Unraveling the compromised biomechanical performance of type 2 diabetes- and Roux-en-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties View Full Text


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Article Info

DATE

2018-04-12

AUTHORS

Carlos Marin, Georgios Papantonakis, Kathleen Sels, G. Harry van Lenthe, Guillaume Falgayrac, Roman Vangoitsenhoven, Bart Van der Schueren, Guillaume Penel, Frank Luyten, Katleen Vandamme, Greet Kerckhofs

ABSTRACT

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility. To achieve this, a combinatory approach including microfocus X-ray computed tomography, 3-point bending, finite element modeling and Raman spectroscopy, was used. Compared to aged-matched lean controls, the obese mice displayed decreased cortical thickness, trabecular bone loss, decreased stiffness and increased Young’s modulus. For the bypass mice, these alterations were even more pronounced, and additionally they showed low mineral-to-matrix ratio in the cortical endosteal area. Accumulation of the advanced glycation end-product (AGE) pentosidine was found in the cortex of obese and bypass groups and this accumulation was correlated with an increased Young’s modulus. In conclusion, we found that the increased fracture risk in T2DM- and post-RYGB bones is mainly driven by accumulation of AGEs and macro-structural alterations, generating biomechanical dysfunctionality. More... »

PAGES

5881

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-018-24229-x

    DOI

    http://dx.doi.org/10.1038/s41598-018-24229-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103229953

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29651097


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    353 schema:name Biomaterials – BIOMAT, Department of Oral Health Sciences, KU Leuven, Leuven, Belgium
    354 Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium
    355 Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    356 Prometheus - Division of Skeletal Tissue Engineering Leuven, KU Leuven, Leuven, Belgium
    357 Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    358 rdf:type schema:Organization
    359 grid-institutes:grid.7942.8 schema:alternateName Biomechanics lab, Institute of Mechanics, Materials, and Civil Engineering, UCLouvain, Louvain-la-Neuve, Belgium
    360 schema:name Biomechanics lab, Institute of Mechanics, Materials, and Civil Engineering, UCLouvain, Louvain-la-Neuve, Belgium
    361 Prometheus - Division of Skeletal Tissue Engineering Leuven, KU Leuven, Leuven, Belgium
    362 Skeletal Biology and Engineering Research Center, Department of Development and Regeneration, KU Leuven, Leuven, Belgium
    363 rdf:type schema:Organization
     




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