Betamethasone prevents human rhinovirus- and cigarette smoke- induced loss of respiratory epithelial barrier function View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Eva E. Waltl, Regina Selb, Julia Eckl-Dorna, Christian A. Mueller, Clarissa R. Cabauatan, Thomas Eiwegger, Yvonne Resch-Marat, Katarzyna Niespodziana, Susanne Vrtala, Rudolf Valenta, Verena Niederberger

ABSTRACT

The respiratory epithelium is a barrier against pathogens and allergens and a target for therapy in respiratory allergy, asthma and chronic obstructive pulmonary disease (COPD). We investigated barrier-damaging factors and protective factors by real-time measurement of respiratory cell barrier integrity. Barrier integrity to cigarette smoke extract (CSE), house dust mite (HDM) extract, interferon-γ (IFN-γ) or human rhinovirus (HRV) infection alone or in combination was assessed. Corticosteroids, lipopolysaccharide (LPS), and nasal mucus proteins were tested for their ability to prevent loss of barrier integrity. Real-time impedance-based measurement revealed different patterns of CSE-, HDM-, IFN-γ- and HRV-induced damage. When per se non-damaging concentrations of harmful factors were combined, a synergetic effect was observed only for CSE and HDM. Betamethasone prevented the damaging effect of HRV and CSE, but not damage caused by HDM or IFN-γ. Real-time impedance-based measurement of respiratory epithelial barrier function is useful to study factors, which are harmful or protective. The identification of a synergetic damaging effect of CSE and HDM as well as the finding that Betamethasone protects against HRV- and CSE-induced damage may be important for asthma and COPD. More... »

PAGES

9688

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-27022-y

DOI

http://dx.doi.org/10.1038/s41598-018-27022-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105019179

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29946071


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27022-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27022-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-27022-y'


 

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