Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Gurmeet Kaur, Lakshminarayan M. Iyer, Srikrishna Subramanian, L. Aravind

ABSTRACT

SH3-fold-β-barrel domains of the chromo-like superfamily recognize epigenetic marks in eukaryotic proteins. Their provenance has been placed either in archaea, based on apparent structural similarity to chromatin-compacting Sul7d and Cren7 proteins, or in bacteria based on the presence of sequence homologs. Using sequence and structural evidence we establish that the archaeal Cren7/Sul7 proteins emerged from a zinc ribbon (ZnR) ancestor. Further, we show that the ancestral eukaryotic chromo-like domains evolved from bacterial versions, likely acquired from early endosymbioses, which already possessed an aromatic cage for recognition of modified amino-groups. These bacterial versions are part of a radiation of secreted SH3-fold domains, which spawned both chromo-like domains and classical SH3 domains in the context of peptide-recognition in the peptidoglycan or the extracellular matrix. This establishes that Cren7/Sul7 converged to a "SH3"-like state from a ZnR precursor via the loss of metal-chelation and acquisition of stronger hydrophobic interactions; it is unlikely to have participated in the evolution of the chromo-like domains. We show that archaea possess several Cren7/Sul7-related proteins with intact Zn-chelating ligands, which we predict to play previously unstudied roles in chromosome segregation during cell-division comparable to the PRC barrel and CdvA domain proteins. More... »

PAGES

6196

References to SciGraph publications

  • 2003-02. Evolutionary history, structural features and biochemical diversity of the NlpC/P60 superfamily of enzymes in GENOME BIOLOGY
  • 2003-11. Structure and conserved RNA binding of the PAZ domain in NATURE
  • 2016-10. Classification of the treble clef zinc finger: noteworthy lessons for structure and function evolution in SCIENTIFIC REPORTS
  • 2011. Classification of Proteins: Available Structural Space for Molecular Modeling in HOMOLOGY MODELING
  • 2010-03. Bacterial nucleoid-associated proteins, nucleoid structure and gene expression in NATURE REVIEWS MICROBIOLOGY
  • 2015-03. Insights into the interaction between Cren7 and DNA: the role of loop β3–β4 in EXTREMOPHILES
  • 1998-03. The hyperthermophile chromosomal protein Sac7d sharply kinks DNA in NATURE
  • 2002-10. The PRC-barrel: a widespread, conserved domain shared by photosynthetic reaction center subunits and proteins of RNA metabolism in GENOME BIOLOGY
  • 1997-09. Crystal structure of the nucleosome core particle at 2.8 Å resolution in NATURE
  • 2010-08. Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1995-02. Protein modules and signalling networks in NATURE
  • 2003-11. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain in NATURE
  • 2008-12. Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score in BMC BIOINFORMATICS
  • 2015-12. The UBR-box and its relationship to binuclear RING-like treble clef zinc fingers in BIOLOGY DIRECT
  • 2012-05. Archaeal chromatin proteins in SCIENCE CHINA LIFE SCIENCES
  • 2002-03. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-24467-z

    DOI

    http://dx.doi.org/10.1038/s41598-018-24467-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103361135

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29670199


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaur", 
            "givenName": "Gurmeet", 
            "id": "sg:person.01132275734.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132275734.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iyer", 
            "givenName": "Lakshminarayan M.", 
            "id": "sg:person.012162224357.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Microbial Technology", 
              "id": "https://www.grid.ac/institutes/grid.417641.1", 
              "name": [
                "Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector 39A, 160036, Chandigarh, India"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Subramanian", 
            "givenName": "Srikrishna", 
            "id": "sg:person.01154440104.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154440104.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Center for Biotechnology Information", 
              "id": "https://www.grid.ac/institutes/grid.419234.9", 
              "name": [
                "National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aravind", 
            "givenName": "L.", 
            "id": "sg:person.01106662166.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1006/jsbi.2001.4335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000207821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.68.3.1633-1648.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000912282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11427-012-4322-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000993697", 
              "https://doi.org/10.1007/s11427-012-4322-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2010.07136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001421836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2958.2010.07136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001421836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c1mb05061c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001437973"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nsmb.1856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002123783", 
              "https://doi.org/10.1038/nsmb.1856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13062-015-0066-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002458419", 
              "https://doi.org/10.1186/s13062-015-0066-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13062-015-0066-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002458419", 
              "https://doi.org/10.1186/s13062-015-0066-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2004.06.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002906603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-1878(200002)22:2<124::aid-bies4>3.0.co;2-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002991844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.35.22595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004677537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(00)89105-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005553881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-440x(98)80073-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006171592"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(03)00004-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006918144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0968-0004(03)00004-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006918144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-588-6_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007357774", 
              "https://doi.org/10.1007/978-1-61779-588-6_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/16.9.2473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007541479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373573a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008518821", 
              "https://doi.org/10.1038/373573a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.24818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009523155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/38444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010210236", 
              "https://doi.org/10.1038/38444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/38444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010210236", 
              "https://doi.org/10.1038/38444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010393487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mbio.02327-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010847164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010962604", 
              "https://doi.org/10.1038/32455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010962604", 
              "https://doi.org/10.1038/32455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012068306", 
              "https://doi.org/10.1038/nature722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012068306", 
              "https://doi.org/10.1038/nature722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012248325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00792-014-0725-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012606510", 
              "https://doi.org/10.1007/s00792-014-0725-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.35.22589", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012731106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkv397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013758164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015025248", 
              "https://doi.org/10.1038/nature02129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015025248", 
              "https://doi.org/10.1038/nature02129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2000.3841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015025415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkm1128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016684904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/wrna.1210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017013452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/21.10.2430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017493883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0320227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017826578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bst0320227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017826578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep32070", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018407520", 
              "https://doi.org/10.1038/srep32070"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-7799(94)90081-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019129102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00398-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019202497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.9.9.1743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021086697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1110/ps.9.9.1743", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021086697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jsbi.2001.4398", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021532651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2015.02.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021878290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.3.638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021901623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022420805", 
              "https://doi.org/10.1038/nature02123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022420805", 
              "https://doi.org/10.1038/nature02123"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0021921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026271421"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2014.05.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028027588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028983560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1521-1878(199811)20:11<884::aid-bies3>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029521375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0022-2836(05)80134-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030477247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711589105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030854486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2008.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032185145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.23.4658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032647723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/29.8.1703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033909177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2015.07.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034086581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-biochem-010909-095056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034143727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2010.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034784205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90406-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034861692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m113.501940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035521109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.sbi.2006.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035755485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jsbi.2001.4393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037757495"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.24489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038886742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2003-4-2-r11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039399488", 
              "https://doi.org/10.1186/gb-2003-4-2-r11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0282(1997)43:5<383::aid-bip4>3.0.co;2-r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039994134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(94)90167-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040364375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-0-12-387685-0.00004-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040486131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2002-3-11-research0061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040608000", 
              "https://doi.org/10.1186/gb-2002-3-11-research0061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jsb.2014.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043898845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.7.1427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044919398"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045491167", 
              "https://doi.org/10.1038/nrmicro2261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045491167", 
              "https://doi.org/10.1038/nrmicro2261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.20140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045901500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.14.6881", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046231734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/25.17.3389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047265454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijpara.2007.07.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048177202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048388104", 
              "https://doi.org/10.1186/1471-2105-9-531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.str.2004.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048829607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1999.2827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049990023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/23.21.4229", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050753686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-440x(93)90145-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051930269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-440x(93)90145-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051930269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkn1006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052453917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053671309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar900273t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055151990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ar900273t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055151990"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi8015982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi8015982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209071"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1158868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062457795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.aac7745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062666325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1389203053545444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069179074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2017.1315494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085296056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2017.1363937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091249551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1098928092", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bty041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100672015"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-12", 
        "datePublishedReg": "2018-12-01", 
        "description": "SH3-fold-\u03b2-barrel domains of the chromo-like superfamily recognize epigenetic marks in eukaryotic proteins. Their provenance has been placed either in archaea, based on apparent structural similarity to chromatin-compacting Sul7d and Cren7 proteins, or in bacteria based on the presence of sequence homologs. Using sequence and structural evidence we establish that the archaeal Cren7/Sul7 proteins emerged from a zinc ribbon (ZnR) ancestor. Further, we show that the ancestral eukaryotic chromo-like domains evolved from bacterial versions, likely acquired from early endosymbioses, which already possessed an aromatic cage for recognition of modified amino-groups. These bacterial versions are part of a radiation of secreted SH3-fold domains, which spawned both chromo-like domains and classical SH3 domains in the context of peptide-recognition in the peptidoglycan or the extracellular matrix. This establishes that Cren7/Sul7 converged to a \"SH3\"-like state from a ZnR precursor via the loss of metal-chelation and acquisition of stronger hydrophobic interactions; it is unlikely to have participated in the evolution of the chromo-like domains. We show that archaea possess several Cren7/Sul7-related proteins with intact Zn-chelating ligands, which we predict to play previously unstudied roles in chromosome segregation during cell-division comparable to the PRC barrel and CdvA domain proteins.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-018-24467-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2726065", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes", 
        "pagination": "6196", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9fe3b85a76bc203e85b9353a6db07bc0a13c4ef7fc0ec332701159489e9a34da"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29670199"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-018-24467-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1103361135"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-018-24467-z", 
          "https://app.dimensions.ai/details/publication/pub.1103361135"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000604.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-018-24467-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24467-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24467-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24467-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24467-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    364 TRIPLES      21 PREDICATES      114 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-018-24467-z schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N4765850140544fecbd218656d1419812
    4 schema:citation sg:pub.10.1007/978-1-61779-588-6_1
    5 sg:pub.10.1007/s00792-014-0725-y
    6 sg:pub.10.1007/s11427-012-4322-y
    7 sg:pub.10.1038/32455
    8 sg:pub.10.1038/373573a0
    9 sg:pub.10.1038/38444
    10 sg:pub.10.1038/nature02123
    11 sg:pub.10.1038/nature02129
    12 sg:pub.10.1038/nature722
    13 sg:pub.10.1038/nrmicro2261
    14 sg:pub.10.1038/nsmb.1856
    15 sg:pub.10.1038/srep32070
    16 sg:pub.10.1186/1471-2105-9-531
    17 sg:pub.10.1186/gb-2002-3-11-research0061
    18 sg:pub.10.1186/gb-2003-4-2-r11
    19 sg:pub.10.1186/s13062-015-0066-5
    20 https://app.dimensions.ai/details/publication/pub.1098928092
    21 https://doi.org/10.1002/(sici)1097-0282(1997)43:5<383::aid-bip4>3.0.co;2-r
    22 https://doi.org/10.1002/(sici)1521-1878(199811)20:11<884::aid-bies3>3.0.co;2-h
    23 https://doi.org/10.1002/(sici)1521-1878(200002)22:2<124::aid-bies4>3.0.co;2-e
    24 https://doi.org/10.1002/prot.20140
    25 https://doi.org/10.1002/prot.24489
    26 https://doi.org/10.1002/prot.24818
    27 https://doi.org/10.1002/wrna.1210
    28 https://doi.org/10.1006/jmbi.1999.2827
    29 https://doi.org/10.1006/jmbi.2000.3841
    30 https://doi.org/10.1006/jsbi.2001.4335
    31 https://doi.org/10.1006/jsbi.2001.4393
    32 https://doi.org/10.1006/jsbi.2001.4398
    33 https://doi.org/10.1016/0092-8674(95)90406-9
    34 https://doi.org/10.1016/0167-7799(94)90081-7
    35 https://doi.org/10.1016/0959-440x(93)90145-b
    36 https://doi.org/10.1016/0968-0004(94)90167-8
    37 https://doi.org/10.1016/b978-0-12-387685-0.00004-4
    38 https://doi.org/10.1016/j.ijpara.2007.07.018
    39 https://doi.org/10.1016/j.jsb.2010.05.011
    40 https://doi.org/10.1016/j.jsb.2014.09.001
    41 https://doi.org/10.1016/j.jsb.2015.02.004
    42 https://doi.org/10.1016/j.jsb.2015.07.011
    43 https://doi.org/10.1016/j.sbi.2006.04.006
    44 https://doi.org/10.1016/j.sbi.2008.02.006
    45 https://doi.org/10.1016/j.sbi.2014.05.008
    46 https://doi.org/10.1016/j.str.2004.06.004
    47 https://doi.org/10.1016/j.str.2004.06.014
    48 https://doi.org/10.1016/s0022-2836(05)80134-2
    49 https://doi.org/10.1016/s0959-440x(98)80073-0
    50 https://doi.org/10.1016/s0960-9822(00)00398-5
    51 https://doi.org/10.1016/s0968-0004(00)89105-7
    52 https://doi.org/10.1016/s0968-0004(03)00004-5
    53 https://doi.org/10.1021/ar900273t
    54 https://doi.org/10.1021/bi8015982
    55 https://doi.org/10.1039/c1mb05061c
    56 https://doi.org/10.1042/bst0320227
    57 https://doi.org/10.1073/pnas.0711589105
    58 https://doi.org/10.1073/pnas.93.14.6881
    59 https://doi.org/10.1074/jbc.273.35.22589
    60 https://doi.org/10.1074/jbc.273.35.22595
    61 https://doi.org/10.1074/jbc.m113.501940
    62 https://doi.org/10.1080/15384101.2017.1315494
    63 https://doi.org/10.1080/15384101.2017.1363937
    64 https://doi.org/10.1093/bioinformatics/bty041
    65 https://doi.org/10.1093/emboj/16.9.2473
    66 https://doi.org/10.1093/emboj/21.10.2430
    67 https://doi.org/10.1093/nar/23.21.4229
    68 https://doi.org/10.1093/nar/25.17.3389
    69 https://doi.org/10.1093/nar/27.23.4658
    70 https://doi.org/10.1093/nar/29.3.638
    71 https://doi.org/10.1093/nar/29.8.1703
    72 https://doi.org/10.1093/nar/30.7.1427
    73 https://doi.org/10.1093/nar/gkg161
    74 https://doi.org/10.1093/nar/gki408
    75 https://doi.org/10.1093/nar/gki524
    76 https://doi.org/10.1093/nar/gkm1128
    77 https://doi.org/10.1093/nar/gkn1006
    78 https://doi.org/10.1093/nar/gkr367
    79 https://doi.org/10.1093/nar/gkv397
    80 https://doi.org/10.1110/ps.9.9.1743
    81 https://doi.org/10.1111/j.1365-2958.2010.07136.x
    82 https://doi.org/10.1126/science.1158868
    83 https://doi.org/10.1126/science.aac7745
    84 https://doi.org/10.1128/iai.68.3.1633-1648.2000
    85 https://doi.org/10.1128/mbio.02327-14
    86 https://doi.org/10.1146/annurev-biochem-010909-095056
    87 https://doi.org/10.1371/journal.pone.0021921
    88 https://doi.org/10.2174/1389203053545444
    89 schema:datePublished 2018-12
    90 schema:datePublishedReg 2018-12-01
    91 schema:description SH3-fold-β-barrel domains of the chromo-like superfamily recognize epigenetic marks in eukaryotic proteins. Their provenance has been placed either in archaea, based on apparent structural similarity to chromatin-compacting Sul7d and Cren7 proteins, or in bacteria based on the presence of sequence homologs. Using sequence and structural evidence we establish that the archaeal Cren7/Sul7 proteins emerged from a zinc ribbon (ZnR) ancestor. Further, we show that the ancestral eukaryotic chromo-like domains evolved from bacterial versions, likely acquired from early endosymbioses, which already possessed an aromatic cage for recognition of modified amino-groups. These bacterial versions are part of a radiation of secreted SH3-fold domains, which spawned both chromo-like domains and classical SH3 domains in the context of peptide-recognition in the peptidoglycan or the extracellular matrix. This establishes that Cren7/Sul7 converged to a "SH3"-like state from a ZnR precursor via the loss of metal-chelation and acquisition of stronger hydrophobic interactions; it is unlikely to have participated in the evolution of the chromo-like domains. We show that archaea possess several Cren7/Sul7-related proteins with intact Zn-chelating ligands, which we predict to play previously unstudied roles in chromosome segregation during cell-division comparable to the PRC barrel and CdvA domain proteins.
    92 schema:genre research_article
    93 schema:inLanguage en
    94 schema:isAccessibleForFree true
    95 schema:isPartOf N026c79cdc3954426a3ecfacadd4d10a7
    96 N771d846aa9164885b5667be1ef7232e3
    97 sg:journal.1045337
    98 schema:name Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes
    99 schema:pagination 6196
    100 schema:productId N018025e0be984a1f8ff920244f1ec832
    101 N3be7ce5a8e2446a39552fdab51cb4813
    102 N585dcba8b8ad4b1e85bd502677b0f807
    103 N7e98c2ecbe8b4236856f879f610d511f
    104 N9ba798e348ec46e8ba089e30d66bd05d
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103361135
    106 https://doi.org/10.1038/s41598-018-24467-z
    107 schema:sdDatePublished 2019-04-10T15:14
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher N1826d6f4b4344f4896b06522aa05f843
    110 schema:url https://www.nature.com/articles/s41598-018-24467-z
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N018025e0be984a1f8ff920244f1ec832 schema:name nlm_unique_id
    115 schema:value 101563288
    116 rdf:type schema:PropertyValue
    117 N026c79cdc3954426a3ecfacadd4d10a7 schema:volumeNumber 8
    118 rdf:type schema:PublicationVolume
    119 N1508dd6a9efb45659016c9f240d587da rdf:first sg:person.01106662166.38
    120 rdf:rest rdf:nil
    121 N1826d6f4b4344f4896b06522aa05f843 schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 N3be7ce5a8e2446a39552fdab51cb4813 schema:name doi
    124 schema:value 10.1038/s41598-018-24467-z
    125 rdf:type schema:PropertyValue
    126 N4765850140544fecbd218656d1419812 rdf:first sg:person.01132275734.28
    127 rdf:rest N589e67d51f9047c7abbe0a7bed0f0024
    128 N585dcba8b8ad4b1e85bd502677b0f807 schema:name dimensions_id
    129 schema:value pub.1103361135
    130 rdf:type schema:PropertyValue
    131 N589e67d51f9047c7abbe0a7bed0f0024 rdf:first sg:person.012162224357.20
    132 rdf:rest N60878fb0a47d4de0b12cae9b790a6446
    133 N60878fb0a47d4de0b12cae9b790a6446 rdf:first sg:person.01154440104.53
    134 rdf:rest N1508dd6a9efb45659016c9f240d587da
    135 N771d846aa9164885b5667be1ef7232e3 schema:issueNumber 1
    136 rdf:type schema:PublicationIssue
    137 N7e98c2ecbe8b4236856f879f610d511f schema:name pubmed_id
    138 schema:value 29670199
    139 rdf:type schema:PropertyValue
    140 N9ba798e348ec46e8ba089e30d66bd05d schema:name readcube_id
    141 schema:value 9fe3b85a76bc203e85b9353a6db07bc0a13c4ef7fc0ec332701159489e9a34da
    142 rdf:type schema:PropertyValue
    143 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    144 schema:name Biological Sciences
    145 rdf:type schema:DefinedTerm
    146 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    147 schema:name Genetics
    148 rdf:type schema:DefinedTerm
    149 sg:grant.2726065 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-018-24467-z
    150 rdf:type schema:MonetaryGrant
    151 sg:journal.1045337 schema:issn 2045-2322
    152 schema:name Scientific Reports
    153 rdf:type schema:Periodical
    154 sg:person.01106662166.38 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    155 schema:familyName Aravind
    156 schema:givenName L.
    157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106662166.38
    158 rdf:type schema:Person
    159 sg:person.01132275734.28 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    160 schema:familyName Kaur
    161 schema:givenName Gurmeet
    162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132275734.28
    163 rdf:type schema:Person
    164 sg:person.01154440104.53 schema:affiliation https://www.grid.ac/institutes/grid.417641.1
    165 schema:familyName Subramanian
    166 schema:givenName Srikrishna
    167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154440104.53
    168 rdf:type schema:Person
    169 sg:person.012162224357.20 schema:affiliation https://www.grid.ac/institutes/grid.419234.9
    170 schema:familyName Iyer
    171 schema:givenName Lakshminarayan M.
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162224357.20
    173 rdf:type schema:Person
    174 sg:pub.10.1007/978-1-61779-588-6_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007357774
    175 https://doi.org/10.1007/978-1-61779-588-6_1
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s00792-014-0725-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1012606510
    178 https://doi.org/10.1007/s00792-014-0725-y
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s11427-012-4322-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000993697
    181 https://doi.org/10.1007/s11427-012-4322-y
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/32455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010962604
    184 https://doi.org/10.1038/32455
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/373573a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008518821
    187 https://doi.org/10.1038/373573a0
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/38444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010210236
    190 https://doi.org/10.1038/38444
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nature02123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022420805
    193 https://doi.org/10.1038/nature02123
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature02129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015025248
    196 https://doi.org/10.1038/nature02129
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nature722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012068306
    199 https://doi.org/10.1038/nature722
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nrmicro2261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045491167
    202 https://doi.org/10.1038/nrmicro2261
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nsmb.1856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002123783
    205 https://doi.org/10.1038/nsmb.1856
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/srep32070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018407520
    208 https://doi.org/10.1038/srep32070
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1186/1471-2105-9-531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048388104
    211 https://doi.org/10.1186/1471-2105-9-531
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1186/gb-2002-3-11-research0061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040608000
    214 https://doi.org/10.1186/gb-2002-3-11-research0061
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1186/gb-2003-4-2-r11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039399488
    217 https://doi.org/10.1186/gb-2003-4-2-r11
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1186/s13062-015-0066-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002458419
    220 https://doi.org/10.1186/s13062-015-0066-5
    221 rdf:type schema:CreativeWork
    222 https://app.dimensions.ai/details/publication/pub.1098928092 schema:CreativeWork
    223 https://doi.org/10.1002/(sici)1097-0282(1997)43:5<383::aid-bip4>3.0.co;2-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1039994134
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1002/(sici)1521-1878(199811)20:11<884::aid-bies3>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1029521375
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/(sici)1521-1878(200002)22:2<124::aid-bies4>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1002991844
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/prot.20140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045901500
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1002/prot.24489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038886742
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1002/prot.24818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009523155
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1002/wrna.1210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017013452
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1006/jmbi.1999.2827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049990023
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1006/jmbi.2000.3841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015025415
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1006/jsbi.2001.4335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000207821
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1006/jsbi.2001.4393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037757495
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1006/jsbi.2001.4398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021532651
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/0092-8674(95)90406-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034861692
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/0167-7799(94)90081-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019129102
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/0959-440x(93)90145-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1051930269
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/0968-0004(94)90167-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040364375
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/b978-0-12-387685-0.00004-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040486131
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.ijpara.2007.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048177202
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.jsb.2010.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034784205
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.jsb.2014.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043898845
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.jsb.2015.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021878290
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.jsb.2015.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034086581
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.sbi.2006.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035755485
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.sbi.2008.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032185145
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.sbi.2014.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028027588
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.str.2004.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002906603
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.str.2004.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048829607
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0022-2836(05)80134-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030477247
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/s0959-440x(98)80073-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006171592
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/s0960-9822(00)00398-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019202497
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s0968-0004(00)89105-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005553881
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/s0968-0004(03)00004-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006918144
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1021/ar900273t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055151990
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1021/bi8015982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209071
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1039/c1mb05061c schema:sameAs https://app.dimensions.ai/details/publication/pub.1001437973
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1042/bst0320227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017826578
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.0711589105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030854486
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1073/pnas.93.14.6881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046231734
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1074/jbc.273.35.22589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012731106
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1074/jbc.273.35.22595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004677537
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1074/jbc.m113.501940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035521109
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1080/15384101.2017.1315494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085296056
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1080/15384101.2017.1363937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091249551
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1093/bioinformatics/bty041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100672015
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1093/emboj/16.9.2473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007541479
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/emboj/21.10.2430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017493883
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1093/nar/23.21.4229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050753686
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1093/nar/25.17.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047265454
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1093/nar/27.23.4658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032647723
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1093/nar/29.3.638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021901623
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1093/nar/29.8.1703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033909177
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1093/nar/30.7.1427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044919398
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1093/nar/gkg161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028983560
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1093/nar/gki408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010393487
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1093/nar/gki524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053671309
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1093/nar/gkm1128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016684904
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1093/nar/gkn1006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052453917
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1093/nar/gkr367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012248325
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1093/nar/gkv397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013758164
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1110/ps.9.9.1743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021086697
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1111/j.1365-2958.2010.07136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001421836
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1126/science.1158868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457795
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1126/science.aac7745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062666325
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1128/iai.68.3.1633-1648.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000912282
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1128/mbio.02327-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010847164
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1146/annurev-biochem-010909-095056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034143727
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1371/journal.pone.0021921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026271421
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.2174/1389203053545444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069179074
    358 rdf:type schema:CreativeWork
    359 https://www.grid.ac/institutes/grid.417641.1 schema:alternateName Institute of Microbial Technology
    360 schema:name Bioinformatics Centre, CSIR-Institute of Microbial Technology, Sector 39A, 160036, Chandigarh, India
    361 rdf:type schema:Organization
    362 https://www.grid.ac/institutes/grid.419234.9 schema:alternateName National Center for Biotechnology Information
    363 schema:name National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 20894, Bethesda, MD, USA
    364 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...