Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-15

AUTHORS

Santosh D. Bhosale, Robert Moulder, Mikko S. Venäläinen, Juhani S. Koskinen, Niina Pitkänen, Markus T. Juonala, Mika A. P. Kähönen, Terho J. Lehtimäki, Jorma S. A. Viikari, Laura L. Elo, David R. Goodlett, Riitta Lahesmaa, Olli T. Raitakari

ABSTRACT

To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N = 43, Age = 30–45 years) were compared with plaque free controls (N = 43) (matched for age, sex, body weight and systolic blood pressure). Seven proteins (p < 0.05) that have been previously linked with atherosclerotic phenotypes were differentially abundant. Fibulin 1 proteoform C (FBLN1C), Beta-ala-his-dipeptidase (CNDP1), Cadherin-13 (CDH13), Gelsolin (GSN) and 72 kDa type IV collagenase (MMP2) were less abundant in cases, whereas Apolipoproteins C-III (APOC3) and apolipoprotein E (APOE) were more abundant. Using machine learning analysis, a biomarker panel of FBLN1C, APOE and CDH13 was identified, which classified cases from controls with an area under receiver-operating characteristic curve (AUROC) value of 0.79. Furthermore, using selected reaction monitoring mass spectrometry (SRM-MS) the decreased abundance of FBLN1C was verified. In relation to previous associations of FBLN1C with atherosclerotic lesions, the observation could reflect its involvement in the initiation of the plaque formation, or represent a particular risk phenotype. More... »

PAGES

9209

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27265-9

DOI

http://dx.doi.org/10.1038/s41598-018-27265-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104570292

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29907817


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carotid Artery Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Finland", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhosale", 
        "givenName": "Santosh D.", 
        "id": "sg:person.01372252722.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372252722.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moulder", 
        "givenName": "Robert", 
        "id": "sg:person.01160467712.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160467712.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ven\u00e4l\u00e4inen", 
        "givenName": "Mikko S.", 
        "id": "sg:person.0726003076.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726003076.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland", 
            "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koskinen", 
        "givenName": "Juhani S.", 
        "id": "sg:person.012257600004.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012257600004.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.1374.1", 
          "name": [
            "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pitk\u00e4nen", 
        "givenName": "Niina", 
        "id": "sg:person.01255754206.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255754206.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Juonala", 
        "givenName": "Markus T.", 
        "id": "sg:person.01053160654.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053160654.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Faculty of Medicine, Tampere, Finland", 
          "id": "http://www.grid.ac/institutes/grid.412330.7", 
          "name": [
            "Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Faculty of Medicine, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "K\u00e4h\u00f6nen", 
        "givenName": "Mika A. P.", 
        "id": "sg:person.01335473265.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473265.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland", 
          "id": "http://www.grid.ac/institutes/grid.502801.e", 
          "name": [
            "Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lehtim\u00e4ki", 
        "givenName": "Terho J.", 
        "id": "sg:person.0654341265.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viikari", 
        "givenName": "Jorma S. A.", 
        "id": "sg:person.016547631637.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016547631637.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elo", 
        "givenName": "Laura L.", 
        "id": "sg:person.01144243561.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144243561.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmaceutical Science, University of Maryland, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.411024.2", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
            "Department of Pharmaceutical Science, University of Maryland, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodlett", 
        "givenName": "David R.", 
        "id": "sg:person.01044126157.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044126157.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.452861.c", 
          "name": [
            "Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lahesmaa", 
        "givenName": "Riitta", 
        "id": "sg:person.0767010034.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767010034.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland", 
          "id": "http://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland", 
            "Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raitakari", 
        "givenName": "Olli T.", 
        "id": "sg:person.01267360065.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00216-012-6203-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041147659", 
          "https://doi.org/10.1007/s00216-012-6203-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.3901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032398342", 
          "https://doi.org/10.1038/nmeth.3901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018367071", 
          "https://doi.org/10.1038/nmeth.2369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035821098", 
          "https://doi.org/10.1038/nbt1275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-12-77", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014582441", 
          "https://doi.org/10.1186/1471-2105-12-77"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.1511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049469421", 
          "https://doi.org/10.1038/nbt.1511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001371417", 
          "https://doi.org/10.1038/nature01323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00418-009-0628-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036401404", 
          "https://doi.org/10.1007/s00418-009-0628-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4939-7057-5_31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090342830", 
          "https://doi.org/10.1007/978-1-4939-7057-5_31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-12-107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023619874", 
          "https://doi.org/10.1186/1475-2840-12-107"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-06-15", 
    "datePublishedReg": "2018-06-15", 
    "description": "To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N\u2009=\u200943, Age\u2009=\u200930\u201345 years) were compared with plaque free controls (N\u2009=\u200943) (matched for age, sex, body weight and systolic blood pressure). Seven proteins (p\u2009<\u20090.05) that have been previously linked with atherosclerotic phenotypes were differentially abundant. Fibulin 1 proteoform C (FBLN1C), Beta-ala-his-dipeptidase (CNDP1), Cadherin-13 (CDH13), Gelsolin (GSN) and 72\u2009kDa type IV collagenase (MMP2) were less abundant in cases, whereas Apolipoproteins C-III (APOC3) and apolipoprotein E (APOE) were more abundant. Using machine learning analysis, a biomarker panel of FBLN1C, APOE and CDH13 was identified, which classified cases from controls with an area under receiver-operating characteristic curve (AUROC) value of 0.79. Furthermore, using selected reaction monitoring mass spectrometry (SRM-MS) the decreased abundance of FBLN1C was verified. In relation to previous associations of FBLN1C with atherosclerotic lesions, the observation could reflect its involvement in the initiation of the plaque formation, or represent a particular risk phenotype.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-27265-9", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8839578", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4245674", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8842120", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4250379", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4251009", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4250761", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4251354", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4245198", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4246637", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4250095", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4250588", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5494084", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "apolipoprotein E", 
      "asymptomatic carotid artery plaques", 
      "plaque-free controls", 
      "premature carotid atherosclerosis", 
      "carotid artery plaques", 
      "receiver-operating characteristic curve values", 
      "Young Finns Study", 
      "serum protein biomarkers", 
      "carotid atherosclerotic plaques", 
      "type IV collagenase", 
      "cardiovascular risk", 
      "serum proteomic profiling", 
      "carotid atherosclerosis", 
      "artery plaques", 
      "ultrasound examination", 
      "characteristic curve values", 
      "atherosclerotic lesions", 
      "atherosclerotic plaques", 
      "atherosclerotic phenotype", 
      "risk phenotype", 
      "biomarker panel", 
      "plaque formation", 
      "serum samples", 
      "apolipoprotein C", 
      "Fbln1c", 
      "curve values", 
      "cadherin 13", 
      "previous associations", 
      "label-free quantitative proteomic analysis", 
      "plaques", 
      "protein biomarkers", 
      "early phase", 
      "biomarkers", 
      "beta-Ala", 
      "quantitative proteomic analysis", 
      "decreased abundance", 
      "proteomic profiling", 
      "free controls", 
      "phenotype", 
      "atherosclerosis", 
      "proteomic analysis", 
      "lesions", 
      "gelsolin", 
      "risk", 
      "collagenase", 
      "control", 
      "cases", 
      "examination", 
      "CDH13", 
      "association", 
      "involvement", 
      "subjects", 
      "initiation", 
      "samples", 
      "dipeptidase", 
      "protein", 
      "study", 
      "mass spectrometry", 
      "profiling", 
      "analysis", 
      "panel", 
      "presence", 
      "area", 
      "formation", 
      "part", 
      "values", 
      "observations", 
      "reaction", 
      "spectrometry", 
      "relation", 
      "phase", 
      "abundance", 
      "machine"
    ], 
    "name": "Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis", 
    "pagination": "9209", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104570292"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-27265-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29907817"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-27265-9", 
      "https://app.dimensions.ai/details/publication/pub.1104570292"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_794.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-27265-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27265-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27265-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27265-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27265-9'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      120 URIs      102 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-27265-9 schema:about N28b0b088b222405cbad9c124f09fda96
2 N308a02f9566c41119d35d670b46a7a30
3 N4cfe7e28037b4654882b8f08153ef0ce
4 N60c8fc61f90f4538a7281b395d32f9fc
5 N74ad910a592a4b8592078ebaa184b5f3
6 N82c3f33c0c054c92a0f3aa5409d42f34
7 N85702d52c85442368645059e455b32a8
8 Nafa3193672c24624882f3e19918d8129
9 Nb149d753fd0444eb915201134229ab80
10 Ncc2c6dabbca24330a3e82c1b3ad7a58c
11 Nd51a5d13b8e04167bcdafc5f9d58f32e
12 Ne1676fe431ad4255b5afa3aca24c4dc5
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author Neae2489363b74bef8163d68fa68485b0
16 schema:citation sg:pub.10.1007/978-1-4939-7057-5_31
17 sg:pub.10.1007/s00216-012-6203-4
18 sg:pub.10.1007/s00418-009-0628-7
19 sg:pub.10.1038/nature01323
20 sg:pub.10.1038/nbt.1511
21 sg:pub.10.1038/nbt1275
22 sg:pub.10.1038/nmeth.2369
23 sg:pub.10.1038/nmeth.3901
24 sg:pub.10.1186/1471-2105-12-77
25 sg:pub.10.1186/1475-2840-12-107
26 schema:datePublished 2018-06-15
27 schema:datePublishedReg 2018-06-15
28 schema:description To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N = 43, Age = 30–45 years) were compared with plaque free controls (N = 43) (matched for age, sex, body weight and systolic blood pressure). Seven proteins (p < 0.05) that have been previously linked with atherosclerotic phenotypes were differentially abundant. Fibulin 1 proteoform C (FBLN1C), Beta-ala-his-dipeptidase (CNDP1), Cadherin-13 (CDH13), Gelsolin (GSN) and 72 kDa type IV collagenase (MMP2) were less abundant in cases, whereas Apolipoproteins C-III (APOC3) and apolipoprotein E (APOE) were more abundant. Using machine learning analysis, a biomarker panel of FBLN1C, APOE and CDH13 was identified, which classified cases from controls with an area under receiver-operating characteristic curve (AUROC) value of 0.79. Furthermore, using selected reaction monitoring mass spectrometry (SRM-MS) the decreased abundance of FBLN1C was verified. In relation to previous associations of FBLN1C with atherosclerotic lesions, the observation could reflect its involvement in the initiation of the plaque formation, or represent a particular risk phenotype.
29 schema:genre article
30 schema:isAccessibleForFree true
31 schema:isPartOf Nf0669a8474084ead9d0a4b90cd2305d7
32 Nfb51cff3ede9472ca73d2b5e67ccb867
33 sg:journal.1045337
34 schema:keywords CDH13
35 Fbln1c
36 Young Finns Study
37 abundance
38 analysis
39 apolipoprotein C
40 apolipoprotein E
41 area
42 artery plaques
43 association
44 asymptomatic carotid artery plaques
45 atherosclerosis
46 atherosclerotic lesions
47 atherosclerotic phenotype
48 atherosclerotic plaques
49 beta-Ala
50 biomarker panel
51 biomarkers
52 cadherin 13
53 cardiovascular risk
54 carotid artery plaques
55 carotid atherosclerosis
56 carotid atherosclerotic plaques
57 cases
58 characteristic curve values
59 collagenase
60 control
61 curve values
62 decreased abundance
63 dipeptidase
64 early phase
65 examination
66 formation
67 free controls
68 gelsolin
69 initiation
70 involvement
71 label-free quantitative proteomic analysis
72 lesions
73 machine
74 mass spectrometry
75 observations
76 panel
77 part
78 phase
79 phenotype
80 plaque formation
81 plaque-free controls
82 plaques
83 premature carotid atherosclerosis
84 presence
85 previous associations
86 profiling
87 protein
88 protein biomarkers
89 proteomic analysis
90 proteomic profiling
91 quantitative proteomic analysis
92 reaction
93 receiver-operating characteristic curve values
94 relation
95 risk
96 risk phenotype
97 samples
98 serum protein biomarkers
99 serum proteomic profiling
100 serum samples
101 spectrometry
102 study
103 subjects
104 type IV collagenase
105 ultrasound examination
106 values
107 schema:name Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis
108 schema:pagination 9209
109 schema:productId N0109523a221c421f962e9fe21d4e9f40
110 N139d51482fad45ab8cd2fb04aae9707e
111 N99d9d27070f84526a355aa4af51abab6
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104570292
113 https://doi.org/10.1038/s41598-018-27265-9
114 schema:sdDatePublished 2022-09-02T16:02
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher N1a0f6e5253de429e872687b9c91e5604
117 schema:url https://doi.org/10.1038/s41598-018-27265-9
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N0109523a221c421f962e9fe21d4e9f40 schema:name dimensions_id
122 schema:value pub.1104570292
123 rdf:type schema:PropertyValue
124 N139d51482fad45ab8cd2fb04aae9707e schema:name pubmed_id
125 schema:value 29907817
126 rdf:type schema:PropertyValue
127 N1a0f6e5253de429e872687b9c91e5604 schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 N28b0b088b222405cbad9c124f09fda96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Proteome
131 rdf:type schema:DefinedTerm
132 N308a02f9566c41119d35d670b46a7a30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Carotid Artery Diseases
134 rdf:type schema:DefinedTerm
135 N32244fea19c1437b816adf209b036a4a rdf:first sg:person.016547631637.99
136 rdf:rest N5c85b7afaaaa4c3880ccd1a55da96612
137 N4cfe7e28037b4654882b8f08153ef0ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Male
139 rdf:type schema:DefinedTerm
140 N5c85b7afaaaa4c3880ccd1a55da96612 rdf:first sg:person.01144243561.23
141 rdf:rest N8df09f662e32496989155a3fe0910d64
142 N60c8fc61f90f4538a7281b395d32f9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Ultrasonography
144 rdf:type schema:DefinedTerm
145 N74ad910a592a4b8592078ebaa184b5f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 N752b16603ae04d3dbbc5aca8abfa8b2d rdf:first sg:person.01053160654.47
149 rdf:rest Na4332aa051654eb09f42aede132d3d1f
150 N752ed07571af4599a4dd5a87a344d39c rdf:first sg:person.012257600004.22
151 rdf:rest N7994b6d991d344c39e16e1874f771162
152 N7994b6d991d344c39e16e1874f771162 rdf:first sg:person.01255754206.07
153 rdf:rest N752b16603ae04d3dbbc5aca8abfa8b2d
154 N7c1c7cb59bea42079bb3c787d52665b4 rdf:first sg:person.01267360065.55
155 rdf:rest rdf:nil
156 N82c3f33c0c054c92a0f3aa5409d42f34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Adult
158 rdf:type schema:DefinedTerm
159 N85702d52c85442368645059e455b32a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Plaque, Atherosclerotic
161 rdf:type schema:DefinedTerm
162 N8b604e17f9fe4b93bda2192c35319587 rdf:first sg:person.01160467712.17
163 rdf:rest Na41e7982100641b99ec3e7910d58f6eb
164 N8df09f662e32496989155a3fe0910d64 rdf:first sg:person.01044126157.13
165 rdf:rest Nfd60dd0597bd43d7868d0492b59d0a9f
166 N99d9d27070f84526a355aa4af51abab6 schema:name doi
167 schema:value 10.1038/s41598-018-27265-9
168 rdf:type schema:PropertyValue
169 Na41e7982100641b99ec3e7910d58f6eb rdf:first sg:person.0726003076.15
170 rdf:rest N752ed07571af4599a4dd5a87a344d39c
171 Na4332aa051654eb09f42aede132d3d1f rdf:first sg:person.01335473265.62
172 rdf:rest Ncd7e7599ccef4acf859d84f1e0795ebe
173 Nafa3193672c24624882f3e19918d8129 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Proteomics
175 rdf:type schema:DefinedTerm
176 Nb149d753fd0444eb915201134229ab80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Finland
178 rdf:type schema:DefinedTerm
179 Ncc2c6dabbca24330a3e82c1b3ad7a58c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 Ncd7e7599ccef4acf859d84f1e0795ebe rdf:first sg:person.0654341265.88
183 rdf:rest N32244fea19c1437b816adf209b036a4a
184 Nd51a5d13b8e04167bcdafc5f9d58f32e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Female
186 rdf:type schema:DefinedTerm
187 Ne1676fe431ad4255b5afa3aca24c4dc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Blood Proteins
189 rdf:type schema:DefinedTerm
190 Neae2489363b74bef8163d68fa68485b0 rdf:first sg:person.01372252722.98
191 rdf:rest N8b604e17f9fe4b93bda2192c35319587
192 Nf0669a8474084ead9d0a4b90cd2305d7 schema:volumeNumber 8
193 rdf:type schema:PublicationVolume
194 Nfb51cff3ede9472ca73d2b5e67ccb867 schema:issueNumber 1
195 rdf:type schema:PublicationIssue
196 Nfd60dd0597bd43d7868d0492b59d0a9f rdf:first sg:person.0767010034.41
197 rdf:rest N7c1c7cb59bea42079bb3c787d52665b4
198 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
199 schema:name Medical and Health Sciences
200 rdf:type schema:DefinedTerm
201 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
202 schema:name Cardiorespiratory Medicine and Haematology
203 rdf:type schema:DefinedTerm
204 sg:grant.4245198 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
205 rdf:type schema:MonetaryGrant
206 sg:grant.4245674 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
207 rdf:type schema:MonetaryGrant
208 sg:grant.4246637 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
209 rdf:type schema:MonetaryGrant
210 sg:grant.4250095 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
211 rdf:type schema:MonetaryGrant
212 sg:grant.4250379 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
213 rdf:type schema:MonetaryGrant
214 sg:grant.4250588 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
215 rdf:type schema:MonetaryGrant
216 sg:grant.4250761 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
217 rdf:type schema:MonetaryGrant
218 sg:grant.4251009 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
219 rdf:type schema:MonetaryGrant
220 sg:grant.4251354 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
221 rdf:type schema:MonetaryGrant
222 sg:grant.5494084 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
223 rdf:type schema:MonetaryGrant
224 sg:grant.8839578 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
225 rdf:type schema:MonetaryGrant
226 sg:grant.8842120 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-27265-9
227 rdf:type schema:MonetaryGrant
228 sg:journal.1045337 schema:issn 2045-2322
229 schema:name Scientific Reports
230 schema:publisher Springer Nature
231 rdf:type schema:Periodical
232 sg:person.01044126157.13 schema:affiliation grid-institutes:grid.411024.2
233 schema:familyName Goodlett
234 schema:givenName David R.
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044126157.13
236 rdf:type schema:Person
237 sg:person.01053160654.47 schema:affiliation grid-institutes:grid.410552.7
238 schema:familyName Juonala
239 schema:givenName Markus T.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053160654.47
241 rdf:type schema:Person
242 sg:person.01144243561.23 schema:affiliation grid-institutes:grid.452861.c
243 schema:familyName Elo
244 schema:givenName Laura L.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144243561.23
246 rdf:type schema:Person
247 sg:person.01160467712.17 schema:affiliation grid-institutes:grid.452861.c
248 schema:familyName Moulder
249 schema:givenName Robert
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160467712.17
251 rdf:type schema:Person
252 sg:person.012257600004.22 schema:affiliation grid-institutes:grid.1374.1
253 schema:familyName Koskinen
254 schema:givenName Juhani S.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012257600004.22
256 rdf:type schema:Person
257 sg:person.01255754206.07 schema:affiliation grid-institutes:grid.1374.1
258 schema:familyName Pitkänen
259 schema:givenName Niina
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255754206.07
261 rdf:type schema:Person
262 sg:person.01267360065.55 schema:affiliation grid-institutes:grid.410552.7
263 schema:familyName Raitakari
264 schema:givenName Olli T.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267360065.55
266 rdf:type schema:Person
267 sg:person.01335473265.62 schema:affiliation grid-institutes:grid.412330.7
268 schema:familyName Kähönen
269 schema:givenName Mika A. P.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335473265.62
271 rdf:type schema:Person
272 sg:person.01372252722.98 schema:affiliation grid-institutes:grid.452861.c
273 schema:familyName Bhosale
274 schema:givenName Santosh D.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372252722.98
276 rdf:type schema:Person
277 sg:person.016547631637.99 schema:affiliation grid-institutes:grid.410552.7
278 schema:familyName Viikari
279 schema:givenName Jorma S. A.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016547631637.99
281 rdf:type schema:Person
282 sg:person.0654341265.88 schema:affiliation grid-institutes:grid.502801.e
283 schema:familyName Lehtimäki
284 schema:givenName Terho J.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654341265.88
286 rdf:type schema:Person
287 sg:person.0726003076.15 schema:affiliation grid-institutes:grid.452861.c
288 schema:familyName Venäläinen
289 schema:givenName Mikko S.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726003076.15
291 rdf:type schema:Person
292 sg:person.0767010034.41 schema:affiliation grid-institutes:grid.452861.c
293 schema:familyName Lahesmaa
294 schema:givenName Riitta
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767010034.41
296 rdf:type schema:Person
297 sg:pub.10.1007/978-1-4939-7057-5_31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090342830
298 https://doi.org/10.1007/978-1-4939-7057-5_31
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s00216-012-6203-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041147659
301 https://doi.org/10.1007/s00216-012-6203-4
302 rdf:type schema:CreativeWork
303 sg:pub.10.1007/s00418-009-0628-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036401404
304 https://doi.org/10.1007/s00418-009-0628-7
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nature01323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001371417
307 https://doi.org/10.1038/nature01323
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nbt.1511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049469421
310 https://doi.org/10.1038/nbt.1511
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/nbt1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035821098
313 https://doi.org/10.1038/nbt1275
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/nmeth.2369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018367071
316 https://doi.org/10.1038/nmeth.2369
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/nmeth.3901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032398342
319 https://doi.org/10.1038/nmeth.3901
320 rdf:type schema:CreativeWork
321 sg:pub.10.1186/1471-2105-12-77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014582441
322 https://doi.org/10.1186/1471-2105-12-77
323 rdf:type schema:CreativeWork
324 sg:pub.10.1186/1475-2840-12-107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023619874
325 https://doi.org/10.1186/1475-2840-12-107
326 rdf:type schema:CreativeWork
327 grid-institutes:grid.1374.1 schema:alternateName Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
328 schema:name Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
329 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
330 rdf:type schema:Organization
331 grid-institutes:grid.410552.7 schema:alternateName Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
332 Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
333 schema:name Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
334 Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland
335 Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
336 rdf:type schema:Organization
337 grid-institutes:grid.411024.2 schema:alternateName Department of Pharmaceutical Science, University of Maryland, Baltimore, Maryland, USA
338 schema:name Department of Pharmaceutical Science, University of Maryland, Baltimore, Maryland, USA
339 Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
340 rdf:type schema:Organization
341 grid-institutes:grid.412330.7 schema:alternateName Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Faculty of Medicine, Tampere, Finland
342 schema:name Department of Clinical Physiology, Tampere University Hospital and University of Tampere, Faculty of Medicine, Tampere, Finland
343 rdf:type schema:Organization
344 grid-institutes:grid.452861.c schema:alternateName Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
345 schema:name Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
346 rdf:type schema:Organization
347 grid-institutes:grid.502801.e schema:alternateName Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
348 schema:name Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...