Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

M. Keshavarz, M. Skill, M. I. Hollenhorst, S. Maxeiner, M. Walecki, U. Pfeil, W. Kummer, G. Krasteva-Christ

ABSTRACT

The mechanisms of controlling airway smooth muscle (ASM) tone are of utmost clinical importance as inappropriate constriction is a hallmark in asthma and chronic obstructive pulmonary disease. Receptors for acetylcholine and serotonin, two relevant mediators in this context, appear to be incorporated in specialized, cholesterol-rich domains of the plasma membrane, termed caveolae due to their invaginated shape. The structural protein caveolin-1 partly accounts for anchoring of these receptors. We here determined the role of the other major caveolar protein, caveolin-3 (cav-3), in orchestrating cholinergic and serotonergic ASM responses, utilizing newly generated cav-3 deficient mice. Cav-3 deficiency fully abrogated serotonin-induced constriction of extrapulmonary airways in organ baths while leaving intrapulmonary airways unaffected, as assessed in precision cut lung slices. The selective expression of cav-3 in tracheal, but not intrapulmonary bronchial epithelial cells, revealed by immunohistochemistry, might explain the differential effects of cav-3 deficiency on serotonergic ASM constriction. The cholinergic response of extrapulmonary airways was not altered, whereas a considerable increase was observed in cav-3-/- intrapulmonary bronchi. Thus, cav-3 differentially organizes serotonergic and cholinergic signaling in ASM through mechanisms that are specific for airways of certain caliber and anatomical position. This may allow for selective and site-specific intervention in hyperreactive states. More... »

PAGES

7508

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-25445-1

DOI

http://dx.doi.org/10.1038/s41598-018-25445-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103889286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29760450


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