Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSHarutoyo Hirano, Renjo Takama, Ryo Matsumoto, Hiroshi Tanaka, Hiroki Hirano, Zu Soh, Teiji Ukawa, Tsuneo Takayanagi, Haruka Morimoto, Ryuji Nakamura, Noboru Saeki, Haruki Hashimoto, Shogo Matsui, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Masashi Kawamoto, Masao Yoshizumi, Yukihito Higashi, Toshio Tsuji
ABSTRACTThis paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application. More... »
PAGES9263
http://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3
DOIhttp://dx.doi.org/10.1038/s41598-018-27392-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1104575323
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29915185
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Shizuoka University",
"id": "https://www.grid.ac/institutes/grid.263536.7",
"name": [
"Academic Institute, College of Engineering, Shizuoka University, 739-8527, Hamamatsu, Japan"
],
"type": "Organization"
},
"familyName": "Hirano",
"givenName": "Harutoyo",
"id": "sg:person.015206541113.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015206541113.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Graduate School of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Takama",
"givenName": "Renjo",
"id": "sg:person.012277337703.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012277337703.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Graduate School of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Matsumoto",
"givenName": "Ryo",
"id": "sg:person.010532377173.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010532377173.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Graduate School of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Tanaka",
"givenName": "Hiroshi",
"id": "sg:person.07357457015.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07357457015.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Graduate School of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Hirano",
"givenName": "Hiroki",
"id": "sg:person.0771052731.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771052731.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of System Cybernetics, Faculty of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Soh",
"givenName": "Zu",
"id": "sg:person.07626266604.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07626266604.19"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nihon Kohden corporation, 359-8580, Tokorozawa, Japan"
],
"type": "Organization"
},
"familyName": "Ukawa",
"givenName": "Teiji",
"id": "sg:person.0755753203.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755753203.76"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nihon Kohden corporation, 359-8580, Tokorozawa, Japan"
],
"type": "Organization"
},
"familyName": "Takayanagi",
"givenName": "Tsuneo",
"id": "sg:person.01032751434.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032751434.78"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Nihon Kohden corporation, 359-8580, Tokorozawa, Japan"
],
"type": "Organization"
},
"familyName": "Morimoto",
"givenName": "Haruka",
"id": "sg:person.01147200034.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147200034.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Anesthesiology and Critical Care, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Ryuji",
"id": "sg:person.0616116424.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616116424.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Anesthesiology and Critical Care, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Saeki",
"givenName": "Noboru",
"id": "sg:person.014122464431.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014122464431.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Hashimoto",
"givenName": "Haruki",
"id": "sg:person.07355012021.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07355012021.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Matsui",
"givenName": "Shogo",
"id": "sg:person.01306203115.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306203115.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Kishimoto",
"givenName": "Shinji",
"id": "sg:person.0661233057.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661233057.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Oda",
"givenName": "Nozomu",
"id": "sg:person.01134534272.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134534272.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Kajikawa",
"givenName": "Masato",
"id": "sg:person.01210455371.89",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210455371.89"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Maruhashi",
"givenName": "Tatsuya",
"id": "sg:person.0643551771.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643551771.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Anesthesiology and Critical Care, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Kawamoto",
"givenName": "Masashi",
"id": "sg:person.0714344153.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714344153.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 734-8553, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Yoshizumi",
"givenName": "Masao",
"id": "sg:person.0752036564.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752036564.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University Hospital",
"id": "https://www.grid.ac/institutes/grid.470097.d",
"name": [
"Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, 734-8553, Hiroshima, Japan",
"Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, 734-8551, Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Higashi",
"givenName": "Yukihito",
"id": "sg:person.01146203271.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146203271.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hiroshima University",
"id": "https://www.grid.ac/institutes/grid.257022.0",
"name": [
"Department of System Cybernetics, Faculty of Engineering, Hiroshima University, 739-8527, Higashi-Hiroshima, Japan"
],
"type": "Organization"
},
"familyName": "Tsuji",
"givenName": "Toshio",
"id": "sg:person.012576464331.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012576464331.16"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1053/j.ajkd.2008.12.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000437042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0741-5214(93)90147-e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000572048"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0047-6374(79)90084-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001532295"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0047-6374(79)90084-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001532295"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199901143400207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003372113"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1995.1823",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005817598"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc14-s081",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009852107"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.67.1003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011336447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.atherosclerosis.2004.08.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011439398"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0002-9149(87)90165-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014231029"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000441-195008000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021245151"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00000441-195008000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021245151"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11517-012-0955-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023093171",
"https://doi.org/10.1007/s11517-012-0955-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/heartjnl-2013-304739",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023878962"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0735-1097(03)00994-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026539755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0735-1097(03)00994-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026539755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0735-1097(01)01746-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031448054"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.285.19.2486",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033739611"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jbi.2005.02.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037399825"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jvs.2014.12.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039063344"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.atherosclerosis.2013.05.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039734399"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.9746/sicetr.49.1029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042073201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.13.6.658",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045983549"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199007053230105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046925494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/jaha.116.004385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063345317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4286/jjmi.82.259",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072442826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1109/sii.2011.6147490",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093365775"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12",
"datePublishedReg": "2018-12-01",
"description": "This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5\u2009\u00b1\u200912.0% for the healthy subjects, 23.6\u2009\u00b1\u200912.7% for subjects at high risk of arteriosclerosis and 14.5\u2009\u00b1\u200915.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p\u2009<\u20090.01). The proposed method may have potential for clinical application.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-018-27392-3",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.5927990",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"name": "Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation",
"pagination": "9263",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"eb1ffc9fc7fbe3411fa050652809704e7eba7972edf0a59919f4284a9dd0fe8c"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"29915185"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-018-27392-3"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1104575323"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-018-27392-3",
"https://app.dimensions.ai/details/publication/pub.1104575323"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:42",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000571.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-018-27392-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3'
This table displays all metadata directly associated to this object as RDF triples.
301 TRIPLES
21 PREDICATES
53 URIs
21 LITERALS
9 BLANK NODES