Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-11

AUTHORS

Maxime Barbier, Oana Dumitrescu, Catherine Pichat, Gérard Carret, Anne-Sophie Ronnaux-Baron, Ghislaine Blasquez, Christine Godin-Benhaim, Sandrine Boisset, Anne Carricajo, Véronique Jacomo, Isabelle Fredenucci, Michèle Pérouse de Montclos, Charlotte Genestet, Jean-Pierre Flandrois, Florence Ader, Philip Supply, Gérard Lina, Thierry Wirth, Jean-Philippe Rasigade

ABSTRACT

Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200 y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20 y, THD identified a sustained influence of Northern Africa, but not Europe where tuberculosis incidence decreased sharply. Evolving interactions between human populations, thus, measurably influence the local population structure of Mtb. Relevant information on such interactions can be inferred using THD from Mtb genotypes. More... »

PAGES

5855

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-018-24034-6

DOI

http://dx.doi.org/10.1038/s41598-018-24034-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103224858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29643428


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356 grid-institutes:grid.463727.3 schema:alternateName INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, Lille, France
357 schema:name INSERM U1019, CNRS-UMR 8204, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, Université de Lille, Lille, France
358 rdf:type schema:Organization
 




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