Acceptability of placebo multiparticulate formulations in children and adults View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-15

AUTHORS

Felipe L. Lopez, Punam Mistry, Hannah K. Batchelor, Joanne Bennett, Alastair Coupe, Terry B. Ernest, Mine Orlu, Catherine Tuleu

ABSTRACT

Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of multiparticulates in healthy children and adults. A randomised, single-blind acceptability testing was performed involving 71 children (4-12 years) and 61 adults (18-37 years). Each participant received three 500 mg samples of microcrystalline cellulose pellets administered on a medicine spoon with water at 5-10 minutes intervals. Acceptability was measured based on voluntary intake of the samples, facial expressions, ratings on hedonic scales and reported willingness to take multiparticulates everyday as a medicine. Multiparticulates were voluntarily swallowed by 92% of children and 100% of adults. However, palatability issues were identified, with emphasis on textural aspects. Grittiness perception received negative ratings on hedonic scales by 60% of children and 51% of adults. Researcher observations revealed that 72% of children and 42% of adults displayed negative facial expressions towards the samples. Children reported their willingness to take multiparticulates as a medicine in 30% of the cases, compared to 74% in adults. This study demonstrates that multiparticulates may be a suitable formulation platform for children and adults, although palatability concerns have been highlighted. Additional work is required to define acceptability criteria and to standardise methodologies. More... »

PAGES

9210

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27446-6

DOI

http://dx.doi.org/10.1038/s41598-018-27446-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104570313

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29907752


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology and Cognitive Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Psychology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Compounding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Emotions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Acceptance of Health Care", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, University College London, London, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Pharmacy, University College London, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lopez", 
        "givenName": "Felipe L.", 
        "id": "sg:person.01312102215.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312102215.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mistry", 
        "givenName": "Punam", 
        "id": "sg:person.011425042065.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425042065.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.6572.6", 
          "name": [
            "School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Batchelor", 
        "givenName": "Hannah K.", 
        "id": "sg:person.01324223724.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324223724.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer Global R&D, Sandwich, Kent United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer Global R&D, Sandwich, Kent United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennett", 
        "givenName": "Joanne", 
        "id": "sg:person.011515456530.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011515456530.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer Global R&D, Sandwich, Kent United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.418566.8", 
          "name": [
            "Pfizer Global R&D, Sandwich, Kent United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coupe", 
        "givenName": "Alastair", 
        "id": "sg:person.01065074666.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065074666.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline, Harlow, Essex United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "GlaxoSmithKline, Harlow, Essex United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ernest", 
        "givenName": "Terry B.", 
        "id": "sg:person.0676344173.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676344173.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, University College London, London, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Pharmacy, University College London, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orlu", 
        "givenName": "Mine", 
        "id": "sg:person.012614327177.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012614327177.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Pharmacy, University College London, London, United Kingdom", 
          "id": "http://www.grid.ac/institutes/grid.83440.3b", 
          "name": [
            "School of Pharmacy, University College London, London, United Kingdom"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuleu", 
        "givenName": "Catherine", 
        "id": "sg:person.0671515603.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671515603.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11325-013-0872-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016338008", 
          "https://doi.org/10.1007/s11325-013-0872-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-6405-3-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005591217", 
          "https://doi.org/10.1186/1742-6405-3-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1177/2168479013500287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034309526", 
          "https://doi.org/10.1177/2168479013500287"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06-15", 
    "datePublishedReg": "2018-06-15", 
    "description": "Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of multiparticulates in healthy children and adults. A randomised, single-blind acceptability testing was performed involving 71 children (4-12 years) and 61 adults (18-37 years). Each participant received three 500\u2009mg samples of microcrystalline cellulose pellets administered on a medicine spoon with water at 5-10\u2009minutes intervals. Acceptability was measured based on voluntary intake of the samples, facial expressions, ratings on hedonic scales and reported willingness to take multiparticulates everyday as a medicine. Multiparticulates were voluntarily swallowed by 92% of children and 100% of adults. However, palatability issues were identified, with emphasis on textural aspects. Grittiness perception received negative ratings on hedonic scales by 60% of children and 51% of adults. Researcher observations revealed that 72% of children and 42% of adults displayed negative facial expressions towards the samples. Children reported their willingness to take multiparticulates as a medicine in 30% of the cases, compared to 74% in adults. This study demonstrates that multiparticulates may be a suitable formulation platform for children and adults, although palatability concerns have been highlighted. Additional work is required to define acceptability criteria and to standardise methodologies.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-27446-6", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "design of medicines", 
      "patient acceptability", 
      "healthy children", 
      "palatability issues", 
      "adults", 
      "children", 
      "minute intervals", 
      "acceptability testing", 
      "medicine", 
      "acceptability", 
      "multiparticulate formulations", 
      "hedonic scale", 
      "expression", 
      "intake", 
      "formulation platform", 
      "important consideration", 
      "voluntary intake", 
      "additional work", 
      "study", 
      "participants", 
      "ratings", 
      "acceptability criteria", 
      "aim", 
      "multiparticulates", 
      "samples", 
      "intervals", 
      "spoon", 
      "negative ratings", 
      "negative facial expressions", 
      "testing", 
      "criteria", 
      "cases", 
      "researcher observations", 
      "willingness", 
      "scale", 
      "concern", 
      "facial expressions", 
      "cellulose pellets", 
      "perception", 
      "microcrystalline cellulose pellets", 
      "aspects", 
      "emphasis", 
      "observations", 
      "pellets", 
      "consideration", 
      "issues", 
      "formulation", 
      "design", 
      "platform", 
      "work", 
      "methodology", 
      "textural aspects", 
      "water", 
      "acceptability of multiparticulates", 
      "single-blind acceptability testing", 
      "medicine spoon", 
      "Grittiness perception", 
      "suitable formulation platform", 
      "palatability concerns", 
      "placebo multiparticulate formulations"
    ], 
    "name": "Acceptability of placebo multiparticulate formulations in children and adults", 
    "pagination": "9210", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104570313"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-27446-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29907752"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-27446-6", 
      "https://app.dimensions.ai/details/publication/pub.1104570313"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_771.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-27446-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27446-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27446-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27446-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27446-6'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      22 PREDICATES      99 URIs      88 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-27446-6 schema:about N1950b5d3f3574233ae8dd9aba562b34c
2 N3890ef2f92204fbb8ed90a82e30fcdf7
3 N410f20fee3354c84bd7ffb4df7137bcd
4 N483ded39a8344ff292a041eac141a487
5 N702099476af347d0821152af1234e41a
6 N8b35653d3eb64b078a8df57053cd115e
7 N8c53a37332d7424abe34f292a39b01ce
8 N977769c23f634a52bfc8ac1eee9e70c8
9 Na5d5ca27caa94ce79654e83eaa6c3f71
10 Nb92f463fa52a4ec68b078f2976c35572
11 anzsrc-for:17
12 anzsrc-for:1701
13 schema:author Nb78ece57374e4ef6b19e3b18737d69d7
14 schema:citation sg:pub.10.1007/s11325-013-0872-x
15 sg:pub.10.1177/2168479013500287
16 sg:pub.10.1186/1742-6405-3-30
17 schema:datePublished 2018-06-15
18 schema:datePublishedReg 2018-06-15
19 schema:description Patient acceptability is an important consideration in the design of medicines for children. The aim of this study was to investigate acceptability of multiparticulates in healthy children and adults. A randomised, single-blind acceptability testing was performed involving 71 children (4-12 years) and 61 adults (18-37 years). Each participant received three 500 mg samples of microcrystalline cellulose pellets administered on a medicine spoon with water at 5-10 minutes intervals. Acceptability was measured based on voluntary intake of the samples, facial expressions, ratings on hedonic scales and reported willingness to take multiparticulates everyday as a medicine. Multiparticulates were voluntarily swallowed by 92% of children and 100% of adults. However, palatability issues were identified, with emphasis on textural aspects. Grittiness perception received negative ratings on hedonic scales by 60% of children and 51% of adults. Researcher observations revealed that 72% of children and 42% of adults displayed negative facial expressions towards the samples. Children reported their willingness to take multiparticulates as a medicine in 30% of the cases, compared to 74% in adults. This study demonstrates that multiparticulates may be a suitable formulation platform for children and adults, although palatability concerns have been highlighted. Additional work is required to define acceptability criteria and to standardise methodologies.
20 schema:genre article
21 schema:inLanguage en
22 schema:isAccessibleForFree true
23 schema:isPartOf Ne12b53d721b0409fabedf7d965f8a08b
24 Nf01a8fd00e064686a306a09c5a773f7f
25 sg:journal.1045337
26 schema:keywords Grittiness perception
27 acceptability
28 acceptability criteria
29 acceptability of multiparticulates
30 acceptability testing
31 additional work
32 adults
33 aim
34 aspects
35 cases
36 cellulose pellets
37 children
38 concern
39 consideration
40 criteria
41 design
42 design of medicines
43 emphasis
44 expression
45 facial expressions
46 formulation
47 formulation platform
48 healthy children
49 hedonic scale
50 important consideration
51 intake
52 intervals
53 issues
54 medicine
55 medicine spoon
56 methodology
57 microcrystalline cellulose pellets
58 minute intervals
59 multiparticulate formulations
60 multiparticulates
61 negative facial expressions
62 negative ratings
63 observations
64 palatability concerns
65 palatability issues
66 participants
67 patient acceptability
68 pellets
69 perception
70 placebo multiparticulate formulations
71 platform
72 ratings
73 researcher observations
74 samples
75 scale
76 single-blind acceptability testing
77 spoon
78 study
79 suitable formulation platform
80 testing
81 textural aspects
82 voluntary intake
83 water
84 willingness
85 work
86 schema:name Acceptability of placebo multiparticulate formulations in children and adults
87 schema:pagination 9210
88 schema:productId N1b72240884dd4f14b61e4b769decfa1c
89 N5da23cc582784958a15cb4b10b6018e0
90 N9d721309013347298f786687785aa566
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104570313
92 https://doi.org/10.1038/s41598-018-27446-6
93 schema:sdDatePublished 2021-12-01T19:40
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N758382b1db20469e89090b37b52fef3b
96 schema:url https://doi.org/10.1038/s41598-018-27446-6
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N1950b5d3f3574233ae8dd9aba562b34c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Adult
102 rdf:type schema:DefinedTerm
103 N1b72240884dd4f14b61e4b769decfa1c schema:name doi
104 schema:value 10.1038/s41598-018-27446-6
105 rdf:type schema:PropertyValue
106 N21b515fc1203486d9038491f398e5b01 rdf:first sg:person.012614327177.19
107 rdf:rest N6690a8f431f54f6a80864d3ae1fcac2b
108 N3890ef2f92204fbb8ed90a82e30fcdf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adolescent
110 rdf:type schema:DefinedTerm
111 N410f20fee3354c84bd7ffb4df7137bcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Drug Compounding
113 rdf:type schema:DefinedTerm
114 N451a3a80adcd4f16957df0ae54011056 rdf:first sg:person.01065074666.98
115 rdf:rest Nefcefa2d19f247c29b98233f945979f1
116 N483ded39a8344ff292a041eac141a487 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Patient Acceptance of Health Care
118 rdf:type schema:DefinedTerm
119 N5da23cc582784958a15cb4b10b6018e0 schema:name pubmed_id
120 schema:value 29907752
121 rdf:type schema:PropertyValue
122 N6690a8f431f54f6a80864d3ae1fcac2b rdf:first sg:person.0671515603.50
123 rdf:rest rdf:nil
124 N68696dc40bae4f36aca73358096d4667 rdf:first sg:person.01324223724.17
125 rdf:rest N6fbe0b165acf456aa4eba3f648254ae0
126 N6fbe0b165acf456aa4eba3f648254ae0 rdf:first sg:person.011515456530.98
127 rdf:rest N451a3a80adcd4f16957df0ae54011056
128 N702099476af347d0821152af1234e41a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Child, Preschool
130 rdf:type schema:DefinedTerm
131 N758382b1db20469e89090b37b52fef3b schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N78ce094dec15450cab4320d448261272 rdf:first sg:person.011425042065.33
134 rdf:rest N68696dc40bae4f36aca73358096d4667
135 N8b35653d3eb64b078a8df57053cd115e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N8c53a37332d7424abe34f292a39b01ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Child
140 rdf:type schema:DefinedTerm
141 N977769c23f634a52bfc8ac1eee9e70c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Female
143 rdf:type schema:DefinedTerm
144 N9d721309013347298f786687785aa566 schema:name dimensions_id
145 schema:value pub.1104570313
146 rdf:type schema:PropertyValue
147 Na5d5ca27caa94ce79654e83eaa6c3f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Humans
149 rdf:type schema:DefinedTerm
150 Nb78ece57374e4ef6b19e3b18737d69d7 rdf:first sg:person.01312102215.78
151 rdf:rest N78ce094dec15450cab4320d448261272
152 Nb92f463fa52a4ec68b078f2976c35572 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Emotions
154 rdf:type schema:DefinedTerm
155 Ne12b53d721b0409fabedf7d965f8a08b schema:issueNumber 1
156 rdf:type schema:PublicationIssue
157 Nefcefa2d19f247c29b98233f945979f1 rdf:first sg:person.0676344173.38
158 rdf:rest N21b515fc1203486d9038491f398e5b01
159 Nf01a8fd00e064686a306a09c5a773f7f schema:volumeNumber 8
160 rdf:type schema:PublicationVolume
161 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
162 schema:name Psychology and Cognitive Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
165 schema:name Psychology
166 rdf:type schema:DefinedTerm
167 sg:journal.1045337 schema:issn 2045-2322
168 schema:name Scientific Reports
169 schema:publisher Springer Nature
170 rdf:type schema:Periodical
171 sg:person.01065074666.98 schema:affiliation grid-institutes:grid.418566.8
172 schema:familyName Coupe
173 schema:givenName Alastair
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065074666.98
175 rdf:type schema:Person
176 sg:person.011425042065.33 schema:affiliation grid-institutes:grid.6572.6
177 schema:familyName Mistry
178 schema:givenName Punam
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011425042065.33
180 rdf:type schema:Person
181 sg:person.011515456530.98 schema:affiliation grid-institutes:grid.418566.8
182 schema:familyName Bennett
183 schema:givenName Joanne
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011515456530.98
185 rdf:type schema:Person
186 sg:person.012614327177.19 schema:affiliation grid-institutes:grid.83440.3b
187 schema:familyName Orlu
188 schema:givenName Mine
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012614327177.19
190 rdf:type schema:Person
191 sg:person.01312102215.78 schema:affiliation grid-institutes:grid.83440.3b
192 schema:familyName Lopez
193 schema:givenName Felipe L.
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312102215.78
195 rdf:type schema:Person
196 sg:person.01324223724.17 schema:affiliation grid-institutes:grid.6572.6
197 schema:familyName Batchelor
198 schema:givenName Hannah K.
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324223724.17
200 rdf:type schema:Person
201 sg:person.0671515603.50 schema:affiliation grid-institutes:grid.83440.3b
202 schema:familyName Tuleu
203 schema:givenName Catherine
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671515603.50
205 rdf:type schema:Person
206 sg:person.0676344173.38 schema:affiliation grid-institutes:grid.418236.a
207 schema:familyName Ernest
208 schema:givenName Terry B.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676344173.38
210 rdf:type schema:Person
211 sg:pub.10.1007/s11325-013-0872-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016338008
212 https://doi.org/10.1007/s11325-013-0872-x
213 rdf:type schema:CreativeWork
214 sg:pub.10.1177/2168479013500287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034309526
215 https://doi.org/10.1177/2168479013500287
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1742-6405-3-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005591217
218 https://doi.org/10.1186/1742-6405-3-30
219 rdf:type schema:CreativeWork
220 grid-institutes:grid.418236.a schema:alternateName GlaxoSmithKline, Harlow, Essex United Kingdom
221 schema:name GlaxoSmithKline, Harlow, Essex United Kingdom
222 rdf:type schema:Organization
223 grid-institutes:grid.418566.8 schema:alternateName Pfizer Global R&D, Sandwich, Kent United Kingdom
224 schema:name Pfizer Global R&D, Sandwich, Kent United Kingdom
225 rdf:type schema:Organization
226 grid-institutes:grid.6572.6 schema:alternateName School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom
227 schema:name School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom
228 rdf:type schema:Organization
229 grid-institutes:grid.83440.3b schema:alternateName School of Pharmacy, University College London, London, United Kingdom
230 schema:name School of Pharmacy, University College London, London, United Kingdom
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...