Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-11

AUTHORS

Maxime Barbier, Oana Dumitrescu, Catherine Pichat, Gérard Carret, Anne-Sophie Ronnaux-Baron, Ghislaine Blasquez, Christine Godin-Benhaim, Sandrine Boisset, Anne Carricajo, Véronique Jacomo, Isabelle Fredenucci, Michèle Pérouse de Montclos, Charlotte Genestet, Jean-Pierre Flandrois, Florence Ader, Philip Supply, Gérard Lina, Thierry Wirth, Jean-Philippe Rasigade

ABSTRACT

Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200 y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20 y, THD identified a sustained influence of Northern Africa, but not Europe where tuberculosis incidence decreased sharply. Evolving interactions between human populations, thus, measurably influence the local population structure of Mtb. Relevant information on such interactions can be inferred using THD from Mtb genotypes. More... »

PAGES

5855

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6

DOI

http://dx.doi.org/10.1038/s41598-018-24034-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103224858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29643428


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/21", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "History and Archaeology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/2103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Historical Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Africa, Northern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Bacterial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Datasets as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "France", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Migration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Minisatellite Repeats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mycobacterium tuberculosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phylogeography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tuberculosis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratoire Biologie Int\u00e9grative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.424469.9", 
          "name": [
            "Institut de Syst\u00e9matique, Evolution, Biodiversit\u00e9, UMR-CNRS 7205, Mus\u00e9um National d\u2019Histoire Naturelle, Universit\u00e9 Pierre et Marie Curie, Ecole Pratique des Hautes Etudes, Sorbonne Universit\u00e9s, Paris, France", 
            "Laboratoire Biologie Int\u00e9grative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbier", 
        "givenName": "Maxime", 
        "id": "sg:person.0622162173.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622162173.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France", 
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dumitrescu", 
        "givenName": "Oana", 
        "id": "sg:person.01203524444.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203524444.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pichat", 
        "givenName": "Catherine", 
        "id": "sg:person.0775336700.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775336700.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carret", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.01105774657.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105774657.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Comit\u00e9 D\u00e9partemental d\u2019Hygi\u00e8ne Sociale, CLAT69, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Comit\u00e9 D\u00e9partemental d\u2019Hygi\u00e8ne Sociale, CLAT69, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ronnaux-Baron", 
        "givenName": "Anne-Sophie", 
        "id": "sg:person.0652761063.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652761063.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Comit\u00e9 D\u00e9partemental d\u2019Hygi\u00e8ne Sociale, CLAT69, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Comit\u00e9 D\u00e9partemental d\u2019Hygi\u00e8ne Sociale, CLAT69, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blasquez", 
        "givenName": "Ghislaine", 
        "id": "sg:person.013132362523.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013132362523.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Agence R\u00e9gionale de Sant\u00e9 Auvergne-Rh\u00f4ne-Alpes, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Agence R\u00e9gionale de Sant\u00e9 Auvergne-Rh\u00f4ne-Alpes, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Godin-Benhaim", 
        "givenName": "Christine", 
        "id": "sg:person.014373415410.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014373415410.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire TIMC-IMAG, UMR 5525 CNRS-UJF, UFR de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Grenoble, France", 
          "id": "http://www.grid.ac/institutes/grid.450307.5", 
          "name": [
            "Laboratoire de Bact\u00e9riologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France", 
            "Laboratoire TIMC-IMAG, UMR 5525 CNRS-UJF, UFR de M\u00e9decine, Universit\u00e9 Grenoble Alpes, Grenoble, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Boisset", 
        "givenName": "Sandrine", 
        "id": "sg:person.01074116263.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074116263.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire des Agents Infectieux et d\u2019Hygi\u00e8ne, CHU de Saint-Etienne, Saint-Etienne, France", 
          "id": "http://www.grid.ac/institutes/grid.412954.f", 
          "name": [
            "Laboratoire des Agents Infectieux et d\u2019Hygi\u00e8ne, CHU de Saint-Etienne, Saint-Etienne, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carricajo", 
        "givenName": "Anne", 
        "id": "sg:person.0763173455.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763173455.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire Biomnis, Lyon, France", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratoire Biomnis, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacomo", 
        "givenName": "V\u00e9ronique", 
        "id": "sg:person.01206176231.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206176231.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fredenucci", 
        "givenName": "Isabelle", 
        "id": "sg:person.012113614214.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012113614214.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rouse de Montclos", 
        "givenName": "Mich\u00e8le", 
        "id": "sg:person.010212573723.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010212573723.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.462394.e", 
          "name": [
            "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Genestet", 
        "givenName": "Charlotte", 
        "id": "sg:person.01057426707.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057426707.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Biom\u00e9trie et Biologie Evolutive, UMR CNRS 5558, University of Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.25697.3f", 
          "name": [
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
            "Laboratoire de Biom\u00e9trie et Biologie Evolutive, UMR CNRS 5558, University of Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flandrois", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.0746243633.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746243633.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service des Maladies Infectieuses et Tropicales, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413306.3", 
          "name": [
            "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France", 
            "Service des Maladies Infectieuses et Tropicales, H\u00f4pital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ader", 
        "givenName": "Florence", 
        "id": "sg:person.01054316012.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054316012.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille, Lille, France", 
          "id": "http://www.grid.ac/institutes/grid.463727.3", 
          "name": [
            "INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille, Lille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Supply", 
        "givenName": "Philip", 
        "id": "sg:person.0771012421.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771012421.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France", 
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lina", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.01177061631.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177061631.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire Biologie Int\u00e9grative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.424469.9", 
          "name": [
            "Institut de Syst\u00e9matique, Evolution, Biodiversit\u00e9, UMR-CNRS 7205, Mus\u00e9um National d\u2019Histoire Naturelle, Universit\u00e9 Pierre et Marie Curie, Ecole Pratique des Hautes Etudes, Sorbonne Universit\u00e9s, Paris, France", 
            "Laboratoire Biologie Int\u00e9grative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wirth", 
        "givenName": "Thierry", 
        "id": "sg:person.0670605774.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670605774.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France", 
          "id": "http://www.grid.ac/institutes/grid.413852.9", 
          "name": [
            "Institut de Syst\u00e9matique, Evolution, Biodiversit\u00e9, UMR-CNRS 7205, Mus\u00e9um National d\u2019Histoire Naturelle, Universit\u00e9 Pierre et Marie Curie, Ecole Pratique des Hautes Etudes, Sorbonne Universit\u00e9s, Paris, France", 
            "Laboratoire Biologie Int\u00e9grative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France", 
            "Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France", 
            "Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rasigade", 
        "givenName": "Jean-Philippe", 
        "id": "sg:person.01226143321.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226143321.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/srep45326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084133157", 
          "https://doi.org/10.1038/srep45326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047846730", 
          "https://doi.org/10.1038/nature05562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016429632", 
          "https://doi.org/10.1038/ng.2744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-0-387-78189-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043092450", 
          "https://doi.org/10.1007/978-0-387-78189-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012540401", 
          "https://doi.org/10.1038/ng.3704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2180-6-23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013028388", 
          "https://doi.org/10.1186/1471-2180-6-23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.3195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045241239", 
          "https://doi.org/10.1038/ng.3195"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04-11", 
    "datePublishedReg": "2018-04-11", 
    "description": "Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200\u2009y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20\u2009y, THD identified a sustained influence of Northern Africa, but not Europe where tuberculosis incidence decreased sharply. Evolving interactions between human populations, thus, measurably influence the local population structure of Mtb. Relevant information on such interactions can be inferred using THD from Mtb genotypes.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-018-24034-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "human migration", 
      "former French colonies", 
      "global population structure", 
      "French colonies", 
      "historical migration", 
      "commercial exchange", 
      "northern Africa", 
      "sustained influence", 
      "MTB genotypes", 
      "southern Europe", 
      "phylogeographic distribution", 
      "France", 
      "Middle Africa", 
      "Europe", 
      "Africa", 
      "human population", 
      "local population structure", 
      "geographic proximity", 
      "long-term timescales", 
      "population shape", 
      "Eastern", 
      "MTB populations", 
      "migration", 
      "colonies", 
      "population structure", 
      "regional scale", 
      "exchange", 
      "population", 
      "lesser extent", 
      "extent", 
      "proximity", 
      "timescales", 
      "influence", 
      "patterns", 
      "such interactions", 
      "structure", 
      "information", 
      "interaction", 
      "shape", 
      "scale", 
      "relevant information", 
      "tuberculosis", 
      "distribution", 
      "tuberculosis incidence", 
      "technique", 
      "tuberculosis patients", 
      "Mycobacterium tuberculosis", 
      "incidence", 
      "genotypes", 
      "Mtb", 
      "patients", 
      "THD", 
      "density technique"
    ], 
    "name": "Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France", 
    "pagination": "5855", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103224858"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-018-24034-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29643428"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-018-24034-6", 
      "https://app.dimensions.ai/details/publication/pub.1103224858"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_765.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-018-24034-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6'


 

This table displays all metadata directly associated to this object as RDF triples.

358 TRIPLES      21 PREDICATES      99 URIs      84 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-018-24034-6 schema:about N0a94a4d7e22a454499f593acf10fc8e7
2 N0ff2672bdae04128b5b484058f2d0fe8
3 N1caedde2bbb6484c80689dae684d84af
4 N2f946eb6d8f14fee8237b95d5dc7585a
5 N3438a49c871249df8f2a466bff72d31e
6 N40de685cf7974568aaa4216349f649ff
7 N45100ec6d8a14d35915736407055af1c
8 N94c35fd88c8b4933b2d33544b84b8abb
9 Na0644d7f5ef448ee8c18a9472a08c054
10 Nd32dbdbcf6854e1587dcf17174f9ca58
11 Nd83391ef6f734604a75bc76f7beb1082
12 Ne6af07115cb84d728be5be5cc4c25b09
13 Nfba2d87f91d44d8bb4a50a9d79eade17
14 Nfbc73953fb354794a46064bbc4bcd14b
15 anzsrc-for:21
16 anzsrc-for:2103
17 schema:author Naa7a1cff211a455680a87df93e6be5b1
18 schema:citation sg:pub.10.1007/978-0-387-78189-1
19 sg:pub.10.1038/nature05562
20 sg:pub.10.1038/ng.2744
21 sg:pub.10.1038/ng.3195
22 sg:pub.10.1038/ng.3704
23 sg:pub.10.1038/srep45326
24 sg:pub.10.1186/1471-2180-6-23
25 schema:datePublished 2018-04-11
26 schema:datePublishedReg 2018-04-11
27 schema:description Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200 y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20 y, THD identified a sustained influence of Northern Africa, but not Europe where tuberculosis incidence decreased sharply. Evolving interactions between human populations, thus, measurably influence the local population structure of Mtb. Relevant information on such interactions can be inferred using THD from Mtb genotypes.
28 schema:genre article
29 schema:isAccessibleForFree true
30 schema:isPartOf N44a6456c083c48bdbb83ab271ed08767
31 N6929499dc3e242d4b536ef90a3b7f8d7
32 sg:journal.1045337
33 schema:keywords Africa
34 Eastern
35 Europe
36 France
37 French colonies
38 MTB genotypes
39 MTB populations
40 Middle Africa
41 Mtb
42 Mycobacterium tuberculosis
43 THD
44 colonies
45 commercial exchange
46 density technique
47 distribution
48 exchange
49 extent
50 former French colonies
51 genotypes
52 geographic proximity
53 global population structure
54 historical migration
55 human migration
56 human population
57 incidence
58 influence
59 information
60 interaction
61 lesser extent
62 local population structure
63 long-term timescales
64 migration
65 northern Africa
66 patients
67 patterns
68 phylogeographic distribution
69 population
70 population shape
71 population structure
72 proximity
73 regional scale
74 relevant information
75 scale
76 shape
77 southern Europe
78 structure
79 such interactions
80 sustained influence
81 technique
82 timescales
83 tuberculosis
84 tuberculosis incidence
85 tuberculosis patients
86 schema:name Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France
87 schema:pagination 5855
88 schema:productId N90f317c2a8ca4bcbb48be05738bce99a
89 Nae1887f5b76f4e2692962557400acfc3
90 Naf1eed0c2fe946288d7089676d6ca154
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103224858
92 https://doi.org/10.1038/s41598-018-24034-6
93 schema:sdDatePublished 2022-10-01T06:44
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N6918fc4b3557460abeaa19036d3eef8b
96 schema:url https://doi.org/10.1038/s41598-018-24034-6
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N09bf37ba23a040b282b986de406d50c0 rdf:first sg:person.014373415410.97
101 rdf:rest Nd91e1f7a10d14d80a12c6d504ae8403a
102 N0a94a4d7e22a454499f593acf10fc8e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Incidence
104 rdf:type schema:DefinedTerm
105 N0c4dc2a78aa1472e96bf8d8b51761afe rdf:first sg:person.01105774657.78
106 rdf:rest N89d9a37c1702447596f245fbb7ee234b
107 N0ff2672bdae04128b5b484058f2d0fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Phylogeography
109 rdf:type schema:DefinedTerm
110 N1610e18cadf74b8bac921378fd8bbb6d rdf:first sg:person.0775336700.86
111 rdf:rest N0c4dc2a78aa1472e96bf8d8b51761afe
112 N1c2f3913dbc64b8aba4e7de0bc3aa1b0 rdf:first sg:person.012113614214.35
113 rdf:rest N2eaf25e866804d5197cba45f2d4bfa41
114 N1caedde2bbb6484c80689dae684d84af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Cross-Sectional Studies
116 rdf:type schema:DefinedTerm
117 N2146bef0444342318c1e00c0f3c03502 rdf:first sg:person.013132362523.07
118 rdf:rest N09bf37ba23a040b282b986de406d50c0
119 N2eaf25e866804d5197cba45f2d4bfa41 rdf:first sg:person.010212573723.10
120 rdf:rest Nb0f0169d15ae472f8c622953fbae41c2
121 N2f946eb6d8f14fee8237b95d5dc7585a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Tuberculosis
123 rdf:type schema:DefinedTerm
124 N3438a49c871249df8f2a466bff72d31e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Retrospective Studies
126 rdf:type schema:DefinedTerm
127 N40de685cf7974568aaa4216349f649ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N44a6456c083c48bdbb83ab271ed08767 schema:issueNumber 1
131 rdf:type schema:PublicationIssue
132 N45100ec6d8a14d35915736407055af1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Mycobacterium tuberculosis
134 rdf:type schema:DefinedTerm
135 N5b31404981a4424a84a5008b2002f2d4 rdf:first sg:person.0771012421.20
136 rdf:rest Neb240b53a12e45abaf7243b05902c761
137 N5e123f9b4aa64ec8b6e764894e8075d1 rdf:first sg:person.01206176231.14
138 rdf:rest N1c2f3913dbc64b8aba4e7de0bc3aa1b0
139 N6918fc4b3557460abeaa19036d3eef8b schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N6929499dc3e242d4b536ef90a3b7f8d7 schema:volumeNumber 8
142 rdf:type schema:PublicationVolume
143 N826c487756084fc58544c4e620e54cf9 rdf:first sg:person.01054316012.48
144 rdf:rest N5b31404981a4424a84a5008b2002f2d4
145 N89688cbeb79d496397965eef40a13ff6 rdf:first sg:person.0670605774.69
146 rdf:rest Na0a97d12e02b4f82ac16cbcceb53c346
147 N89d9a37c1702447596f245fbb7ee234b rdf:first sg:person.0652761063.63
148 rdf:rest N2146bef0444342318c1e00c0f3c03502
149 N90f317c2a8ca4bcbb48be05738bce99a schema:name dimensions_id
150 schema:value pub.1103224858
151 rdf:type schema:PropertyValue
152 N94c35fd88c8b4933b2d33544b84b8abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Minisatellite Repeats
154 rdf:type schema:DefinedTerm
155 Na0644d7f5ef448ee8c18a9472a08c054 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Africa, Northern
157 rdf:type schema:DefinedTerm
158 Na0a97d12e02b4f82ac16cbcceb53c346 rdf:first sg:person.01226143321.15
159 rdf:rest rdf:nil
160 Naa7a1cff211a455680a87df93e6be5b1 rdf:first sg:person.0622162173.28
161 rdf:rest Nb54e1a43e0764e23a61b27b2196ba0bc
162 Nae1887f5b76f4e2692962557400acfc3 schema:name doi
163 schema:value 10.1038/s41598-018-24034-6
164 rdf:type schema:PropertyValue
165 Naf1eed0c2fe946288d7089676d6ca154 schema:name pubmed_id
166 schema:value 29643428
167 rdf:type schema:PropertyValue
168 Nb0f0169d15ae472f8c622953fbae41c2 rdf:first sg:person.01057426707.21
169 rdf:rest Nb6816cbff18541d8947089c58aa71c98
170 Nb54e1a43e0764e23a61b27b2196ba0bc rdf:first sg:person.01203524444.51
171 rdf:rest N1610e18cadf74b8bac921378fd8bbb6d
172 Nb6816cbff18541d8947089c58aa71c98 rdf:first sg:person.0746243633.02
173 rdf:rest N826c487756084fc58544c4e620e54cf9
174 Nd32dbdbcf6854e1587dcf17174f9ca58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Datasets as Topic
176 rdf:type schema:DefinedTerm
177 Nd83391ef6f734604a75bc76f7beb1082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Human Migration
179 rdf:type schema:DefinedTerm
180 Nd91e1f7a10d14d80a12c6d504ae8403a rdf:first sg:person.01074116263.56
181 rdf:rest Ndc8f9d6a98e346a48ec10e0944fa8e83
182 Ndc8f9d6a98e346a48ec10e0944fa8e83 rdf:first sg:person.0763173455.82
183 rdf:rest N5e123f9b4aa64ec8b6e764894e8075d1
184 Ne6af07115cb84d728be5be5cc4c25b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name France
186 rdf:type schema:DefinedTerm
187 Neb240b53a12e45abaf7243b05902c761 rdf:first sg:person.01177061631.15
188 rdf:rest N89688cbeb79d496397965eef40a13ff6
189 Nfba2d87f91d44d8bb4a50a9d79eade17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name DNA, Bacterial
191 rdf:type schema:DefinedTerm
192 Nfbc73953fb354794a46064bbc4bcd14b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Haplotypes
194 rdf:type schema:DefinedTerm
195 anzsrc-for:21 schema:inDefinedTermSet anzsrc-for:
196 schema:name History and Archaeology
197 rdf:type schema:DefinedTerm
198 anzsrc-for:2103 schema:inDefinedTermSet anzsrc-for:
199 schema:name Historical Studies
200 rdf:type schema:DefinedTerm
201 sg:journal.1045337 schema:issn 2045-2322
202 schema:name Scientific Reports
203 schema:publisher Springer Nature
204 rdf:type schema:Periodical
205 sg:person.010212573723.10 schema:affiliation grid-institutes:grid.413852.9
206 schema:familyName Pérouse de Montclos
207 schema:givenName Michèle
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010212573723.10
209 rdf:type schema:Person
210 sg:person.01054316012.48 schema:affiliation grid-institutes:grid.413306.3
211 schema:familyName Ader
212 schema:givenName Florence
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054316012.48
214 rdf:type schema:Person
215 sg:person.01057426707.21 schema:affiliation grid-institutes:grid.462394.e
216 schema:familyName Genestet
217 schema:givenName Charlotte
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057426707.21
219 rdf:type schema:Person
220 sg:person.01074116263.56 schema:affiliation grid-institutes:grid.450307.5
221 schema:familyName Boisset
222 schema:givenName Sandrine
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074116263.56
224 rdf:type schema:Person
225 sg:person.01105774657.78 schema:affiliation grid-institutes:grid.413852.9
226 schema:familyName Carret
227 schema:givenName Gérard
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105774657.78
229 rdf:type schema:Person
230 sg:person.01177061631.15 schema:affiliation grid-institutes:grid.413852.9
231 schema:familyName Lina
232 schema:givenName Gérard
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177061631.15
234 rdf:type schema:Person
235 sg:person.01203524444.51 schema:affiliation grid-institutes:grid.413852.9
236 schema:familyName Dumitrescu
237 schema:givenName Oana
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203524444.51
239 rdf:type schema:Person
240 sg:person.01206176231.14 schema:affiliation grid-institutes:None
241 schema:familyName Jacomo
242 schema:givenName Véronique
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206176231.14
244 rdf:type schema:Person
245 sg:person.012113614214.35 schema:affiliation grid-institutes:grid.413852.9
246 schema:familyName Fredenucci
247 schema:givenName Isabelle
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012113614214.35
249 rdf:type schema:Person
250 sg:person.01226143321.15 schema:affiliation grid-institutes:grid.413852.9
251 schema:familyName Rasigade
252 schema:givenName Jean-Philippe
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226143321.15
254 rdf:type schema:Person
255 sg:person.013132362523.07 schema:affiliation grid-institutes:None
256 schema:familyName Blasquez
257 schema:givenName Ghislaine
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013132362523.07
259 rdf:type schema:Person
260 sg:person.014373415410.97 schema:affiliation grid-institutes:None
261 schema:familyName Godin-Benhaim
262 schema:givenName Christine
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014373415410.97
264 rdf:type schema:Person
265 sg:person.0622162173.28 schema:affiliation grid-institutes:grid.424469.9
266 schema:familyName Barbier
267 schema:givenName Maxime
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622162173.28
269 rdf:type schema:Person
270 sg:person.0652761063.63 schema:affiliation grid-institutes:None
271 schema:familyName Ronnaux-Baron
272 schema:givenName Anne-Sophie
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652761063.63
274 rdf:type schema:Person
275 sg:person.0670605774.69 schema:affiliation grid-institutes:grid.424469.9
276 schema:familyName Wirth
277 schema:givenName Thierry
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670605774.69
279 rdf:type schema:Person
280 sg:person.0746243633.02 schema:affiliation grid-institutes:grid.25697.3f
281 schema:familyName Flandrois
282 schema:givenName Jean-Pierre
283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746243633.02
284 rdf:type schema:Person
285 sg:person.0763173455.82 schema:affiliation grid-institutes:grid.412954.f
286 schema:familyName Carricajo
287 schema:givenName Anne
288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763173455.82
289 rdf:type schema:Person
290 sg:person.0771012421.20 schema:affiliation grid-institutes:grid.463727.3
291 schema:familyName Supply
292 schema:givenName Philip
293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771012421.20
294 rdf:type schema:Person
295 sg:person.0775336700.86 schema:affiliation grid-institutes:grid.413852.9
296 schema:familyName Pichat
297 schema:givenName Catherine
298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775336700.86
299 rdf:type schema:Person
300 sg:pub.10.1007/978-0-387-78189-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043092450
301 https://doi.org/10.1007/978-0-387-78189-1
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/nature05562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047846730
304 https://doi.org/10.1038/nature05562
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/ng.2744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016429632
307 https://doi.org/10.1038/ng.2744
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/ng.3195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045241239
310 https://doi.org/10.1038/ng.3195
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/ng.3704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012540401
313 https://doi.org/10.1038/ng.3704
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/srep45326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084133157
316 https://doi.org/10.1038/srep45326
317 rdf:type schema:CreativeWork
318 sg:pub.10.1186/1471-2180-6-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013028388
319 https://doi.org/10.1186/1471-2180-6-23
320 rdf:type schema:CreativeWork
321 grid-institutes:None schema:alternateName Agence Régionale de Santé Auvergne-Rhône-Alpes, Lyon, France
322 Comité Départemental d’Hygiène Sociale, CLAT69, Lyon, France
323 Laboratoire Biomnis, Lyon, France
324 schema:name Agence Régionale de Santé Auvergne-Rhône-Alpes, Lyon, France
325 Comité Départemental d’Hygiène Sociale, CLAT69, Lyon, France
326 Laboratoire Biomnis, Lyon, France
327 rdf:type schema:Organization
328 grid-institutes:grid.25697.3f schema:alternateName Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558, University of Lyon, Lyon, France
329 schema:name Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France
330 Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558, University of Lyon, Lyon, France
331 rdf:type schema:Organization
332 grid-institutes:grid.412954.f schema:alternateName Laboratoire des Agents Infectieux et d’Hygiène, CHU de Saint-Etienne, Saint-Etienne, France
333 schema:name Laboratoire des Agents Infectieux et d’Hygiène, CHU de Saint-Etienne, Saint-Etienne, France
334 rdf:type schema:Organization
335 grid-institutes:grid.413306.3 schema:alternateName Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
336 schema:name Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France
337 Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France
338 rdf:type schema:Organization
339 grid-institutes:grid.413852.9 schema:alternateName Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France
340 schema:name Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France
341 Institut de Systématique, Evolution, Biodiversité, UMR-CNRS 7205, Muséum National d’Histoire Naturelle, Université Pierre et Marie Curie, Ecole Pratique des Hautes Etudes, Sorbonne Universités, Paris, France
342 Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France
343 Laboratoire Biologie Intégrative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France
344 rdf:type schema:Organization
345 grid-institutes:grid.424469.9 schema:alternateName Laboratoire Biologie Intégrative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France
346 schema:name Institut de Systématique, Evolution, Biodiversité, UMR-CNRS 7205, Muséum National d’Histoire Naturelle, Université Pierre et Marie Curie, Ecole Pratique des Hautes Etudes, Sorbonne Universités, Paris, France
347 Laboratoire Biologie Intégrative des Populations, Ecole Pratique des Hautes Etudes, PSL Research University, Paris, France
348 rdf:type schema:Organization
349 grid-institutes:grid.450307.5 schema:alternateName Laboratoire TIMC-IMAG, UMR 5525 CNRS-UJF, UFR de Médecine, Université Grenoble Alpes, Grenoble, France
350 schema:name Laboratoire TIMC-IMAG, UMR 5525 CNRS-UJF, UFR de Médecine, Université Grenoble Alpes, Grenoble, France
351 Laboratoire de Bactériologie, Institut de Biologie et de Pathologie, CHU de Grenoble, Grenoble, France
352 rdf:type schema:Organization
353 grid-institutes:grid.462394.e schema:alternateName Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France
354 schema:name Centre International de Recherche en Infectiologie, CIRI, University of Lyon, Lyon, France
355 rdf:type schema:Organization
356 grid-institutes:grid.463727.3 schema:alternateName INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, Lille, France
357 schema:name INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, Lille, France
358 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...