistance to treatment paved the way toward the development of single agent drugs that target multiple molecular signatures amplified within the malignancy. The discovered crosstalk between EGFR and HER3 as well as the role of HER3 in mediating EGFR resistance made these two receptor tyrosine kinases attractive targets. MEHD7945A or duligotuzumab is a single immunotherapy agent that dually targets both molecular signatures. In this study, a positron emission tomography (PET) companion diagnostic to MEHD7945A is reported and evaluated in pancreatic cancer. Tumor accretion and whole body pharmacokinetics of 89Zr-MEHD7945A were established. Specificity of the probe for EGFR and/or HER3 was further examined. More... »

PAGES

9043

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27454-6

DOI

http://dx.doi.org/10.1038/s41598-018-27454-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104468859

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29899472


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