Regulation of Mesenchymal Stem Cell Differentiation by Nanopatterning of Bulk Metallic Glass View Full Text


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Article Info

DATE

2018-06-08

AUTHORS

Ayomiposi M. Loye, Emily R. Kinser, Sabrine Bensouda, Mahdis Shayan, Rose Davis, Rui Wang, Zheng Chen, Udo D. Schwarz, Jan Schroers, Themis R. Kyriakides

ABSTRACT

Mesenchymal stem cell (MSC) differentiation is regulated by surface modification including texturing, which is applied to materials to enhance tissue integration. Here, we used Pt57.5Cu14.7Ni5.3P22.5 bulk metallic glass (Pt-BMG) with nanopatterned surfaces achieved by thermoplastic forming to influence differentiation of human MSCs. Pt-BMGs are a unique class of amorphous metals with high strength, elasticity, corrosion resistance, and an unusual plastic-like processability. It was found that flat and nanopattened Pt-BMGs induced osteogenic and adipogenic differentiation, respectively. In addition, osteogenic differentiation on flat BMG exceeded that observed on medical grade titanium and was associated with increased formation of focal adhesions and YAP nuclear localization. In contrast, cells on nanopatterned BMGs exhibited rounded morphology, formed less focal adhesions and had mostly cytoplasmic YAP. These changes were preserved on nanopatterns made of nanorods with increased stiffness due to shorter aspect ratios, suggesting that MSC differentiation was primarily influenced by topography. These observations indicate that both elemental composition and nanotopography can modulate biochemical cues and influence MSCs. Moreover, the processability and highly tunable nature of Pt-BMGs enables the creation of a wide range of surface topographies that can be reproducibly and systematically studied, leading to the development of implants capable of engineering MSC functions. More... »

PAGES

8758

References to SciGraph publications

  • 2013-02-26. Critical fictive temperature for plasticity in metallic glasses in NATURE COMMUNICATIONS
  • 2012-05-27. Extracellular-matrix tethering regulates stem-cell fate in NATURE MATERIALS
  • 2013-03-24. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels in NATURE MATERIALS
  • 2017-01-23. Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications in SCIENTIFIC REPORTS
  • 2014-05-21. Materials as stem cell regulators in NATURE MATERIALS
  • 2016-09-12. Regulation of cell-cell fusion by nanotopography in SCIENTIFIC REPORTS
  • 2009-01. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-06-10. The Use of Adipose Stem Cells in Cranial Facial Surgery in STEM CELL REVIEWS AND REPORTS
  • 2012-07-24. Erratum: Extracellular-matrix tethering regulates stem-cell fate in NATURE MATERIALS
  • 2016-09-09. Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies in STEM CELL RESEARCH & THERAPY
  • 2015-05-27. Mechanism of regulation of stem cell differentiation by matrix stiffness in STEM CELL RESEARCH & THERAPY
  • 2011-03-22. Risk factors in the development of stem cell therapy in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2014-05-21. Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate in NATURE MATERIALS
  • 2015-05-18. Vertical nanopillars for in situ probing of nuclear mechanics in adherent cells in NATURE NANOTECHNOLOGY
  • 2014-10-09. Non-invasive characterization of the adipogenic differentiation of human bone marrow-derived mesenchymal stromal cells by HS-SPME/GC-MS in SCIENTIFIC REPORTS
  • 2011-06-08. Role of YAP/TAZ in mechanotransduction in NATURE
  • 2013-01-21. Tunable Tensile Ductility in Metallic Glasses in SCIENTIFIC REPORTS
  • 2009-09-09. Bulk metallic glasses for biomedical applications in JOM
  • 2013-11-01. Immunobiology of mesenchymal stem cells in CELL DEATH & DIFFERENTIATION
  • 2014-08-10. Interplay of matrix stiffness and protein tethering in stem cell differentiation in NATURE MATERIALS
  • 2016-10-06. Metals for bone implants: safety, design, and efficacy in BIOMANUFACTURING REVIEWS
  • 2017-09-27. Mechanobiology of YAP and TAZ in physiology and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2009-02-01. Nanomoulding with amorphous metals in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-27098-6

    DOI

    http://dx.doi.org/10.1038/s41598-018-27098-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104381252

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29884812


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