Kv1.3 activity perturbs the homeostatic properties of astrocytes in glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Alfonso Grimaldi, Giuseppina D’Alessandro, Maria Amalia Di Castro, Clotilde Lauro, Vikrant Singh, Francesca Pagani, Luigi Sforna, Francesca Grassi, Silvia Di Angelantonio, Luigi Catacuzzeno, Heike Wulff, Cristina Limatola, Myriam Catalano

ABSTRACT

Glial cells actively maintain the homeostasis of brain parenchyma, regulating neuronal excitability and preserving the physiological composition of the extracellular milieu. Under pathological conditions, some functions of glial cells could be compromised, exacerbating the neurotoxic processes. We investigated if the homeostatic activities of astrocytes and microglia could be modulated by the voltage-gated K+ channel Kv1.3. To this end we used in vitro and in vivo systems to model cell-to-cell interactions in tumoral conditions, using a specific inhibitor of Kv1.3 channels, 5-(4-phenoxybutoxy) psoralen (PAP-1). We demonstrated that PAP-1 increases astrocytic glutamate uptake, reduces glioma-induced neurotoxicity, and decreases microglial migration and phagocytosis. We also found in a tumor blood brain barrier model that Kv1.3 activity is required for its integrity. The crucial role of Kv1.3 channels as modulators of glial cell activity was confirmed in a mouse model of glioma, where PAP-1 treatment reduces tumor volume only in the presence of active glutamate transporters GLT-1. In the same mouse model, PAP-1 reduces astrogliosis and microglial infiltration. PAP-1 also reduces tumor cell invasion. All these findings point to Kv1.3 channels as potential targets to re-instruct glial cells toward their homeostatic functions, in the context of brain tumors. More... »

PAGES

7654

References to SciGraph publications

  • 2005-05. Involvement of regulatory volume decrease in the migration of nasopharyngeal carcinoma cells in CELL RESEARCH
  • 2012-12. The characteristics of bone marrow-derived endothelial progenitor cells and their effect on glioma in CANCER CELL INTERNATIONAL
  • 2018-05. Voltage Gated Potassium Channel Kv1.3 Is Upregulated on Activated Astrocytes in Experimental Autoimmune Encephalomyelitis in NEUROCHEMICAL RESEARCH
  • 2008-05. Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1990-11. Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake in NATURE
  • 2017-12. A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation in JOURNAL OF NEUROINFLAMMATION
  • 2014-10. A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium in CELL DEATH & DISEASE
  • 2016-12. Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia in JOURNAL OF NEUROINFLAMMATION
  • 2010-06. Adenosine A1 Receptors and Microglial Cells Mediate CX3CL1-Induced Protection of Hippocampal Neurons Against Glu-Induced Death in NEUROPSYCHOPHARMACOLOGY
  • 2008-02. Microglia-derived TGF-β as an important regulator of glioblastoma invasion—an inhibition of TGF-β-dependent effects by shRNA against human TGF-β type II receptor in ONCOGENE
  • 2014-12. Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells in NATURE COMMUNICATIONS
  • 2006-11. Local potassium signaling couples neuronal activity to vasodilation in the brain in NATURE NEUROSCIENCE
  • 2006-01. Astrocyte–endothelial interactions at the blood–brain barrier in NATURE REVIEWS NEUROSCIENCE
  • 2002-09. The voltage-gated potassium channels and their relatives in NATURE
  • 2016-09. Ionic immune suppression within the tumour microenvironment limits T cell effector function in NATURE
  • 2015-09. Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2016-04. KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages in CELL DEATH & DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-25940-5

    DOI

    http://dx.doi.org/10.1038/s41598-018-25940-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103931902

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29769580


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