Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Conrad Wiegand, Peter Heusser, Claudia Klinger, Dirk Cysarz, Arndt Büssing, Thomas Ostermann, Andreas Savelsbergh

ABSTRACT

Stress is an important co-factor for the genesis and maintenance of many diseases and is known to have an effect on gene expression via epigenetic regulation. MicroRNAs (miRNAs) appear to function as one of the key factors of this regulation. This is the first study to investigate the response of 11 stress-associated miRNAs in human saliva - as a non-invasive source - in an experimental condition of acute psychological stress, and also their correlation with established psychological (subjective stress perception), physiological (heart rate and heart rate variability) and biochemical stress parameters (salivary cortisol and alpha-amylase). 24 healthy participants between 20 and 35 years of age were investigated, using the Trier Social Stress Test (TSST) to induce acute psychological stress. Stress-associated changes were significant for miR-20b, -21 and 26b, and changes in miR-16 and -134 were close to significance, recommending further research on these miRNAs in the context of stress reactions. Significant correlations with alpha-amylase suggest their integration in sympathetic stress regulation processes. Additionally, our results demonstrate the TSST as a reliable tool for studying salivary miRNAs as non-invasive indicators of epigenetic processes in acute psychological stress reactions. More... »

PAGES

7112

References to SciGraph publications

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-25554-x

DOI

http://dx.doi.org/10.1038/s41598-018-25554-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103754115

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29740073


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