Novel antibiofilm chemotherapies target nitrogen from glutamate and glutamine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tal Hassanov, Iris Karunker, Nitai Steinberg, Ayelet Erez, Ilana Kolodkin-Gal

ABSTRACT

Bacteria in nature often reside in differentiated communities termed biofilms, which are an active interphase between uni-cellular and multicellular life states for bacteria. Here we demonstrate that the development of B. subtilis biofilms is dependent on the use of glutamine or glutamate as a nitrogen source. We show a differential metabolic requirement within the biofilm; while glutamine is necessary for the dividing cells at the edges, the inner cell mass utilizes lactic acid. Our results indicate that biofilm cells preserve a short-term memory of glutamate metabolism. Finally, we establish that drugs that target glutamine and glutamate utilization restrict biofilm development. Overall, our work reveals a spatial regulation of nitrogen and carbon metabolism within the biofilm, which contributes to the fitness of bacterial complex communities. This acquired metabolic division of labor within biofilm can serve as a target for novel anti-biofilm chemotherapies. More... »

PAGES

7097

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z

DOI

http://dx.doi.org/10.1038/s41598-018-25401-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103754085

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29740028


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