Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1–4 in Children from Viet Nam View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Martin Linster, Lien Anh Ha, Ngo Ngoc Quang Minh, Yihui Chen, Zhu Zhe, Tran Anh Tuan, Ha Manh Tuan, Yvonne C. F. Su, H. Rogier van Doorn, Mahesh Moorthy, Gavin J. D. Smith

ABSTRACT

HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory samples were screened for HPIV1-4 by real-time PCR. Demographic and clinical data of patients infected with different HPIV were compared. We used a hemi-nested PCR approach to generate viral genome sequences from HPIV-positive samples and conducted a comprehensive phylogenetic analysis. In total, 170 samples tested positive for HPIV. HPIV3 was most commonly detected in our cohort and 80 co-detections of HPIV with other respiratory viruses were found. Phylogenetic analyses suggest local endemic circulation as well as punctuated introductions of new HPIV lineages. Viral gene flow analysis revealed that Viet Nam is a net importer of viral genetic diversity. Epidemiological analyses imply similar disease severity for all HPIV species. HPIV sequences from Viet Nam formed local clusters and were interspersed with sequences from diverse geographic regions. Combined, this new knowledge will help to investigate global HPIV circulation patterns in more detail and ultimately define more suitable vaccine strains. More... »

PAGES

6833

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-24767-4

DOI

http://dx.doi.org/10.1038/s41598-018-24767-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103641013

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29717150


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linster", 
        "givenName": "Martin", 
        "id": "sg:person.01027074767.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027074767.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oxford University Clinical Research Unit", 
          "id": "https://www.grid.ac/institutes/grid.412433.3", 
          "name": [
            "Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam", 
            "Murdoch\u2019s Children Research Institute, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ha", 
        "givenName": "Lien Anh", 
        "id": "sg:person.011105700057.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105700057.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital 1", 
          "id": "https://www.grid.ac/institutes/grid.440249.f", 
          "name": [
            "Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam", 
            "Children\u2019s Hospital 1, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Minh", 
        "givenName": "Ngo Ngoc Quang", 
        "id": "sg:person.0706745211.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706745211.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Yihui", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhe", 
        "givenName": "Zhu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital 1", 
          "id": "https://www.grid.ac/institutes/grid.440249.f", 
          "name": [
            "Children\u2019s Hospital 1, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuan", 
        "givenName": "Tran Anh", 
        "id": "sg:person.01024205156.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024205156.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital 2", 
          "id": "https://www.grid.ac/institutes/grid.440251.6", 
          "name": [
            "Children\u2019s Hospital 2, Ho Chi Minh City, Vietnam"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tuan", 
        "givenName": "Ha Manh", 
        "id": "sg:person.01364236111.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364236111.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National University of Singapore", 
          "id": "https://www.grid.ac/institutes/grid.4280.e", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Yvonne C. F.", 
        "id": "sg:person.012264177747.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012264177747.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam", 
            "Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Doorn", 
        "givenName": "H. Rogier", 
        "id": "sg:person.01076204103.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076204103.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Christian Medical College & Hospital", 
          "id": "https://www.grid.ac/institutes/grid.11586.3b", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore", 
            "Department of Clinical Virology, Christian Medical College, Vellore, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moorthy", 
        "givenName": "Mahesh", 
        "id": "sg:person.01331577525.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331577525.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University", 
          "id": "https://www.grid.ac/institutes/grid.26009.3d", 
          "name": [
            "Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore", 
            "Duke Global Health Institute, Duke University, Durham, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Gavin J. D.", 
        "id": "sg:person.016356542404.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016356542404.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1126/science.1154137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000200290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcv.2011.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001537709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/513975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001760519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature14460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002982180", 
          "https://doi.org/10.1038/nature14460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0160606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005811287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(09)70069-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007072554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jviromet.2011.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008744185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2148-7-214", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010584451", 
          "https://doi.org/10.1186/1471-2148-7-214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coviro.2012.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013166621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mss075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013930907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61901-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015914815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkr859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016911031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jcm.43.9.4515-4521.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017057293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-251-9_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018752572", 
          "https://doi.org/10.1007/978-1-59745-251-9_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/507638", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021633217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jmv.21271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021980760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-200107000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022003538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006454-200107000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022003538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023935382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jviromet.2006.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025811685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2012.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029663259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4236/ojrd.2016.63007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032046097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2008.11.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032244192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033367403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037623568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181ff2fac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041016618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3181ff2fac", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041016618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0196-6553(90)90206-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041106860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01680-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041871966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1109314108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042116987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/cmr.16.2.242-264.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048748500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1090727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050953218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000053882.70365.c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052660905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.inf.0000053882.70365.c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052660905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep14268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053336879", 
          "https://doi.org/10.1038/srep14268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268804003450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053961684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0950268804003450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053961684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/150.6.851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059699204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/162.3.746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059702205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/infdis/169.2.248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059704280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3182113989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060342035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3182113989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060342035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/inf.0b013e3182113989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060342035"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory samples were screened for HPIV1-4 by real-time PCR. Demographic and clinical data of patients infected with different HPIV were compared. We used a hemi-nested PCR approach to generate viral genome sequences from HPIV-positive samples and conducted a comprehensive phylogenetic analysis. In total, 170 samples tested positive for HPIV. HPIV3 was most commonly detected in our cohort and 80 co-detections of HPIV with other respiratory viruses were found. Phylogenetic analyses suggest local endemic circulation as well as punctuated introductions of new HPIV lineages. Viral gene flow analysis revealed that Viet Nam is a net importer of viral genetic diversity. Epidemiological analyses imply similar disease severity for all HPIV species. HPIV sequences from Viet Nam formed local clusters and were interspersed with sequences from diverse geographic regions. Combined, this new knowledge will help to investigate global HPIV circulation patterns in more detail and ultimately define more suitable vaccine strains.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-018-24767-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1\u20134 in Children from Viet Nam", 
    "pagination": "6833", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "008e2b789a352afd132d078f02116d0d403d41f0fddaa779cd05de20d14b5b6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29717150"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-24767-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103641013"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-24767-4", 
      "https://app.dimensions.ai/details/publication/pub.1103641013"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-018-24767-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24767-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24767-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24767-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24767-4'


 

This table displays all metadata directly associated to this object as RDF triples.

274 TRIPLES      21 PREDICATES      66 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-24767-4 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author N4d17e145c6f24b06b35ba5c549aa497f
4 schema:citation sg:pub.10.1007/978-1-59745-251-9_3
5 sg:pub.10.1038/nature14460
6 sg:pub.10.1038/srep14268
7 sg:pub.10.1186/1471-2148-7-214
8 https://doi.org/10.1002/jmv.21271
9 https://doi.org/10.1016/0196-6553(90)90206-8
10 https://doi.org/10.1016/j.coviro.2012.02.001
11 https://doi.org/10.1016/j.jcv.2011.04.010
12 https://doi.org/10.1016/j.jpeds.2008.11.034
13 https://doi.org/10.1016/j.jviromet.2006.12.007
14 https://doi.org/10.1016/j.jviromet.2011.11.012
15 https://doi.org/10.1016/j.virol.2012.08.027
16 https://doi.org/10.1016/s0140-6736(12)61901-1
17 https://doi.org/10.1016/s1473-3099(09)70069-6
18 https://doi.org/10.1017/s0950268804003450
19 https://doi.org/10.1073/pnas.1109314108
20 https://doi.org/10.1086/507638
21 https://doi.org/10.1086/513975
22 https://doi.org/10.1093/bioinformatics/bts199
23 https://doi.org/10.1093/infdis/150.6.851
24 https://doi.org/10.1093/infdis/162.3.746
25 https://doi.org/10.1093/infdis/169.2.248
26 https://doi.org/10.1093/molbev/mss075
27 https://doi.org/10.1093/nar/gkr859
28 https://doi.org/10.1097/00006454-200107000-00003
29 https://doi.org/10.1097/01.inf.0000053882.70365.c9
30 https://doi.org/10.1097/inf.0b013e3181ff2fac
31 https://doi.org/10.1097/inf.0b013e3182113989
32 https://doi.org/10.1126/science.1090727
33 https://doi.org/10.1126/science.1154137
34 https://doi.org/10.1128/cmr.16.2.242-264.2003
35 https://doi.org/10.1128/jcm.43.9.4515-4521.2005
36 https://doi.org/10.1128/jvi.01680-06
37 https://doi.org/10.1371/journal.pone.0160606
38 https://doi.org/10.1371/journal.ppat.1002134
39 https://doi.org/10.1371/journal.ppat.1003786
40 https://doi.org/10.4236/ojrd.2016.63007
41 schema:datePublished 2018-12
42 schema:datePublishedReg 2018-12-01
43 schema:description HPIVs are serologically and genetically grouped into four species that account for up to 10% of all hospitalizations due to acute respiratory infection in children under the age of five. Genetic and epidemiological data for the four HPIVs derived from two pediatric cohorts in Viet Nam are presented. Respiratory samples were screened for HPIV1-4 by real-time PCR. Demographic and clinical data of patients infected with different HPIV were compared. We used a hemi-nested PCR approach to generate viral genome sequences from HPIV-positive samples and conducted a comprehensive phylogenetic analysis. In total, 170 samples tested positive for HPIV. HPIV3 was most commonly detected in our cohort and 80 co-detections of HPIV with other respiratory viruses were found. Phylogenetic analyses suggest local endemic circulation as well as punctuated introductions of new HPIV lineages. Viral gene flow analysis revealed that Viet Nam is a net importer of viral genetic diversity. Epidemiological analyses imply similar disease severity for all HPIV species. HPIV sequences from Viet Nam formed local clusters and were interspersed with sequences from diverse geographic regions. Combined, this new knowledge will help to investigate global HPIV circulation patterns in more detail and ultimately define more suitable vaccine strains.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree true
47 schema:isPartOf N041c46597b4b42cd8235351b94349113
48 N2f25468fb01848c599062f6b36f4db3c
49 sg:journal.1045337
50 schema:name Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1–4 in Children from Viet Nam
51 schema:pagination 6833
52 schema:productId N0631ac58ae19451590717179a13810d1
53 N06609c82070844388201e2d36226dd4a
54 N5a090ca456904b5c89155773f2fe6851
55 N9081e709d3a340aaaa61b718f2f0aa80
56 Nba03f4e2319b42efbcc78fef10681c9b
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103641013
58 https://doi.org/10.1038/s41598-018-24767-4
59 schema:sdDatePublished 2019-04-10T20:43
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Ne432ac66c9da4a78a4b46862b5157426
62 schema:url https://www.nature.com/articles/s41598-018-24767-4
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N041c46597b4b42cd8235351b94349113 schema:volumeNumber 8
67 rdf:type schema:PublicationVolume
68 N0631ac58ae19451590717179a13810d1 schema:name dimensions_id
69 schema:value pub.1103641013
70 rdf:type schema:PropertyValue
71 N06609c82070844388201e2d36226dd4a schema:name pubmed_id
72 schema:value 29717150
73 rdf:type schema:PropertyValue
74 N27b83bc82d134faf884ee4191e421218 rdf:first sg:person.011105700057.85
75 rdf:rest Ncbc6feab424145cbaa07b82c6fa73109
76 N2f25468fb01848c599062f6b36f4db3c schema:issueNumber 1
77 rdf:type schema:PublicationIssue
78 N4d17e145c6f24b06b35ba5c549aa497f rdf:first sg:person.01027074767.94
79 rdf:rest N27b83bc82d134faf884ee4191e421218
80 N5a090ca456904b5c89155773f2fe6851 schema:name readcube_id
81 schema:value 008e2b789a352afd132d078f02116d0d403d41f0fddaa779cd05de20d14b5b6d
82 rdf:type schema:PropertyValue
83 N6190f1ff1cc74cebb31c88dcb6ec4a60 rdf:first sg:person.01076204103.30
84 rdf:rest N6929913fe32047fab346460a39dd3928
85 N68426657f76b4b538ac56a07033e51d6 rdf:first sg:person.016356542404.96
86 rdf:rest rdf:nil
87 N6929913fe32047fab346460a39dd3928 rdf:first sg:person.01331577525.28
88 rdf:rest N68426657f76b4b538ac56a07033e51d6
89 N79b702ea9d144b01a8537cd1c59ff175 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
90 schema:familyName Zhe
91 schema:givenName Zhu
92 rdf:type schema:Person
93 N9081e709d3a340aaaa61b718f2f0aa80 schema:name nlm_unique_id
94 schema:value 101563288
95 rdf:type schema:PropertyValue
96 N947e2f7d03aa4a87b1bb8f3c83a1fb41 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
97 schema:familyName Chen
98 schema:givenName Yihui
99 rdf:type schema:Person
100 Naae7de7fe3564f22a9702e0b822f1bb3 rdf:first N947e2f7d03aa4a87b1bb8f3c83a1fb41
101 rdf:rest Ncdb8ee861a2e4a4a8a35018e9f6e16ce
102 Nba03f4e2319b42efbcc78fef10681c9b schema:name doi
103 schema:value 10.1038/s41598-018-24767-4
104 rdf:type schema:PropertyValue
105 Nba19b536f15946f6810baa58db68da4c rdf:first sg:person.01024205156.68
106 rdf:rest Nbec3703d0e974a4cb5a75b33a7837b4e
107 Nbec3703d0e974a4cb5a75b33a7837b4e rdf:first sg:person.01364236111.65
108 rdf:rest Nf5515827f93a4d56ac5000c491a3c49e
109 Ncbc6feab424145cbaa07b82c6fa73109 rdf:first sg:person.0706745211.52
110 rdf:rest Naae7de7fe3564f22a9702e0b822f1bb3
111 Ncdb8ee861a2e4a4a8a35018e9f6e16ce rdf:first N79b702ea9d144b01a8537cd1c59ff175
112 rdf:rest Nba19b536f15946f6810baa58db68da4c
113 Ne432ac66c9da4a78a4b46862b5157426 schema:name Springer Nature - SN SciGraph project
114 rdf:type schema:Organization
115 Nf5515827f93a4d56ac5000c491a3c49e rdf:first sg:person.012264177747.25
116 rdf:rest N6190f1ff1cc74cebb31c88dcb6ec4a60
117 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biological Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
121 schema:name Genetics
122 rdf:type schema:DefinedTerm
123 sg:journal.1045337 schema:issn 2045-2322
124 schema:name Scientific Reports
125 rdf:type schema:Periodical
126 sg:person.01024205156.68 schema:affiliation https://www.grid.ac/institutes/grid.440249.f
127 schema:familyName Tuan
128 schema:givenName Tran Anh
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024205156.68
130 rdf:type schema:Person
131 sg:person.01027074767.94 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
132 schema:familyName Linster
133 schema:givenName Martin
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027074767.94
135 rdf:type schema:Person
136 sg:person.01076204103.30 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
137 schema:familyName van Doorn
138 schema:givenName H. Rogier
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076204103.30
140 rdf:type schema:Person
141 sg:person.011105700057.85 schema:affiliation https://www.grid.ac/institutes/grid.412433.3
142 schema:familyName Ha
143 schema:givenName Lien Anh
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011105700057.85
145 rdf:type schema:Person
146 sg:person.012264177747.25 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
147 schema:familyName Su
148 schema:givenName Yvonne C. F.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012264177747.25
150 rdf:type schema:Person
151 sg:person.01331577525.28 schema:affiliation https://www.grid.ac/institutes/grid.11586.3b
152 schema:familyName Moorthy
153 schema:givenName Mahesh
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331577525.28
155 rdf:type schema:Person
156 sg:person.01364236111.65 schema:affiliation https://www.grid.ac/institutes/grid.440251.6
157 schema:familyName Tuan
158 schema:givenName Ha Manh
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364236111.65
160 rdf:type schema:Person
161 sg:person.016356542404.96 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
162 schema:familyName Smith
163 schema:givenName Gavin J. D.
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016356542404.96
165 rdf:type schema:Person
166 sg:person.0706745211.52 schema:affiliation https://www.grid.ac/institutes/grid.440249.f
167 schema:familyName Minh
168 schema:givenName Ngo Ngoc Quang
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706745211.52
170 rdf:type schema:Person
171 sg:pub.10.1007/978-1-59745-251-9_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018752572
172 https://doi.org/10.1007/978-1-59745-251-9_3
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/nature14460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002982180
175 https://doi.org/10.1038/nature14460
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/srep14268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053336879
178 https://doi.org/10.1038/srep14268
179 rdf:type schema:CreativeWork
180 sg:pub.10.1186/1471-2148-7-214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010584451
181 https://doi.org/10.1186/1471-2148-7-214
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1002/jmv.21271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021980760
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0196-6553(90)90206-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041106860
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.coviro.2012.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013166621
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.jcv.2011.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001537709
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.jpeds.2008.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032244192
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.jviromet.2006.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025811685
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.jviromet.2011.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008744185
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.virol.2012.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029663259
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0140-6736(12)61901-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015914815
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s1473-3099(09)70069-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007072554
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1017/s0950268804003450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053961684
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1073/pnas.1109314108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042116987
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1086/507638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021633217
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1086/513975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001760519
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/bioinformatics/bts199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037623568
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/infdis/150.6.851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059699204
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/infdis/162.3.746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059702205
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1093/infdis/169.2.248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059704280
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/molbev/mss075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013930907
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/nar/gkr859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016911031
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1097/00006454-200107000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022003538
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1097/01.inf.0000053882.70365.c9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052660905
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/inf.0b013e3181ff2fac schema:sameAs https://app.dimensions.ai/details/publication/pub.1041016618
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1097/inf.0b013e3182113989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060342035
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1126/science.1090727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050953218
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1126/science.1154137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000200290
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1128/cmr.16.2.242-264.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048748500
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1128/jcm.43.9.4515-4521.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017057293
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1128/jvi.01680-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041871966
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1371/journal.pone.0160606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005811287
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.ppat.1002134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033367403
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1371/journal.ppat.1003786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023935382
246 rdf:type schema:CreativeWork
247 https://doi.org/10.4236/ojrd.2016.63007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032046097
248 rdf:type schema:CreativeWork
249 https://www.grid.ac/institutes/grid.11586.3b schema:alternateName Christian Medical College & Hospital
250 schema:name Department of Clinical Virology, Christian Medical College, Vellore, India
251 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
252 rdf:type schema:Organization
253 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
254 schema:name Duke Global Health Institute, Duke University, Durham, North Carolina, USA
255 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
256 rdf:type schema:Organization
257 https://www.grid.ac/institutes/grid.412433.3 schema:alternateName Oxford University Clinical Research Unit
258 schema:name Murdoch’s Children Research Institute, Melbourne, Australia
259 Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
262 schema:name Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.440249.f schema:alternateName Children's Hospital 1
265 schema:name Children’s Hospital 1, Ho Chi Minh City, Vietnam
266 Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.440251.6 schema:alternateName Children's Hospital 2
269 schema:name Children’s Hospital 2, Ho Chi Minh City, Vietnam
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
272 schema:name Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
273 Oxford University Clinical Research Unit-Viet Nam, Ho Chi Minh City, Vietnam
274 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...