The silkrose of Bombyx mori effectively prevents vibriosis in penaeid prawns via the activation of innate immunity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Muhammad Fariz Zahir Ali, Indri Afriani Yasin, Takashi Ohta, Atsushi Hashizume, Atsushi Ido, Takayuki Takahashi, Chiemi Miura, Takeshi Miura

ABSTRACT

We previously identified novel bioactive polysaccharides from Bactrocera cucurbitae and Antheraea yamamai that activate innate immunity in RAW264 murine macrophages. However, in terms of potential applications in the cultivation of prawns, there were problems with the availability of these insects. However, we have now identified a polysaccharide from Bombyx mori that activates innate immunity in RAW264 cells and penaeid prawns. This purified polysaccharide, termed silkrose of B. mori (silkrose-BM), has a molecular weight of 1,150,000 and produces a single symmetrical peak on HPLC. Eight of nine constitutive monosaccharides of silkrose-BM are concomitant with dipterose of B. cucurbitae (dipterose-BC) and silkrose of A. yamamai (silkrose-AY). The major differences are found in the molar ratios of the monosaccharides. Silkrose-BM is approximately 500-fold less potent than silkrose-AY (EC50: 2.5 and 0.0043 μg/mL, respectively) in a nitrite oxide (NO) production assay using RAW264 cells. However, the maximum NO production for silkrose-BM and AY were comparable and higher than that of the lipopolysaccharide of Escherichia coli. The survival of penaeid prawns (Litopenaeus vannamei and Marsupenaeus japonicus) after infection with Vibrio penaecida was significantly improved by both dietary silkrose-BM and B. mori pupae. This suggests that silkrose-BM effectively prevents vibriosis in penaeid prawns via the activation of innate immunity. More... »

PAGES

8836

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27241-3

DOI

http://dx.doi.org/10.1038/s41598-018-27241-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104412671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29892000


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