Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-06-13

AUTHORS

Arnab Chattopadhyay, Xinying Yang, Pallavi Mukherjee, Dawoud Sulaiman, Hannah R. Fogelman, Victor Grijalva, Steven Dubinett, Tonya C. Wasler, Manash K. Paul, Ramin Salehi-Rad, Julia J. Mack, M. Luisa Iruela-Arispe, Mohamad Navab, Alan M. Fogelman, Srinivasa T. Reddy

ABSTRACT

Having demonstrated that apolipoprotein A-I (apoA-I) mimetic peptides ameliorate cancer in mouse models, we sought to determine the mechanism for the anti-tumorigenic function of these peptides. CT-26 cells (colon cancer cells that implant and grow into tumors in the lungs) were injected into wild-type BALB/c mice. The day after injection, mice were either continued on chow or switched to chow containing 0.06% of a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F). After four weeks, the number of lung tumors was significantly lower in Tg6F-fed mice. Gene expression array analyses of jejunum and lung identified Notch pathway genes significantly upregulated, whereas osteopontin (Spp1) was significantly downregulated by Tg6F in both jejunum and lung. In jejunum, Tg6F increased protein levels for Notch1, Notch2, Dll1, and Dll4. In lung, Tg6F increased protein levels for Notch1 and Dll4 and decreased Spp1. Tg6F reduced oxidized phospholipid levels (E06 immunoreactivity) and reduced 25-hydroxycholesterol (25-OHC) levels, which are known to inhibit Notch1 and induce Spp1, respectively. Notch pathway promotes anti-tumorigenic patrolling monocytes, while Spp1 facilitates pro-tumorigenic myeloid derived suppressor cells (MDSCs) formation. Tg6F-fed mice had higher numbers of patrolling monocytes in jejunum and in lung (p < 0.02), and lower plasma levels of Spp1 with reduced numbers of MDSCs in jejunum and in lung (p < 0.03). We conclude that Tg6F alters levels of specific oxidized lipids and 25-OHC to modulate Notch pathways and Spp1, which alter small intestine immune cells, leading to similar changes in lung that reduce tumor burden. More... »

PAGES

9032

References to SciGraph publications

  • 2008-07-01. Cancer-related inflammation in NATURE
  • 2013-12-20. Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2008-04-30. Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2015-01-23. Immune cell promotion of metastasis in NATURE REVIEWS IMMUNOLOGY
  • 2009-07-02. Population alterations of l-arginase- and inducible nitric oxide synthase-expressed CD11b+/CD14−/CD15+/CD33+ myeloid-derived suppressor cells and CD8+ T lymphocytes in patients with advanced-stage non-small cell lung cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2015-12-04. Cancer immunosurveillance: role of patrolling monocytes in CELL RESEARCH
  • 2013-03-21. The metastasis-promoting roles of tumor-associated immune cells in JOURNAL OF MOLECULAR MEDICINE
  • 2016-06-27. Innate sensing of oxidation-specific epitopes in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2015-07-13. Comprehensive genomic profiles of small cell lung cancer in NATURE
  • 2016-11-03. ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer in SCIENTIFIC REPORTS
  • 2016-08-31. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling in NATURE COMMUNICATIONS
  • 2017-02-03. Notch as a tumour suppressor in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-26755-0

    DOI

    http://dx.doi.org/10.1038/s41598-018-26755-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104468782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29899427


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apolipoprotein A-I", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Jejunum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred BALB C", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Notch", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Burden", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chattopadhyay", 
            "givenName": "Arnab", 
            "id": "sg:person.01222766451.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222766451.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Xinying", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mukherjee", 
            "givenName": "Pallavi", 
            "id": "sg:person.01320454371.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320454371.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Toxicology Interdepartmental Degree Program, Fielding School of Public Health, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
                "Molecular Toxicology Interdepartmental Degree Program, Fielding School of Public Health, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sulaiman", 
            "givenName": "Dawoud", 
            "id": "sg:person.01123231564.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123231564.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fogelman", 
            "givenName": "Hannah R.", 
            "id": "sg:person.01124265445.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124265445.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grijalva", 
            "givenName": "Victor", 
            "id": "sg:person.01102161511.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102161511.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dubinett", 
            "givenName": "Steven", 
            "id": "sg:person.01056561664.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561664.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wasler", 
            "givenName": "Tonya C.", 
            "id": "sg:person.07446526734.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07446526734.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paul", 
            "givenName": "Manash K.", 
            "id": "sg:person.0612252347.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612252347.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salehi-Rad", 
            "givenName": "Ramin", 
            "id": "sg:person.01162125466.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162125466.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mack", 
            "givenName": "Julia J.", 
            "id": "sg:person.0773517637.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773517637.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iruela-Arispe", 
            "givenName": "M. Luisa", 
            "id": "sg:person.012267523157.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267523157.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Navab", 
            "givenName": "Mohamad", 
            "id": "sg:person.01154444643.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154444643.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fogelman", 
            "givenName": "Alan M.", 
            "id": "sg:person.01210003022.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210003022.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
              "id": "http://www.grid.ac/institutes/grid.19006.3e", 
              "name": [
                "Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
                "Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA", 
                "Molecular Toxicology Interdepartmental Degree Program, Fielding School of Public Health, University of California, 90095-1736, Los Angeles, CA, USA", 
                "Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reddy", 
            "givenName": "Srinivasa T.", 
            "id": "sg:person.012220214017.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012220214017.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature07205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024729982", 
              "https://doi.org/10.1038/nature07205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc.2016.145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083524259", 
              "https://doi.org/10.1038/nrc.2016.145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-009-0634-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018285009", 
              "https://doi.org/10.1007/s00432-009-0634-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-013-1508-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025579097", 
              "https://doi.org/10.1007/s00262-013-1508-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001058058", 
              "https://doi.org/10.1038/ncomms12597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3789", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034386589", 
              "https://doi.org/10.1038/nri3789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0523-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018608768", 
              "https://doi.org/10.1007/s00262-008-0523-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2015.144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001833089", 
              "https://doi.org/10.1038/cr.2015.144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri.2016.63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004924731", 
              "https://doi.org/10.1038/nri.2016.63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep36387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031100402", 
              "https://doi.org/10.1038/srep36387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-013-1021-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003763726", 
              "https://doi.org/10.1007/s00109-013-1021-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature14664", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050825100", 
              "https://doi.org/10.1038/nature14664"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-06-13", 
        "datePublishedReg": "2018-06-13", 
        "description": "Having demonstrated that apolipoprotein A-I (apoA-I) mimetic peptides ameliorate cancer in mouse models, we sought to determine the mechanism for the anti-tumorigenic function of these peptides. CT-26 cells (colon cancer cells that implant and grow into tumors in the lungs) were injected into wild-type BALB/c mice. The day after injection, mice were either continued on chow or switched to chow containing 0.06% of a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F). After four weeks, the number of lung tumors was significantly lower in Tg6F-fed mice. Gene expression array analyses of jejunum and lung identified Notch pathway genes significantly upregulated, whereas osteopontin (Spp1) was significantly downregulated by Tg6F in both jejunum and lung. In jejunum, Tg6F increased protein levels for Notch1, Notch2, Dll1, and Dll4. In lung, Tg6F increased protein levels for Notch1 and Dll4 and decreased Spp1. Tg6F reduced oxidized phospholipid levels (E06 immunoreactivity) and reduced 25-hydroxycholesterol (25-OHC) levels, which are known to inhibit Notch1 and induce Spp1, respectively. Notch pathway promotes anti-tumorigenic patrolling monocytes, while Spp1 facilitates pro-tumorigenic myeloid derived suppressor cells (MDSCs) formation. Tg6F-fed mice had higher numbers of patrolling monocytes in jejunum and in lung (p\u2009<\u20090.02), and lower plasma levels of Spp1 with reduced numbers of MDSCs in jejunum and in lung (p\u2009<\u20090.03). We conclude that Tg6F alters levels of specific oxidized lipids and 25-OHC to modulate Notch pathways and Spp1, which alter small intestine immune cells, leading to similar changes in lung that reduce tumor burden.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/s41598-018-26755-0", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2436772", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438817", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "keywords": [
          "Notch pathway", 
          "gene expression array analysis", 
          "Notch pathway genes", 
          "anti-tumorigenic functions", 
          "protein levels", 
          "expression array analysis", 
          "transgenic tomato", 
          "pathway genes", 
          "SPP1", 
          "cell formation", 
          "tumor burden", 
          "mimetic peptide 6F", 
          "array analysis", 
          "mouse model", 
          "wild-type BALB/c mice", 
          "Notch1", 
          "BALB/c mice", 
          "suppressor cell formation", 
          "metastatic lung cancer", 
          "low plasma levels", 
          "Dll4", 
          "pathway", 
          "oral apoA", 
          "CT-26 cells", 
          "alters levels", 
          "patrolling monocytes", 
          "c mice", 
          "plasma levels", 
          "lung cancer", 
          "immune cells", 
          "Tg6F", 
          "lung tumors", 
          "cells", 
          "mimetic peptides", 
          "lung", 
          "phospholipid levels", 
          "jejunum", 
          "peptides", 
          "tomato", 
          "genes", 
          "Dll1", 
          "apolipoprotein A", 
          "mice", 
          "higher number", 
          "Notch2", 
          "similar changes", 
          "monocytes", 
          "cancer", 
          "osteopontin", 
          "apoA", 
          "lipids", 
          "burden", 
          "reduced number", 
          "levels", 
          "myeloid", 
          "mechanism", 
          "tumors", 
          "chow", 
          "MDSCs", 
          "weeks", 
          "intestine", 
          "number", 
          "injection", 
          "function", 
          "days", 
          "formation", 
          "changes", 
          "analysis", 
          "concentrate", 
          "model"
        ], 
        "name": "Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer", 
        "pagination": "9032", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104468782"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-26755-0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29899427"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-26755-0", 
          "https://app.dimensions.ai/details/publication/pub.1104468782"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_768.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/s41598-018-26755-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-26755-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-26755-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-26755-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-26755-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    347 TRIPLES      21 PREDICATES      122 URIs      102 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-26755-0 schema:about N0212c7f951704ca49bcae67060a48d7e
    2 N1438718319cd460b996d815fc1ad5e94
    3 N1d2ce4726c13443680982e7ba1e6a74b
    4 N24550b7e8dbf4ecb8d64b2088261cb1b
    5 N37a94789586444ad8468b2037390fbdb
    6 N6696e060d64f43b38e215316b1de3b21
    7 N8055f3e5bd2f4124be7014a10e9c60e9
    8 N830e4fb2ee414efaa9241ac8310437fb
    9 N976326bf852c4b169f14b3fa15589099
    10 Na3105534689b498d8f2666df4f65877f
    11 Nb236eaa5f80549028d053e523f14175e
    12 Nd644712407de45d182f18abc6d1c1dd5
    13 Nd75703cc1ccf46eabbd0748c8922a297
    14 Ne43c1c8e89274875b1d9c53a5585e349
    15 Ne51670cb8e76403c9b32d91c570bfa38
    16 anzsrc-for:11
    17 anzsrc-for:1112
    18 schema:author N55dac2573dcb47a58453e3726d4dd813
    19 schema:citation sg:pub.10.1007/s00109-013-1021-5
    20 sg:pub.10.1007/s00262-008-0523-4
    21 sg:pub.10.1007/s00262-013-1508-5
    22 sg:pub.10.1007/s00432-009-0634-0
    23 sg:pub.10.1038/cr.2015.144
    24 sg:pub.10.1038/nature07205
    25 sg:pub.10.1038/nature14664
    26 sg:pub.10.1038/ncomms12597
    27 sg:pub.10.1038/nrc.2016.145
    28 sg:pub.10.1038/nri.2016.63
    29 sg:pub.10.1038/nri3789
    30 sg:pub.10.1038/srep36387
    31 schema:datePublished 2018-06-13
    32 schema:datePublishedReg 2018-06-13
    33 schema:description Having demonstrated that apolipoprotein A-I (apoA-I) mimetic peptides ameliorate cancer in mouse models, we sought to determine the mechanism for the anti-tumorigenic function of these peptides. CT-26 cells (colon cancer cells that implant and grow into tumors in the lungs) were injected into wild-type BALB/c mice. The day after injection, mice were either continued on chow or switched to chow containing 0.06% of a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F). After four weeks, the number of lung tumors was significantly lower in Tg6F-fed mice. Gene expression array analyses of jejunum and lung identified Notch pathway genes significantly upregulated, whereas osteopontin (Spp1) was significantly downregulated by Tg6F in both jejunum and lung. In jejunum, Tg6F increased protein levels for Notch1, Notch2, Dll1, and Dll4. In lung, Tg6F increased protein levels for Notch1 and Dll4 and decreased Spp1. Tg6F reduced oxidized phospholipid levels (E06 immunoreactivity) and reduced 25-hydroxycholesterol (25-OHC) levels, which are known to inhibit Notch1 and induce Spp1, respectively. Notch pathway promotes anti-tumorigenic patrolling monocytes, while Spp1 facilitates pro-tumorigenic myeloid derived suppressor cells (MDSCs) formation. Tg6F-fed mice had higher numbers of patrolling monocytes in jejunum and in lung (p < 0.02), and lower plasma levels of Spp1 with reduced numbers of MDSCs in jejunum and in lung (p < 0.03). We conclude that Tg6F alters levels of specific oxidized lipids and 25-OHC to modulate Notch pathways and Spp1, which alter small intestine immune cells, leading to similar changes in lung that reduce tumor burden.
    34 schema:genre article
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N3891a90acd114ed9a25c6a1dc4ef18d7
    37 N55bb1907a8d64f20bedbb1464c43cd10
    38 sg:journal.1045337
    39 schema:keywords BALB/c mice
    40 CT-26 cells
    41 Dll1
    42 Dll4
    43 MDSCs
    44 Notch pathway
    45 Notch pathway genes
    46 Notch1
    47 Notch2
    48 SPP1
    49 Tg6F
    50 alters levels
    51 analysis
    52 anti-tumorigenic functions
    53 apoA
    54 apolipoprotein A
    55 array analysis
    56 burden
    57 c mice
    58 cancer
    59 cell formation
    60 cells
    61 changes
    62 chow
    63 concentrate
    64 days
    65 expression array analysis
    66 formation
    67 function
    68 gene expression array analysis
    69 genes
    70 higher number
    71 immune cells
    72 injection
    73 intestine
    74 jejunum
    75 levels
    76 lipids
    77 low plasma levels
    78 lung
    79 lung cancer
    80 lung tumors
    81 mechanism
    82 metastatic lung cancer
    83 mice
    84 mimetic peptide 6F
    85 mimetic peptides
    86 model
    87 monocytes
    88 mouse model
    89 myeloid
    90 number
    91 oral apoA
    92 osteopontin
    93 pathway
    94 pathway genes
    95 patrolling monocytes
    96 peptides
    97 phospholipid levels
    98 plasma levels
    99 protein levels
    100 reduced number
    101 similar changes
    102 suppressor cell formation
    103 tomato
    104 transgenic tomato
    105 tumor burden
    106 tumors
    107 weeks
    108 wild-type BALB/c mice
    109 schema:name Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer
    110 schema:pagination 9032
    111 schema:productId N24666bec5f2a4d31b5a4bc7123561ec8
    112 N4d6beab2c1854a17b1b6f7412823548a
    113 N52c9754d198e4b8b8ab2762121b9ad4f
    114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104468782
    115 https://doi.org/10.1038/s41598-018-26755-0
    116 schema:sdDatePublished 2022-10-01T06:44
    117 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    118 schema:sdPublisher Nd8cf721be2f945eb986db29e52b0378b
    119 schema:url https://doi.org/10.1038/s41598-018-26755-0
    120 sgo:license sg:explorer/license/
    121 sgo:sdDataset articles
    122 rdf:type schema:ScholarlyArticle
    123 N0212c7f951704ca49bcae67060a48d7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Gene Expression Profiling
    125 rdf:type schema:DefinedTerm
    126 N04a878626e5048ac898cd8650ebb5a86 rdf:first sg:person.01124265445.68
    127 rdf:rest N840c4a8e2ccd4a35b01cafb760c17791
    128 N1438718319cd460b996d815fc1ad5e94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Mice, Inbred C57BL
    130 rdf:type schema:DefinedTerm
    131 N1d2ce4726c13443680982e7ba1e6a74b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Neoplasms, Experimental
    133 rdf:type schema:DefinedTerm
    134 N24550b7e8dbf4ecb8d64b2088261cb1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Receptors, Notch
    136 rdf:type schema:DefinedTerm
    137 N24666bec5f2a4d31b5a4bc7123561ec8 schema:name pubmed_id
    138 schema:value 29899427
    139 rdf:type schema:PropertyValue
    140 N2ca981beb6e546a38550adef9b38a898 rdf:first sg:person.01056561664.44
    141 rdf:rest Nafda68560c2741958e775b3ffb0e276d
    142 N2e7f6096db204a0eb49369506664d762 rdf:first sg:person.0612252347.76
    143 rdf:rest Nd57bb1fdb7ff4a18905ca5857261bebe
    144 N37a94789586444ad8468b2037390fbdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Peptides
    146 rdf:type schema:DefinedTerm
    147 N3891a90acd114ed9a25c6a1dc4ef18d7 schema:issueNumber 1
    148 rdf:type schema:PublicationIssue
    149 N3aab3eebfd2f4d6bb428d3383416bc29 rdf:first Nb4f81e794f634a7598bc2ce2a3dfe48a
    150 rdf:rest Neefb4fb791f547b0b37903cf869015a9
    151 N40ef2c2821084d8e9d770b1aa002b1d8 rdf:first sg:person.01123231564.18
    152 rdf:rest N04a878626e5048ac898cd8650ebb5a86
    153 N4d6beab2c1854a17b1b6f7412823548a schema:name dimensions_id
    154 schema:value pub.1104468782
    155 rdf:type schema:PropertyValue
    156 N52c9754d198e4b8b8ab2762121b9ad4f schema:name doi
    157 schema:value 10.1038/s41598-018-26755-0
    158 rdf:type schema:PropertyValue
    159 N55bb1907a8d64f20bedbb1464c43cd10 schema:volumeNumber 8
    160 rdf:type schema:PublicationVolume
    161 N55dac2573dcb47a58453e3726d4dd813 rdf:first sg:person.01222766451.06
    162 rdf:rest N3aab3eebfd2f4d6bb428d3383416bc29
    163 N57e99dd1c07f4ff0bd0e3f0b56708633 rdf:first sg:person.012267523157.16
    164 rdf:rest Naf5928202e0942b3b287367437f401df
    165 N6696e060d64f43b38e215316b1de3b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Tumor Burden
    167 rdf:type schema:DefinedTerm
    168 N8055f3e5bd2f4124be7014a10e9c60e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Mice, Inbred BALB C
    170 rdf:type schema:DefinedTerm
    171 N830e4fb2ee414efaa9241ac8310437fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Signal Transduction
    173 rdf:type schema:DefinedTerm
    174 N840c4a8e2ccd4a35b01cafb760c17791 rdf:first sg:person.01102161511.72
    175 rdf:rest N2ca981beb6e546a38550adef9b38a898
    176 N976326bf852c4b169f14b3fa15589099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Animals
    178 rdf:type schema:DefinedTerm
    179 Na1f8b4e8ca064048a64c4ce0850a293b rdf:first sg:person.0773517637.74
    180 rdf:rest N57e99dd1c07f4ff0bd0e3f0b56708633
    181 Na3105534689b498d8f2666df4f65877f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Jejunum
    183 rdf:type schema:DefinedTerm
    184 Naf5928202e0942b3b287367437f401df rdf:first sg:person.01154444643.27
    185 rdf:rest Nbb3e445eeb7d4903abd361a8ca5a65be
    186 Nafda68560c2741958e775b3ffb0e276d rdf:first sg:person.07446526734.50
    187 rdf:rest N2e7f6096db204a0eb49369506664d762
    188 Nb236eaa5f80549028d053e523f14175e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Cell Line, Tumor
    190 rdf:type schema:DefinedTerm
    191 Nb4f81e794f634a7598bc2ce2a3dfe48a schema:affiliation grid-institutes:grid.19006.3e
    192 schema:familyName Yang
    193 schema:givenName Xinying
    194 rdf:type schema:Person
    195 Nbb3e445eeb7d4903abd361a8ca5a65be rdf:first sg:person.01210003022.87
    196 rdf:rest Ne2b9f45f22784e218de3cd10d7513118
    197 Nd57bb1fdb7ff4a18905ca5857261bebe rdf:first sg:person.01162125466.04
    198 rdf:rest Na1f8b4e8ca064048a64c4ce0850a293b
    199 Nd644712407de45d182f18abc6d1c1dd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Lung Neoplasms
    201 rdf:type schema:DefinedTerm
    202 Nd75703cc1ccf46eabbd0748c8922a297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Gene Expression Regulation, Neoplastic
    204 rdf:type schema:DefinedTerm
    205 Nd8cf721be2f945eb986db29e52b0378b schema:name Springer Nature - SN SciGraph project
    206 rdf:type schema:Organization
    207 Ne2b9f45f22784e218de3cd10d7513118 rdf:first sg:person.012220214017.91
    208 rdf:rest rdf:nil
    209 Ne43c1c8e89274875b1d9c53a5585e349 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Apolipoprotein A-I
    211 rdf:type schema:DefinedTerm
    212 Ne51670cb8e76403c9b32d91c570bfa38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Lung
    214 rdf:type schema:DefinedTerm
    215 Neefb4fb791f547b0b37903cf869015a9 rdf:first sg:person.01320454371.90
    216 rdf:rest N40ef2c2821084d8e9d770b1aa002b1d8
    217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Medical and Health Sciences
    219 rdf:type schema:DefinedTerm
    220 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    221 schema:name Oncology and Carcinogenesis
    222 rdf:type schema:DefinedTerm
    223 sg:grant.2436772 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-26755-0
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2438817 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-26755-0
    226 rdf:type schema:MonetaryGrant
    227 sg:journal.1045337 schema:issn 2045-2322
    228 schema:name Scientific Reports
    229 schema:publisher Springer Nature
    230 rdf:type schema:Periodical
    231 sg:person.01056561664.44 schema:affiliation grid-institutes:grid.19006.3e
    232 schema:familyName Dubinett
    233 schema:givenName Steven
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056561664.44
    235 rdf:type schema:Person
    236 sg:person.01102161511.72 schema:affiliation grid-institutes:grid.19006.3e
    237 schema:familyName Grijalva
    238 schema:givenName Victor
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102161511.72
    240 rdf:type schema:Person
    241 sg:person.01123231564.18 schema:affiliation grid-institutes:grid.19006.3e
    242 schema:familyName Sulaiman
    243 schema:givenName Dawoud
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123231564.18
    245 rdf:type schema:Person
    246 sg:person.01124265445.68 schema:affiliation grid-institutes:grid.19006.3e
    247 schema:familyName Fogelman
    248 schema:givenName Hannah R.
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124265445.68
    250 rdf:type schema:Person
    251 sg:person.01154444643.27 schema:affiliation grid-institutes:grid.19006.3e
    252 schema:familyName Navab
    253 schema:givenName Mohamad
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154444643.27
    255 rdf:type schema:Person
    256 sg:person.01162125466.04 schema:affiliation grid-institutes:grid.19006.3e
    257 schema:familyName Salehi-Rad
    258 schema:givenName Ramin
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162125466.04
    260 rdf:type schema:Person
    261 sg:person.01210003022.87 schema:affiliation grid-institutes:grid.19006.3e
    262 schema:familyName Fogelman
    263 schema:givenName Alan M.
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210003022.87
    265 rdf:type schema:Person
    266 sg:person.012220214017.91 schema:affiliation grid-institutes:grid.19006.3e
    267 schema:familyName Reddy
    268 schema:givenName Srinivasa T.
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012220214017.91
    270 rdf:type schema:Person
    271 sg:person.01222766451.06 schema:affiliation grid-institutes:grid.19006.3e
    272 schema:familyName Chattopadhyay
    273 schema:givenName Arnab
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222766451.06
    275 rdf:type schema:Person
    276 sg:person.012267523157.16 schema:affiliation grid-institutes:grid.19006.3e
    277 schema:familyName Iruela-Arispe
    278 schema:givenName M. Luisa
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012267523157.16
    280 rdf:type schema:Person
    281 sg:person.01320454371.90 schema:affiliation grid-institutes:grid.19006.3e
    282 schema:familyName Mukherjee
    283 schema:givenName Pallavi
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320454371.90
    285 rdf:type schema:Person
    286 sg:person.0612252347.76 schema:affiliation grid-institutes:grid.19006.3e
    287 schema:familyName Paul
    288 schema:givenName Manash K.
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612252347.76
    290 rdf:type schema:Person
    291 sg:person.07446526734.50 schema:affiliation grid-institutes:grid.19006.3e
    292 schema:familyName Wasler
    293 schema:givenName Tonya C.
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07446526734.50
    295 rdf:type schema:Person
    296 sg:person.0773517637.74 schema:affiliation grid-institutes:grid.19006.3e
    297 schema:familyName Mack
    298 schema:givenName Julia J.
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773517637.74
    300 rdf:type schema:Person
    301 sg:pub.10.1007/s00109-013-1021-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003763726
    302 https://doi.org/10.1007/s00109-013-1021-5
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00262-008-0523-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018608768
    305 https://doi.org/10.1007/s00262-008-0523-4
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00262-013-1508-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025579097
    308 https://doi.org/10.1007/s00262-013-1508-5
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00432-009-0634-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018285009
    311 https://doi.org/10.1007/s00432-009-0634-0
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/cr.2015.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001833089
    314 https://doi.org/10.1038/cr.2015.144
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
    317 https://doi.org/10.1038/nature07205
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nature14664 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050825100
    320 https://doi.org/10.1038/nature14664
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ncomms12597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001058058
    323 https://doi.org/10.1038/ncomms12597
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nrc.2016.145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083524259
    326 https://doi.org/10.1038/nrc.2016.145
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nri.2016.63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004924731
    329 https://doi.org/10.1038/nri.2016.63
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nri3789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034386589
    332 https://doi.org/10.1038/nri3789
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/srep36387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031100402
    335 https://doi.org/10.1038/srep36387
    336 rdf:type schema:CreativeWork
    337 grid-institutes:grid.19006.3e schema:alternateName Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    338 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    339 Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA
    340 Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    341 Molecular Toxicology Interdepartmental Degree Program, Fielding School of Public Health, University of California, 90095-1736, Los Angeles, CA, USA
    342 schema:name Department of Medicine, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    343 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    344 Department of Molecular, Cell and Developmental Biology, College of Letters and Science, University of California, 90095-1736, Los Angeles, CA, USA
    345 Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, 90095-1736, Los Angeles, CA, USA
    346 Molecular Toxicology Interdepartmental Degree Program, Fielding School of Public Health, University of California, 90095-1736, Los Angeles, CA, USA
    347 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...