Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Harutoyo Hirano, Renjo Takama, Ryo Matsumoto, Hiroshi Tanaka, Hiroki Hirano, Zu Soh, Teiji Ukawa, Tsuneo Takayanagi, Haruka Morimoto, Ryuji Nakamura, Noboru Saeki, Haruki Hashimoto, Shogo Matsui, Shinji Kishimoto, Nozomu Oda, Masato Kajikawa, Tatsuya Maruhashi, Masashi Kawamoto, Masao Yoshizumi, Yukihito Higashi, Toshio Tsuji

ABSTRACT

This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application. More... »

PAGES

9263

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3

DOI

http://dx.doi.org/10.1038/s41598-018-27392-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104575323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29915185


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    "description": "This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5\u2009\u00b1\u200912.0% for the healthy subjects, 23.6\u2009\u00b1\u200912.7% for subjects at high risk of arteriosclerosis and 14.5\u2009\u00b1\u200915.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p\u2009<\u20090.01). The proposed method may have potential for clinical application.", 
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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27392-3'


 

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