Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSTal Hassanov, Iris Karunker, Nitai Steinberg, Ayelet Erez, Ilana Kolodkin-Gal
ABSTRACTBacteria in nature often reside in differentiated communities termed biofilms, which are an active interphase between uni-cellular and multicellular life states for bacteria. Here we demonstrate that the development of B. subtilis biofilms is dependent on the use of glutamine or glutamate as a nitrogen source. We show a differential metabolic requirement within the biofilm; while glutamine is necessary for the dividing cells at the edges, the inner cell mass utilizes lactic acid. Our results indicate that biofilm cells preserve a short-term memory of glutamate metabolism. Finally, we establish that drugs that target glutamine and glutamate utilization restrict biofilm development. Overall, our work reveals a spatial regulation of nitrogen and carbon metabolism within the biofilm, which contributes to the fitness of bacterial complex communities. This acquired metabolic division of labor within biofilm can serve as a target for novel anti-biofilm chemotherapies. More... »
PAGES7097
http://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z
DOIhttp://dx.doi.org/10.1038/s41598-018-25401-z
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/29740028
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-25401-z'
This table displays all metadata directly associated to this object as RDF triples.
320 TRIPLES
21 PREDICATES
102 URIs
21 LITERALS
9 BLANK NODES